milrinone has been researched along with isoproterenol in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (27.78) | 18.7374 |
| 1990's | 30 (41.67) | 18.2507 |
| 2000's | 16 (22.22) | 29.6817 |
| 2010's | 5 (6.94) | 24.3611 |
| 2020's | 1 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Bobowski, G; Bristol, JA; Duell, BL; Evans, DB; Sircar, I | 1 |
| Decker, N; Leclerc, G; Marciniak, G; Schwartz, J | 2 |
| Topliss, JG; Yoshida, F | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ebbert, M; Janssens, WJ; Leidig, A; Meuter, C; Peters, T; Wilffert, B; Wilhelm, D | 1 |
| Endoh, M; Katano, Y | 1 |
| Noma, A; Ono, K; Tareen, FM; Yoshida, A | 1 |
| Alicia, M; Chiappe de Cingolani, G; Mundiña, C; Vila Petroff, M; Vittone, L | 1 |
| Böhm, M; Erdmann, E; Gierschik, P | 1 |
| Ichikawa, H; Kawashima, Y; Koide, A; Komai, H; Nakashima, N; Ohashi, T; Shibata, T; Tanaka, K; Yamamoto, F; Yamamoto, H | 1 |
| Canniff, PC; Ezrin, AM; Hamel, DW; Lee, KC; Pagani, ED | 1 |
| Lugnier, C; Muller, B; Stoclet, JC | 1 |
| De Mey, JG; Heesen, BJ | 1 |
| Andersson, KE; Lindgren, S | 1 |
| Bethke, T; Klimkiewicz, A; Kohl, C; Mehl, H; Mende, U; Meyer, W; Neumann, J; Schmitz, W; Scholz, H; von der Leyen, H | 1 |
| Heaslip, R; Nielson, CP; Sturm, RJ; Vestal, RE | 1 |
| Böhm, M; Erdmann, E; Gierschik, P; Jakobs, KH; Pieske, B; Schnabel, P; Ungerer, M | 1 |
| Andersson, KE; Andersson, TL; Lindgren, SH; Vinge, E | 1 |
| Abdul Matlib, M; Grupp, G; Grupp, I; Rapundalo, ST; Schwartz, A; Solaro, RJ | 1 |
| Brown, L; Erdmann, E; Lorenz, B | 1 |
| Copelas, L; Feldman, MD; Grossman, W; Gwathmey, JK; Morgan, JP; Phillips, P; Schoen, FJ; Warren, SE | 1 |
| Decker, N; Grima, M; Schwartz, J | 1 |
| Böhm, M; Diet, F; Erdmann, E; Feiler, G; Kemkes, B; Kreuzer, E; Weinhold, C | 1 |
| Alousi, AA; Evans, DB; Grant, AM; Harris, AL; Silver, PJ | 1 |
| Colucci, WS; Creager, MA; Gauthier, DF; Hartley, LH; Marsh, JD; Quigg, RJ; Ribeiro, JP; Rocco, MB | 1 |
| Andersson, KE; Belfrage, P; Degerman, E; Lindgren, S; Manganiello, VC | 1 |
| Capogrossi, MC; Ferroni, C; Raffaeli, S; Spurgeon, HA | 1 |
| Böhm, M; Diet, F; Erdmann, E; Pieske, B | 1 |
| Evans, DB; Harris, AL; Lemp, BM; Silver, PJ | 1 |
| Böhm, M; Diet, F; Erdmann, E; Kemkes, B | 1 |
| Leier, CV | 1 |
| Baim, DS | 1 |
| Ayres, N; Brannon, TS; Fixler, DE; Parrish, MD; Payne, A | 1 |
| Artman, M; Kithas, PA; Strada, SJ; Wike, JS | 1 |
| Drazen, JM; Rossing, TH | 1 |
| Akita, T; Hartzell, HC; Joyner, RW; Kumar, R; Lu, C | 1 |
| Heber, D; Heers, C; Ravens, U | 1 |
| Green, RD; Ma, H; Yu, HJ | 1 |
| Bénardeau, A; Fischmeister, R; Hatem, S; Kirstein, M; Mercadier, JJ; Rivet-Bastide, M | 1 |
| Barrett, JA; Derian, CK; Rao, PE; Santulli, RJ; Solomon, HF | 1 |
| Dickinson, K; Foster, GA; Frodsham, G; Jones, RB | 1 |
| Gwathmey, JK; Morgan, JP | 1 |
| Andrea, B; Bristow, MR; Brown, JM; Campbell, DN; Fullerton, DA; Grover, FL; Jaggers, J; Jones, SD; Lindenfeld, J; Wolfel, EE | 1 |
| Balligand, JL; Belhassen, L; Kelly, RA; Smith, TW | 1 |
