milrinone has been researched along with 1-methyl-3-isobutylxanthine in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (22.81) | 18.7374 |
| 1990's | 31 (54.39) | 18.2507 |
| 2000's | 10 (17.54) | 29.6817 |
| 2010's | 3 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantor, EH; Davey, DD; Erhardt, PW; Greenberg, SS; Ingebretsen, WR; Wiggins, J | 1 |
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H | 1 |
| Endoh, M; Katano, Y | 1 |
| Ashikaga, T; Kishi, Y; Numano, F | 1 |
| Buchholz, RA; Pagani, ED; Silver, PJ | 1 |
| Fischmeister, R; Hartzell, HC | 1 |
| Hoffmann, A; Klöcking, HP | 1 |
| De Mey, JG; Heesen, BJ | 1 |
| De Wildt, DJ; Porsius, AJ; Van Rooij, HH; Verrijk, R; Wemer, J | 1 |
| Abdel-Aleem, S; Badr, M; Frangakis, C | 1 |
| Nicholson, CD; Shahid, M | 1 |
| Himmel, HM; Ravens, U; Schappert, T | 1 |
| Bethke, T; Mehl, H; Meyer, W; Schmitz, W; Scholz, H; Thomas, K; Wenzlaff, H | 1 |
| Majewski, H; Minatoguchi, S | 1 |
| Ascuitto, RJ; McDonough, KH; Ramage, D; Ross-Ascuitto, NT | 1 |
| Abdul Matlib, M; Grupp, G; Grupp, I; Rapundalo, ST; Schwartz, A; Solaro, RJ | 1 |
| Meyer, W; Scholz, H | 1 |
| Ahn, HS; Eardley, D; Prioli, N; Watkins, R | 1 |
| Earl, CQ; Linden, J; Weglicki, WB | 1 |
| Brown, L; Erdmann, E; Lorenz, B | 1 |
| Copelas, L; Feldman, MD; Grossman, W; Gwathmey, JK; Morgan, JP; Phillips, P; Schoen, FJ; Warren, SE | 1 |
| Kim, D; Marsh, JD; Olson, EM; Smith, TW | 1 |
| Kamata, K; Nakanishi, T; Ogawa, S; Takao, A | 1 |
| Gillespie, E | 1 |
| Bethke, T; Brunkhorst, D; Meyer, W; Nigbur, R; Scholz, H; von der Leyen, H | 1 |
| Coker, SJ; Holbrook, M | 1 |
| Kamiya, J; Kawai, K; Kobari, T; Maruyama, M | 1 |
| Cottney, J; Marsden, G; Nicholson, CD; Shahid, M | 1 |
| Akita, T; Hartzell, HC; Joyner, RW; Kumar, R; Lu, C | 1 |
| Haverich, A; Scholz, H; Schumacher, C; Wenzlaff, H; Zimmermann, W | 1 |
| Heber, D; Heers, C; Ravens, U | 1 |
| Bethke, T; Klimkiewicz, A; Meyer, W; Schmitz, W; Scholz, H; Schumacher, C; Starbatty, J; Wenzlaff, H; Zimmermann, W | 1 |
| Balligand, JL; Belhassen, L; Kelly, RA; Smith, TW | 1 |
| Al-Nakkash, L; Cotton, CU; Drumm, ML; Kelley, TJ | 1 |
| Bruce, E; Flemmal, K; Grossman, W; Gutstein, DE; Gwathmey, JK; Markis, JE; Morgan, JP; Ransil, BJ; Travers, KE | 1 |
| Erdmann, E | 1 |
| Bakre, MM; Visweswariah, SS | 1 |
| Horita, T; Kasugai, S; Miyamoto, K; Ohya, K; Waki, Y | 1 |
| Carcillo, JA; Dubey, RK; Gillespie, DG; Jackson, EK; Mi, Z | 1 |
| Bonnet, PA; Crilley, TK; Wanstall, JC | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| Majluf-Cruz, A; Omburo, GA; Zhu, WH | 1 |
| Jeffery, TK; Wanstall, JC | 1 |
| Al-Nakkash, L; Hwang, TC | 1 |
| Arita, M; Dohi, K; Kiyosue, T; Matsui, K; Wang, JC | 1 |
| Ikeda, M; Kawase, T; Matsumoto, S; Nishikawa, T; Takahashi, T; Yoshida, S | 1 |
| Lipsius, SL; Samarel, AM; Wang, YG | 1 |
| Majewski, H; Rechtman, MP; Van der Zypp, A | 1 |
| Cherry, JA; Pho, V; Thompson, BE | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| de Lamirande, E; Gagnon, C; Lefièvre, L | 1 |
| Colman, RW; Zhang, W | 1 |
| Barman, SA; White, RE; Zhu, S | 1 |
| Geras-Raaka, E; Gershengorn, MC; Neumann, S | 1 |
| Alam, MH; Lee, J; Miyano, T | 1 |
1 review(s) available for milrinone and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
1 trial(s) available for milrinone and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Blood Platelets; Calcium; Calcium Signaling; Cilostazol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cytoskeleton; Enzyme Activation; Hemostatics; Humans; Hydrolysis; Milrinone; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Tetrazoles; Thrombin | 2007 |
55 other study(ies) available for milrinone and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Cardiotonic Agents; Dogs; Heart; Imidazoles; In Vitro Techniques; Molecular Structure; Muscle Relaxation; Muscle, Smooth, Vascular; Quinoxalines | 1991 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi | 2012 |
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines | 1992 |
Phosphodiesterases in vascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Kinetics; Milrinone; Muscle, Smooth, Vascular; Pyridones | 1992 |
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans; Isoenzymes; Kinetics; Milrinone; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Myocardium; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Rats | 1992 |
Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Rana esculenta | 1990 |
Inhibition of thrombin-induced tissue-type plasminogen activator release by agents which increase intracellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Colforsin; Cyclic AMP; Ear, External; In Vitro Techniques; Milrinone; Perfusion; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Solutions; Swine; Thrombin; Tissue Plasminogen Activator | 1990 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Mesenteric Arteries; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pertussis Toxin; Pyridones; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Renal Circulation; Sodium Fluoride; Sympathectomy; Vascular Resistance; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Cardiovascular responses to milrinone in pertussis toxin-pretreated pithed rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Azepines; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; GTP-Binding Proteins; Heart Rate; Male; Milrinone; Pertussis Toxin; Premedication; Pyridones; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1990 |
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats | 1991 |
Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Heart; Heart Ventricles; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Organic Chemicals; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rats; Rats, Inbred Strains; Rolipram | 1990 |
Combined effects of volatile anesthetics and phosphodiesterase inhibitors on contractile performance in guinea pig hearts.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Depression, Chemical; Guinea Pigs; Halothane; Hemodynamics; In Vitro Techniques; Isoflurane; Male; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Stimulation, Chemical | 1991 |
Effects of the triazolopyrimidine trapidil on force of contraction, beating frequency and phosphodiesterase I--IV activity in guinea-pig hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromatography, DEAE-Cellulose; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Theophylline; Trapidil | 1991 |
Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiotonic Agents; Colforsin; Cyclic AMP; Decerebrate State; Electric Stimulation; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Milrinone; Nitroprusside; Norepinephrine; Pyridones; Rats; Rats, Inbred Strains; Sympathetic Nervous System | 1991 |
The effects of milrinone in the neonatal pig heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cells, Cultured; Coronary Circulation; Coronary Disease; Cyclic AMP; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Milrinone; Muscle, Smooth, Vascular; Myocardium; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyridones; Swine; Systole; Time Factors | 1991 |
Myocardial actions of milrinone: characterization of its mechanism of action.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphatases; Animals; Calcium; Cardiotonic Agents; Dogs; Guinea Pigs; Hemodynamics; Isoproterenol; Milrinone; Mitochondria; Myocardial Contraction; Myocardium; Myofibrils; Pyridones; Rats; Sarcolemma | 1986 |
Phosphodiesterase-inhibiting properties of newer inotropic agents.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Theophylline | 1986 |
Effects of several newer cardiotonic drugs on cardiac cyclic AMP metabolism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Colforsin; Cyclic AMP; Enoximone; Guinea Pigs; Hydrolysis; Imidazoles; Isoenzymes; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridones | 1986 |
Inhibition of cyclic AMP-dependent protein kinase activity by the cardiotonic drugs amrinone and milrinone.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amrinone; Animals; Cardiotonic Agents; Cyclic AMP; Dogs; In Vitro Techniques; Milrinone; Muscles; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Pyridones | 1986 |
Reduced positive inotropic effects in diseased human ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Calcium; Dobutamine; Dopamine; Dose-Response Relationship, Drug; Female; Heart Diseases; Histamine; Humans; Isoproterenol; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Theophylline | 1986 |
