miltefosine has been researched along with edelfosine in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.33) | 18.7374 |
| 1990's | 21 (35.00) | 18.2507 |
| 2000's | 22 (36.67) | 29.6817 |
| 2010's | 12 (20.00) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banfi, P; Borras, L; Carganico, G; Fos, E; Gambetta, RA; Lobato, C; Mauleón, D; Suesa, N; Zunino, F | 1 |
| Bartolmäs, T; Danker, K; Fischer, A; Heyn, T; Mickeleit, M; Reutter, W | 1 |
| Andresen, TL; Jensen, SS; Jørgensen, K; Madsen, R | 1 |
| Jolliffe, KA; Obando, D; Sorrell, TC; Widmer, F; Wright, LC | 1 |
| Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pérez-Victoria, JM | 1 |
| Alzate, JF; Arias, A; de la Iglesia-Vicente, J; Jiménez-Ruiz, A; Mollinedo, F; Rico, E | 1 |
| Baquedano, Y; Font, M; Jiménez-Ruiz, A; Moreno-Mateos, D; Palop, JA; Plano, D; Sanmartín, C | 1 |
| Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H | 1 |
| Baquedano, Y; Espuelas, S; Font, M; Gutierrez, KJ; Jiménez-Ruiz, A; Moreno, E; Nguewa, P; Palop, JA; Sanmartín, C | 1 |
| Camarasa, MJ; Carneiro, FAC; de Castro, S; de Lucio, H; Gago, F; Gutiérrez, KJ; Jiménez-Ruiz, A; Ruiz-Santaquiteria, M; Sánchez-Murcia, PA; Toro, MA; Velázquez, S | 1 |
| Camarasa, MJ; de Castro, S; de Lucio, H; Gago, F; Gutiérrez, KJ; Jiménez, MÁ; Jiménez-Ruiz, A; Ruiz-Santaquiteria, M; Sánchez-Murcia, PA; Toro, MA; Velázquez, S | 1 |
| Angeli, A; Azqueta, A; Carta, F; Espuelas, S; Etxebeste-Mitxeltorena, M; Moreno, E; Parkkila, S; Sanmartín, C; Supuran, CT | 1 |
| Antonio Palop, J; Espuelas, S; Etxebeste-Mitxeltorena, M; Garnica, P; Jiménez-Ruiz, A; Moreno, E; Plano, D; Sanmartín, C | 1 |
| Eibl, H; Kötting, J; Marschner, NW; Neumüller, W; Unger, C | 1 |
| Fleer, EA; Kaufmann-Kolle, P | 1 |
| Eibl, H; Kötting, J; Marschner, NW; Unger, C | 1 |
| Eibl, H; Kötting, J; Marschner, N; Unger, C | 1 |
| Berkovic, D; Doenecke, D; Eibl, H; Hochhuth, C; Unger, C | 1 |
| Eibl, H; Fleer, EA; Kuo, JF; Raynor, RL; Shoji, M; Vogler, WR | 1 |
| Bauer, S; Remmele, T; Stricker, H; Sturm, V; Wowra, B; Zeller, WJ | 1 |
| Eibl, H; Kim, DJ; Nagel, GA; Unger, C; Vehmeyer, K | 1 |
| Berger, MR; Scherf, HR; Schmähl, D; Schuler, B | 1 |
| Geilen, CC; Haase, A; Orfanos, CE; Wieder, T | 1 |
| Bruyneel, EA; Mareel, MM; Steelant, WF; Van den Eeckhout, EG | 1 |
| Berkovic, D; Berkovic, K; Eibl, H; Fleer, EA; Unger, C | 1 |
| Berkovic, D; Fleer, EA; Grunwald, U; Hiddemann, W | 1 |
| Croft, SL; Snowdon, D; Yardley, V | 1 |
| van Heugten, HG; Verdonck, LF | 1 |
| Boggs, K; Jackowski, S; Rock, CO | 1 |
| Berkovic, D; Fleer, EA; Hiddemann, W; Kuduz, J | 1 |
| Arthur, G; Bittman, R | 1 |
| Civoli, F; Daniel, LW | 1 |
| Berkovic, D | 1 |
| Grosman, N | 1 |
| Bartelink, H; Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 2 |
| de Castro, SL; Meirelles, MN; Santa-Rita, RM; Santos Barbosa, H | 1 |
| Hart, D; Heise, N; Klenner, T; Lux, H; Opperdoes, FR | 1 |
| Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 1 |
| Castanys, S; Gamarro, F; Jiménez, IA; Parodi-Talice, A; Pérez-Victoria, FJ; Pérez-Victoria, JM; Ravelo, AG | 1 |
