milrinone and rolipram

milrinone has been researched along with rolipram in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.99)	18.7374
1990's	36 (53.73)	18.2507
2000's	23 (34.33)	29.6817
2010's	4 (5.97)	24.3611
2020's	2 (2.99)	2.80

Authors

Authors	Studies
Adachi, H; Saeki, T; Saito, I; Souda, S; Takase, Y; Watanabe, N	1
Cantor, E; Chou, YL; Di Meo, SV; Erhardt, PW; Hagedorn, AA; Hanna, RG; Ingebretsen, WR; Lampe, JW	1
Ichimura, M; Kase, H; Kubo, K; Mihara, A; Nagashima, K; Nomoto, Y; Ohno, T; Takai, H; Yamada, K; Yao, K	1
Beleta, J; Castellana, C; Dal Piaz, V; Doménech, T; Giovannoni, MP; Palacios, JM; Segarra, V	1
Beleta, J; Crespo, MI; Doménech, T; López, M; Miralpeix, M; Pagès, L; Palacios, JM; Ryder, H; Segarra, V; Vega, A	1
Adachi, H; Ishibashi, K; Ishihara, H; Kabasawa, Y; Kakiki, M; Kodama, K; Matsukura, M; Miyazaki, K; Nishino, M; Ozaki, H; Takase, Y; Watanabe, N	1
Chun, HO; Kim, DH; Kim, HJ; Kim, JH; Kwak, JH; Lee, YS; Park, H; Shin, HJ	1
Hughes, RA; Manallack, DT; Thompson, PE	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X	1
Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H	1
Bucki, A; Chłoń-Rzepa, G; Funk, P; Gawalska, A; Lemrová, B; Nowak, B; Pawłowski, M; Pociecha, K; Ručilová, V; Soural, M; Świerczek, A; Vanda, D; Wyska, E; Zadrożna, M; Zajdel, P	1
Endoh, M; Katano, Y	1
Mensah, LM; Murray, KJ; Worby, A	1
Cortijo, J; Morcillo, EJ; Ortiz, JL; Vallés, JM	1
Andersson, KE; Degerman, E; Lindgren, S; Manganiello, V; Rascón, A	1
Andersson, KE; Lindgren, S	1
Nicholson, CD; Shahid, M	1
Bode, DC; Brunton, LL; Kanter, JR	1
Heaslip, R; Nielson, CP; Sturm, RJ; Vestal, RE	1
Anker, G; Lagarde, M; Macovschi, O; Némoz, G; Prigent, AF; Valette, L	1
Cottney, J; Marsden, G; Nicholson, CD; Shahid, M	1
Weiss, RM; Wheeler, MA	1
Akita, T; Hartzell, HC; Joyner, RW; Kumar, R; Lu, C	1
Green, RD; Ma, H; Yu, HJ	1
Imai, A; Nashida, T; Shimomura, H	1
Barrett, JA; Derian, CK; Rao, PE; Santulli, RJ; Solomon, HF	1
Arlock, P; Mörner, SE	1
Lagarde, M; Marcoz, P; Nemoz, G; Prigent, AF	1
Heaslip, R; Molnar-Kimber, K; Weichman, B; Yonno, L	1
Andersson, KE; Bouskela, E; Cyrino, FZ; Lindgren, S; Svensjö, E	1
