milrinone and amrinone

milrinone has been researched along with amrinone in 125 studies

Research

Studies (125)

Timeframe	Studies, this research(%)	All Research%
pre-1990	65 (52.00)	18.7374
1990's	37 (29.60)	18.2507
2000's	21 (16.80)	29.6817
2010's	2 (1.60)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barney, CL; Burkhard, T; Ertel, MA; Kariya, T; Kastner, PR; Marshall, FN; Matthews, DP; McCarthy, JR; Shea, PJ; Whitten, JP	1
Bobowski, G; Bristol, JA; Burke, SE; Evans, DB; Newton, RS; Sircar, I; Steffen, RP; Weishaar, RE	1
Bristol, JA; Kobylarz, D; Moos, WH; Sircar, I; Weishaar, RE	1
Bristol, JA; Humblet, CC; McPhail, AT; Moos, WH; Rithner, C; Sircar, I; Weishaar, RE	1
Bobowski, G; Bristol, JA; Duell, BL; Evans, DB; Sircar, I	1
Erhardt, PW	1
Hayes, JS; Kauffman, RF; Krushinski, JH; Pollock, GD; Robertson, DW; Wilson, H	1
Beedle, EE; Elzey, TK; Hayes, JS; Jones, ND; Kauffman, RF; Robertson, DW; Swartzendruber, JK; Wilson, H	1
Bristol, JA; Evans, DB; Moos, WH; Sircar, I; Weishaar, RE	1
Blas, SD; Cody, V; Davis, FB; Davis, PJ; Wojtczak, A	1
Bacon, ER; Dority, JA; Eissenstat, MA; Fritz, RK; Kumar, V; Kuo, GH; Lesher, GY; Reuman, M; Robinson, S; Singh, B	1
Belluco, P; Benetollo, F; Bombieri, G; Dorigo, P; Fraccarollo, D; Gaion, RM; Maragno, I; Mosti, L; Orsini, F	1
Benetollo, F; Bombieri, G; Borea, PA; Dorigo, P; Floreani, M; Fossa, P; Fraccarollo, D; Maragno, I; Mosti, L; Orsini, F; Sansebastiano, L; Santostasi, G	1
Hidaka, H; Inoue, Y; Kimura, Y; Sudo, T; Tachibana, K; Tochizawa, S; Toga, K	1
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bavetsias, V; Bayliss, R; Fearon, D; Jones, K; van Montfort, RLM; Westwood, IM	1
Herzig, JW; Quast, U	1
Belluco, P; Borea, PA; Carpenedo, F; Dorigo, P; Floreani, M; Gaion, RM; Guerra, L; Mosti, L	1
Barthelemy, J; Duchene-Marullaz, P; Paire, M; Trolese-Mongheal, Y	1
Honerjäger, P; Nawrath, H	1
Lehot, JJ	1
Abdel-Aleem, S; Badr, M; Frangakis, C	1
Himmel, HM; Ravens, U; Schappert, T	1
Chen, HL; Lin, BB	1
Costa, R; De Marino, V; Marino, A	1
Honerjäger, P	1
Drexler, H; Löllgen, H	1
Hagen, A; Hagen, V; Heer, S; Klauschenz, E; Lohmann, D; Mitzner, R; Niedrich, H; Rumler, A	1
Alousi, AA; Johnson, DC	1
Blinks, JR; Endoh, M; Taira, N; Yanagisawa, T	1
Meyer, W; Scholz, H	1
Braunwald, E; Colucci, WS; Wright, RF	1
Ahn, HS; Eardley, D; Prioli, N; Watkins, R	1
Earl, CQ; Linden, J; Weglicki, WB	1
Keren, G; LeJemtel, TH; Reis, D; Sonnenblick, EH	1
Boels, PJ; Brutsaert, DL; Sys, SU	1
Alousi, AA; Evans, DB; Grant, AM; Harris, AL; Silver, PJ	1
Falotico, R; Haertlein, BJ; Lakas-Weiss, CS; Salata, JJ; Tobia, AJ	1
Baim, DS	2
Hess, ML; Wood, MA	1
Kitada, Y; Kobayashi, M; Morita, M; Muroyama, A; Narimatsu, A; Ohizumi, Y; Satoh, N	1
Chen, WX; Jiang, YC; Liu, YQ; Song, XO; Tang, Y	1
Haider, N; Heinisch, G; Offenberger, S	1
Hagen, A; Hagen, V; Heer, S; Mitzner, R; Niedrich, H	1
Houslay, MD; Price, B; Pyne, NJ	1
Weiss, RM; Wheeler, MA	1
Johnston, GD	1
Janicki, JS; Maskin, CS; Weber, KT	1
Andersson, KE	1
Dhainaut, JF	1
Chiotti, D; Presbitero, P	1
Paton, DM; Stone, TW	1
LeJemtel, TH; Levitt, B; Scortichini, D; Sonnenblick, EH	1
Goldstein, RA; Naccarelli, GV	1
Blas, SD; Cody, V; Davis, FB; Davis, PJ; Mylotte, KM; Schoenl, M	1
Komajda, M	1
Leier, CV	1
Colombo, F; Libretti, A	1
LeJemtel, TH; Mancini, DM; Sonnenblick, EH	1
Beavo, JA; Chang, ML; Harrison, SA	1
Brutsaert, DL; Chalant, CH; Goenen, MJ; Sys, SU	1
Binah, O; Danilo, P; Rosen, M; Sodowick, B; Vulliemoz, Y	1
Kenyon, JL; Reeves, JP; Sutko, JL	1
Tommaso, CL	1
Beavo, JA; Cadd, GG; Gallis, B; Harrison, SA; Reifsnyder, DH	1
Ruggie, N	1
Hertzeanu, H; Pines, A	1
Ferrier, GR; Lukas, A	1
Kapur, PA; Makela, VH	1
Benotti, J; Benziger, DP; Chatterjee, K; Cody, R; Edelson, J; Hood, WB; Krebs, C; Luczkowec, C; Schwartz, R; Stroshane, R	1
Farah, AE	1
Hasegawa, GR	1
Sato, Y; Taira, N; Wada, Y	1
Dorigo, P; Gaion, RM; Giacometti, A; Maragno, I; Marcomini, A	1
Levine, WG; Raza, H	1
Birner, P; Hofmann, HJ	1
Cody, V; Davis, FB; Davis, PJ; Edwards, L; Schoenl, M; Warnick, PR	1
Coceani, F; Coe, JY; Olley, PM; Vella, G	1
Lemke, JV	1
Goldfarb, JP; LeJemtel, TH; Manzione, NC; Maskin, CS; Sternlieb, I	1
Goldberg, LI	1
Carlier, J; D'Orio, V; el Allaf, D	1
Le Jemtel, TH; Maskin, CS; Sonnenblick, EH	1
Alonso Francia, C; Calvo Cebollero, I; Diarte de Miguel, JA; Gomollón García, JP; Placer Peralta, LJ	1
Canepari, M; Cappelli, V; Polla, B; Reggiani, C; Zanardi, MC	1
Han, W; Qin, Y; Yang, Z; Zhang, Z; Zhou, S	1
Acar, D; Klaus, W; Rump, AF	1
Blazincic, B; Klaus, W; Rump, AF	1
Muschick, P; Rohde, E; Wiesner, B	1
Lindeborg, DM; Pearl, RG	1
Joseph, G; Klaus, W; Zhao, Y	1
Levy, JH; Salmenperä, M	1
Pfaffendorf, M; van Wezel, HB; van Zwieten, PA; Vroom, MB	1
Clark, WA; Denes, P; Fernandez, RN; Heaney, L; Marius-Nunez, AL; Ranganini, A; Silber, E	1
Davis, FB; Davis, PJ; Lin, HY; Yen, PM	1
Baisden, CE; Butterworth, JF; Ittleman, FP; Prielipp, RC; Rathmell, JP; Royster, RL; Testa, L; Villamaria, F; Viscomi, C; Williams, E	1
McCloskey, WW	1
Fuijmoto, J; Fuijwara, T; Ka, H; Kaneko, Y; Kanemoto, S; Kobayashi, J; Nagata, N; Okabe, H	1
Heintz, B; Kirsten, D; Kirsten, R; Nelson, K	1
Fujishima, K; Hachisu, M; Yamamoto, A	1
Baba, T; Goto, Y; Kanda, M; Noguchi, T; Nonogi, H; Sumida, H; Yasuda, S	1
Hamada, Y; Kashu, Y; Kawachi, K; Nakata, T; Sato, M; Watanabe, Y; Yamamoto, T	1
Iribe, G; Matsunaga, A; Yamada, H; Yoshimura, N	1
Akamatsu, H; Maekawa, N; Mikawa, K; Nishina, K; Niwa, Y; Obara, H; Shiga, M	1
Kiyota, T; Matsuda, F; Sadohara, T; Sugahara, K; Sugita, M; Terasaki, H	1
Majewski, H; Rechtman, MP; Van der Zypp, A	1
Furuya, H; Ishimaru, K; Kawaraguchi, Y; Kitaguchi, K; Sha, K; Shimokawa, M; Takahashi, M; Yanaidani, F	1
Fukuda, H; Hirabayashi, Y; Igarashi, T; Saitoh, K; Shimizu, R; Suzuki, H	1
Ikeda, T; Kazama, T; Kikura, M; Sato, S	1
Kikura, M; Sato, S	2
Chanani, NK; Cowan, DB; del Nido, PJ; Garcia, LM; McGowan, FX; Poutias, DN; Takeuchi, K	1
Azuma, M; Kemmotsu, O; Morimoto, Y; Tachibana, K; Yamane, M	1
Kimura, T; Kuwashima, H; Matsumura, C	1
Mochizuki, M; Nishimura, R; Sasaki, N; Takao, K; Tobata, D	1
Kanmura, Y; Matsumoto, K; Onomoto, M; Sakata, R; Suehiro, S; Tsuneyoshi, I; Yonetani, A	1
Adachi, H; Kakiki, M; Kishi, Y	1