| Al-Nakkash, L; Cotton, CU; Drumm, ML; Kelley, TJ | 1 |
| Bruce, E; Flemmal, K; Grossman, W; Gutstein, DE; Gwathmey, JK; Markis, JE; Morgan, JP; Ransil, BJ; Travers, KE | 1 |
| Erdmann, E | 1 |
| Bellomo, R; Cole, L; Ronco, C | 1 |
| Alton, EW; Bush, KA; Chadwick, S; Delaney, SJ; Farley, R; Geddes, DM; Jaffe, A; Middleton, PG; Rolleston, S; Smith, SN; Wainwright, B | 1 |
| Newling, R; Shimada, Y; Yamamoto, F; Yamamoto, H | 1 |
| Aimono, M; Fujimura, N; Iwasaki, H; Nakayama, Y; Namiki, A; Narimatsu, E | 1 |
| Kiyota, T; Matsuda, F; Sadohara, T; Sugahara, K; Sugita, M; Terasaki, H | 1 |
| Fuentes, T; Galindo, A; García Estañ, J; Hernández, J; Vargas, ML | 1 |
| Bertel, O; Brunner-La Rocca, HP; Kiowski, W; Oechslin, E; Schad, K; Schalcher, C; Scharf, C; Schindler, R; Suetsch, G | 1 |
| Bobalova, J; Mutafova-Yambolieva, VN; Smyth, L | 1 |
| Böhm, M; Cremers, B; Maack, C; Schäfers, HJ; Scheler, M; Südkamp, M; Wendler, O | 1 |
| Atarashi, H; Hirayama, Y; Kameyama, M; Maruyama, M; Saitoh, H; Takano, T | 1 |
| Fischmeister, R; Jurevicius, J; Skeberdis, VA | 1 |
| Cui, H; Green, RD | 1 |
| Ozdem, SS; Sadan, G; Tasatargil, A | 1 |
| Hébert, TE; Rohlicek, CV; Trieu, P; Viau, S | 1 |
| Gupte, SA; Rabbani, G; Sarabu, MR; Vijay, V | 1 |
| Chen, K; Cong, L; Gao, P; Li, J; Li, Q; Mi, S; Wu, X; Zhao, AZ | 1 |
| Agren, P; Blanco, CE; Cogolludo, AL; van der Sterren, S; Villamor, E | 1 |
| Chapo, J; Ida, KK; Joly, KM; Liles, JT; Plato, CF | 1 |
| Adamczyk, A; Azer, J; Bissell, MB; Hua, R; McBoyle, S; Robbins, C; Rose, RA; Springer, J | 1 |
| Andersen, GØ; Ata, SH; Dahl, CP; Levy, FO; Orstavik, O; Osnes, JB; Qvigstad, E; Riise, J; Skomedal, T | 1 |
| Antzelevitch, C; Barajas-Martinez, H; Gurabi, Z; Hu, D; Koncz, I; Patocskai, B | 1 |
| Burton, F; Dietrichs, ES; Ghasemi, M; Selli, AL; Smith, G; Watters, T | 1 |
2 review(s) available for milrinone and isoproterenol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Hemodynamic support and the role of dopamine.
Topics: Acute Kidney Injury; Cardiac Output, Low; Cardiotonic Agents; Critical Care; Dobutamine; Dopamine; Epinephrine; Fluid Therapy; Hemodynamics; Humans; Isoproterenol; Milrinone; Norepinephrine; Phenylephrine; Pyridones; Renal Circulation; Renal Replacement Therapy; Vasoconstrictor Agents | 1998 |
1 trial(s) available for milrinone and isoproterenol
| Article | Year |
|---|---|
Interaction of sildenafil with cAMP-mediated vasodilation in vivo.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Brachial Artery; Cyclic AMP; Cyclic GMP; Forearm; Heart Rate; Hemodynamics; Humans; Isoproterenol; Male; Milrinone; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2002 |
69 other study(ies) available for milrinone and isoproterenol
| Article | Year |
|---|---|
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Dogs; Heart Failure; Imidazoles; Myocardial Contraction; Pyridazines; Structure-Activity Relationship | 1985 |
Cardiotonic agents. 1. Synthesis and structure-activity relationships in a new class of 3-, 4-, and 5-pyridyl-2(1H)-quinolone derivatives.