Chun, SY; Conti, M; Hsueh, AJ; Tsafriri, A; Zhang, R	1
Dahl, SG; Lagente, V; Payne, AN; Planquois, JM; Ruffin-Morin, Y	2
Dubois, M; Grynberg, A; Lagarde, M; Picq, M; Prigent, AF	1
Bonnet, PA; Chevillard, C; Michel, A; Vittet, D; Zurbonsen, K	1
Kobayashi, J; Kurita, C; Nagai, H; Nagao, T; Nakao, T; Tanaka, H; Usami, E; Watanabe, S; Yamazaki, F; Yoshimura, T	1
Inagaki, N; Kobayashi, J; Nagai, H; Nagao, T; Nakao, T; Tanaka, H; Usami, E; Watanabe, S; Yamazaki, F; Yoshimura, T	1
Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A	1
Majluf-Cruz, A; Omburo, GA; Zhu, WH	1
Cervin, A; Lindgren, S	1
Bertin, B; Boichot, E; Germain, N; Lagente, V; Legendre, A; Martin, B; Payne, A	1
Aardal, S; Helle, KB; Lillestłl, IK	1
Frith, S; O'Donnell, JM	1
Bivalacqua, TJ; Champion, HC; Doherty, PC; Hellstrom, WJ; Kadowitz, PJ; Rajasekaran, M; Sikka, SC	1
Crews, JD; Whalen, MM	1
Gelfand, EW; Ikemura, T; Joetham, A; Kanehiro, A; Makela, M; Ohmori, K; Schwarze, J	1
Chambers, DJ; Featherstone, RL; Kelly, FJ	1
Hisaoka, T; Kobayashi, S; Kohno, M; Matsuzaki, M; Mochizuki, M; Ohkusa, T; Ono, K; Tanigawa, T; Yamada, J; Yano, M	1
Cherry, JA; Pho, V; Thompson, BE	1
Botana, LM; de la Rosa, LA; Vieytes, MR; Vilariño, N	1
Horiuchi, H; Kawasaki, S; Kinoshita, T; Takaoka, K; Tsutsumimoto, T; Wakabayashi, S	1
Conti, M; DePaolo, LV; Jensen, JT; Schwinof, KM; Stouffer, RL; Zelinski-Wooten, MB	1
Domenech, C; Lluch, S; Martinez-León, JB; Medina, P; Prieto, F; Segarra, G; Vila, JM	1
Frøkiaer, J; Knepper, MA; Kwon, TH; Li, C; Nielsen, S; Wang, W	1
Bobalova, J; Mutafova-Yambolieva, VN; Smyth, L	1
Cone, J; Fong, M; Hensley, J; Kambayashi, J; Liu, Y; Movsesian, MA; Shakur, Y; Yoshitake, M	1
Clancy, JP; Cobb, BR; Fan, L; Kovacs, TE; Sorscher, EJ	1
Hernández, J; Juan-Fita, MJ; Vargas, ML	1
Cui, H; Green, RD	1
Armstrong, DT; Gilchrist, RB; Thomas, RE; Thompson, JG	1
Bobalova, J; Mutafova-Yambolieva, VN	1
Birowo, P; Kedia, GT; Kuczyk, MA; Rahardjo, D; Sandner, P; Scheller, F; Sonnenberg, JE; Thon, WF; Uckert, S	1
Geras-Raaka, E; Gershengorn, MC; Neumann, S	1
Andersen, GØ; Ata, SH; Dahl, CP; Levy, FO; Orstavik, O; Osnes, JB; Qvigstad, E; Riise, J; Skomedal, T	1
Maronde, E	1

