milrinone and cyclic gmp

milrinone has been researched along with cyclic gmp in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (9.52)	18.7374
1990's	29 (46.03)	18.2507
2000's	24 (38.10)	29.6817
2010's	4 (6.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ichimura, M; Kase, H; Kubo, K; Mihara, A; Nagashima, K; Nomoto, Y; Ohno, T; Takai, H; Yamada, K; Yao, K	1
Noma, A; Ono, K; Tareen, FM; Yoshida, A	1
Ashikaga, T; Kishi, Y; Numano, F	1
Buchholz, RA; Pagani, ED; Silver, PJ	1
Andersson, KE; Degerman, E; Lindgren, S; Manganiello, V; Rascón, A	1
Lugnier, C; Muller, B; Stoclet, JC	1
Fischmeister, R; Hartzell, HC	1
Bode, DC; Brunton, LL; Kanter, JR	1
Anker, G; Lagarde, M; Macovschi, O; Némoz, G; Prigent, AF; Valette, L	1
Kamiya, J; Kawai, K; Kobari, T; Maruyama, M	1
Houslay, MD; Price, B; Pyne, NJ	1
Bentley, RG; Hamel, LT; Harris, AL; Lemp, BM; Lepore, RE; O'Connor, B; Silver, PJ	1
Weiss, RM; Wheeler, MA	1
Beavo, JA; Chang, ML; Harrison, SA	1
Beavo, JA; Cadd, GG; Gallis, B; Harrison, SA; Reifsnyder, DH	1
Bacon, ER; Bode, DC; Buchholz, RA; Dundore, RL; Lesher, GY; Pagani, ED; Silver, PJ; Singh, B	1
Imai, A; Nashida, T; Shimomura, H	1
Bénardeau, A; Fischmeister, R; Hatem, S; Kirstein, M; Mercadier, JJ; Rivet-Bastide, M	1
Colicelli, J; Pillai, R; Staub, SF	1
Lundberg, JM; Modin, A; Weitzberg, E	1
Dickinson, K; Foster, GA; Frodsham, G; Jones, RB	1
Lagarde, M; Marcoz, P; Nemoz, G; Prigent, AF	1
Chiu, T; Reid, IA	1
Asazuma, N; Kume, S; Ozaki, Y; Qi, R; Satoh, K; Yang, LB; Yatomi, Y	1
Dubois, M; Grynberg, A; Lagarde, M; Picq, M; Prigent, AF	1
Matsumoto, S	1
Bakre, MM; Visweswariah, SS	1
Cotton, CU; Drumm, ML; Kelley, TJ	1
Majluf-Cruz, A; Omburo, GA; Zhu, WH	1
Leone, RJ; Scholz, PM; Weiss, HR	1
de Koster, BM; Elferink, JG; VanUffelen, BE	1
Cheung, PP; Colman, RW; Yu, L; Zhang, H	1
Aardal, S; Helle, KB; Lillestłl, IK	1
Bivalacqua, TJ; Champion, HC; Doherty, PC; Hellstrom, WJ; Kadowitz, PJ; Rajasekaran, M; Sikka, SC	1
