minocycline and ferrous-sulfate

Serum concentrations of tetracycline hydrochloride and minocycline hydrochloride were compared when administered with water, milk, a meal, and 300 mg ferrous sulfate in two groups of eight volunteers. Absorption of both antibiotics was significantly decreased by administration with iron (77% inhibition with minocycline and 81% with tetracycline), milk (27% inhibition with minocycline, 65% with tetracycline), and food (13% inhibition with minocycline and 46% with tetracycline). The inhibitory effect on absorption with food and milk was significantly greater for tetracycline than for minocycline.

Topics: Animals; Delayed-Action Preparations; Ferrous Compounds; Food; Humans; Intestinal Absorption; Iron; Milk; Minocycline; Tetracycline; Tetracyclines; Time Factors