mifepristone has been researched along with promegestone in 110 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (34.55) | 18.7374 |
| 1990's | 49 (44.55) | 18.2507 |
| 2000's | 15 (13.64) | 29.6817 |
| 2010's | 8 (7.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doré, JC; Gilbert, J; Ojasoo, T; Raynaud, JP | 1 |
| DeMarzo, AM; Edwards, DP; Nordeen, SK; Oñate, SA | 1 |
| Descomps, B; Laffargue, F; Lobaccaro-Henri, C; Saintot, M; Thaler-Dao, H; Zahradnik, HP | 1 |
| Bhakta, A; Kloosterboer, HJ; Mizutani, T; Moudgil, VK | 1 |
| Baker, ME; Rodbard, D; Rondinone, CM | 1 |
| Bélanger, L; Bocquel, MT; Chambon, P; Meyer, ME; Turcotte, B | 1 |
| Chao, CC; Ebede, P; Gallo, MA; Thomas, T; Thomas, TJ | 1 |
| Eliezer, N; Hurd, C; Moudgil, VK; Nakao, M | 1 |
| Skafar, DF | 1 |
| Svec, F | 1 |
| Katzenellenbogen, BS; Keith, D; Read, LD; Slamon, DJ | 1 |
| Bircher, JA; Hathaway, LD; Moore, MR | 1 |
| Ruh, MF; Ruh, TS; Turner, JW; Ward, DT | 1 |
| Kokai, Y; Lyttle, CR; Modiano, JF; Nowell, PC; Pykett, MJ; Weiner, DB | 1 |
| Beato, M; Gross, B; Kalff, M | 1 |
| Arai, K; Arakawa, S; Kambegawa, A; Okinaga, S | 1 |
| Counterman, LJ; Haslam, SZ; Wang, S | 1 |
| Dauvois, S; Dumont, M; Haagensen, DE; Labrie, F; Simard, J | 1 |
| Bader, C; Monet, JD; Thomas, M | 1 |
| Gompel, A; Kuttenn, F; Malet, C; Mauvais-Jarvis, P | 2 |
| Gompel, A; Kuttenn, F; Lalardrie, JP; Malet, C; Mauvais-Jarvis, P; Spritzer, P | 1 |
| Hagley, RD; Hissom, JR; Moore, MR | 1 |
| Matsumoto, K; Shimizu, I; Tanizawa, O; Terakawa, N | 1 |
| Carlson, KE; Coppey, M; Katzenellenbogen, JA; Magdelenat, H | 1 |
| Edwards, DP; el-Ashry, D; Kühnel, B; Nordeen, SK | 1 |
| Chalbos, D; Chambon, M; Rochefort, H; Vial, HJ | 1 |
| Bowden, RT; Hissom, JR; Moore, MR | 1 |
| Greene, GL; Katzenellenbogen, BS; Read, LD | 1 |
| Beck, B; Chasserot-Bolaz, S; Pogson, CI; Santana, MA | 1 |
| Crastes de Paulet, A; Gagne, D; Pons, M | 1 |
| Gagne, D; Labhilili, M; Pons, M | 1 |
| Anter, MJ; Hurd, C; Moudgil, VK | 1 |
| Assailly, J; Bader, CA; Brami, M; Dautigny, N; Monet, JD; Thomas, M; Ulmann, A | 1 |
| Mazella, J; Sun, B; Tseng, L | 1 |
| Beuving, DC; Campbell, JA; Gibson, RE; Spilman, CH | 1 |
| Albertson, B; Dimattina, M; Falk, RJ; Loriaux, DL; Seyler, DE | 1 |
| Edwards, DP; Elashry-Stowers, D; Speers, WC; Zava, DT | 1 |
| Moore, MR | 1 |
| Crews, D; Lindzey, J | 1 |
| Hurd, C; Miller, MM; Moudgil, VK | 1 |
| Bagchi, MK; Edwards, DP; Elliston, JF; O'Malley, BW; Tsai, MJ; Tsai, SY | 1 |
| Gompel, A; Kuttenn, F; Mauvais-Jarvis, P | 1 |
| Gauthier, Y; Schneider, W; Shyamala, G | 1 |
| Greene, GL; Katzenellenbogen, BS; Miller, JS; Read, LD; Snider, CE | 1 |
| Hurd, C; Moudgil, VK | 1 |
| Brandon, DD; Chrousos, GP; Kawai, S; Loriaux, DL; Nieman, LK; Udelsman, R | 1 |
| Lecaque, D; Philibert, D; Secchi, J; Tournemine, C | 1 |
| Djiane, J; Houdebine, LM; Jahn, GA | 1 |
| Barfield, RJ; Etgen, AM; Vathy, IU | 1 |
| Bardon, S; Derocq, D; Gill, PG; Rochefort, H; Vignon, F | 1 |
