milrinone and cilostazol

milrinone has been researched along with cilostazol in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.70)18.2507
2000's12 (52.17)29.6817
2010's9 (39.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hidaka, H; Inoue, Y; Kimura, Y; Sudo, T; Tachibana, K; Tochizawa, S; Toga, K1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Bruzzese, D; Di Braccio, M; Fossa, P; Grossi, G; Leoncini, G; Mosti, L; Piras, D; Roma, G; Signorello, MG1
Alfei, S; Cichero, E; Damonte, G; Di Braccio, M; Fossa, P; Grossi, G; Leoncini, G; Signorello, MG1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Arita, M; Dohi, K; Kiyosue, T; Matsui, K; Wang, JC1
Cone, J; Fong, M; Kambayashi, J; Liu, Y; Sakurai, K; Sun, B; Tandon, N; Wang, S; Yoshitake, M1
Cone, J; Fong, M; Kambayashi, J; Liu, Y; Wang, S; Yoshitake, M1
Cone, J; Fong, M; Liu, Y; Wang, S; Yoshitake, M1
Colman, RW; Ke, H; Zhang, W1
Cone, J; Fong, M; Hensley, J; Kambayashi, J; Liu, Y; Movsesian, MA; Shakur, Y; Yoshitake, M1
Clancy, JP; Cobb, BR; Fan, L; Kovacs, TE; Sorscher, EJ1
Ikomi, F; Nakamura, K; Ohhashi, T1
Guan, Q; Montrose, DC; Quilley, J; Rajagopalan, S; Smith, CJ; Zhao, H1
Colman, RW; Zhang, W1
Adderley, S; Bowles, EA; Hanson, MS; Sprague, RS; Sridharan, M; Stephenson, AH1
Fong, M; Kambayashi, J; Liu, Y; Yoshitake, M1
Hashimoto, K; Ishima, T1
Baek, AE; Kanthi, Y; Liao, H; Pinsky, DJ; Sutton, NR1
Antzelevitch, C; Koncz, I; Szél, T1
Chang, NC; Lee, TM; Lin, SZ1
Antzelevitch, C; Gurabi, Z; Koncz, I; Nesterenko, VV; Patocskai, B1
Antzelevitch, C; Barajas-Martinez, H; Gurabi, Z; Hu, D; Koncz, I; Patocskai, B1

Reviews

1 review(s) available for milrinone and cilostazol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for milrinone and cilostazol

ArticleYear
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A.
    Blood, 2007, Sep-01, Volume: 110, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Blood Platelets; Calcium; Calcium Signaling; Cilostazol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cytoskeleton; Enzyme Activation; Hemostatics; Humans; Hydrolysis; Milrinone; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Tetrazoles; Thrombin

2007

Other Studies

21 other study(ies) available for milrinone and cilostazol

ArticleYear
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
    Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Isoenzymes; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolines; Quinolones; Recombinant Proteins; Semicarbazides; Urea

2000
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosp
    Journal of medicinal chemistry, 2007, Jun-14, Volume: 50, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Catalytic Domain; Coumarins; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; In Vitro Techniques; Models, Molecular; Morpholines; Phosphodiesterase Inhibitors; Piperazines; Platelet Aggregation Inhibitors

2007
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones.
    European journal of medicinal chemistry, 2013, Volume: 62

    Topics: Benzimidazoles; Blood Platelets; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Platelet Aggregation Inhibitors; Pyrimidinones; Reference Values; Structure-Activity Relationship

2013
Effects of pimobendan on the L-type Ca2+ current and developed tension in guinea-pig ventricular myocytes and papillary muscle: comparison with IBMX, milrinone, and cilostazol.
    Cardiovascular drugs and therapy, 1999, Volume: 13, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Cardiotonic Agents; Cilostazol; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Milrinone; Myocardial Contraction; Papillary Muscles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyridazines; Tetrazoles

1999
Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:4

    Topics: Animals; Blood Platelets; Cilostazol; Collagen; Coronary Vessels; Cyclic AMP; Dose-Response Relationship, Drug; Heart Ventricles; Humans; In Vitro Techniques; Male; Milrinone; Muscle, Smooth, Vascular; Myocardial Contraction; Perfusion; Platelet Aggregation Inhibitors; Rabbits; Tetrazoles; Vasodilator Agents

1999
Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:3

    Topics: Adenosine; Animals; Blood Pressure; Cilostazol; Dose-Response Relationship, Drug; Heart Rate; Humans; Intermittent Claudication; Male; Milrinone; Myocardial Ischemia; Pentoxifylline; Phosphodiesterase Inhibitors; Rabbits; Tetrazoles; Thioinosine

