milrinone has been researched along with zaprinast in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.00) | 18.7374 |
| 1990's | 21 (52.50) | 18.2507 |
| 2000's | 14 (35.00) | 29.6817 |
| 2010's | 2 (5.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Frierson, MR; Kondo, K; Konishi, Y; Lee, SJ; Macina, OT; Miskowski, TA; Riviello, CM; Sircar, JC; Sugitani, M; Yu, DT | 1 |
| Coates, WJ; Connolly, B; Dhanak, D; Flynn, ST; Worby, A | 1 |
| Adachi, H; Ishibashi, K; Ishihara, H; Kabasawa, Y; Kakiki, M; Kodama, K; Matsukura, M; Miyazaki, K; Nishino, M; Ozaki, H; Takase, Y; Watanabe, N | 1 |
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bucki, A; Chłoń-Rzepa, G; Funk, P; Gawalska, A; Lemrová, B; Nowak, B; Pawłowski, M; Pociecha, K; Ručilová, V; Soural, M; Świerczek, A; Vanda, D; Wyska, E; Zadrożna, M; Zajdel, P | 1 |
| Becker, LT; Buchholz, RA; Clas, DM; Dundore, RL; Habeeb, PG; Pratt, PF | 1 |
| Abdel-Aleem, S; Badr, M; Frangakis, C | 1 |
| Heaslip, R; Nielson, CP; Sturm, RJ; Vestal, RE | 1 |
| Ahn, HS; Crim, W; Pitts, B; Romano, M; Sybertz, E | 1 |
| Weiss, RM; Wheeler, MA | 1 |
| Chambers, A; Clarke, WR; Doepfner, P; Uezono, S | 1 |
| Lagarde, M; Marcoz, P; Nemoz, G; Prigent, AF | 1 |
| Heaslip, R; Molnar-Kimber, K; Weichman, B; Yonno, L | 1 |
| Brown, A; Chiu, PJ; Hartman, BD; Kurowski, S; Leach, MW; Vemulapalli, S | 1 |
| Dahl, SG; Lagente, V; Payne, AN; Planquois, JM; Ruffin-Morin, Y | 2 |
| Bakre, MM; Visweswariah, SS | 1 |
| Eberhart, RC; Prager, MD; Sly, MK | 1 |
| Horita, T; Kasugai, S; Miyamoto, K; Ohya, K; Waki, Y | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| Cervin, A; Lindgren, S | 1 |
| Aardal, S; Helle, KB; Lillestłl, IK | 1 |
| Frith, S; O'Donnell, JM | 1 |
| Bivalacqua, TJ; Champion, HC; Doherty, PC; Hellstrom, WJ; Kadowitz, PJ; Rajasekaran, M; Sikka, SC | 1 |
| Gong, GX; Scholz, PM; Straznicka, M; Tse, J; Weiss, HR; Yan, L | 1 |
| Boichot, E; Germain, N; Lagente, V; Planquois, JM | 1 |
| Chambers, DJ; Featherstone, RL; Kelly, FJ | 1 |
| Cherry, JA; Pho, V; Thompson, BE | 1 |
| Bloch, KD; Holzmann, A; Manktelow, C; Weimann, J; Zapol, WM | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| Ozdem, SS; Sadan, G; Tasatargil, A | 1 |
| Gozal, Y; Matot, I | 1 |
| Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N | 1 |
| Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N; Watanabe, A | 1 |
| Crisostomo, P; Kher, A; Meldrum, DR; Pitcher, JM; Tsai, BM; Wang, M | 1 |
| Beierwaltes, WH | 1 |
| Barman, SA; White, RE; Zhu, S | 1 |
| Gao, X; Jensen, BL; Persson, AE; Sällström, J; Skøtt, O | 1 |
| Dou, D; Gao, Y; Guo, Y; Liu, J; Xu, X; Ying, L; Yu, X | 1 |
1 review(s) available for milrinone and zaprinast
| Article | Year |
|---|---|
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
39 other study(ies) available for milrinone and zaprinast
| Article | Year |
|---|---|
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Animals; Blood Platelets; Cattle; Cells, Cultured; Cyclooxygenase Inhibitors; Humans; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Imidazoles; Isoenzymes; Phosphodiesterase Inhibitors; Pyridines; Structure-Activity Relationship | 1993 |
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Biological Availability; Blood Pressure; Coronary Vessels; Cyclic Nucleotide Phosphodiesterases, Type 5; Dinoprost; Hypertension, Pulmonary; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine; Vasodilator Agents | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Female; Humans; Imidazoles; Inflammation; Male; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Rats, Wistar | 2021 |
Differential hemodynamic responses to selective inhibitors of cyclic nucleotide phosphodiesterases in conscious rats.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Blood Pressure; Cardiac Output; Hemodynamics; Kinetics; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats; Rats, Inbred Strains; Regional Blood Flow | 1992 |
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats | 1991 |
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Adult; Calcimycin; Chromatography, Ion Exchange; Humans; Isoenzymes; Isoproterenol; Middle Aged; Milrinone; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Superoxides | 1990 |
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Brain; Calmodulin; Male; Milrinone; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Pyridones; Rabbits; Vinca Alkaloids | 1989 |
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Animals; Cyclic GMP; Enzyme Activation; Female; Guinea Pigs; Insulin; Kinetics; Milrinone; Purinones; Pyridones; Pyrrolidinones; Rolipram; Ureter | 1988 |
The type III phosphodiesterase inhibitor milrinone and type V PDE inhibitor dipyridamole individually and synergistically reduce elevated pulmonary vascular resistance.
