Page last updated: 2024-08-23

miglustat and n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin

miglustat has been researched along with n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's8 (88.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aerts, JM; Donker-Koopman, WE; Overhand, M; Overkleeft, HS; Risseeuw, MD; van den Berg, RJ; van der Marel, GA1
Aerts, JM; Bijl, N; Boot, RG; Copeland, D; Ghauharali, K; Groen, AK; Groener, JE; Liu, H; Meijer, AJ; O'Shea, TJ; Ottenhoff, R; Overkleeft, HS; Song, H; van den Berg, RJ; van der Marel, GA; van Eijk, M; Wennekes, T; Yew, N1
Codd, R; Liao, V; Lifa, T; Liu, J; Obando, D1
Aay, N; Chan, V; Du, H; Finn, P; Galan, A; Hanel, A; Harrison, A; Kearney, P; Koltun, E; Lamb, P; Larson, C; Mohan, R; Nachtigall, J; Noson, K; Nuss, J; Ogilvie, K; Qian, F; Richards, S; Rosen, J; Tam, D; Wang, T; Won, KA; Zhang, J1
Aay, N; Aoyama, R; Arcalas, A; Bentzien, F; Cancilla, B; Chan, V; Du, H; Finn, P; Galan, A; Hanel, A; Harrison, A; Kearney, P; Koltun, ES; Lamb, P; Larson, CJ; Mohan, R; Nachtigall, J; Nuss, J; Ogilvie, K; Plonowski, A; Qian, F; Richards, S; Rosen, J; Tam, D; Wang, T; Won, KA; Yakes, M; Zhang, J; Zhang, W1
Aerts, JM; Bikker, P; Boot, R; de Bruijn, AC; Donker-Koopman, WE; Ghisaidoobe, A; Godschalk, FD; Guijt, MC; Hagens, P; Halma, JM; Luitjens, SB; Overkleeft, HS; Rogaar, E; Strijland, A; van den Berg, RJ; van der Marel, G; van Rixel, VH; Van't Hart, SM; Wijzenbroek, M; Zweegers, T1
Aerts, JM; Boot, RG; Donker-Koopman, WE; Ghisaidoobe, A; Overkleeft, HS; Strijland, A; van den Berg, RJ; van der Marel, GA; Wennekes, T1
Aerts, JM; Butt, SS; Donker-Koopman, WE; Ghisaidoobe, AT; Koomen, GJ; Leemhuis, M; Overkleeft, HS; Scheij, S; Strijland, A; van Boeckel, CA; van den Berg, RJ; van den Nieuwendijk, AM; van der Marel, GA; van der Stelt, M; van Loevezijn, A; Wennekes, T1
Aureli, M; Bassi, R; Bragonzi, A; Cabrini, G; D'Alonzo, D; De Fenza, M; De Fino, I; Dechecchi, MC; Esposito, A; Gambari, R; Guaragna, A; Lampronti, I; Lippi, G; Loberto, N; Munari, S; Palumbo, G; Ranucci, S; Rossi, A; Santangelo, A; Tamanini, A; Tironi, M1

Reviews

1 review(s) available for miglustat and n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin

ArticleYear
The many faces of the adamantyl group in drug design.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Adamantane; Animals; Antimalarials; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Agents; Iron Chelating Agents; Iron Overload; Malaria; Solubility

2011

Other Studies

8 other study(ies) available for miglustat and n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin

ArticleYear
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Dec-01, Volume: 19, Issue:23

    Topics: Amines; Bridged Bicyclo Compounds, Heterocyclic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glucosidases; Molecular Conformation; Structure-Activity Relationship

2009
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Absorption; Animals; Blood Glucose; Carbohydrate Metabolism; Glycated Hemoglobin; Glycosphingolipids; Imino Sugars; Mice; Mice, Obese; Obesity; Rats; Rats, Zucker; Structure-Activity Relationship; Viscera

2010
Discovery of a new class of glucosylceramide synthase inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Nov-15, Volume: 21, Issue:22

    Topics: Administration, Oral; Animals; Drug Discovery; Enzyme Inhibitors; Glucosyltransferases; Humans; Mice; Mice, Inbred C57BL; Structure-Activity Relationship

2011
Discovery and characterization of an inhibitor of glucosylceramide synthase.
    Journal of medicinal chemistry, 2012, May-10, Volume: 55, Issue:9

    Topics: Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Gangliosides; Glucose Tolerance Test; Glucosyltransferases; Humans; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Nude; Phenylalanine; Rats; Rats, Sprague-Dawley; Rats, Zucker; Structure-Activity Relationship; Triglycerides

2012
Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.
    ACS medicinal chemistry letters, 2011, Feb-10, Volume: 2, Issue:2

    Topics:

2011
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.
    ACS medicinal chemistry letters, 2011, Jul-14, Volume: 2, Issue:7

    Topics:

2011
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
    Journal of medicinal chemistry, 2014, Nov-13, Volume: 57, Issue:21

    Topics: 1-Deoxynojirimycin; beta-Glucosidase; Biphenyl Compounds; Enzyme Inhibitors; Glucosylceramidase; Glucosyltransferases; Humans; Imino Sugars

2014
Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease.
    European journal of medicinal chemistry, 2019, Aug-01, Volume: 175

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; beta-Glucosidase; Bronchi; Cystic Fibrosis; Dose-Response Relationship, Drug; Humans; Imino Sugars; Inflammation; Inhibitory Concentration 50; Mice; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Stereoisomerism

2019