Topics: Animals; Atrial Function; Cardiotonic Agents; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Pyridines; Quinolines; Structure-Activity Relationship | 1986 |
Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2(1H)-quinolone derivatives.
Topics: Animals; Atrial Function; Cardiotonic Agents; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Indicators and Reagents; Male; Myocardial Contraction; Pyridines; Quinolines; Structure-Activity Relationship | 1986 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor.
Topics: Action Potentials; Animals; Benzimidazoles; Carbachol; Female; Guinea Pigs; Heart Rate; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Norepinephrine; Ouabain; Oxindoles; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Quinazolines; Stimulation, Chemical; Vasodilator Agents | 1992 |
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines | 1992 |
Synergistic action of cyclic GMP on catecholamine-induced chloride current in guinea-pig ventricular cells.
Topics: Animals; Catecholamines; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Histamine; Ion Channels; Isoproterenol; Membrane Potentials; Milrinone; Myocardium; Pyridones | 1992 |
Positive lusitropic effect and diminished myofibrillar sensitivity to calcium produced by cAMP on toad (Bufo arenarum Hensel) ventricle.
Topics: Animals; Bucladesine; Bufo arenarum; Calcium; Isometric Contraction; Isoproterenol; Milrinone; Myocardial Contraction; Papaverine; Pyridones; Ventricular Function | 1992 |
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Topics: Amino Acid Sequence; Antibodies; Cardiomyopathy, Dilated; Coronary Disease; GTP-Binding Proteins; Heart; Humans; Isoproterenol; Milrinone; Molecular Sequence Data; Myocardium; Pyridones; Radioimmunoassay | 1992 |
Harmful effects of inotropic agents on myocardial protection.
Topics: Animals; Body Temperature; Bucladesine; Calcium; Cardiotonic Agents; Creatine Kinase; Diltiazem; Hemodynamics; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Reperfusion Injury; Pyridones; Rats; Rats, Inbred Strains; Ryanodine | 1991 |
Cardiovascular and renal effects of milrinone in beta-adrenoreceptor blocked and non-blocked anaesthetized dogs.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Gas Analysis; Dogs; Dopamine; Electrolytes; Female; Heart; Hemodynamics; Hydrogen-Ion Concentration; Isoproterenol; Kidney; Male; Mannitol; Milrinone; Pyridones; Renal Circulation; Urodynamics; Vascular Resistance | 1991 |
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium | 1990 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Mesenteric Arteries; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pertussis Toxin; Pyridones; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Renal Circulation; Sodium Fluoride; Sympathectomy; Vascular Resistance; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Comparison of the effects of milrinone and OPC 3911 with those of isoprenaline, forskolin and dibutyryl-cAMP in rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Bucladesine; Calcium; Colforsin; In Vitro Techniques; Isoproterenol; Male; Milrinone; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Pyridones; Quinolones; Rats; Rats, Inbred Strains; Vasodilation | 1991 |
Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts.
Topics: Adult; Calcium; Chromatography, DEAE-Cellulose; Electric Stimulation; Female; Heart; Heart Failure; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Ouabain; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones | 1991 |
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Adult; Calcimycin; Chromatography, Ion Exchange; Humans; Isoenzymes; Isoproterenol; Middle Aged; Milrinone; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Superoxides | 1990 |
Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adult; Carbachol; Cardiomyopathy, Dilated; Cardiotonic Agents; Coronary Disease; Female; GTP-Binding Proteins; Humans; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Pertussis Toxin; Phenylisopropyladenosine; Pyridones; Receptors, Adrenergic, beta; Receptors, Cholinergic; Receptors, Purinergic; Virulence Factors, Bordetella | 1990 |
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels.