Graf, BM; Grube, C; Martin, E; Stowe, DF; Zausig, YA; Zink, W	1
Furuya, H; Inoue, S; Tanwiphongtrakun, T	1

Reviews

23 review(s) available for milrinone and amrinone

Article	Year
In search of the digitalis replacement. Journal of medicinal chemistry, 1987, Volume: 30, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiotonic Agents; Cyclic AMP; Digitalis Glycosides; Heart Failure; Humans; Myocardial Contraction; Receptors, Adrenergic, beta; Structure-Activity Relationship	1987
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacology of bipyridine phosphodiesterase III inhibitors. European journal of anaesthesiology. Supplement, 1992, Volume: 5 Topics: Amrinone; Cardiotonic Agents; Humans; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Vasodilator Agents	1992
[Physiological bases and therapeutic uses of inodilator drugs]. La Clinica terapeutica, 1991, Jan-31, Volume: 136, Issue:2 Topics: Amrinone; Cardiotonic Agents; Deoxyepinephrine; Dobutamine; Dopamine; Heart Failure; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Sympathomimetics; Vasodilator Agents	1991
Pharmacology of bipyridine phosphodiesterase III inhibitors. American heart journal, 1991, Volume: 121, Issue:6 Pt 2 Topics: Amrinone; Cyclic AMP; Humans; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Vasodilation	1991
Use of inotropes in the critical care setting. Critical care medicine, 1990, Volume: 18, Issue:1 Pt 2 Topics: Amrinone; Cardiotonic Agents; Dobutamine; Dopamine; Enoximone; Epinephrine; Humans; Imidazoles; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Pyridones; Stimulation, Chemical	1990
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2. The New England journal of medicine, 1986, Feb-06, Volume: 314, Issue:6 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Administration, Oral; Aminopyridines; Amrinone; Cardiotonic Agents; Coenzymes; Enoximone; Heart; Heart Failure; Hemodynamics; Humans; Imidazoles; Injections, Intravenous; Milrinone; Nifedipine; Oxyfedrine; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Quinazolines; Ubiquinone	1986
The role of novel inotropic agents in the treatment of heart failure. Journal of cardiovascular pharmacology, 1986, Volume: 8 Suppl 9 Topics: Amrinone; Animals; Cardiotonic Agents; Dobutamine; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Milrinone; Myocardial Contraction; Physical Exertion; Pyridazines; Pyridones; Time Factors	1986
Long-term oral therapy of congestive heart failure with phosphodiesterase inhibitors. The American journal of the medical sciences, 1989, Volume: 297, Issue:2 Topics: Administration, Oral; Amrinone; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Phosphodiesterase Inhibitors; Pyridones	1989
Effects of new inotropic agents on exercise performance. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiac Output; Cardiotonic Agents; Chronic Disease; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Muscles; Oxygen; Oxygen Consumption; Physical Exertion; Pulmonary Wedge Pressure; Pyridones; Time Factors	1986
Some new positive inotropic agents. Acta medica Scandinavica. Supplementum, 1986, Volume: 707 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; Dobutamine; Dopamine; Drug Tolerance; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Phosphodiesterase Inhibitors; Practolol; Prenalterol; Pyridones	1986
[New inotropic drugs]. Cardiologia (Rome, Italy), 1988, Volume: 33, Issue:8 Topics: Adrenergic beta-Agonists; Amrinone; Cardiotonic Agents; Deoxyepinephrine; Enoximone; Ethanolamines; Heart; Humans; Imidazoles; Milrinone; Myocardial Contraction; Propanolamines; Pyridazines; Pyridones; Vasodilator Agents; Xamoterol	1988
[Rational and irrational approach to the inotropic agent therapy of heart failure]. La Clinica terapeutica, 1988, Sep-30, Volume: 126, Issue:6 Topics: Amrinone; Cardiotonic Agents; Digitalis Glycosides; Heart Failure; Humans; Imidazoles; Milrinone; Pyridones; Vasodilator Agents	1988
Non-glycoside, non-catecholamine inotropic agents in the treatment of congestive heart failure. The American journal of medicine, 1986, Feb-28, Volume: 80, Issue:2B Topics: Administration, Oral; Aminopyridines; Amrinone; Arrhythmias, Cardiac; Calcium; Cardiac Output; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Injections, Intravenous; Milrinone; Physical Exertion; Pyridones; Thrombocytopenia; Time Factors	1986
Congestive heart failure. The Medical clinics of North America, 1986, Volume: 70, Issue:4 Topics: Aminopyridines; Amrinone; Angiotensin-Converting Enzyme Inhibitors; Cardiac Glycosides; Cardiotonic Agents; Diuretics; Dobutamine; Dopamine; Heart Failure; Humans; Hydralazine; Milrinone; Nitrates; Nitroprusside; Prazosin; Pyridones; Sympathomimetics; Vasodilator Agents	1986
[New inotropic agents in the treatment of refractory congestive heart failure]. Harefuah, 1988, Mar-15, Volume: 114, Issue:6 Topics: Amrinone; Cardiotonic Agents; Heart Failure; Humans; Milrinone; Pyridones	1988
Milrinone, a new agent for the treatment of congestive heart failure. Clinical pharmacy, 1986, Volume: 5, Issue:3 Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Milrinone; Pyridones	1986
Advances in cardiovascular pharmacology. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 6 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aminopyridines; Amrinone; Animals; Calcium Channel Blockers; Cardiovascular Agents; Dopamine; Heart Rate; Humans; Imidazoles; Milrinone; Myocardial Contraction; Pyridones; Receptors, Histamine; Vasodilator Agents	1984
The new inotropic phosphodiesterase inhibitors. Archives internationales de physiologie et de biochimie, 1984, Volume: 92, Issue:4 Topics: Aminopyridines; Amrinone; Calcium; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Quinazolines; Stimulation, Chemical; Time Factors; Xanthines	1984
[Therapeutic options in cardiogenic shock]. Revista espanola de cardiologia, 1995, Volume: 48, Issue:9 Topics: Amrinone; Angioplasty, Balloon, Coronary; Assisted Circulation; Cardiotonic Agents; Coronary Artery Bypass; Dobutamine; Dopamine; Humans; Milrinone; Myocardial Infarction; Nitroglycerin; Phosphodiesterase Inhibitors; Pyridones; Shock, Cardiogenic; Thrombolytic Therapy; Vasodilator Agents	1995