| Agarwal, MK; Eliezer, N; Hurd, C; Lombardo, G; Moudgil, VK | 1 |
| Bailly, A; Le Page, C; Milgrom, E; Rauch, M | 1 |
| Katzenellenbogen, BS; Mullick, A | 1 |
| Bower, MA; Maller, JL; Sadler, SE | 1 |
| Horwitz, KB | 1 |
| Lecaque, D; Secchi, J | 1 |
| O'Malley, BW; Oñate, SA; Tsai, MJ; Tsai, SY | 1 |
| Alban, P; Dinda, S; Hurd, C; Jhanwar, SC; Khattree, N; Moudgil, VK; Nag, K | 1 |
| Callard, IP; Giannoukos, G | 1 |
| Miyauchi, A; Osuga, Y; Taketani, Y | 1 |
| Altmann, M; Beck, CA; DeMarzo, A; Edwards, DP; Weigel, NL; Zhang, Y | 1 |
| Danielsen, M; Zhang, S | 1 |
| Horwitz, KB; Mohamed, MK; Takimoto, GS; Tung, L | 1 |
| Bartsch, J; Beato, M; Truss, M | 1 |
| Auzou, G; Balaguer, P; Jausons-Loffreda, N; Pons, M | 1 |
| Cann, JR; Coombs, RO; Howlett, GJ; Jacobsen, MP; Winzor, DJ | 1 |
| Beck, G; Chasserot-Golaz, S | 1 |
| Ishaque, A; Kazmi, SM; Lau, C; Plante, RK; Visconti, V | 1 |
| Horwitz, KB; Sartorius, CA; Takimoto, GS; Tung, L | 1 |
| Bona, BJ; Edwards, DP; Lieberman, BA; Nordeen, SK | 1 |
| Cairns, C; Cairns, W; Okret, S | 1 |
| Dickson, RB; Lippman, ME; Shi, YE; Sobel, ME; Thompson, EW; Torri, J; Yamada, Y; Yieh, L | 1 |
| Beitins, IZ; Krey, LC; Padmanabhan, V | 1 |
| Joosten, JW; Kloosterboer, HJ; Schoonen, WG | 1 |
| Baker, C; Hawkins, P; Norris, B; Quinn, PG; Sheridan, PL; Wei, LL | 1 |
| Beato, M; Pecci, A; Pelster, D; Scholz, A | 1 |
| Greyling, MD; Potgieter, HC; van Aarde, RJ | 1 |
| Grimison, B; Groshong, SD; Horwitz, KB; Langan, TA; Lange, CA; Owen, GI; Schauer, IE; Sclafani, RA; Todd, MC | 1 |
| Dinda, S; Herman, M; Hurd, C; Iwasaki, K; Kloosterboer, HJ; Moudgil, VK; Underwood, B | 1 |
| Kahmann, S; Klein-Hitpass, L; Vassen, L | 1 |
| Boonyaratanakornkit, V; Edwards, DP; Mahesh, VB; O'Conner, JL; Prendergast, P; Wade, MF | 1 |
| Hornung, D; Milgrom, E; Ryan, I; Savouret, JF; Seppälä, M; Taylor, RN; Vaisse, C; Vigne, JL | 1 |
| Altmann, M; Edwards, DP; Leonhardt, SA | 1 |
| Baumann, CT; Hager, GL; Htun, H; Irie, M; Lim, CS; Smith, CL; Xian, W | 1 |
| Edwards, DP; Giangrande, PH; Leonhardt, SA; McDonnell, DP; Tetel, MJ | 1 |
| Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK; Nag, K | 1 |
| Edwards, DP; Giangrande, PH; Kimbrel, EA; McDonnell, DP | 1 |
| Benhamou, B; Gofflo, D; Guillot, B; Moras, D; Ossart, C; Philibert, D; Robin-Jagerschmidt, C; Vergezac, A; Wurtz, JM | 1 |
| Carlen, PL; Edwards, HE; Epps, T; J MacLusky, N | 1 |
| Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK | 1 |
| García-Becerra, R; Gutiérrez-Sagal, R; Pasapera, AM; Savouret, JF; Ulloa-Aguirre, A | 1 |
| Chao, V; Dreher, E; Mueller, MD; Pritts, EA; Taylor, RN; Vigne, JL | 1 |
| Chakrabarti, G; Manna, PR; Mukhopadhyay, AK; Schwarzenbach, H; Stocco, DM | 1 |
| Dunlap, KA; Stormshak, F | 1 |
| Cui, X; Hopp, TA; Lazard, Z; Lee, AV; Zhang, P | 1 |
| Edwards, DP; Elbi, C; Fletcher, TM; Hager, GL; Rayasam, GV; Walker, DA; Wolford, R | 1 |
| Al-Azzawi, F; Pringle, JH; Taylor, AH; Thompson, J; Wahab, M | 1 |
| Chen, CL; Liao, QP; Lu, Y; Yu, L | 1 |
| Ratnam, M; Shatnawi, A; Tran, T | 1 |