| Croft, SL; Escobar, P; Marques, C; Matu, S | 1 |
| Croft, SL; Duchêne, M; Seifert, K | 1 |
| Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW | 1 |
| Castanys, S; Gamarro, F; Ouellette, M; Pérez-Victoria, FJ | 1 |
| Barbosa, HS; de Castro, SL; Henriques-Pons, A; Santa-Rita, RM | 1 |
| Azzouz, S; Garcia, RG; Maache, M; Osuna, A | 1 |
| Henriquez, FL; Ingram, PR; McBride, J; Roberts, CW | 1 |
| Barbosa, HS; de Castro, SL; Lira, R; Santa-Rita, RM; Urbina, JA | 1 |
| Azzouz, S; Dos Santos, MF; Maache, M; Osuna, A; Petavy, AF; Sarciron, ME | 1 |
| Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T | 1 |
| Azzouz, S; Maache, M; Osuna, A; Petavy, AF; Sánchez-Moreno, M | 1 |
| Cabrera-Serra, MG; Piñero, JE; Valladares, B | 1 |
| van Blitterswijk, WJ; Verheij, M | 1 |
| Acuña, AU; Castro, BM; Delgado, J; Fedorov, A; Hornillos, V; Mollinedo, F; Prieto, M | 1 |
| Dakir, EL; Dakir, el H; López-Abán, J; Mollinedo, F; Muro, A; Varela-M, RE; Yepes, E | 1 |
| Cabello, J; Mohler, WA; Mollinedo, F; Reis-Sobreiro, M; Rodríguez-Matellán, AG; Sáenz-Narciso, B; Sánchez-Blanco, A | 1 |
| Gajate, C; Legarda-Ceballos, AL; López-Abán, J; Mollinedo, F; Muro, A; Rojas-Caraballo, J; Ruano, AL; Yepes, E | 1 |
| Chen, M; Iovanna, JL; Lan, W; Liu, X; Luo, B; Peng, L; Xia, Y; Zhou, Z | 1 |
| Aslanidis, C; Buechler, C | 1 |
| Bajorath, J; Batista, J; Braxmeier, T; Friedrichson, T; Jennings, G; Schlechtingen, G | 1 |
6 review(s) available for miltefosine and edelfosine
| Article | Year |
|---|---|
The inhibition of cell signaling pathways by antitumor ether lipids.
Topics: Animals; Antineoplastic Agents; Calcium; Furans; Humans; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Receptors, Cell Surface; Signal Transduction | 1998 |
Cytotoxic etherphospholipid analogues.
Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; In Vitro Techniques; Phospholipid Ethers; Phosphorylcholine | 1998 |
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
Topics: Antineoplastic Agents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Signal Transduction | 2001 |
Antiprotozoal activities of phospholipid analogues.
Topics: Animals; Antiprotozoal Agents; Leishmania; Parasitic Sensitivity Tests; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Structure-Activity Relationship; Trypanosoma | 2003 |
Anticancer mechanisms and clinical application of alkylphospholipids.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; Organophosphates; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Quaternary Ammonium Compounds; Signal Transduction | 2013 |
Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Diagnosis, Differential; Disease Models, Animal; Disease Progression; Humans; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; Liver Neoplasms; Oxidative Stress; Phospholipid Ethers; Phosphorylcholine; Plasmalogens; Severity of Illness Index | 2020 |
54 other study(ies) available for miltefosine and edelfosine
| Article | Year |
|---|---|
Synthesis of alkyl chain-modified ether lipids and evaluation of their in vitro cytotoxicity.
