minalrestat has been researched along with sorbinil in 3 studies
| Studies (minalrestat) | Trials (minalrestat) | Recent Studies (post-2010) (minalrestat) | Studies (sorbinil) | Trials (sorbinil) | Recent Studies (post-2010) (sorbinil) |
|---|---|---|---|---|---|
| 9 | 0 | 1 | 500 | 44 | 43 |
| Protein | Taxonomy | minalrestat (IC50) | sorbinil (IC50) |
|---|---|---|---|
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 5.05 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.8698 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.5 | |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 5.1333 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 1.3166 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 3.04 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 1.7292 | |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | 2.95 | |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | 0.8845 | |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | 1.1 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M | 1 |
| Dhagat, U; El-Kabbani, O; Endo, S; Hara, A | 1 |
| El-Kabbani, O; Endo, S; Hara, A; Kitade, Y; Kuwata, K; Matsunaga, T; Zhao, HT | 1 |
3 other study(ies) available for minalrestat and sorbinil
| Article | Year |
|---|---|
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics | 2007 |
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Animals; Binding Sites; Enzyme Inhibitors; Mice; Models, Molecular; Protein Binding; Substrate Specificity | 2008 |
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.
Topics: Aldehyde Reductase; Aldehydes; Aldo-Keto Reductases; Antineoplastic Agents; Benzopyrans; Biomarkers, Tumor; Catalytic Domain; Computer Simulation; Databases, Factual; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesol; HeLa Cells; Humans; Kinetics; Models, Molecular; Protein Binding; Recombinant Proteins; Substrate Specificity | 2010 |