Reviews

1 review(s) available for milrinone and rolipram

Article	Year
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10 Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines	2005

Article

Year

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005

Other Studies

66 other study(ies) available for milrinone and rolipram

Article	Year
Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Coronary Vessels; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Muscle, Smooth, Vascular; Quinazolines; Spectrometry, Fluorescence; Structure-Activity Relationship; Swine; Vasodilation	1994
(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase. Journal of medicinal chemistry, 1993, Apr-16, Volume: 36, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Cardiotonic Agents; Dogs; Heart; Hemodynamics; Imidazoles; Myocardium; Phosphodiesterase Inhibitors; Pyrroles; Pyrrolidinones; Structure-Activity Relationship	1993
Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232). Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Animals; Aorta; Calcium; Cardiotonic Agents; Cattle; Dogs; Guinea Pigs; Heart Failure; In Vitro Techniques; Male; Molecular Conformation; Molecular Structure; Myocardial Contraction; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Quinazolines; Stereoisomerism; Trifluoperazine; Vasodilator Agents; Ventricular Pressure	1996
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. Journal of medicinal chemistry, 1997, May-09, Volume: 40, Issue:10 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Guinea Pigs; Magnetic Resonance Spectroscopy; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Radioligand Assay; Rats; Rolipram; Structure-Activity Relationship	1997
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors. Journal of medicinal chemistry, 1998, Oct-08, Volume: 41, Issue:21 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Asthmatic Agents; Binding, Competitive; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Drug Evaluation, Preclinical; Eosinophils; Guinea Pigs; In Vitro Techniques; Male; Models, Molecular; Myocardium; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Rolipram; Structure-Activity Relationship; Thiophenes	1998
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Biological Availability; Blood Pressure; Coronary Vessels; Cyclic Nucleotide Phosphodiesterases, Type 5; Dinoprost; Hypertension, Pulmonary; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine; Vasodilator Agents	2000
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorganic & medicinal chemistry letters, 2002, Sep-02, Volume: 12, Issue:17 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inhibitory Concentration 50; Kinetics; Rats; Sophora; Structure-Activity Relationship	2002
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship	2008
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15 Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi	2012
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases. European journal of medicinal chemistry, 2021, Jan-01, Volume: 209 Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Female; Humans; Imidazoles; Inflammation; Male; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Rats, Wistar	2021
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines	1992
Myofibrillar bound cyclic nucleotide phosphodiesterase in heart and skeletal muscle. Biochemical Society transactions, 1992, Volume: 20, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cell Fractionation; Guinea Pigs; Kinetics; Milrinone; Muscles; Myocardium; Myofibrils; Pyridazines; Pyridones; Pyrrolidinones; Rats; Rolipram; Xanthines	1992
Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline. Fundamental & clinical pharmacology, 1992, Volume: 6, Issue:6 Topics: Animals; Capillary Permeability; Evans Blue; Guinea Pigs; Milrinone; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyridones; Pyrrolidinones; Respiratory System; Rolipram; Theophylline	1992
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta. Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug Interactions; Isoenzymes; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Pyridones; Pyrrolidinones; Quinolones; Rats; Rolipram; Serotonin; Vasodilator Agents	1991
Effects of selective phosphodiesterase inhibitors on isolated coronary, lung and renal arteries from man and rat. Acta physiologica Scandinavica, 1991, Volume: 142, Issue:1 Topics: Aged; Animals; Coronary Vessels; Female; Humans; In Vitro Techniques; Male; Middle Aged; Milrinone; Phosphodiesterase Inhibitors; Pulmonary Artery; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Renal Artery; Rolipram; Vasodilation; Vasodilator Agents	1991
Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Heart; Heart Ventricles; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Organic Chemicals; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rats; Rats, Inbred Strains; Rolipram	1990
Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue. Circulation research, 1991, Volume: 68, Issue:4 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic GMP; Heart Ventricles; Isoenzymes; Kinetics; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Rolipram; Substrate Specificity	1991