Inotropic therapy in the critically ill patient. International anesthesiology clinics, 1993,Spring, Volume: 31, Issue:2 Topics: Amrinone; Cardiac Glycosides; Cardiotonic Agents; Catecholamines; Critical Illness; Enoximone; Humans; Milrinone; Pyridones	1993
Use of intravenous inotropic therapy in the home. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, May-01, Volume: 55, Issue:9 Topics: Amrinone; Cardiotonic Agents; Dobutamine; Heart Failure; Home Infusion Therapy; Humans; Infusions, Intravenous; Milrinone; Pyridones	1998
Clinical pharmacokinetics of vasodilators. Part II. Clinical pharmacokinetics, 1998, Volume: 35, Issue:1 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Alprostadil; Amrinone; Carbazoles; Carvedilol; Enoximone; Female; Humans; Iloprost; Imidazoles; Indoramin; Isosorbide Dinitrate; Labetalol; Milrinone; Molsidomine; Nitroglycerin; Nitroprusside; Oxyfedrine; Pentaerythritol Tetranitrate; Phosphodiesterase Inhibitors; Piperazines; Prazosin; Pregnancy; Propanolamines; Pyridones; Theophylline; Trapidil; Vasodilator Agents	1998

Trials

7 trial(s) available for milrinone and amrinone

Article	Year
Pharmacokinetics of the bipyridines amrinone and milrinone. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Administration, Oral; Aminopyridines; Amrinone; Clinical Trials as Topic; Half-Life; Heart Failure; Humans; Infusions, Parenteral; Kinetics; Male; Milrinone; Pyridones; Random Allocation; Time Factors	1986
A multicenter, randomized, blind comparison of amrinone with milrinone after elective cardiac surgery. Anesthesia and analgesia, 1998, Volume: 86, Issue:4 Topics: Adult; Aged; Amrinone; Blood Pressure; Cardiac Output; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Central Venous Pressure; Drug Costs; Elective Surgical Procedures; Female; Fluid Therapy; Hemodynamics; Humans; Injections, Intravenous; Lung; Male; Middle Aged; Milrinone; Myocardial Contraction; Phenylephrine; Phosphodiesterase Inhibitors; Plasma Substitutes; Pyridones; Single-Blind Method; Vascular Resistance; Vasoconstrictor Agents; Ventricular Dysfunction	1998
Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone. Japanese circulation journal, 1999, Volume: 63, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aged; Amrinone; Cardiopulmonary Bypass; Cyclic Nucleotide Phosphodiesterases, Type 3; Dopamine; Female; Hemodynamics; Hot Temperature; Humans; Infant, Newborn; Male; Middle Aged; Milrinone; Phosphodiesterase Inhibitors; Respiratory Physiological Phenomena; Time Factors	1999
Effects of the phosphodiesterase III inhibitors olprinone, milrinone, and amrinone on hepatosplanchnic oxygen metabolism. Critical care medicine, 2000, Volume: 28, Issue:3 Topics: Amrinone; Analysis of Variance; Blood Gas Analysis; Cardiac Surgical Procedures; Hemodynamics; Humans; Imidazoles; Liver; Middle Aged; Milrinone; Oxygen; Phosphodiesterase Inhibitors; Postoperative Care; Prospective Studies; Pyridones; Splanchnic Circulation	2000
[Differences in hemodynamic effects of amrinone, milrinone and olprinon after cardiopulmonary bypass in valvular cardiac surgery]. Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:9 Topics: Aged; Amrinone; Cardiopulmonary Bypass; Female; Heart Valve Diseases; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Male; Middle Aged; Milrinone; Phosphodiesterase Inhibitors; Postoperative Care; Pyridones	2000
The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting. Anesthesia and analgesia, 2002, Volume: 94, Issue:1 Topics: Aged; Amrinone; Cardiotonic Agents; Coronary Artery Bypass; Dopamine; Double-Blind Method; Echocardiography, Transesophageal; Female; Hemodynamics; Humans; Infusions, Intravenous; Male; Milrinone; Oxygen Consumption; Postoperative Complications; Preoperative Care; Stroke Volume; Ventricular Dysfunction	2002
Effects of preemptive therapy with milrinone or amrinone on perioperative platelet function and haemostasis in patients undergoing coronary bypass grafting. Platelets, 2003, Volume: 14, Issue:5 Topics: Aged; Amrinone; Coronary Artery Bypass; Female; Hematologic Tests; Hemostasis; Humans; Male; Middle Aged; Milrinone; Perioperative Care; Phosphodiesterase Inhibitors; Platelet Aggregation; Premedication; Vasodilator Agents	2003

Other Studies

95 other study(ies) available for milrinone and amrinone

Article	Year
Synthesis and cardiotonic activity of novel biimidazoles. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Chemical Phenomena; Chemistry; Dogs; Furans; Heart Rate; Imidazoles; Isoenzymes; Milrinone; Molecular Structure; Myocardial Contraction; Pyridones; Rats; Stimulation, Chemical; Structure-Activity Relationship; Thiazoles; Thiophenes	1990
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for t Journal of medicinal chemistry, 1989, Volume: 32, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Female; Fibrinolytic Agents; Heart Failure; Humans; Imidazoles; Male; Myocardial Contraction; Platelet Aggregation; Pyridazines; Structure-Activity Relationship; Vasodilator Agents	1989
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correl Journal of medicinal chemistry, 1987, Volume: 30, Issue:11 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Female; Guinea Pigs; Imidazoles; Male; Myocardial Contraction; Myocardium; Pyridazines; Structure-Activity Relationship	1987
Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity. Journal of medicinal chemistry, 1987, Volume: 30, Issue:11 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiotonic Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Myocardial Contraction; Spectrophotometry, Infrared; X-Ray Diffraction	1987
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents. Journal of medicinal chemistry, 1985, Volume: 28, Issue:10 Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Dogs; Heart Failure; Imidazoles; Myocardial Contraction; Pyridazines; Structure-Activity Relationship	1985
Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)spiro[cycloalkane- 1,3'-[3H]indol]-2'(1'H)-ones. Journal of medicinal chemistry, 1987, Volume: 30, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chemical Phenomena; Chemistry; Dogs; Female; Indoles; Isoenzymes; Male; Myocardial Contraction; Myocardium; Pyridazines; Sarcoplasmic Reticulum; Spiro Compounds; Stimulation, Chemical; Structure-Activity Relationship	1987
Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone. Journal of medicinal chemistry, 1986, Volume: 29, Issue:5 Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Crystallography; Dogs; Magnetic Resonance Spectroscopy; Milrinone; Models, Molecular; Myocardial Contraction; Pyridones; X-Ray Diffraction	1986
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure. Journal of medicinal chemistry, 1984, Volume: 27, Issue:9 Topics: Animals; Cardiotonic Agents; Dogs; Guinea Pigs; Heart Failure; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines	1984
Structure-activity relationships of milrinone analogues determined in vitro in a rabbit heart membrane Ca(2+)-ATPase model. Journal of medicinal chemistry, 1995, May-26, Volume: 38, Issue:11 Topics: Amrinone; Animals; Binding Sites; Binding, Competitive; Calcium-Transporting ATPases; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Heart; Hydrogen Bonding; In Vitro Techniques; Intracellular Membranes; Membranes; Milrinone; Molecular Conformation; Molecular Structure; Muscle, Skeletal; Myocardial Contraction; Myocardium; Prealbumin; Pyridones; Rabbits; Sarcoplasmic Reticulum; Stimulation, Chemical; Structure-Activity Relationship; Thyroxine	1995
Novel cAMP PDE III inhibitors: imidazo[4,5-b]pyridin-2(3H)-ones and thiazolo[4,5-b]pyridin-2(3H)-ones and their analogs. Journal of medicinal chemistry, 1994, Jan-21, Volume: 37, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Dogs; Imidazoles; In Vitro Techniques; Magnetic Resonance Spectroscopy; Milrinone; Pyridines; Pyridones; Thiazoles	1994
A pharmacological, crystallographic, and quantum chemical study of new inotropic agents. Journal of medicinal chemistry, 1993, Aug-20, Volume: 36, Issue:17 Topics: Amrinone; Animals; Cardiotonic Agents; Crystallography; Electric Stimulation; Guinea Pigs; Male; Milrinone; Models, Molecular; Molecular Conformation; Myocardial Contraction; Pyridones; Structure-Activity Relationship	1993
Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies. Journal of medicinal chemistry, 1996, Sep-13, Volume: 39, Issue:19 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Atrial Function; Cardiotonic Agents; Cattle; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 3; Electric Stimulation; Guinea Pigs; Heart Atria; Male; Milrinone; Models, Molecular; Molecular Conformation; Myocardial Contraction; Pyridones; Pyrimidines; Reserpine; Stimulation, Chemical; Structure-Activity Relationship	1996
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Isoenzymes; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolines; Quinolones; Recombinant Proteins; Semicarbazides; Urea	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorganic & medicinal chemistry, 2018, 07-15, Volume: 26, Issue:11 Topics: Aminopyridines; Crystallography, X-Ray; Drug Delivery Systems; Inhibitory Concentration 50; Molecular Structure; Peptide Fragments; Peptide Library; Protein Kinase Inhibitors	2018
On the role of Ca++ binding proteins as possible targets for Ca++ sensitizing agents. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Amrinone; Animals; Bepridil; Calcium; Calcium-Binding Proteins; Calmodulin; Cardiotonic Agents; Dose-Response Relationship, Drug; Milrinone; Models, Cardiovascular; Myocardial Contraction; Piperazines; Pyridones; Swine; Trifluoperazine; Troponin; Troponin C	1992
Antagonism towards endogenous adenosine and inhibition of cGI-PDE in the cardiac effects of amrinone, milrinone and related analogues. General pharmacology, 1992, Volume: 23, Issue:3 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Amrinone; Animals; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Pyridones; Reserpine	1992
Arrhythmogenic potencies of amrinone and milrinone in unanesthetized dogs with myocardial infarct. General pharmacology, 1992, Volume: 23, Issue:1 Topics: Amrinone; Analysis of Variance; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Dogs; Heart Rate; Injections, Intravenous; Milrinone; Myocardial Contraction; Myocardial Infarction; Phenytoin; Pyridones; Quinidine	1992
[New positive inotropic drugs]. Annales francaises d'anesthesie et de reanimation, 1991, Volume: 10, Issue:1 Topics: Adrenergic Agonists; Amrinone; Cardiotonic Agents; Dopamine; Enoximone; Hemodynamics; Humans; Imidazoles; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Shock, Cardiogenic	1991
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues. Life sciences, 1991, Volume: 48, Issue:18 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats	1991
Combined effects of volatile anesthetics and phosphodiesterase inhibitors on contractile performance in guinea pig hearts. Anesthesia and analgesia, 1991, Volume: 73, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Depression, Chemical; Guinea Pigs; Halothane; Hemodynamics; In Vitro Techniques; Isoflurane; Male; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Stimulation, Chemical	1991
In-vivo effects of amrinone and milrinone on left ventricular dP/dt, intraventricular pressure and heart rate in pentobarbital-anesthetized guinea pigs. Research communications in chemical pathology and pharmacology, 1991, Volume: 74, Issue:2 Topics: Amrinone; Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Injections, Intravenous; Male; Milrinone; Myocardial Contraction; Pentobarbital; Pyridones; Vasodilation; Ventricular Function, Left	1991
[Potential cardiotonic agents. 6. Synthesis and cardiovascular properties of 5-(4-pyridinyl)-, 6-methyl-5-(4-pyridinyl)- and 6-methyl-5-phenyl-substituted 3-cyano-2-oxaalkyoxy-pyridines]. Die Pharmazie, 1990, Volume: 45, Issue:3 Topics: Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Dogs; Guinea Pigs; Heart Rate; Hemodynamics; In Vitro Techniques; Milrinone; Nitriles; Pyridines; Pyridones; Structure-Activity Relationship	1990