Topics: Animals; Blood Platelets; Cyclic AMP; Guanfacine; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Milrinone; Muscle Tonus; Muscle, Smooth; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Quinolones; Rats; Rats, Inbred Strains; Vinca Alkaloids | 1990 |
Myocardial actions of milrinone: characterization of its mechanism of action.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphatases; Animals; Calcium; Cardiotonic Agents; Dogs; Guinea Pigs; Hemodynamics; Isoproterenol; Milrinone; Mitochondria; Myocardial Contraction; Myocardium; Myofibrils; Pyridones; Rats; Sarcolemma | 1986 |
Reduced positive inotropic effects in diseased human ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Calcium; Dobutamine; Dopamine; Dose-Response Relationship, Drug; Female; Heart Diseases; Histamine; Humans; Isoproterenol; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Theophylline | 1986 |
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Failure; Humans; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Strophanthidin | 1987 |
Inhibition of some new cardiotonic agents by tetrodotoxin.
Topics: Animals; Cardiotonic Agents; Dihydropyridines; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Imidazoles; In Vitro Techniques; Ion Channels; Isoproterenol; Milrinone; Myocardial Contraction; Protoveratrines; Pyridines; Pyridones; Quinazolines; Tetrodotoxin | 1986 |
Subsensitivity of the failing human heart to isoprenaline and milrinone is related to beta-adrenoceptor downregulation.
Topics: Aging; Cardiotonic Agents; Coronary Disease; Electric Stimulation; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Pyridones; Receptors, Adrenergic, beta | 1988 |
Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amrinone; Animals; Cerebral Arteries; Coronary Vessels; Dinoprost; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyridones; Renal Artery; Sodium Nitrite | 1989 |
Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization.
Topics: Adult; Exercise; Female; Heart Failure; Heart Rate; Humans; Isoproterenol; Male; Middle Aged; Milrinone; Norepinephrine; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones; Receptors, Adrenergic, beta | 1989 |
Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels.
Topics: Adult; Aged; Calcium Channel Blockers; Colforsin; Female; Humans; In Vitro Techniques; Isoproterenol; Male; Middle Aged; Milrinone; Muscle, Smooth, Vascular; Norepinephrine; Ouabain; Phosphodiesterase Inhibitors; Potassium; Pyridones; Quinolones; Splanchnic Circulation; Vasodilator Agents | 1989 |
Milrinone enhances cytosolic calcium transient and contraction in rat cardiac myocytes during beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cytosol; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Rats | 1989 |
Screening of positive inotropic agents in isolated cardiac preparations from different sources.
Topics: Animals; Atrial Function; Calcium; Cardiotonic Agents; Drug Evaluation, Preclinical; Heart; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Piperazines; Pyridones; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Reference Values; Ventricular Function | 1989 |
The vasorelaxant effects of milrinone and other vasodilators are attenuated by ouabain.
Topics: Animals; Aorta, Thoracic; Colforsin; Drug Interactions; Female; Guinea Pigs; Hydralazine; In Vitro Techniques; Isoproterenol; Isoquinolines; Isosorbide; Milrinone; Nitroprusside; Ouabain; Pyridones; Sodium-Potassium-Exchanging ATPase; Sulfonamides; Vasodilator Agents; Verapamil | 1988 |
Enhancement of the effectiveness of milrinone to increase force of contraction by stimulation of cardiac beta-adrenoceptors in the failing human heart.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Cardiotonic Agents; Drug Synergism; Heart; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Middle Aged; Milrinone; Pyridones; Receptors, Adrenergic, beta; Stimulation, Chemical | 1988 |
General overview and update of positive inotropic therapy.
Topics: Amrinone; Blood Pressure; Cardiotonic Agents; Digitoxin; Dobutamine; Dopamine; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Isoproterenol; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Pyridones; Stroke Volume; Time Factors | 1986 |
Effects of amrinone on myocardial energetics in severe congestive heart failure.
Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Dogs; Enoximone; Heart; Heart Failure; Humans; Imidazoles; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones | 1985 |
Milrinone effects in the isolated immature rabbit heart.