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:5 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Adult; Calcimycin; Chromatography, Ion Exchange; Humans; Isoenzymes; Isoproterenol; Middle Aged; Milrinone; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Superoxides	1990
Concanavalin A stimulates the Rolipram-sensitive isoforms of cyclic nucleotide phosphodiesterase in rat thymic lymphocytes. Biochemical and biophysical research communications, 1990, Jun-29, Volume: 169, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Concanavalin A; Cyclic AMP; Cyclic GMP; Cytosol; Isoenzymes; Kinetics; Lymphocyte Activation; Lymphocytes; Milrinone; Pyridones; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Thymus Gland	1990
A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles. British journal of pharmacology, 1989, Volume: 98 Suppl Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; In Vitro Techniques; Milrinone; Myocardial Contraction; Organic Chemicals; Papillary Muscles; Pyridones; Pyrrolidinones; Rats; Rolipram; Theophylline	1989
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Animals; Cyclic GMP; Enzyme Activation; Female; Guinea Pigs; Insulin; Kinetics; Milrinone; Purinones; Pyridones; Pyrrolidinones; Rolipram; Ureter	1988
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors. Circulation, 1994, Volume: 90, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Female; Isoproterenol; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rolipram; Ventricular Function	1994
Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes. Molecular pharmacology, 1993, Volume: 44, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Cyclic AMP; Depression, Chemical; Down-Regulation; Drug Synergism; Heart; Isoproterenol; Kinetics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram	1993
Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland. Archives of oral biology, 1995, Volume: 40, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calmodulin; Chromatography, Agarose; Cyclic GMP; Enzyme Activation; Isoenzymes; Kinetics; Male; Milrinone; Molecular Weight; Parotid Gland; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram	1995
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators. Journal of immunology (Baltimore, Md. : 1950), 1995, Jan-01, Volume: 154, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzoxazines; CD18 Antigens; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytoplasmic Granules; Endothelium, Vascular; Humans; Infant, Newborn; Isoproterenol; Macrophage-1 Antigen; Milrinone; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones; Pyrrolidinones; Respiratory Burst; Rolipram; Umbilical Veins	1995
Mechanical and electrophysiological effects of milrinone on the force-frequency relationship in mammalian myocardium. Acta physiologica Scandinavica, 1994, Volume: 150, Issue:2 Topics: Action Potentials; Animals; Calcium; Cardiotonic Agents; Drug Interactions; Ferrets; Guinea Pigs; Heart; Male; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram; Sarcoplasmic Reticulum	1994
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents. Molecular pharmacology, 1993, Volume: 44, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Concanavalin A; Cyclic AMP; Cyclic GMP; Cytosol; In Vitro Techniques; Isoenzymes; Lymphocyte Activation; Male; Milrinone; Nitroprusside; Purinones; Pyridones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; T-Lymphocytes	1993
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors. Agents and actions, 1993, Volume: 39 Spec No Topics: Cell Survival; Cells, Cultured; Endotoxins; Humans; Interleukin-1; Isoenzymes; Milrinone; Monocytes; Phosphodiesterase Inhibitors; Purinones; Pyridones; Pyrrolidinones; Quinazolines; Rolipram; Tumor Necrosis Factor-alpha; Vinca Alkaloids	1993
Effects of two vasodilatory phosphodiesterase inhibitors on bradykinin-induced permeability increase in the hamster cheek pouch. Agents and actions, 1993, Volume: 39, Issue:1-2 Topics: Animals; Arterioles; Bradykinin; Capillary Permeability; Cheek; Cricetinae; Fluorescein-5-isothiocyanate; Male; Mesocricetus; Milrinone; Mouth Mucosa; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram; Terbutaline; Vasodilator Agents	1993
Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Developmental biology, 1996, Sep-15, Volume: 178, Issue:2 Topics: Animals; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Cyclic AMP; Female; Gene Expression Regulation, Developmental; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rolipram	1996
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug Synergism; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Osmolar Concentration; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea	1996
Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:10 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Cyclic GMP; Fatty Acids; Fatty Acids, Omega-3; Kinetics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rats; Rats, Wistar; Rolipram	1996
Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. Pulmonary pharmacology, 1996, Volume: 9, Issue:4 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Guanidines; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Leukotriene C4; Male; Milrinone; Muscle Tonus; Ovalbumin; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea	1996