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Failure; Humans; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Strophanthidin | 1987 |
Mechanism of the positive inotropic effect of milrinone in cultured embryonic chick ventricular cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cells, Cultured; Chick Embryo; Cyclic AMP; Heart; Ion Channels; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Stimulation, Chemical; Vasodilator Agents | 1987 |
Effect of milrinone on myocardial mechanical function and cyclic AMP content in the fetal rabbit.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cardiotonic Agents; Cyclic AMP; Fetal Heart; Heart; In Vitro Techniques; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Rabbits | 1987 |
Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Dose-Response Relationship, Drug; Humans; Milrinone; Platelet Aggregation Inhibitors; Pyridones; Quinazolines; Theophylline | 1988 |
Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Benzimidazoles; Cardiotonic Agents; Chromatography, DEAE-Cellulose; Electric Stimulation; Guinea Pigs; Imidazoles; In Vitro Techniques; Male; Milrinone; Myocardial Contraction; Oxindoles; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Vasodilator Agents | 1988 |
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Cardiotonic Agents; Coronary Disease; Electrocardiography; Heart Rate; Male; Milrinone; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Rabbits; Theophylline | 1989 |
Characterization of MS-857, a new and potent cardiotonic agent, in isolated mammalian cardiac muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cardiotonic Agents; Cats; Cyclic AMP; Cyclic GMP; Dogs; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Macaca mulatta; Male; Milrinone; Myocardial Contraction; Pyridones; Rabbits; Rats; Rats, Inbred Strains; Reserpine; Tetrahydroisoquinolines | 1989 |
A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; In Vitro Techniques; Milrinone; Myocardial Contraction; Organic Chemicals; Papillary Muscles; Pyridones; Pyrrolidinones; Rats; Rolipram; Theophylline | 1989 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Female; Isoproterenol; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rolipram; Ventricular Function | 1994 |
Effects of saterinone and its enantiomers R(+)-saterinone and S(-)-saterinone on the phosphodiesterase isoenzymes from ventricular tissue of failing human hearts and porcine hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Cardiac Output, Low; Cardiomyopathy, Dilated; Cardiotonic Agents; Chromatography, DEAE-Cellulose; Female; Heart Ventricles; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Male; Middle Aged; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Pyridones; Stereoisomerism; Swine | 1994 |
Positive inotropic activity of 5-amino-6-cyano-1,3-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrim idine-2,4-dione in cardiac muscle from guinea-pig and man. Part 6: Compounds with positive inotropic activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Pyrimidinones | 1993 |
Characterization of the phosphodiesterase inhibition by 2-(3-methoxy-5-methylsulfinyl-2-thienyl)-1H-imidazo-(4,5-c)-pyridine HCl and its sulfide- and sulfone derivatives in myocardial preparations from failing human hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Chromatography, DEAE-Cellulose; Cyclic AMP; Female; Heart Failure; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Pyridones; Sulfides; Sulfones | 1995 |
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Colforsin; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heart; Isoproterenol; Kinetics; Male; Milrinone; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1996 |
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Epithelium; Humans; Isoproterenol; Kinetics; Membrane Potentials; Milrinone; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Phosphodiesterase Inhibitors; Pyridones; Thionucleotides | 1996 |
Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Adult; Analysis of Variance; Cardiotonic Agents; Culture Techniques; Dose-Response Relationship, Drug; Heart Failure; Heart Transplantation; Humans; Isoproterenol; Middle Aged; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Reference Values; Strophanthidin | 1996 |