Pharmacology of the bipyridines: amrinone and milrinone. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Acetylcholine; Aminopyridines; Amrinone; Animals; Calcium; Carbachol; Cardiotonic Agents; Cats; Cyclic AMP; Dibutyryl Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Hemodynamics; Ion Channels; Male; Milrinone; Myocardial Contraction; Norepinephrine; Potassium; Pyridones; Receptors, Muscarinic; Sodium; Stimulation, Chemical; Time Factors; Verapamil	1986
Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aequorin; Aminopyridines; Amrinone; Animals; Calcium; Carbachol; Cardiotonic Agents; Colforsin; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Enoximone; Female; Imidazoles; Male; Milrinone; Myocardial Contraction; Myocardium; Nifedipine; Nucleotides, Cyclic; Pyrazines; Pyridones; Quinolines; Time Factors	1986
Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Theophylline	1986
Effects of several newer cardiotonic drugs on cardiac cyclic AMP metabolism. Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Colforsin; Cyclic AMP; Enoximone; Guinea Pigs; Hydrolysis; Imidazoles; Isoenzymes; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridones	1986
Inhibition of cyclic AMP-dependent protein kinase activity by the cardiotonic drugs amrinone and milrinone. Life sciences, 1986, Nov-17, Volume: 39, Issue:20 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amrinone; Animals; Cardiotonic Agents; Cyclic AMP; Dogs; In Vitro Techniques; Milrinone; Muscles; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Pyridones	1986
Positive inotropic and vasodilating effects of amrinone and milrinone in isolated canine heart. Journal of cardiovascular pharmacology, 1987, Volume: 10, Issue:4 Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Pyridones; Vasodilation	1987
Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries. Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amrinone; Animals; Cerebral Arteries; Coronary Vessels; Dinoprost; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyridones; Renal Artery; Sodium Nitrite	1989
Positive inotropic and hemodynamic properties of flosequinan, a new vasodilator, and a sulfone metabolite. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:3 Topics: Amrinone; Anesthesia; Animals; Ferrets; Heart Failure; Heart Rate; Hemodynamics; In Vitro Techniques; Infusions, Intravenous; Male; Milrinone; Myocardial Contraction; Papillary Muscles; Pentobarbital; Pyridones; Quinolines; Vasodilator Agents	1989
Effect of phosphodiesterase inhibition on myocardial oxygen consumption and coronary blood flow. The American journal of cardiology, 1989, Jan-03, Volume: 63, Issue:2 Topics: Amrinone; Animals; Coronary Circulation; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones	1989
In vitro characterization of the effects of MCI-154, a novel cardiotonic agent, on cardiac tissues. Japanese journal of pharmacology, 1989, Volume: 49, Issue:3 Topics: Amrinone; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cardiotonic Agents; Cats; Dogs; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Myocardium; Pyridazines; Pyridones; Rabbits; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Sodium-Potassium-Exchanging ATPase	1989
[Studies on the mutagenicity of amrinone and milrinone]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1989, Volume: 20, Issue:2 Topics: Amrinone; Animals; Chromosome Aberrations; Mice; Micronucleus Tests; Milrinone; Mutagenicity Tests; Pyridones	1989
Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type. Die Pharmazie, 1989, Volume: 44, Issue:9 Topics: Amrinone; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Milrinone; Myocardial Contraction; Pyridazines; Pyridones	1989
[Potential cardiotonic agents. 1. Synthesis and pharmacologic properties of 3-cyano-2-oxaalkylamino-5-(4-pyridinyl)pyridines]. Die Pharmazie, 1989, Volume: 44, Issue:1 Topics: Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Milrinone; Pyridines; Pyridones	1989
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue. Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Amrinone; Animals; Carbamates; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Kinetics; Milrinone; Myocardium; Peptide Hydrolases; Pyridazines; Pyridones; Quinazolines; Trypsin	1987
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Animals; Cyclic GMP; Enzyme Activation; Female; Guinea Pigs; Insulin; Kinetics; Milrinone; Purinones; Pyridones; Pyrrolidinones; Rolipram; Ureter	1988
Alternatives to the digitalis glycosides for heart failure. British medical journal (Clinical research ed.), 1985, Mar-16, Volume: 290, Issue:6471 Topics: Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; Heart Failure; Humans; Milrinone; Pyridones	1985
[Use of new inotropic agents in the treatment of acute cardiac failure]. Annales francaises d'anesthesie et de reanimation, 1988, Volume: 7, Issue:2 Topics: Adrenergic Agonists; Amrinone; Calcium Channel Blockers; Cardiotonic Agents; Dobutamine; Dopamine; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Myocardial Contraction; Pyridones	1988
Actions of amrinone and milrinone on the guinea-pig ileum. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:7 Topics: Amrinone; Animals; Evoked Potentials; Female; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Milrinone; Muscle Contraction; Muscle, Smooth; Pyridones; Vasodilator Agents	1988
Effects of phosphodiesterase inhibition on skeletal muscle vasculature. The American journal of cardiology, 1989, Jan-03, Volume: 63, Issue:2 Topics: Amrinone; Animals; Heart Failure; Humans; Milrinone; Muscles; Phosphodiesterase Inhibitors; Physical Exertion; Pyridones; Regional Blood Flow; Vasomotor System	1989
Electrophysiology of phosphodiesterase inhibitors. The American journal of cardiology, 1989, Jan-03, Volume: 63, Issue:2 Topics: Amrinone; Arrhythmias, Cardiac; Cardiotonic Agents; Electrocardiography; Electrophysiology; Heart Conduction System; Heart Failure; Hemodynamics; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones	1989
Milrinone and thyroid hormone stimulate myocardial membrane Ca2+-ATPase activity and share structural homologies. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:23 Topics: Aminopyridines; Amrinone; Animals; Calcimycin; Calcium-Transporting ATPases; Erythrocytes; Female; Male; Milrinone; Myocardium; Pyridones; Rabbits; Sarcolemma; Structure-Activity Relationship; Sulfonamides; Thyroxine; Triiodothyronine; Vanadium	1985