Topics: Animals; Cell Division; Cell Survival; Chemical Phenomena; Chemistry, Physical; Growth Inhibitors; Hemolysis; Humans; In Vitro Techniques; Lysophospholipids; Platelet Activating Factor; Rabbits; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Glucosamine-glycerophospholipids that activate cell-matrix adhesion and migration.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Glucosamine; Glycerophospholipids; Glycolipids; Humans; Structure-Activity Relationship | 2005 |
Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Ethers; Humans; Lipids; Liposomes; Phospholipases A; Phospholipases A2; Phosphorylation; Prodrugs; Proto-Oncogene Proteins c-akt; Stereoisomerism; Structure-Activity Relationship | 2005 |
Synthesis, antifungal and antimicrobial activity of alkylphospholipids.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Erythrocytes; Fungi; Molecular Structure; Phospholipids; Structure-Activity Relationship | 2007 |
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic | 2008 |
Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Leishmania infantum; Membrane Potential, Mitochondrial; Phospholipid Ethers; Phosphorylcholine; Recombinant Proteins; Transfection | 2008 |
Selenocyanates and diselenides: a new class of potent antileishmanial agents.
Topics: Aminophenols; Animals; Antiprotozoal Agents; Cell Line, Tumor; Cyanates; Humans; Inhibitory Concentration 50; Leishmania infantum; Leishmaniasis, Visceral; Life Cycle Stages; Monocytes; Neoplasms; Phospholipid Ethers; Phosphorylcholine; Selenium Compounds; Structure-Activity Relationship | 2011 |
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Neoplasms; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt | 2013 |
Novel hybrid selenosulfonamides as potent antileishmanial agents.
Topics: Antiprotozoal Agents; Leishmania donovani; Leishmania infantum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Selenium; Sulfonamides | 2014 |
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity
Topics: Antiprotozoal Agents; Cell Proliferation; Cells, Cultured; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Leishmania infantum; Molecular Dynamics Simulation; Molecular Structure; NADH, NADPH Oxidoreductases; Peptides; Structure-Activity Relationship | 2017 |
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.
Topics: Antiprotozoal Agents; Drug Stability; Hydrocarbons; Leishmania infantum; NADH, NADPH Oxidoreductases; Peptides; Protein Conformation, alpha-Helical; Proteolysis; Protozoan Proteins | 2018 |
Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Dose-Response Relationship, Drug; Female; Jejunum; Leishmania donovani; Organ Culture Techniques; Rats; Rats, Wistar; Sulfonamides; Trypanocidal Agents | 2020 |
Pre-clinical evidences of the antileishmanial effects of diselenides and selenocyanates.
Topics: Antiprotozoal Agents; Cell Survival; Cyanates; Drug Evaluation, Preclinical; Humans; Leishmania infantum; NADH, NADPH Oxidoreductases; Parasitic Sensitivity Tests; Protozoan Proteins; Selenium Compounds; Structure-Activity Relationship; THP-1 Cells | 2020 |
Hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine: a comparison of hemolytic activity, serum binding and tissue distribution.
Topics: Animals; Antineoplastic Agents; Female; Hemolysis; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Tissue Distribution | 1992 |
Morphological changes of adherent and nonadherent cells by treatment with hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine observed by scanning electron microscopy.
Topics: Antineoplastic Agents; Cell Adhesion; Humans; Microscopy, Electron, Scanning; Phospholipid Ethers; Phosphorylcholine; Tumor Cells, Cultured | 1992 |
Determination of alkylphosphocholines and of alkyl-glycero-phosphocholines in biological fluids and tissues.
Topics: Animals; Antineoplastic Agents; Body Fluids; Female; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Viscera | 1992 |
Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Densitometry; Drug Administration Schedule; Female; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 1992 |
Effects of antineoplastic phospholipids on parameters of cell differentiation in U937 cells.
