minocycline and cefuzonam

The Antibacterial activity of minocycline (MINO) and that of cefuzonam (CZON) were assessed with clinical isolates of 19 species, and compared with that of other antibiotics. MINO was highly active against methicilli-sensitive Staphylococcus aureus (MSSA), Neisseria gonorrhoeae, Moraxella (Branhamella) catarrhalis, Haemophilus influenzae, Helicobacter pylori, Flavobacterium meningosepticum, Acinetobacter calcoaceticus, Peptostreptococcus spp. and Propionibacterium acnes, but not as effective against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas cepacia and Alcaligenes xylosoxidans. CZON was highly active against MSSA, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, N. Gonorrhoeae, M(B). catarrhalis, H. influenzae, H. pylori, P. mirabilis, Peptostreptococcus spp. and P. acnes, but not effective against MRSA. It was minimally active against Gram-negative rods (E. coli, K. pneumoniae, etc.) and bacteria that do not ferment glucose.

Topics: Bacteria; Ceftizoxime; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Minocycline; Staphylococcus aureus

We performed an in vitro assessment of the antibacterial activity of therapy with cefuzonam (CZON) plus minocycline (MINO) against methicillin-resistant Staphylococcus aures (MRSA) infections. 1. Studies using MINO-susceptible and MINO-resistant MRSA strains suggested that the antibacterial activity of CZON + MINO was dependent on the antibiotic action of MINO, similarly to the case with cefotiam (CTM) + MINO. 2. The antibacterial activity (including the FIC index) of this combination was slightly inferior to that of CTM + MINO. However, the time course of antibacterial efficacy of CZON + MINO in MRSA pretreated with MINO was comparable to that of CTM + MINO. 3. CZON + MINO appeared to be a very useful combination in patients with mixed infections due to MRSA and Gram-negative bacteria.

Topics: Ceftizoxime; Drug Therapy, Combination; Methicillin Resistance; Minocycline; Staphylococcus aureus

The influence of Mueller-Hinton (MH) broth (from BBL Microbiology Systems, and Difco Laboratories) of minimum inhibitory concentrations (MIC) of cefuzoname (CZON), flomoxef (FMOX), imipenem (IPM), and minocycline (MINO) for 100 strains of Staphylococcus aureus was investigated. Antibacterial activity of MINO was stronger than any other antibiotics. MICs of CZON for 16 strains (14 of 50 methicillin-resistant S. aureus (MRSA), 2 of 50 methicillin-sensitive S. aureus) were greater than or equal to 4-fold greater when tested in BBL MH broth than when tested in Difco MH broth, thus, different media altered categories of some strains (8 of 50 MRSA) from susceptible to resistant. MICs of FMOX in the BBL MH broth for 12 of 50 MRSA strains rose greater than or equal to 4-fold compared to the Difco MH broth. On the other hand, MICs of IPM and MINO were affected very little by the different brand of MH broth used.

Topics: Ceftizoxime; Cephalosporins; Culture Media; Drug Resistance, Microbial; Imipenem; Minocycline; Staphylococcus aureus; Tetracyclines