Page last updated: 2024-08-23

milacemide and glycine

milacemide has been researched along with glycine in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (20.00)	18.7374
1990's	19 (76.00)	18.2507
2000's	1 (4.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK	1
Deutsch, SI; Mastropaolo, J; Norris, DO; Novitzki, MR; O'Connor, DA	1
Deutsch, SI; Lukacs, LG; Mastropaolo, J; Norris, DO; Novitzki, MR; O'Connor, DA	1
Deutsch, SI; Handerson, H; Hashtroudi, S; Herting, RL; Schwartz, BL	1
Yadid, G; Youdim, MB; Zinder, O	2
Patsalos, PN; Ratnaraj, N; Semba, J	1
Bonsignori, A; Dostert, P; Marrari, P; O'Brien, EM; Strolin Benedetti, M; Tipton, KF	1
Cocchiara, G; Colombo, M; Dostert, P; Strolin Benedetti, M	1
Godfraind, JM	1
Arnolde, SM; Cordi, AA; Handelmann, GE; Mueller, LL; Nevins, ME	1
Miller, RJ; Reynolds, IJ	1
Duvdevani, Y; Kerem, D; Youdim, MB	1
Fahn, S; Garcia De Yebenes, J; Jackson-Lewis, V; Pezzoli, G; Truong, DD	1
Cavalier, R; David-Remacle, M; Janssens de Varebeke, P; Youdim, MB	1
Youdim, MB	1
McCrodden, JM; O'Brien, EM; Tipton, KF; Youdim, MB	1
Diaz-Olivo, R; Fahn, S; Gordon, MF; Hunt, AL	1
Patsalos, PN; Semba, J	1
Curzon, G; Patsalos, PN; Semba, J	1
Doheny, MH; Nagaki, S; Patsalos, PN	1
Lockhart, BP; Maurice, T; Privat, A; Su, TP	1
Khandwala, H; Loomis, CW	1
Semba, J	1
Hammonds, MD; Kee, BS; Shim, SS	1

Reviews

2 review(s) available for milacemide and glycine

Article	Year
[Glycine therapy of schizophrenia; its rationale and a review of clinical trials]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1998, Volume: 18, Issue:3 Topics: Acetamides; Alanine; Amino Acid Transport Systems, Neutral; Animals; Carrier Proteins; Cycloserine; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Prodrugs; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine	1998
Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site. European archives of psychiatry and clinical neuroscience, 2008, Volume: 258, Issue:1 Topics: Acetamides; Alanine; Antipsychotic Agents; Clozapine; Cognition; Cycloserine; Dopamine Agents; Drug Synergism; Drug Therapy, Combination; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Humans; Monoamine Oxidase Inhibitors; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Schizophrenic Psychology; Serine	2008

Article

Year

[Glycine therapy of schizophrenia; its rationale and a review of clinical trials].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1998, Volume: 18, Issue:3

Topics: Acetamides; Alanine; Amino Acid Transport Systems, Neutral; Animals; Carrier Proteins; Cycloserine; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Prodrugs; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine

1998

Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site.

European archives of psychiatry and clinical neuroscience, 2008, Volume: 258, Issue:1

Topics: Acetamides; Alanine; Antipsychotic Agents; Clozapine; Cognition; Cycloserine; Dopamine Agents; Drug Synergism; Drug Therapy, Combination; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Humans; Monoamine Oxidase Inhibitors; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Schizophrenic Psychology; Serine

2008

Trials

2 trial(s) available for milacemide and glycine

Article	Year
Glycine prodrug facilitates memory retrieval in humans. Neurology, 1991, Volume: 41, Issue:9 Topics: Acetamides; Adult; Female; Glycine; Humans; Learning; Male; Memory; N-Methylaspartate; Placebos; Prodrugs; Synaptic Transmission	1991
Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders. Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:4 Topics: Acetamides; Administration, Oral; Adult; Aged; Basal Ganglia; Blood-Brain Barrier; Double-Blind Method; Female; Glycine; Humans; Male; Middle Aged; Movement Disorders; Synaptic Transmission; Videotape Recording	1993

Article

Year

Glycine prodrug facilitates memory retrieval in humans.

Neurology, 1991, Volume: 41, Issue:9

Topics: Acetamides; Adult; Female; Glycine; Humans; Learning; Male; Memory; N-Methylaspartate; Placebos; Prodrugs; Synaptic Transmission

1991

Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders.

Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:4

Topics: Acetamides; Administration, Oral; Adult; Aged; Basal Ganglia; Blood-Brain Barrier; Double-Blind Method; Female; Glycine; Humans; Male; Middle Aged; Movement Disorders; Synaptic Transmission; Videotape Recording

1993

Other Studies

21 other study(ies) available for milacemide and glycine

Article	Year
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1 Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Esters; Glycine; Male; Mice; Mice, Inbred Strains; Neurotoxins; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glycine; Seizures; Spinal Cord; Strychnine	1998
Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2 Topics: Acetamides; Animals; Behavior, Animal; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Electroshock; Glycine; Hindlimb; Male; Mice; Monoamine Oxidase Inhibitors; Reflex	1992
Effects of milacemide, a glycine prodrug, on ethanol's antiseizure efficacy. Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:2 Topics: Acetamides; Animals; Anticonvulsants; Drug Synergism; Electroshock; Ethanol; Glycine; Injections, Intraperitoneal; Male; Mice; Prodrugs; Receptors, N-Methyl-D-Aspartate	1992
Effects of the glycine prodrug milacemide (2-N-pentylaminoacetamide) on catecholamine secretion from isolated adrenal medulla chromaffin cells. British journal of pharmacology, 1991, Volume: 104, Issue:3 Topics: Acetamides; Adrenal Medulla; Animals; Catecholamines; Cattle; Chromaffin System; Glycine; In Vitro Techniques; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Proteins	1991
Simple and rapid micro-analytical procedures for the estimation of milacemide and its metabolite glycinamide in rat plasma and cerebrospinal fluid by high-performance liquid chromatography. Journal of chromatography, 1991, Apr-19, Volume: 565, Issue:1-2 Topics: Acetamides; Animals; Chromatography, High Pressure Liquid; Fluorescence; Glycine; Monoamine Oxidase Inhibitors; Rats	1991
Is the oxidation of milacemide by monoamine oxidase a major factor in its anticonvulsant actions? Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11 Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Glycine; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction	1991
Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide? Journal of neural transmission. Supplementum, 1990, Volume: 32 Topics: Acetamides; Animals; Flavin-Adenine Dinucleotide; Glycine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Polyamine Oxidase; Putrescine; Rats; Rats, Inbred Strains; Selegiline	1990
Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells. British journal of pharmacology, 1990, Volume: 100, Issue:1 Topics: Acetamides; Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Iontophoresis; Kainic Acid; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid	1990
Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4 Topics: Acetamides; Amnesia; Animals; Avoidance Learning; Benzamides; Exploratory Behavior; Glycine; Male; Mice; Monoamine Oxidase Inhibitors; Prodrugs; Rats; Selegiline	1989
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Molecular pharmacology, 1989, Volume: 36, Issue:5 Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1989
The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl. European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3 Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Glycine; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Phenethylamines; Prodrugs; Rats; Seizures; Selegiline	1988
Glycine involvement in DDT-induced myoclonus. Movement disorders : official journal of the Movement Disorder Society, 1988, Volume: 3, Issue:1 Topics: Acetamides; Animals; Anticonvulsants; Brain Chemistry; DDT; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Myoclonus; Prodrugs; Rats; Rats, Inbred Strains	1988
Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine oxidase B. Journal of neurochemistry, 1988, Volume: 50, Issue:4 Topics: Acetamides; Animals; Biotransformation; Blood Platelets; Brain; Cattle; Chromaffin System; Female; Glycine; Humans; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Placenta; Pregnancy; Rats; Rats, Inbred Strains	1988
Uptake and receptor sites for glycine in isolated bovine adrenal medulla chromaffin cells. Neuroscience, 1993, Volume: 55, Issue:4 Topics: Acetamides; Adrenal Medulla; Alanine; Animals; beta-Alanine; Cattle; Cell Membrane; Choline; Cysteine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kinetics; Ouabain; Receptors, Glycine; Sarcosine; Sodium; Strychnine; Taurine; Temperature	1993
Parkinson's disease and milacemide. Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:5 Topics: Acetamides; Animals; Brain; Glycine; Humans; Macaca mulatta; Monoamine Oxidase Inhibitors; Motor Skills; Neurologic Examination; Parkinson Disease; Receptors, N-Methyl-D-Aspartate	1994
The interactions of milacemide with monoamine oxidase. Biochemical pharmacology, 1994, Feb-11, Volume: 47, Issue:4 Topics: Acetamides; Aldehydes; Animals; Anticonvulsants; Glycine; Kinetics; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Rats	1994
Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid. European journal of pharmacology, 1993, Jan-19, Volume: 230, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetamides; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Glycine; Homovanillic Acid; Male; Rats; Rats, Sprague-Dawley; Taurine	1993
Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemide. British journal of pharmacology, 1993, Volume: 108, Issue:4 Topics: Acetamides; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Glycine; Half-Life; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1993
A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:2 Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Frontal Lobe; Glycine; Hippocampus; Male; Microdialysis; Prodrugs; Rats; Rats, Sprague-Dawley	1996
Reversion of beta 25-35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists. Brain research, 1996, Aug-26, Volume: 731, Issue:1-2 Topics: Acetamides; Amnesia; Amyloid beta-Peptides; Animals; Antimetabolites; Avoidance Learning; Behavior, Animal; Binding Sites; Cycloserine; Glycine; Male; Mice; Monoamine Oxidase Inhibitors; Peptide Fragments; Receptors, N-Methyl-D-Aspartate	1996
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. Pain, 1998, Volume: 77, Issue:1 Topics: Acetamides; Animals; Anticonvulsants; Clorgyline; Glycine; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Monoamine Oxidase Inhibitors; Nociceptors; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Values; Selegiline; Strychnine	1998