Topics: Antigens, Surface; Antineoplastic Agents; Blotting, Northern; Cell Transformation, Neoplastic; DNA Probes; Fatty Alcohols; Gene Expression Regulation, Neoplastic; Histones; Leukemia, Promyelocytic, Acute; Lysophosphatidylcholines; Phorbol Esters; Phospholipid Ethers; Phospholipids; Phosphorylcholine; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate | 1990 |
Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells.
Topics: Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Phospholipid Ethers; Phosphoproteins; Phosphorylation; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Interstitial chemotherapy of experimental gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Glioma; Humans; Injections, Intralesional; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Phospholipid Ethers; Phosphorylcholine; Polyesters; Rats; Rats, Inbred Strains | 1990 |
Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Female; Hematopoietic Stem Cells; Leukocyte Count; Lysophosphatidylcholines; Mice; Phospholipid Ethers; Phosphorylcholine | 1989 |
Therapeutic activity of ET-18-OCH3 and hexadecylphosphocholine against mammary tumors in BD-VI rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Choline; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Male; Mammary Neoplasms, Experimental; Phospholipid Ethers; Phosphorylcholine; Rats | 1987 |
The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Cell Division; Cell Line; Choline-Phosphate Cytidylyltransferase; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine | 1995 |
Capillary gas chromatography of hexadecylphosphocholine in Caco-2T cells and cell culture media.
Topics: Antineoplastic Agents; Cell Death; Chromatography, Gas; Chromatography, Ion Exchange; Culture Media; Dose-Response Relationship, Drug; Humans; Phospholipid Ethers; Phosphorylcholine; Trimethylsilyl Compounds; Tumor Cells, Cultured | 1995 |
Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines.
Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Humans; Leukemia; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Induction of resistance to hexadecylphosphocholine in the highly sensitive human epidermoid tumour cell line KB.
Topics: Antineoplastic Agents; Choline; Drug Resistance, Neoplasm; Humans; Inositol; KB Cells; Phospholipid Ethers; Phosphorylcholine | 1996 |
The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei.
Topics: Animals; Antineoplastic Agents; Chagas Disease; Cricetinae; Female; Furans; Leishmania donovani; Leishmaniasis, Visceral; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1996 |
Ether lipids are effective cytotoxic drugs against multidrug-resistant acute leukemia cells and can act by the induction of apoptosis.
Topics: Adult; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Phospholipid Ethers; Phosphorylcholine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Stem Cell Assay | 1997 |
The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Recombinant Proteins | 1998 |
Expression of two 50 kDa proteins is associated with sensitivity towards etherlipid analogues in the human leukaemia cell line HL 60.
Topics: Antineoplastic Agents; Cell Differentiation; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Neoplasm Proteins; Phospholipid Ethers; Phosphorylcholine | 1997 |
Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Survival; Culture Media, Serum-Free; Drug Resistance; Enzyme Activation; Furans; HL-60 Cells; Humans; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1998 |
Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Enzyme Inhibitors; Gallic Acid; Imidazoles; Leukocytes; Male; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Staurosporine; Synaptosomes | 1998 |
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Endothelium, Vascular; Gamma Rays; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Signal Transduction; U937 Cells | 1999 |
Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Life Cycle Stages; Lysophospholipids; Macrophages; Mice; Microscopy, Electron; Phospholipid Ethers; Phosphorylcholine; Temperature; Time Factors; Trypanosoma cruzi | 2000 |
Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.
Topics: Acylation; Acyltransferases; Alcohol Oxidoreductases; Alkyl and Aryl Transferases; Animals; Antiprotozoal Agents; Leishmania mexicana; Microbodies; Phospholipid Ethers; Phosphorylcholine | 2000 |
Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.
Topics: Animals; Antibiotics, Antineoplastic; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Daunorubicin; Drug Resistance, Multiple; Fluorescence; Humans; Leishmania tropica; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine | 2001 |
Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B.
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania; Macrophages, Peritoneal; Mice; Phospholipid Ethers; Phosphorylcholine; Species Specificity | 2002 |
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.