Gong, GX; Scholz, PM; Straznicka, M; Tse, J; Weiss, HR; Yan, L	1
Becker, AJ; Forssmann, WG; Harringer, W; Jonas, U; Stief, CG; Truss, MC; Uckert, S	1
Ikeda, M; Kawase, T; Matsumoto, S; Nishikawa, T; Takahashi, T; Yoshida, S	1
Crews, JD; Whalen, MM	1
Clancy, J; Kraft, P; Lombardi, E; Qiu, Y	1
Hisaoka, T; Kobayashi, S; Kohno, M; Matsuzaki, M; Mochizuki, M; Ohkusa, T; Ono, K; Tanigawa, T; Yamada, J; Yano, M	1
Casadei, B; Musialek, P; Paterson, DJ; Rigg, L; Terrar, DA	1
Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD	1
Herring, N; Paterson, DJ	1
Herring, N; Paterson, DJ; Zaman, JA	1
Fukuda, J; Keino-Masu, K; Masu, M; Tsukada, S	1
Brenna, KJ; Colman, RW; Manns, JM; Sheth, SB	1
Bertel, O; Brunner-La Rocca, HP; Kiowski, W; Oechslin, E; Schad, K; Schalcher, C; Scharf, C; Schindler, R; Suetsch, G	1
Lazar, MJ; Punjabi, K; Scholz, PM; Tse, J; Weiss, HR	1
Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SM; Kim, SZ; Lee, HS; Wen, JF	1
Birk, S; Edvinsson, L; Kruuse, C; Olesen, J	1
Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N	1
Asplund Persson, A; Bengtsson, T; Grenegård, M; Lindström, E; Whiss, PA; Zalavary, S	1
Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N; Watanabe, A	1
Davidov, T; Lazar, M; Molino, B; Rodriguez, R; Scholz, PM; Su, J; Tse, J; Weiss, HR; Zhang, Q	1
Beierwaltes, WH	1
Laique, F; McNamara, PJ; Muang-In, S; Whyte, HE	1
Banafsche, R; Gebhard, MM; Klar, E; Kume, M; Nobiling, R; Yamamoto, Y; Yamaoka, Y	1
Habbazettl, H; Hentschel, T; Koster, A; Kuebler, WM; Kuppe, H; Riad, A; Tschope, C; Weimann, J; Yin, N	1
Gupte, SA; Rabbani, G; Sarabu, MR; Vijay, V	1
Gao, X; Jensen, BL; Persson, AE; Sällström, J; Skøtt, O	1
Birowo, P; Kedia, GT; Kuczyk, MA; Rahardjo, D; Sandner, P; Scheller, F; Sonnenberg, JE; Thon, WF; Uckert, S	1
Dou, D; Gao, Y; Guo, Y; Liu, J; Xu, X; Ying, L; Yu, X	1
Aue, A; Dünnes, S; Friebe, A; Groneberg, D; Groneberg, K; Nikolaev, V; Voussen, B	1