Topics: Animals; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Female; Infusion Pumps; Lung; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyridones; Rabbits; Vascular Resistance | 1994 |
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Concanavalin A; Cyclic AMP; Cyclic GMP; Cytosol; In Vitro Techniques; Isoenzymes; Lymphocyte Activation; Male; Milrinone; Nitroprusside; Purinones; Pyridones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; T-Lymphocytes | 1993 |
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors.
Topics: Cell Survival; Cells, Cultured; Endotoxins; Humans; Interleukin-1; Isoenzymes; Milrinone; Monocytes; Phosphodiesterase Inhibitors; Purinones; Pyridones; Pyrrolidinones; Quinazolines; Rolipram; Tumor Necrosis Factor-alpha; Vinca Alkaloids | 1993 |
In vivo inhibition of platelet adhesion by a cGMP-mediated mechanism in balloon catheter injured rat carotid artery.
Topics: Animals; Carotid Artery Diseases; Catheterization; Male; Milrinone; Nitroprusside; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinones; Pyridones; Rats | 1996 |
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug Synergism; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Osmolar Concentration; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1996 |
Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Guanidines; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Leukotriene C4; Male; Milrinone; Muscle Tonus; Ovalbumin; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1996 |
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones | 1997 |
Anti-platelet action of nitric oxide and selective phosphodiesterase inhibitors.
Topics: Animals; Cells, Cultured; Milrinone; Nitric Oxide; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinones; Pyridones; Rabbits | 1997 |
Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone Marrow Cells; Bone Resorption; Bucladesine; Calcification, Physiologic; Carcinoma 256, Walker; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Mice; Milrinone; Osteoclasts; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridones; Rats; Rats, Wistar; Xanthines | 1997 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
The effect of selective phosphodiesterase inhibitors on mucociliary activity in the upper and lower airways in vitro.
Topics: Culture Techniques; Dose-Response Relationship, Drug; Humans; Maxillary Sinus; Microscopy, Phase-Contrast; Milrinone; Mucociliary Clearance; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Respiratory System; Rolipram; Trachea | 1998 |
Relaxing effects of cyclic GMP and cyclic AMP-enhancing agents on the long-lasting contraction to endothelin-1 in the porcine coronary artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Isradipine; Milrinone; Muscle, Smooth, Vascular; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Swine; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation; Verapamil; Vinca Alkaloids | 1998 |
Behavioral effects of family-selective inhibitors of cyclic nucleotide phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Cyclic Nucleotide Phosphodiesterases, Type 1; Desipramine; Isoquinolines; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Rolipram; Tetrahydroisoquinolines; Vinca Alkaloids | 1999 |
Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4).
Topics: Alprostadil; Animals; Cats; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Male; Milrinone; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Rolipram | 1999 |
Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Heart; Milrinone; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines | 1999 |
Reduced airway hyperresponsiveness by phosphodiesterase 3 and 4 inhibitors in guinea-pigs.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Analysis of Variance; Animals; Guinea Pigs; Male; Milrinone; Ovalbumin; Phosphodiesterase Inhibitors; Purinones; Respiratory Hypersensitivity | 1999 |
Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs.
Topics: Animals; Bicarbonates; Calcium Chloride; Hypothermia, Induced; Lung; Lung Transplantation; Magnesium; Milrinone; Oxygen; Phosphodiesterase Inhibitors; Potassium Chloride; Pulmonary Gas Exchange; Purinones; Rats; Rats, Wistar; Reperfusion Injury; Rolipram; Sodium Chloride; Theophylline; Vascular Resistance | 2000 |
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid | 2001 |
Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lipopolysaccharides; Milrinone; Multivariate Analysis; Nitric Oxide; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Vasodilation | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Electric Stimulation; Guinea Pigs; Histamine; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Quinoxalines; Receptors, Adrenergic; Receptors, Cholinergic; Signal Transduction; Tetrodotoxin; Theophylline | 2003 |
Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Analysis of Variance; Animals; Cats; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hypertension, Pulmonary; Infusions, Intravenous; Injections, Intralesional; Male; Milrinone; Phosphoric Diester Hydrolases; Probability; Pulmonary Circulation; Purinones; Random Allocation; Risk Factors; Sensitivity and Specificity; Vascular Resistance | 2004 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli.
Topics: Adenine; Animals; Carbachol; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids | 2004 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Gallbladder; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids | 2005 |
Zaprinast attenuates hypoxic pulmonary artery injury and causes less aortic relaxation than milrinone.
Topics: Animals; Aorta; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Synergism; Hypertension, Pulmonary; Hypoxia; Inflammation; Interleukin-1; Lung; Lung Diseases; Male; Milrinone; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Pulmonary Artery; Purinones; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasodilator Agents | 2005 |
cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Furosemide; Kinetics; Male; Milrinone; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Rats; Rats, Sprague-Dawley; Renin; Second Messenger Systems | 2006 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Pulmonary; Milrinone; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium Channels, Calcium-Activated; Protein Kinase C; Pulmonary Artery; Purinones; Rats; Vasoconstriction | 2008 |
Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3.
Topics: Animals; Blood Pressure; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Juxtaglomerular Apparatus; Kidney Cortex; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Milrinone; Nitric Oxide Synthase Type I; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Purinones; Renal Circulation; Renin; Sodium Chloride, Dietary | 2010 |
Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity.
Topics: Animals; Chromones; Coronary Vessels; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Milrinone; Models, Animal; Morpholines; Nifedipine; Nitroglycerin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinones; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 2012 |