[New cardiotonic agents]. Annales de cardiologie et d'angeiologie, 1985, Volume: 34, Issue:10 Topics: Aminopyridines; Amrinone; Cardiotonic Agents; Colforsin; Deoxyepinephrine; Humans; Imidazoles; Levodopa; Milrinone; Practolol; Prenalterol; Propanolamines; Pyridones; Quinazolines; Xamoterol	1985
General overview and update of positive inotropic therapy. The American journal of medicine, 1986, Oct-31, Volume: 81, Issue:4C Topics: Amrinone; Blood Pressure; Cardiotonic Agents; Digitoxin; Dobutamine; Dopamine; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Isoproterenol; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Pyridones; Stroke Volume; Time Factors	1986
New positive inotropic drugs for the treatment of congestive heart failure. The American journal of cardiology, 1985, Jan-11, Volume: 55, Issue:2 Topics: Aminopyridines; Amrinone; Cardiac Output; Cardiotonic Agents; Dipeptides; Dobutamine; Enalapril; Heart Failure; Humans; Milrinone; Myocardial Contraction; Pyridones; Stimulation, Chemical; Vascular Resistance; Vasodilator Agents	1985
Differential inhibition of cardiac cyclic nucleotide phosphodiesterase isozymes by cardiotonic drugs. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Aminopyridines; Amrinone; Animals; Antibodies, Monoclonal; Cardiotonic Agents; Cattle; Cyclic GMP; Enoximone; Imidazoles; Isoenzymes; Mice; Milrinone; Myocardium; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pyridones; Rabbits	1986
Inotropic effects of amrinone and milrinone on contraction and relaxation of isolated cardiac muscle. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; Cats; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Humans; Hypoxia; Milrinone; Myocardial Contraction; Oxygen; Pyridones; Ranidae; Rats; Sarcoplasmic Reticulum; Stimulation, Chemical; Temperature; Time Factors	1986
The inotropic effects of amrinone and milrinone on neonatal and young canine cardiac muscle. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Age Factors; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Cyclic AMP; Dogs; Heart; Lactates; Lactic Acid; Milrinone; Myocardial Contraction; Pyridones; Time Factors	1986
Effects of amrinone and milrinone on calcium influx into the myocardium. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Aminopyridines; Amrinone; Animals; Calcium; Cattle; Cyclic AMP; Guinea Pigs; Milrinone; Myocardial Contraction; Myocardium; Purkinje Fibers; Pyridones; Rabbits; Rats; Sodium; Time Factors	1986
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Molecular pharmacology, 1986, Volume: 29, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Amrinone; Animals; Antibodies, Monoclonal; Cardiotonic Agents; Cattle; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Cyclic GMP; Enoximone; Imidazoles; Immune Sera; Kinetics; Mice; Mice, Inbred BALB C; Milrinone; Molecular Weight; Myocardium; Phosphodiesterase Inhibitors; Phosphorylation; Pyridones	1986
Effects of amrinone on myocardial energetics in severe congestive heart failure. The American journal of cardiology, 1985, Jul-22, Volume: 56, Issue:3 Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Dogs; Enoximone; Heart; Heart Failure; Humans; Imidazoles; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones	1985
Electrophysiological effects of amrinone and milrinone in an isolated canine cardiac tissue model of ischemia and reperfusion. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1 Topics: Amrinone; Animals; Coronary Disease; Dogs; Electrophysiology; Heart Conduction System; Male; Milrinone; Perfusion; Purkinje Fibers; Pyridones	1988
Is milrinone equivalent to amrinone during enflurane anesthesia in the dog? Anesthesia and analgesia, 1988, Volume: 67, Issue:4 Topics: Amrinone; Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Catecholamines; Dogs; Dose-Response Relationship, Drug; Enflurane; Hemodynamics; Milrinone; Pyridones	1988
Historical perspectives on inotropic agents. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: Alkaloids; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Catecholamines; Cats; Digitalis; Digitalis Glycosides; Dogs; Europe; Glucagon; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Milrinone; Plants, Medicinal; Plants, Toxic; Pyridones; Ranidae; United States	1986
Comparative study of cardiovascular profiles of milrinone and amrinone by use of isolated, blood-perfused dog heart preparations. Heart and vessels, 1986, Volume: 2, Issue:4 Topics: Amrinone; Animals; Atrioventricular Node; Blood Flow Velocity; Coronary Circulation; Dogs; Female; Heart Conduction System; In Vitro Techniques; Male; Milrinone; Papillary Muscles; Pyridones; Sinoatrial Node	1986
[Interaction of amrinone and milrinone with endogenous adenosine in isolated atria of goats]. Cardiologia (Rome, Italy), 1987, Volume: 32, Issue:3 Topics: Adenosine; Amrinone; Animals; Cardiotonic Agents; Drug Interactions; Guinea Pigs; Heart; Heart Atria; Heart Rate; Male; Milrinone; Myocardial Contraction; Pyridones	1987
In vivo and in vitro effects of amrinone and milrinone on hepatic xenobiotic metabolism in rats. Pharmacology, 1987, Volume: 35, Issue:2 Topics: Amrinone; Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; In Vitro Techniques; Liver; Male; Microsomes, Liver; Milrinone; Mixed Function Oxygenases; Pharmaceutical Preparations; Pyridones; Rats; Rats, Inbred Strains; Vasodilator Agents	1987
On the conformational structure of bipyridine cardiotonics. Die Pharmazie, 1987, Volume: 42, Issue:6 Topics: Amrinone; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Milrinone; Molecular Conformation; Pyridones	1987
Competition of milrinone, a non-iodinated cardiac inotropic agent, with thyroid hormone for binding sites on human serum prealbumin (TBPA). Biochemical pharmacology, 1987, Nov-01, Volume: 36, Issue:21 Topics: Amrinone; Binding, Competitive; Blood Protein Electrophoresis; Cardiotonic Agents; Humans; Milrinone; Models, Molecular; Molecular Conformation; Prealbumin; Protein Binding; Pyridones; Radioimmunoassay; Thyroid Hormones	1987