Trials

1 trial(s) available for milrinone and cyclic gmp

Article	Year
Interaction of sildenafil with cAMP-mediated vasodilation in vivo. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Brachial Artery; Cyclic AMP; Cyclic GMP; Forearm; Heart Rate; Hemodynamics; Humans; Isoproterenol; Male; Milrinone; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents	2002

Article

Year

Interaction of sildenafil with cAMP-mediated vasodilation in vivo.

Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5

Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Brachial Artery; Cyclic AMP; Cyclic GMP; Forearm; Heart Rate; Hemodynamics; Humans; Isoproterenol; Male; Milrinone; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents

2002

Other Studies

62 other study(ies) available for milrinone and cyclic gmp

Article	Year
Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232). Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Animals; Aorta; Calcium; Cardiotonic Agents; Cattle; Dogs; Guinea Pigs; Heart Failure; In Vitro Techniques; Male; Molecular Conformation; Molecular Structure; Myocardial Contraction; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Quinazolines; Stereoisomerism; Trifluoperazine; Vasodilator Agents; Ventricular Pressure	1996
Synergistic action of cyclic GMP on catecholamine-induced chloride current in guinea-pig ventricular cells. The Journal of physiology, 1992, Volume: 453 Topics: Animals; Catecholamines; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Histamine; Ion Channels; Isoproterenol; Membrane Potentials; Milrinone; Myocardium; Pyridones	1992
Phosphodiesterases in vascular endothelial cells. Advances in second messenger and phosphoprotein research, 1992, Volume: 25 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Kinetics; Milrinone; Muscle, Smooth, Vascular; Pyridones	1992
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function. Basic research in cardiology, 1992, Volume: 87 Suppl 1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans; Isoenzymes; Kinetics; Milrinone; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Myocardium; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Rats	1992
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta. Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug Interactions; Isoenzymes; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Pyridones; Pyrrolidinones; Quinolones; Rats; Rolipram; Serotonin; Vasodilator Agents	1991
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria. Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium	1990
Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells. Molecular pharmacology, 1990, Volume: 38, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Rana esculenta	1990
Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue. Circulation research, 1991, Volume: 68, Issue:4 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic GMP; Heart Ventricles; Isoenzymes; Kinetics; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Rolipram; Substrate Specificity	1991
Concanavalin A stimulates the Rolipram-sensitive isoforms of cyclic nucleotide phosphodiesterase in rat thymic lymphocytes. Biochemical and biophysical research communications, 1990, Jun-29, Volume: 169, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Concanavalin A; Cyclic AMP; Cyclic GMP; Cytosol; Isoenzymes; Kinetics; Lymphocyte Activation; Lymphocytes; Milrinone; Pyridones; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Thymus Gland	1990
Characterization of MS-857, a new and potent cardiotonic agent, in isolated mammalian cardiac muscles. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cardiotonic Agents; Cats; Cyclic AMP; Cyclic GMP; Dogs; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Macaca mulatta; Male; Milrinone; Myocardial Contraction; Pyridones; Rabbits; Rats; Rats, Inbred Strains; Reserpine; Tetrahydroisoquinolines	1989
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue. Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Amrinone; Animals; Carbamates; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Kinetics; Milrinone; Myocardium; Peptide Hydrolases; Pyridazines; Pyridones; Quinazolines; Trypsin	1987
Inhibition of the low Km cyclic AMP phosphodiesterase and activation of the cyclic AMP system in vascular smooth muscle by milrinone. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Dogs; Enzyme Activation; Female; Guinea Pigs; Isoenzymes; Macaca fascicularis; Male; Milrinone; Muscle, Smooth, Vascular; Protein Kinases; Pyridones; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Vasodilation	1988
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Animals; Cyclic GMP; Enzyme Activation; Female; Guinea Pigs; Insulin; Kinetics; Milrinone; Purinones; Pyridones; Pyrrolidinones; Rolipram; Ureter	1988
Differential inhibition of cardiac cyclic nucleotide phosphodiesterase isozymes by cardiotonic drugs. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Aminopyridines; Amrinone; Animals; Antibodies, Monoclonal; Cardiotonic Agents; Cattle; Cyclic GMP; Enoximone; Imidazoles; Isoenzymes; Mice; Milrinone; Myocardium; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pyridones; Rabbits	1986
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Molecular pharmacology, 1986, Volume: 29, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Amrinone; Animals; Antibodies, Monoclonal; Cardiotonic Agents; Cattle; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Cyclic GMP; Enoximone; Imidazoles; Immune Sera; Kinetics; Mice; Mice, Inbred BALB C; Milrinone; Molecular Weight; Myocardium; Phosphodiesterase Inhibitors; Phosphorylation; Pyridones	1986
Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Aorta; Blood Pressure; Cardiotonic Agents; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Imidazoles; Injections, Intravenous; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridines; Pyridones; Rats; Rats, Sprague-Dawley; Species Specificity; Structure-Activity Relationship; Thiazoles; Vasodilator Agents; Ventricular Function, Left	1995
Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland. Archives of oral biology, 1995, Volume: 40, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calmodulin; Chromatography, Agarose; Cyclic GMP; Enzyme Activation; Isoenzymes; Kinetics; Male; Milrinone; Molecular Weight; Parotid Gland; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram	1995
Nitric oxide regulates the calcium current in isolated human atrial myocytes. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anura; Calcium Channels; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Humans; Isoproterenol; Kinetics; Male; Membrane Potentials; Middle Aged; Milrinone; Molsidomine; Nitric Oxide; Patch-Clamp Techniques; Pyridones; Time Factors; Vasodilator Agents	1995
Mutational mapping of kinetic and pharmacological properties of a human cardiac cAMP phosphodiesterase. The Journal of biological chemistry, 1994, Dec-02, Volume: 269, Issue:48 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Base Sequence; Cyclic GMP; DNA Mutational Analysis; DNA Primers; Humans; Isoquinolines; Kinetics; Milrinone; Molecular Sequence Data; Myocardium; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Pyridones; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Deletion; Tetrahydroisoquinolines	1994
Nitric oxide regulates peptide release from parasympathetic nerves and vascular reactivity to vasoactive intestinal polypeptide in vivo. European journal of pharmacology, 1994, Aug-11, Volume: 261, Issue:1-2 Topics: Animals; Arginine; Atropine; Blood Pressure; Cyclic GMP; Electric Stimulation; Female; Male; Milrinone; Neuropeptides; Nitric Oxide; Nitroarginine; Nitroprusside; Parasympathetic Nervous System; Phosphodiesterase Inhibitors; Pyridones; Regional Blood Flow; Submandibular Gland; Swine; Vascular Resistance; Vasoactive Intestinal Peptide; Vasodilation	1994
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. British journal of pharmacology, 1993, Volume: 108, Issue:4 Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Enzyme Activation; Isoproterenol; Male; Milrinone; Myocardial Ischemia; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Quinolines; Rats; Rats, Wistar; Vasodilator Agents	1993
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents. Molecular pharmacology, 1993, Volume: 44, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Concanavalin A; Cyclic AMP; Cyclic GMP; Cytosol; In Vitro Techniques; Isoenzymes; Lymphocyte Activation; Male; Milrinone; Nitroprusside; Purinones; Pyridones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; T-Lymphocytes	1993
Role of cyclic GMP-inhibitable phosphodiesterase and nitric oxide in the beta adrenoceptor control of renin secretion. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Animals; Blood Pressure; Cyclic GMP; Heart Rate; Male; Milrinone; Nitric Oxide; Phosphodiesterase Inhibitors; Pyridones; Rabbits; Renin	1996
Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:2 Topics: Adenosine Diphosphate; Adrenergic alpha-Agonists; Blood Platelets; Bucladesine; Cyclic AMP; Cyclic GMP; Epinephrine; Epoprostenol; Humans; In Vitro Techniques; Light; Milrinone; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyridones; Scattering, Radiation	1996
Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:10 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Cyclic GMP; Fatty Acids; Fatty Acids, Omega-3; Kinetics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rats; Rats, Wistar; Rolipram	1996
Effect of molsidomine on basal Ca2+ current in rat cardiac cells. Life sciences, 1997, Volume: 60, Issue:6 Topics: Animals; Calcium; Colforsin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Heart; Heart Ventricles; In Vitro Techniques; Milrinone; Molsidomine; Myocardium; Nitric Oxide; Patch-Clamp Techniques; Pyridones; Rats; Vasodilator Agents	1997
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity. FEBS letters, 1997, May-26, Volume: 408, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones	1997
Regulation of amiloride-sensitive sodium absorption in murine airway epithelium by C-type natriuretic peptide. The American journal of physiology, 1998, Volume: 274, Issue:6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Absorption; Amiloride; Animals; Biological Transport; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Membrane Potentials; Mice; Milrinone; Mutation; Nasal Mucosa; Natriuretic Peptide, C-Type; Phosphodiesterase Inhibitors; Proteins; Pyridones; Sodium; Trachea	1998
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism. Life sciences, 1998, Volume: 63, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram	1998
Positive functional effects of milrinone and methylene blue are not additive in control and hypertrophic canine hearts. The Journal of surgical research, 1998, Volume: 77, Issue:1 Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Heart; Hemodynamics; Hypertrophy, Left Ventricular; Methylene Blue; Milrinone; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones; Reference Values	1998