2000
Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cilostazol; Contraindications; Cyclic Nucleotide Phosphodiesterases, Type 3; Heart; Hemodynamics; In Vitro Techniques; Male; Milrinone; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rabbits; Tetrazoles; Vasodilator Agents

2001
Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis.
    Molecular pharmacology, 2002, Volume: 62, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Binding Sites; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Milrinone; Models, Molecular; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Tetrazoles

2002
Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Interactions; Heart; Humans; Isoenzymes; Milrinone; Myocardium; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Rabbits; Rolipram; Tetrazoles; Tissue Distribution

2002
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.
    American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:3 Pt 1

    Topics: Adenosine Deaminase; Anions; Cell Line; Chlorine; Cilostazol; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Epithelium; Glyburide; Humans; Hypoglycemic Agents; Milrinone; Mutation; Papaverine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Purinergic P1; Rolipram; Sildenafil Citrate; Sulfones; Tetrazoles; Time Factors

2003
Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles.
    Journal of vascular research, 2006, Volume: 43, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arterioles; Aspirin; Cerebrovascular Circulation; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclooxygenase Inhibitors; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Milrinone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors; Pressure; Prostaglandins; Rabbits; Tetrazoles; Vasodilation; Vasodilator Agents

2006
Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Angioplasty, Balloon; Animals; Aorta; Carboxylic Acids; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Milrinone; Nitriles; Phosphodiesterase Inhibitors; Phosphorylation; Quinolones; Rats; Rats, Sprague-Dawley; Tetrazoles; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2007
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Adult; Aged; Animals; Blotting, Western; Cilostazol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Erythrocyte Membrane; Female; Humans; Iloprost; Male; Middle Aged; Milrinone; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Rabbits; Tetrazoles; Up-Regulation

2008
Cilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle.
    Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:1

    Topics: Adenosine; AMP Deaminase; Animals; Cilostazol; Dose-Response Relationship, Drug; Electric Stimulation; Male; Milrinone; Models, Animal; Muscle Contraction; Muscle, Skeletal; Phosphodiesterase 3 Inhibitors; Piperazines; Rabbits; Regional Blood Flow; Tetrazoles; Vasodilator Agents

2010
Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.
    PloS one, 2011, Mar-01, Volume: 6, Issue:3

    Topics: Animals; Cilostazol; Drug Synergism; Inositol 1,4,5-Trisphosphate Receptors; JNK Mitogen-Activated Protein Kinases; Milrinone; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurites; PC12 Cells; Peptide Elongation Factor 1; Phosphatidylinositol 3-Kinases; Phosphodiesterase 3 Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; raf Kinases; ras Proteins; Rats; Receptor, trkA; Signal Transduction; Tetrazoles

2011
Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3).
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:11

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphatases; Antigens, CD; Apyrase; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Humans; Macrophages; Milrinone; Tetrazoles; Transcription, Genetic; Ubiquitination

2013
Cellular mechanisms underlying the effects of milrinone and cilostazol to suppress arrhythmogenesis associated with Brugada syndrome.
    Heart rhythm, 2013, Volume: 10, Issue:11

    Topics: Action Potentials; Animals; Brugada Syndrome; Cilostazol; Disease Models, Animal; Dogs; Drug Therapy, Combination; Heart Conduction System; Heart Rate; Milrinone; Phosphodiesterase 3 Inhibitors; Tetrazoles

2013
Differential effect of phosphodiesterase-3 inhibitors on sympathetic hyperinnervation in healed rat infarcts.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:2

    Topics: Animals; Cilostazol; Heart; Male; Milrinone; Myocardial Infarction; Phosphodiesterase 3 Inhibitors; Rats; Rats, Wistar; Sympathetic Nervous System; Tetrazoles

2014
Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine, cilostazol, and milrinone.
    Circulation. Arrhythmia and electrophysiology, 2014, Volume: 7, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cilostazol; Disease Models, Animal; Dogs; Electrocardiography; Heart Conduction System; Hypothermia, Induced; Milrinone; Perfusion; Phosphodiesterase 3 Inhibitors; Quinidine; Signal Transduction; Tachycardia, Ventricular; Tetrazoles; Time Factors; Ventricular Fibrillation

2014
Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome.
    Heart rhythm, 2016, Volume: 13, Issue:6

    Topics: Action Potentials; Animals; Cardiac Electrophysiology; Cardiovascular Agents; Cilostazol; Death, Sudden, Cardiac; Disease Models, Animal; Dogs; Electrocardiography; Ion Channels; Isoproterenol; Milrinone; Tachycardia, Ventricular; Tetrazoles; Ventricular Fibrillation

2016