The effect of positive inotropes on the failing human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Calcium; Cardiotonic Agents; Dobutamine; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Pyridones | 1997 |
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones | 1997 |
Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone Marrow Cells; Bone Resorption; Bucladesine; Calcification, Physiologic; Carcinoma 256, Walker; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Mice; Milrinone; Osteoclasts; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridones; Rats; Rats, Wistar; Xanthines | 1997 |
Phosphodiesterases in the rat renal vasculature.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Kidney; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Rats; Rats, Inbred WKY; Renal Circulation | 1997 |
Vasorelaxant effects of SCA40 (a phosphodiesterase III inhibitor) in pulmonary vascular preparations in rats.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Guinea Pigs; Imidazoles; Male; Milrinone; Muscle, Smooth, Vascular; Parasympatholytics; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Pulmonary Artery; Pyrazines; Pyridones; Rats; Rats, Wistar; Trachea; Vasodilation; Vasodilator Agents | 1998 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1998 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Hypertension, Pulmonary; Hypoxia; Imidazoles; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Pyrazines; Pyridones; Rats; Rats, Wistar; Vasodilation | 1998 |
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Mice; Milrinone; Mutation; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Thionucleotides; Xanthines | 1999 |
Effects of pimobendan on the L-type Ca2+ current and developed tension in guinea-pig ventricular myocytes and papillary muscle: comparison with IBMX, milrinone, and cilostazol.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Cardiotonic Agents; Cilostazol; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Milrinone; Myocardial Contraction; Papillary Muscles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyridazines; Tetrazoles | 1999 |
Effects of N(G)-monomethyl-L-arginine on Ca(2+) current and nitric-oxide synthase in rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Milrinone; NADPH Dehydrogenase; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats | 2000 |
Laminin acts via beta 1 integrin signalling to alter cholinergic regulation of L-type Ca(2+) current in cat atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Actins; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium Channels, L-Type; Cats; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeleton; Female; Heart Atria; Integrin beta1; Laminin; Male; Milrinone; Myocardium; Nitric Oxide Donors; Nitrogen Oxides; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Signal Transduction; Spermine; Thionucleotides | 2000 |
Amrinone reduces ischaemia-reperfusion injury in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amrinone; Animals; Cardiotonic Agents; Creatine Kinase; L-Lactate Dehydrogenase; Male; Milrinone; Myocardial Reperfusion Injury; Myocardium; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Vasodilation | 2000 |
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Calmodulin; Chromatography, Ion Exchange; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Sperm Capacitation; Spermatozoa | 2002 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Pulmonary; Milrinone; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium Channels, Calcium-Activated; Protein Kinase C; Pulmonary Artery; Purinones; Rats; Vasoconstriction | 2008 |
Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Biosensing Techniques; Cell Line, Tumor; Cyclic AMP; HEK293 Cells; Humans; Immunoassay; Luminescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Thyrotropin; Rolipram; Signal Transduction; Thyroid Gland; Thyrotropin; Time Factors | 2013 |
Inhibition of PDE3A sustains meiotic arrest and gap junction of bovine growing oocytes in in vitro growth culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cell Communication; Cell Cycle Checkpoints; Cumulus Cells; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Gap Junctions; In Vitro Oocyte Maturation Techniques; Meiosis; Milrinone; Oocytes; Phosphodiesterase 3 Inhibitors; Quinolones | 2018 |