Interaction of cyclic GMP and cyclic AMP during neutrophil migration: involvement of phosphodiesterase type III. Biochemical pharmacology, 1998, Oct-15, Volume: 56, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Movement; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Milrinone; Neutrophils; Phosphodiesterase Inhibitors; Pyridones; Quinolones; Thionucleotides	1998
Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis. Archives of biochemistry and biophysics, 1998, Dec-01, Volume: 360, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Binding Sites; Blood Platelets; Catalysis; Cattle; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cysteine; Histidine; Humans; Kinetics; Milrinone; Molecular Sequence Data; Mutagenesis, Site-Directed	1998
Relaxing effects of cyclic GMP and cyclic AMP-enhancing agents on the long-lasting contraction to endothelin-1 in the porcine coronary artery. Scandinavian journal of clinical and laboratory investigation, 1998, Volume: 58, Issue:8 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Isradipine; Milrinone; Muscle, Smooth, Vascular; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Swine; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation; Verapamil; Vinca Alkaloids	1998
Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). The Journal of urology, 1999, Volume: 162, Issue:5 Topics: Alprostadil; Animals; Cats; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Male; Milrinone; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Rolipram	1999
Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases. Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Heart; Milrinone; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines	1999
Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue. Urology, 2000, Volume: 55, Issue:1 Topics: Colforsin; Cyclic AMP; Cyclic GMP; Heart; Humans; In Vitro Techniques; Male; Milrinone; Myocardium; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones	2000
Effects of N(G)-monomethyl-L-arginine on Ca(2+) current and nitric-oxide synthase in rat ventricular myocytes. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Milrinone; NADPH Dehydrogenase; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats	2000
Inhibition of a phosphodiesterase III in the lysis-sensitive target-induced elevation of cyclic AMP (cAMP) in human natural killer cells. Biochemical pharmacology, 2000, Aug-15, Volume: 60, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Isoquinolines; K562 Cells; Killer Cells, Natural; Milrinone; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rolipram; Tetrahydroisoquinolines	2000
Rabbit corpus cavernosum smooth muscle shows a different phosphodiesterase profile than human corpus cavernosum. The Journal of urology, 2000, Volume: 164, Issue:3 Pt 1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Exonucleases; Humans; Isoenzymes; Male; Milrinone; Muscle Tonus; Muscle, Smooth; Penis; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Rabbits; Second Messenger Systems; Sildenafil Citrate; Species Specificity; Sulfones	2000
Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Transporting ATPases; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dobutamine; Dogs; Hemodynamics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Rolipram; Sarcoplasmic Reticulum; Ventricular Function, Left	2000
Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:10 Topics: Animals; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Hydrazines; Indoles; Isoquinolines; Male; Milrinone; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyrroles; Quinazolines; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Spectrometry, Fluorescence; Sulfonamides; Superoxide Dismutase; Tetrahydroisoquinolines; Thionucleotides; Time Factors; Vasodilator Agents	2000
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation. European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents	2001
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. The Journal of physiology, 2001, Sep-01, Volume: 535, Issue:Pt 2 Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve	2001
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:6 Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Bradycardia; Calcium Channel Blockers; Carbachol; Cardiotonic Agents; Cyclic GMP; Enzyme Inhibitors; Female; Gene Expression; Guanylate Cyclase; Guinea Pigs; Heart Rate; Isoquinolines; Milrinone; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; omega-Conotoxins; Phosphodiesterase Inhibitors; Polysaccharides; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve	2001
Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. Neuroscience letters, 2002, Jan-18, Volume: 318, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Fluorescent Dyes; Ganglia, Spinal; Growth Cones; Guanylate Cyclase; Isoquinolines; Milrinone; Neurites; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peptides; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tetrahydroisoquinolines	2002
Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases. Thrombosis and haemostasis, 2002, Volume: 87, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adult; Blood Platelets; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Humans; Microfilament Proteins; Milrinone; Phosphoproteins; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Processing, Post-Translational; Second Messenger Systems	2002
Negative functional effects of cyclic GMP are altered by cyclic AMP phosphodiesterases in rabbit cardiac myocytes. European journal of pharmacology, 2003, Nov-14, Volume: 481, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Cell Size; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Rabbits; Thionucleotides	2003