Topics: Aging; Animals; Blood Pressure; Cardiotonic Agents; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Organ Size; Oxygen Consumption; Pyridones; Rabbits | 1988 |
Inotropic responses change during postnatal maturation in rabbit.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Colforsin; Female; Heart; Imidazoles; Isoproterenol; Male; Milrinone; Myocardial Contraction; Pyridones; Rabbits; Reference Values; Software | 1988 |
Effects of milrinone on contractile responses of guinea pig trachea, lung parenchyma and pulmonary artery.
Topics: Aminophylline; Animals; Carbachol; Cardiotonic Agents; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isoproterenol; Lung; Male; Milrinone; Muscle Contraction; Norepinephrine; Pulmonary Artery; Pyridones; Trachea | 1986 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Female; Isoproterenol; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rolipram; Ventricular Function | 1994 |
Positive inotropic activity of 5-amino-6-cyano-1,3-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrim idine-2,4-dione in cardiac muscle from guinea-pig and man. Part 6: Compounds with positive inotropic activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Pyrimidinones | 1993 |
Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Cyclic AMP; Depression, Chemical; Down-Regulation; Drug Synergism; Heart; Isoproterenol; Kinetics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1993 |
Nitric oxide regulates the calcium current in isolated human atrial myocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anura; Calcium Channels; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Humans; Isoproterenol; Kinetics; Male; Membrane Potentials; Middle Aged; Milrinone; Molsidomine; Nitric Oxide; Patch-Clamp Techniques; Pyridones; Time Factors; Vasodilator Agents | 1995 |
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzoxazines; CD18 Antigens; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytoplasmic Granules; Endothelium, Vascular; Humans; Infant, Newborn; Isoproterenol; Macrophage-1 Antigen; Milrinone; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones; Pyrrolidinones; Respiratory Burst; Rolipram; Umbilical Veins | 1995 |
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Enzyme Activation; Isoproterenol; Male; Milrinone; Myocardial Ischemia; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Quinolines; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Sarcoplasmic reticulum calcium mobilization in right ventricular pressure-overload hypertrophy in the ferret: relationships to diastolic dysfunction and a negative treppe.
Topics: Action Potentials; Animals; Caffeine; Calcium; Diastole; Electric Stimulation; Ferrets; Hypertrophy, Right Ventricular; Isoproterenol; Kinetics; Male; Membrane Potentials; Milrinone; Myocardial Contraction; Potassium; Pressure; Pyridones; Sarcoplasmic Reticulum | 1993 |
Cardiac allograft failure: successful use of biventricular assist device.
Topics: Adult; Cardiac Output, Low; Cardiotonic Agents; Combined Modality Therapy; Graft Rejection; Heart Transplantation; Heart-Assist Devices; Humans; Isoproterenol; Male; Milrinone; Pyridones; Ultrasonography | 1995 |
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Colforsin; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heart; Isoproterenol; Kinetics; Male; Milrinone; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1996 |
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Epithelium; Humans; Isoproterenol; Kinetics; Membrane Potentials; Milrinone; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Phosphodiesterase Inhibitors; Pyridones; Thionucleotides | 1996 |
Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Adult; Analysis of Variance; Cardiotonic Agents; Culture Techniques; Dose-Response Relationship, Drug; Heart Failure; Heart Transplantation; Humans; Isoproterenol; Middle Aged; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Reference Values; Strophanthidin | 1996 |
The effect of positive inotropes on the failing human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Calcium; Cardiotonic Agents; Dobutamine; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Pyridones | 1997 |
The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects.
Topics: Amiloride; Animals; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Humans; Isoproterenol; Lung; Male; Membrane Potentials; Mice; Milrinone; Mutation; Nose; Phosphodiesterase Inhibitors; Respiratory System; Solutions | 1999 |
Is the use of catecholamine before ischemic arrest safe? Effect of catecholamine on rat heart ischemia/reperfusion injury.
Topics: Adrenergic beta-Agonists; Animals; Dopamine; Epinephrine; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Reperfusion Injury; Norepinephrine; Rats; Rats, Wistar; Temperature | 1999 |
Milrinone, a phosphodiesterase III inhibitor, antagonizes the neuromuscular blocking effect of a non-depolarizing muscle relaxant in vitro.
Topics: Adrenergic beta-Agonists; Aminophylline; Animals; Colforsin; Diaphragm; Drug Interactions; Electric Stimulation; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth; Neuromuscular Nondepolarizing Agents; Phosphodiesterase Inhibitors; Phrenic Nerve; Rats; Rats, Wistar | 1999 |
Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle.
