milrinone has been researched along with 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinone in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bobowski, G; Bristol, JA; Burke, SE; Evans, DB; Newton, RS; Sircar, I; Steffen, RP; Weishaar, RE | 1 |
| Bristol, JA; Kobylarz, D; Moos, WH; Sircar, I; Weishaar, RE | 1 |
| Bristol, JA; Humblet, CC; McPhail, AT; Moos, WH; Rithner, C; Sircar, I; Weishaar, RE | 1 |
| Alvarez, R; Bruno, JJ; Stephenson, RA; Strosberg, AM; Venuti, MC | 1 |
| Bobowski, G; Bristol, JA; Duell, BL; Evans, DB; Sircar, I | 1 |
| Erhardt, PW | 1 |
| Alvarez, R; Bruno, JJ; Jones, GH; Venuti, MC | 1 |
| Hayes, JS; Kauffman, RF; Krushinski, JH; Pollock, GD; Robertson, DW; Wilson, H | 1 |
| Bristol, JA; Evans, DB; Moos, WH; Sircar, I; Weishaar, RE | 1 |
| Becker, LT; Buchholz, RA; Clas, DM; Dundore, RL; Habeeb, PG; Pratt, PF | 1 |
| Clas, DM; Ezrin, AM; Gorczyca, WP; Lee, KC; Silver, PJ | 1 |
| Abdel-Aleem, S; Badr, M; Frangakis, C | 1 |
| Astley, N; Bonner, FW; Eason, CT; Pattison, A | 1 |
| Keren, G; LeJemtel, TH; Reis, D; Sonnenblick, EH | 1 |
| Houslay, MD; Price, B; Pyne, NJ | 1 |
2 review(s) available for milrinone and 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinone
| Article | Year |
|---|---|
In search of the digitalis replacement.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiotonic Agents; Cyclic AMP; Digitalis Glycosides; Heart Failure; Humans; Myocardial Contraction; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1987 |
The role of novel inotropic agents in the treatment of heart failure.
Topics: Amrinone; Animals; Cardiotonic Agents; Dobutamine; Enoximone; Heart Failure; Hemodynamics; Humans; Imidazoles; Milrinone; Myocardial Contraction; Physical Exertion; Pyridazines; Pyridones; Time Factors | 1986 |
13 other study(ies) available for milrinone and 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinone
| Article | Year |
|---|---|
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for t
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Female; Fibrinolytic Agents; Heart Failure; Humans; Imidazoles; Male; Myocardial Contraction; Platelet Aggregation; Pyridazines; Structure-Activity Relationship; Vasodilator Agents | 1989 |
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correl
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Female; Guinea Pigs; Imidazoles; Male; Myocardial Contraction; Myocardium; Pyridazines; Structure-Activity Relationship | 1987 |
Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiotonic Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Myocardial Contraction; Spectrophotometry, Infrared; X-Ray Diffraction | 1987 |
Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Platelets; Cardiotonic Agents; Dogs; Drug Evaluation; Heart Failure; Humans; Myocardium; Platelet Aggregation; Quinazolines; Structure-Activity Relationship | 1988 |
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Dogs; Heart Failure; Imidazoles; Myocardial Contraction; Pyridazines; Structure-Activity Relationship | 1985 |
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Platelets; Dogs; Humans; Imidazoles; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Myocardium; Quinazolines; Quinolines; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship | 1987 |
Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)spiro[cycloalkane- 1,3'-[3H]indol]-2'(1'H)-ones.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chemical Phenomena; Chemistry; Dogs; Female; Indoles; Isoenzymes; Male; Myocardial Contraction; Myocardium; Pyridazines; Sarcoplasmic Reticulum; Spiro Compounds; Stimulation, Chemical; Structure-Activity Relationship | 1987 |
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Topics: Animals; Cardiotonic Agents; Dogs; Guinea Pigs; Heart Failure; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines | 1984 |
Differential hemodynamic responses to selective inhibitors of cyclic nucleotide phosphodiesterases in conscious rats.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Blood Pressure; Cardiac Output; Hemodynamics; Kinetics; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats; Rats, Inbred Strains; Regional Blood Flow | 1992 |
Comparisons of the depressor, inotropic and renal effects of milrinone and CI-930 to different pure vasodilators and diuretics in conscious instrumented dogs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Pressure; Cardiotonic Agents; Diuretics; Dogs; Female; Fenoldopam; Heart Rate; Hydralazine; Male; Milrinone; Myocardial Contraction; Nitroprusside; Pyridazines; Pyridones; Vasodilator Agents | 1991 |
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats | 1991 |
A comparison of the effects of three positive inotropic agents (amrinone, milrinone and medorinone) on platelet aggregation in human whole blood.
Topics: Adenosine Diphosphate; Amiodarone; Arachidonic Acid; Arachidonic Acids; Cardiotonic Agents; Collagen; Fibrinolytic Agents; Humans; Male; Milrinone; Naphthyridines; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridazines; Pyridones | 1990 |
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Amrinone; Animals; Carbamates; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Kinetics; Milrinone; Myocardium; Peptide Hydrolases; Pyridazines; Pyridones; Quinazolines; Trypsin | 1987 |