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria. Circulation research, 2004, Apr-16, Volume: 94, Issue:7 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume	2004
Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries. European journal of pharmacology, 2004, Apr-05, Volume: 489, Issue:1-2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Endothelium, Vascular; Guinea Pigs; Humans; In Vitro Techniques; Male; Milrinone; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Signal Transduction; Vasodilator Agents	2004
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli. The Journal of veterinary medical science, 2004, Volume: 66, Issue:9 Topics: Adenine; Animals; Carbachol; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids	2004
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets. European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3 Topics: Adenosine; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Humans; Milrinone; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Thrombin; Time Factors; Triazoles	2005
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder. The Journal of veterinary medical science, 2005, Volume: 67, Issue:7 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Gallbladder; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids	2005
Reduction in interaction between cGMP and cAMP in dog ventricular myocytes with hypertrophic failure. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:3 Topics: Adenine; Animals; Body Weight; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Drug Interactions; Enzyme Inhibitors; Heart Failure; Hypertrophy, Left Ventricular; Milrinone; Myocardial Contraction; Myocytes, Cardiac; Organ Size; Signal Transduction	2005
cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3. American journal of physiology. Renal physiology, 2006, Volume: 290, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Furosemide; Kinetics; Male; Milrinone; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Rats; Rats, Sprague-Dawley; Renin; Second Messenger Systems	2006
Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. Journal of critical care, 2006, Volume: 21, Issue:2 Topics: Cyclic AMP; Cyclic GMP; Humans; Hypertension, Pulmonary; Infant, Newborn; Milrinone; Oxygen; Phosphodiesterase Inhibitors; Signal Transduction; Vasodilator Agents	2006
Dynamic changes of post-ischemic hepatic microcirculation improved by a pre-treatment of phosphodiesterase-3 inhibitor, milrinone. The Journal of surgical research, 2006, Volume: 136, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Pressure; Cell Communication; Cell Survival; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Endothelial Cells; Heart Rate; Hematocrit; Ischemic Preconditioning; Leukocytes; Liver; Liver Circulation; Liver Transplantation; Male; Microcirculation; Microscopy, Video; Milrinone; Nitric Oxide; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Venules	2006
Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology, 2007, Volume: 106, Issue:1 Topics: Administration, Inhalation; Animals; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Failure; Hypertension, Pulmonary; Male; Milrinone; Phosphodiesterase Inhibitors; Pulmonary Edema; Rats; Rats, Sprague-Dawley	2007
Regulation of human internal mammary and radial artery contraction by extracellular and intracellular calcium channels and cyclic adenosine 3', 5' monophosphate. The Annals of thoracic surgery, 2007, Volume: 83, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclases; Calcium; Calcium Channels; Colforsin; Cyclic AMP; Cyclic GMP; Extracellular Fluid; Humans; In Vitro Techniques; Intracellular Fluid; Isoproterenol; Mammary Arteries; Milrinone; Phenylephrine; Potassium Chloride; Radial Artery; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2007
Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3. American journal of hypertension, 2010, Volume: 23, Issue:11 Topics: Animals; Blood Pressure; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Juxtaglomerular Apparatus; Kidney Cortex; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Milrinone; Nitric Oxide Synthase Type I; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Purinones; Renal Circulation; Renin; Sodium Chloride, Dietary	2010
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. Urology, 2010, Volume: 76, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Colforsin; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Ejaculation; Humans; In Vitro Techniques; Male; Milrinone; Muscle Relaxation; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Adrenergic, alpha; Rolipram; Seminal Vesicles; Sildenafil Citrate; Sulfones	2010
Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity. Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:1 Topics: Animals; Chromones; Coronary Vessels; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Milrinone; Models, Animal; Morpholines; Nifedipine; Nitroglycerin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinones; Signal Transduction; Swine; Vasodilation; Vasodilator Agents	2012
Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase. Pflugers Archiv : European journal of physiology, 2018, Volume: 470, Issue:4 Topics: Animals; Aorta; Blood Platelets; Blood Pressure; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Down-Regulation; Guanylate Cyclase; Mice; Mice, Inbred C57BL; Mice, Knockout; Milrinone; Muscle Relaxation; Myocytes, Smooth Muscle; Nitric Oxide; Signal Transduction	2018