Dissociation between phosphodiesterase inhibition and antiproliferative effects of phosphodiesterase inhibitors on the Dami cell line. Biochemical pharmacology, 1997, Apr-25, Volume: 53, Issue:8 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Cell Division; Cyclic AMP; Humans; Isoenzymes; Isoquinolines; L-Lactate Dehydrogenase; Leukemia, Megakaryoblastic, Acute; Milrinone; Phosphodiesterase Inhibitors; Phthalazines; Pyridones; Pyrrolidinones; Rolipram; Tetrahydroisoquinolines; Tumor Cells, Cultured	1997
Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells. General pharmacology, 1997, Volume: 29, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aminophylline; Bucladesine; Cytokines; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Milrinone; Naphthyridines; Phosphodiesterase Inhibitors; Purinones; Pyridones; Pyrrolidinones; Rolipram; Terbutaline; Tumor Necrosis Factor-alpha	1997
Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors. General pharmacology, 1998, Volume: 30, Issue:2 Topics: Adrenergic beta-Agonists; Bucladesine; Humans; In Vitro Techniques; Interferon-gamma; Interleukins; Leukocytes, Mononuclear; Milrinone; Mitogens; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram; Th1 Cells; Th2 Cells; Theophylline	1998
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents. The Journal of clinical investigation, 1998, Aug-01, Volume: 102, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes	1998
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism. Life sciences, 1998, Volume: 63, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram	1998
The effect of selective phosphodiesterase inhibitors on mucociliary activity in the upper and lower airways in vitro. Auris, nasus, larynx, 1998, Volume: 25, Issue:3 Topics: Culture Techniques; Dose-Response Relationship, Drug; Humans; Maxillary Sinus; Microscopy, Phase-Contrast; Milrinone; Mucociliary Clearance; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Respiratory System; Rolipram; Trachea	1998
Selective phosphodiesterase inhibitors modulate the activity of alveolar macrophages from sensitized guinea-pigs. The European respiratory journal, 1998, Volume: 12, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Allergens; Animals; Arachidonic Acid; Bronchoalveolar Lavage Fluid; Bucladesine; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Isoenzymes; Macrophages, Alveolar; Male; Milrinone; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Respiratory Hypersensitivity; Rolipram	1998
Relaxing effects of cyclic GMP and cyclic AMP-enhancing agents on the long-lasting contraction to endothelin-1 in the porcine coronary artery. Scandinavian journal of clinical and laboratory investigation, 1998, Volume: 58, Issue:8 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Isradipine; Milrinone; Muscle, Smooth, Vascular; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Swine; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation; Verapamil; Vinca Alkaloids	1998
Behavioral effects of family-selective inhibitors of cyclic nucleotide phosphodiesterases. Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Cyclic Nucleotide Phosphodiesterases, Type 1; Desipramine; Isoquinolines; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Rolipram; Tetrahydroisoquinolines; Vinca Alkaloids	1999
Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). The Journal of urology, 1999, Volume: 162, Issue:5 Topics: Alprostadil; Animals; Cats; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Male; Milrinone; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Rolipram	1999
Inhibition of a phosphodiesterase III in the lysis-sensitive target-induced elevation of cyclic AMP (cAMP) in human natural killer cells. Biochemical pharmacology, 2000, Aug-15, Volume: 60, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Isoquinolines; K562 Cells; Killer Cells, Natural; Milrinone; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rolipram; Tetrahydroisoquinolines	2000
Type 4 phosphodiesterase inhibitors attenuate respiratory syncytial virus-induced airway hyper-responsiveness and lung eosinophilia. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Eosinophils; Female; Humans; Methacholine Chloride; Mice; Mice, Inbred BALB C; Milrinone; Neutrophil Infiltration; Neutrophils; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Rolipram	2000
Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:3 Pt 1 Topics: Animals; Bicarbonates; Calcium Chloride; Hypothermia, Induced; Lung; Lung Transplantation; Magnesium; Milrinone; Oxygen; Phosphodiesterase Inhibitors; Potassium Chloride; Pulmonary Gas Exchange; Purinones; Rats; Rats, Wistar; Reperfusion Injury; Rolipram; Sodium Chloride; Theophylline; Vascular Resistance	2000
Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Transporting ATPases; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dobutamine; Dogs; Hemodynamics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Rolipram; Sarcoplasmic Reticulum; Ventricular Function, Left	2000
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochimica et biophysica acta, 2001, Mar-19, Volume: 1518, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid	2001
Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89. Cellular signalling, 2001, Volume: 13, Issue:6 Topics: Adenosine Triphosphatases; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Isoquinolines; Lymphocytes; Microscopy, Fluorescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Sulfonamides; Thapsigargin; Time Factors	2001