Bipyridine derivatives lower arteriolar resistance and improve left ventricular function in newborn lambs. Pediatric research, 1987, Volume: 22, Issue:4 Topics: Amrinone; Animals; Arterioles; Cardiac Output; Cardiotonic Agents; Dose-Response Relationship, Drug; Milrinone; Pulmonary Wedge Pressure; Pyridones; Sheep; Vascular Resistance; Vasodilator Agents	1987
New inotropic drugs: amrinone and milrinone. Journal of the Medical Association of Georgia, 1987, Volume: 76, Issue:12 Topics: Amrinone; Heart Failure; Humans; Milrinone; Pyridones	1987
New positive inotropic agents for congestive heart failure. The New England journal of medicine, 1986, Aug-07, Volume: 315, Issue:6 Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Drug Evaluation; Heart Failure; Humans; Milrinone; Pyridones	1986
The effects of two new inotropic agents on microsomal liver function in patients with congestive heart failure. The American journal of the medical sciences, 1986, Volume: 291, Issue:2 Topics: Adult; Aged; Aminopyridines; Aminopyrine; Amrinone; Breath Tests; Cardiac Output; Cardiotonic Agents; Heart Failure; Humans; Liver; Liver Function Tests; Male; Microsomes, Liver; Middle Aged; Milrinone; Pyridones	1986
Inotropic drugs for treatment of the failing heart. Cardiovascular clinics, 1984, Volume: 14, Issue:3 Topics: Aminophylline; Aminopyridines; Amrinone; Cardiotonic Agents; Catecholamines; Digitalis Glycosides; Glucagon; Heart Failure; Hemodynamics; Humans; Milrinone; Myocardial Contraction; Pyridones; Receptors, Adrenergic, beta; Theophylline	1984
Direct depressant effect of phosphodiesterase inhibitors on ATPase activity of rat cardiac myofibrils. Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:5 Topics: Adenosine Triphosphatases; Amrinone; Animals; Calcium; Dose-Response Relationship, Drug; Heart; Male; Milrinone; Myofibrils; Phosphodiesterase Inhibitors; Pyridones; Rats	1995
[Inotropic effect of novel domestic cardiotonic agent, vesnarinone--test in vitro]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1994, Volume: 25, Issue:3 Topics: Amrinone; Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Pyrazines; Pyridones; Quinolines; Rabbits; Stimulation, Chemical	1994
A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts. British journal of pharmacology, 1994, Volume: 112, Issue:3 Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Electric Stimulation; Heart; Heart Rate; Hydrazones; In Vitro Techniques; Male; Milrinone; Myocardial Ischemia; Myocardium; NAD; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Rabbits; Simendan; Vasodilation; Ventricular Pressure	1994
Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. Arzneimittel-Forschung, 1993, Volume: 43, Issue:12 Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Fluorescence; Hemodynamics; Histocytochemistry; In Vitro Techniques; Male; Milrinone; Myocardial Infarction; Myocardial Ischemia; NAD; Oxygen Consumption; Pyridones; Rabbits	1993
Hemodynamic response and effects on myocardial energetics of 3-cyano-2-morpholino-5-(pyrid-4-yl)pyridine (AWD 122-14) in anesthetized minipigs. Die Pharmazie, 1993, Volume: 48, Issue:9 Topics: Amrinone; Anesthesia; Animals; Calcium Channel Blockers; Cardiotonic Agents; Dopamine; Energy Metabolism; Hemodynamics; Male; Milrinone; Morpholines; Myocardial Contraction; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridines; Pyridones; Swine; Swine, Miniature	1993
[Pharmacologic action profile of crataegus extract in comparison to epinephrine, amirinone, milrinone and digoxin in the isolated perfused guinea pig heart]. Arzneimittel-Forschung, 1995, Volume: 45, Issue:12 Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Crataegus; Digoxin; Epinephrine; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Plant Extracts; Plants, Medicinal; Pyridones; Refractory Period, Electrophysiological; Vasoconstrictor Agents	1995
The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amrinone; Cyclic AMP; Dose-Response Relationship, Drug; Enoximone; Humans; Mammary Arteries; Milrinone; Norepinephrine; Papaverine; Phosphodiesterase Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyridones; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	1996
Effect of phosphodiesterase inhibitors on human arteries in vitro. British journal of anaesthesia, 1996, Volume: 76, Issue:1 Topics: Adolescent; Adult; Amrinone; Analgesics; Anilides; Arginine; Arteries; Dipyridamole; Enoximone; Female; Glyburide; Humans; In Vitro Techniques; Middle Aged; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Theophylline; Vasoconstriction; Vasodilation	1996
Intermittent inotropic therapy in an outpatient setting: a cost-effective therapeutic modality in patients with refractory heart failure. American heart journal, 1996, Volume: 132, Issue:4 Topics: Ambulatory Care; Amrinone; Cardiotonic Agents; Cost-Benefit Analysis; Dobutamine; Drug Administration Schedule; Emergency Service, Hospital; Female; Follow-Up Studies; Heart Failure; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Milrinone; Patient Admission; Patient Education as Topic; Pyridones; Time Factors	1996
Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. The American journal of physiology, 1997, Volume: 273, Issue:4 Topics: Amrinone; Antiviral Agents; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Inhibitors; Genistein; HeLa Cells; Humans; Interferon-gamma; Iodide Peroxidase; Kinetics; Milrinone; Models, Biological; Phosphodiesterase Inhibitors; Propylthiouracil; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyridones; Recombinant Proteins; Signal Transduction; Thyroxine; Triiodothyronine; Vesicular stomatitis Indiana virus; Virus Replication	1997
[Hemodynamic effects of amrinone or milrinone in infant after right heart bypass operation]. Kyobu geka. The Japanese journal of thoracic surgery, 1998, Volume: 51, Issue:7 Topics: Amrinone; Child; Child, Preschool; Dopamine; Heart Bypass, Right; Heart Defects, Congenital; Hemodynamics; Humans; Milrinone; Phosphodiesterase Inhibitors; Postoperative Period; Pyridones	1998