Topics: Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Growth Inhibitors; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2003 |
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Dose-Response Relationship, Drug; Drug Resistance; Drug Resistance, Multiple; Endocytosis; Gene Deletion; Ketoconazole; Leishmaniasis; Lipid Metabolism; Lysophosphatidylcholines; Membrane Transport Proteins; Microscopy, Fluorescence; Mutation; Nuclear Envelope; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Point Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors | 2003 |
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.
Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Animals; Antiprotozoal Agents; Biological Transport; Blotting, Southern; Carrier Proteins; Cell Membrane; Chromosome Mapping; Cloning, Molecular; Cosmids; Dose-Response Relationship, Drug; Drug Resistance; Genotype; Immunoblotting; Leishmania donovani; Membrane Proteins; Membrane Transport Proteins; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Phenotype; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipid Transfer Proteins; Phosphorylcholine; Plasmids; Point Mutation; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2003 |
Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis.
Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Inhibitory Concentration 50; Leishmania; Lysophospholipids; Macrophages, Peritoneal; Mice; Microscopy, Electron; Phospholipid Ethers; Phosphorylcholine | 2004 |
Leishmanicidal activity of edelfosine, miltefosine and ilmofosine.
Topics: Animals; Antiprotozoal Agents; Cell Line; DNA, Protozoan; Flow Cytometry; Leishmania donovani; Mice; Phospholipid Ethers; Phosphorylcholine; Protozoan Proteins; RNA, Protozoan | 2005 |
Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba.
Topics: Acanthamoeba; Acanthamoeba castellanii; Amebicides; Animals; Chlorhexidine; Colony Count, Microbial; Colorimetry; Culture Media; Indicators and Reagents; Oxazines; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Xanthenes | 2005 |
Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis.
Topics: Animals; Chlorocebus aethiops; Drug Synergism; Drug Therapy, Combination; Ergosterol; Ketoconazole; Lysophospholipids; Microscopy, Electron; Microscopy, Electron, Scanning; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2005 |
Aspects of the cytological activity of edelfosine, miltefosine, and ilmofosine in Leishmania donovani.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Cycle; Cell Line; Cricetinae; Female; Humans; Hydrogen-Ion Concentration; Leishmania donovani; Macrophages; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine | 2006 |
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic | 2007 |
Effect of alkyl-lysophospholipids on some aspects of the metabolism of Leishmania donovani.
Topics: Animals; Carbohydrate Metabolism; Humans; Leishmania donovani; Magnetic Resonance Spectroscopy; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Protozoan Proteins; Superoxide Dismutase; Type C Phospholipases | 2007 |
In vivo activity of perifosine against Leishmania amazonensis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine; Survival Analysis | 2008 |
Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids.
Topics: Antineoplastic Agents; Humans; Jurkat Cells; Liposomes; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine | 2013 |
In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.
Topics: Animals; Antineoplastic Agents; Antiparasitic Agents; Apoptosis; Female; Mice; Phospholipid Ethers; Phosphorylcholine; Schistosoma mansoni; Schistosomiasis mansoni | 2014 |
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Cholesterol; Drug Resistance; Embryo, Nonmammalian; Embryonic Development; Humans; Insulin-Like Growth Factor I; Larva; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine | 2014 |
The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Female; Larva; Mice; Phospholipid Ethers; Phosphorylcholine; Strongyloides; Strongyloidiasis | 2016 |
Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation.
Topics: Anti-Obesity Agents; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lipid Droplets; Liver X Receptors; Phospholipid Ethers; Phosphorylcholine; Poly(ADP-ribose) Polymerases; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Quercetin; Signal Transduction | 2019 |
Computational screening for membrane-directed inhibitors of mast cell activation.
Topics: Animals; Cell Degranulation; Cell Line, Tumor; Cell Membrane; Computational Biology; Computer Simulation; Drug Evaluation, Preclinical; Mast Cells; Models, Molecular; Molecular Conformation; Rats | 2010 |