milfasartan and eprosartan

milfasartan has been researched along with eprosartan* in 1 studies

Other Studies

1 other study(ies) available for milfasartan and eprosartan

Article	Year
Selenosartans: novel selenophene analogues of milfasartan and eprosartan. Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3 A series of selenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity. Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cricetinae; Female; Imidazoles; Molecular Structure; Organoselenium Compounds; Ovary; Receptor, Angiotensin, Type 1; Stereoisomerism; Structure-Activity Relationship; Sulfur; Thiophenes	2008

Article

Year

Selenosartans: novel selenophene analogues of milfasartan and eprosartan.

Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3

A series of selenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity.

Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cricetinae; Female; Imidazoles; Molecular Structure; Organoselenium Compounds; Ovary; Receptor, Angiotensin, Type 1; Stereoisomerism; Structure-Activity Relationship; Sulfur; Thiophenes

2008