[Effects of amrinone on renal blood flow and cardiac function, in comparison with those of milrinone and olprinone, in anesthetized dog]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112, Issue:6 Topics: Amrinone; Animals; Cardiotonic Agents; Dogs; Female; Femoral Artery; Hemodynamics; Imidazoles; Male; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Renal Circulation; Vasodilator Agents	1998
Diuretic effect of phosphodiesterase inhibitors depends on baseline renal function in patients with congestive heart failure. The American journal of cardiology, 1999, Apr-15, Volume: 83, Issue:8 Topics: Aged; Aged, 80 and over; Amrinone; Creatinine; Diuresis; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Kidney; Kidney Function Tests; Male; Middle Aged; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Treatment Outcome	1999
Severe heart failure: balancing length and quality of life. Harvard heart letter : from Harvard Medical School, 1999, Volume: 9, Issue:10 Topics: Amrinone; Cardiotonic Agents; Heart Failure; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyrazines; Quality of Life; Quinolines	1999
The effect of phosphodiesterase III inhibitors on human neutrophil function. Critical care medicine, 2000, Volume: 28, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Amrinone; Calcium; Cell-Free System; Cells, Cultured; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Imidazoles; Milrinone; Neutrophils; Phagocytosis; Phosphodiesterase Inhibitors; Pyridones; Reactive Oxygen Species	2000
Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle. Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6 Topics: Acetylcholine; Adrenergic beta-Agonists; Aminophylline; Amrinone; Animals; Bronchodilator Agents; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isoproterenol; Milrinone; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Wistar; Trachea	2000
Amrinone reduces ischaemia-reperfusion injury in rat heart. European journal of pharmacology, 2000, Aug-25, Volume: 402, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amrinone; Animals; Cardiotonic Agents; Creatine Kinase; L-Lactate Dehydrogenase; Male; Milrinone; Myocardial Reperfusion Injury; Myocardium; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Vasodilation	2000
Comparison of the effects of amrinone, milrinone and olprinone in reversing bupivacaine-induced cardiovascular depression. Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:9 Topics: Amrinone; Anesthetics, Local; Animals; Bupivacaine; Depression, Chemical; Dogs; Electrocardiography; Female; Hemodynamics; Imidazoles; Male; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Time Factors	2000
Disaggregatory effects of prostaglandin E1, amrinone and milrinone on platelet aggregation in human whole blood. Platelets, 2000, Volume: 11, Issue:8 Topics: Adenosine Diphosphate; Adult; Alprostadil; Amrinone; Cardiotonic Agents; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Electrochemistry; Humans; Kinetics; Male; Middle Aged; Milrinone; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents	2000
Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1 Topics: Amrinone; Animals; Anti-Inflammatory Agents; Cardiotonic Agents; Cell Line; Cells, Cultured; Cyclooxygenase 2; Cytokines; Endothelium, Vascular; Heart; Inflammation; Intercellular Adhesion Molecule-1; Isoenzymes; Macrophages; Microcirculation; Milrinone; Myocardium; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Signal Transduction	2002
Effects of epinephrine and phosphodiesterase III inhibitors on bupivacaine-induced myocardial depression in guinea-pig papillary muscle. British journal of anaesthesia, 2003, Volume: 90, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Amrinone; Anesthetics, Local; Animals; Bupivacaine; Cyclic Nucleotide Phosphodiesterases, Type 3; Epinephrine; Guinea Pigs; Membrane Potentials; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Sympathomimetics; Synaptic Transmission	2003
Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells. Journal of pharmacological sciences, 2003, Volume: 91, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Adrenal Glands; Amrinone; Angiotensin II; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dimethylphenylpiperazinium Iodide; Histamine; Isoquinolines; Milrinone; Potassium; Pyridazines; Sulfonamides	2003
Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs. The Journal of veterinary medical science, 2004, Volume: 66, Issue:9 Topics: Amrinone; Animals; Blood Pressure; Brain; Cardiotonic Agents; Catecholamines; Coronary Circulation; Digestive System; Dobutamine; Dogs; Dopamine; Eye; Isoflurane; Lung; Microspheres; Milrinone; Muscle, Skeletal; Phosphodiesterase Inhibitors; Regional Blood Flow	2004
Differential pharmacologic sensitivities of phosphodiesterase-3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries. Anesthesia and analgesia, 2005, Volume: 101, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Endothelium, Vascular; Gastroepiploic Artery; Humans; Imidazoles; In Vitro Techniques; Mammary Arteries; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Radial Artery; Vasodilation	2005
Effects of a phosphodiesterase 3 inhibitor, olprinone, on rhythmical change in tension of human gastroepiploic artery. European journal of pharmacology, 2005, Dec-28, Volume: 528, Issue:1-3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Calcium Channel Blockers; Cyclic Nucleotide Phosphodiesterases, Type 3; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastroepiploic Artery; Humans; Imidazoles; In Vitro Techniques; Milrinone; Muscle, Smooth, Vascular; Pyridones; RNA, Messenger; Time Factors; Vasodilation	2005
A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. Anesthesia and analgesia, 2006, Volume: 102, Issue:6 Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Dose-Response Relationship, Drug; Enoximone; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Milrinone; Myocardial Contraction; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Vasodilation	2006
Proper use of phosphodiesterase inhibitors according to the situations. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2006, Volume: 44, Issue:3 Topics: Aged; Amrinone; Blood Pressure; Humans; Male; Milrinone; Phosphodiesterase Inhibitors	2006