Topics: Acetylcholine; Adrenergic beta-Agonists; Aminophylline; Amrinone; Animals; Bronchodilator Agents; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isoproterenol; Milrinone; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Wistar; Trachea | 2000 |
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Topics: Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Milrinone; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Autonomic Nervous System; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Edetic Acid; Electric Stimulation; Isoproterenol; Mesenteric Arteries; Mesenteric Veins; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Rolipram; Second Messenger Systems | 2003 |
Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Arrhythmias, Cardiac; Cyclic Nucleotide Phosphodiesterases, Type 5; Electric Stimulation; Heart Atria; Heart Ventricles; Humans; In Vitro Techniques; Isometric Contraction; Isoproterenol; Mammary Arteries; Milrinone; Muscle, Smooth, Vascular; Myocardial Contraction; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; S-Nitroso-N-Acetylpenicillamine; Saphenous Vein; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2003 |
Possible contribution of the sarcoplasmic reticulum Ca(2+) pump function to electrical and mechanical alternans.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Catecholamines; Cell Polarity; Dogs; Electric Conductivity; Female; Heart Block; Ion Pumps; Isoproterenol; Male; Milrinone; Propranolol; Sarcoplasmic Reticulum; Thapsigargin | 2003 |
Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Cardiotonic Agents; Cell Compartmentation; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; Isoproterenol; Milrinone; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Rana esculenta | 2003 |
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Response Elements; Rolipram | 2003 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Electric Stimulation; Guinea Pigs; Histamine; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Quinoxalines; Receptors, Adrenergic; Receptors, Cholinergic; Signal Transduction; Tetrodotoxin; Theophylline | 2003 |
Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Body Weight; Cardiotonic Agents; Dobutamine; Heart Rate; Hypoxia; Isoproterenol; Male; Milrinone; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left | 2005 |
Regulation of human internal mammary and radial artery contraction by extracellular and intracellular calcium channels and cyclic adenosine 3', 5' monophosphate.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclases; Calcium; Calcium Channels; Colforsin; Cyclic AMP; Cyclic GMP; Extracellular Fluid; Humans; In Vitro Techniques; Intracellular Fluid; Isoproterenol; Mammary Arteries; Milrinone; Phenylephrine; Potassium Chloride; Radial Artery; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adiponectin; Adrenergic beta-Agonists; Androstadienes; Animals; Chromones; Cyclic Nucleotide Phosphodiesterases, Type 3; Insulin; Isoproterenol; Leptin; Male; Milrinone; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Wortmannin | 2007 |
Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.
Topics: Age Factors; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Cyclic AMP; Dinoprostone; Ductus Arteriosus; Fatty Acids, Unsaturated; Hydrazines; Isoproterenol; Milrinone; Muscle Contraction; Xanthones | 2009 |
Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat.
Topics: Aging; Animals; Cardiotonic Agents; Catecholamines; Digoxin; Drug Administration Schedule; Isoproterenol; Milrinone; Myocardial Contraction; Rats | 2011 |
The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Atrial Function; Atrial Natriuretic Factor; Electric Conductivity; Guanylate Cyclase; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Milrinone; Myocytes, Cardiac; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Patch-Clamp Techniques; Peptide Fragments; Phosphodiesterase 3 Inhibitors; Receptors, Atrial Natriuretic Factor; Sinoatrial Node; Stimulation, Chemical; Tetrahydroisoquinolines | 2012 |
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Pyridazines; Quinolines; Quinolones; Rats, Wistar; Rolipram; Simendan; Thiadiazines | 2014 |
Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome.
Topics: Action Potentials; Animals; Cardiac Electrophysiology; Cardiovascular Agents; Cilostazol; Death, Sudden, Cardiac; Disease Models, Animal; Dogs; Electrocardiography; Ion Channels; Isoproterenol; Milrinone; Tachycardia, Ventricular; Tetrazoles; Ventricular Fibrillation | 2016 |
Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study.
Topics: Cardiotonic Agents; Heart Diseases; Humans; Hydrazones; Hypothermia; Isoproterenol; Milrinone; Myocytes, Cardiac; Pyridazines; Simendan | 2023 |