miltiradiene has been researched along with geranylgeraniol* in 1 studies
1 other study(ies) available for miltiradiene and geranylgeraniol
| Article | Year |
|---|---|
Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast.
Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene compounds with significant pharmacological activity, including triptolide, tanshinones, carnosic acid and carnosol. Sufficient accumulation of miltiradiene is vital for the production of these medicinal compounds. In this study, comprehensive engineering strategies were applied to construct a high-yielding miltiradiene producing yeast strain. First, a chassis strain that can accumulate 2.1 g L Topics: Biosynthetic Pathways; Computer Simulation; CRISPR-Cas Systems; Diterpenes; Fermentation; Metabolic Engineering; Metabolic Networks and Pathways; Mutant Chimeric Proteins; Mutation; Plasmids; Saccharomyces cerevisiae; Terpenes | 2020 |