Involvement of phosphodiesterase isozymes in osteoblastic differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002, Volume: 17, Issue:2 Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Isoenzymes; Mice; Milrinone; Osteoblasts; Osteopontin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Sialoglycoproteins	2002
Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. Human reproduction (Oxford, England), 2002, Volume: 17, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Feasibility Studies; Female; Macaca mulatta; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Rolipram; Thiophenes	2002
Relaxation induced by milrinone and rolipram in human penile arteries and veins. European journal of pharmacology, 2002, May-24, Volume: 444, Issue:1-2 Topics: Adult; Child; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Middle Aged; Milrinone; Muscle, Smooth, Vascular; Penis; Phosphodiesterase Inhibitors; Rolipram; Vasodilation	2002
AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:6 Topics: Animals; Aquaporin 1; Aquaporin 2; Aquaporin 3; Aquaporin 4; Aquaporin 6; Aquaporins; Body Water; Cyclic AMP; Hypercalcemia; Kidney; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphorylation; Polyuria; Rats; Rats, Wistar; Rolipram	2002
Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein. Cardiovascular research, 2003, Volume: 57, Issue:1 Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Autonomic Nervous System; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Edetic Acid; Electric Stimulation; Isoproterenol; Mesenteric Arteries; Mesenteric Veins; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Rolipram; Second Messenger Systems	2003
Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Interactions; Heart; Humans; Isoenzymes; Milrinone; Myocardium; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Rabbits; Rolipram; Tetrazoles; Tissue Distribution	2002
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:3 Pt 1 Topics: Adenosine Deaminase; Anions; Cell Line; Chlorine; Cilostazol; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Epithelium; Glyburide; Humans; Hypoglycemic Agents; Milrinone; Mutation; Papaverine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Purinergic P1; Rolipram; Sildenafil Citrate; Sulfones; Tetrazoles; Time Factors	2003
Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium. Pharmacology & toxicology, 2003, Volume: 93, Issue:1 Topics: Adenine; Animals; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; In Vitro Techniques; Isoenzymes; Male; Milrinone; Myocardial Contraction; Norepinephrine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines	2003
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. Biochemical and biophysical research communications, 2003, Jul-18, Volume: 307, Issue:1 Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Response Elements; Rolipram	2003
Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. Biology of reproduction, 2004, Volume: 71, Issue:4 Topics: Animals; Blastocyst; Cattle; Cell Culture Techniques; Cells, Cultured; Embryonic Development; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Isoenzymes; Meiosis; Milrinone; Oocytes; Ovarian Follicle; Phosphoric Diester Hydrolases; Rolipram	2004
Activation of the adenylyl cyclase/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery. European journal of pharmacology, 2006, Apr-24, Volume: 536, Issue:1-2 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bucladesine; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Electric Stimulation; Enzyme Activation; Female; Imines; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Milrinone; NAD; Neural Pathways; Phosphodiesterase Inhibitors; Rolipram; Signal Transduction; Vasodilator Agents	2006
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. Urology, 2010, Volume: 76, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Colforsin; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Ejaculation; Humans; In Vitro Techniques; Male; Milrinone; Muscle Relaxation; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Adrenergic, alpha; Rolipram; Seminal Vesicles; Sildenafil Citrate; Sulfones	2010
Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition. Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Biosensing Techniques; Cell Line, Tumor; Cyclic AMP; HEK293 Cells; Humans; Immunoassay; Luminescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Thyrotropin; Rolipram; Signal Transduction; Thyroid Gland; Thyrotropin; Time Factors	2013
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British journal of pharmacology, 2014, Volume: 171, Issue:23 Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Pyridazines; Quinolines; Quinolones; Rats, Wistar; Rolipram; Simendan; Thiadiazines	2014
Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line. International journal of molecular sciences, 2020, Nov-17, Volume: 21, Issue:22 Topics: Animals; Cell Line; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Early Growth Response Protein 1; Hippocampus; Mice; Milrinone; Phosphodiesterase Inhibitors; Rolipram; Second Messenger Systems; Transcription, Genetic; Transcriptional Activation	2020