| Berry, E; Bulun, S; Chakravarti, D; Clardy, J; Hardt, J; Hoekstra, AV; Kim, JJ; Lu, Z; Marsh, E; Sefton, EC; Yin, P | 1 |
| Edwards, DP; Holley, AK; Jenkins, JT; Kiningham, KK; Moore, MR; Spitz, DR | 1 |
| Richards, JS; Sinha, M; Sriraman, V | 1 |
| Edwards, DP; Narayanan, R; Wardell, SE; Weigel, NL | 1 |
| Brooks, DC; Bulun, SE; Wolfe, A; Yilmaz, MB; Zhao, H | 1 |
| Amazit, L; Bellance, C; Guiochon-Mantel, A; Khan, JA; Lombès, M; Loosfelt, H | 1 |
| Auger, CJ; Bychowski, ME | 1 |
| Callaway, C; Edwards, DP; Goswami, D; Griffin, PR; Kumar, R; Pascal, BD | 1 |
| Bolt, MJ; Edwards, DP; Grimm, SL; Mancini, MA; Treviño, LS; Weigel, NL | 1 |
| Britten, J; Catherino, WH; Cox, J; Malik, M; Patel, A | 1 |
2 review(s) available for mifepristone and promegestone
| Article | Year |
|---|---|
[Antiestrogens and normal human breast cell proliferation].
Topics: 17-Hydroxysteroid Dehydrogenases; Breast; Cell Division; Estradiol; Estrogen Antagonists; Humans; Mifepristone; Progestins; Promegestone; Receptors, Estrogen; Stereoisomerism; Tamoxifen | 1989 |
Antiestrogen action of progesterone in breast tissue.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenoma; Animals; Breast; Cell Division; Cells, Cultured; Estradiol; Estrenes; Estrogen Antagonists; Estrogens; Female; Humans; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Estrogen | 1986 |
108 other study(ies) available for mifepristone and promegestone
| Article | Year |
|---|---|
Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis.
Topics: Animals; Cells, Cultured; Enzyme Induction; Glucocorticoids; Male; Rabbits; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Receptors, Steroid; Steroids; Tyrosine Transaminase | 1988 |
Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor.
Topics: Baculoviridae; Biopolymers; Breast Neoplasms; DNA-Binding Proteins; Humans; Mifepristone; Precipitin Tests; Promegestone; Receptors, Progesterone; Recombinant Proteins; Tumor Cells, Cultured | 1992 |
Effect of the progesterone antagonist RU486 on human myometrial spontaneous contractility and PGI2 release.
Topics: Adult; Dexamethasone; Dose-Response Relationship, Drug; Epoprostenol; Female; Humans; In Vitro Techniques; Mifepristone; Myometrium; Promegestone; Prostaglandins F; Uterine Contraction | 1992 |
Novel antiprogestins Org 31806 and 31710: interaction with mammalian progesterone receptor and DNA binding of antisteroid receptor complexes.
Topics: Animals; Cattle; Chickens; Cytosol; DNA; Estrenes; Female; Furans; Kinetics; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Progesterone; Species Specificity; Uterus | 1992 |
Progestins stimulate the differentiation of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Animals; Cell Differentiation; Dexamethasone; Estradiol; Glycerolphosphate Dehydrogenase; Hydrocortisone; Mice; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Glucocorticoid; Triglycerides | 1992 |
Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.
Topics: alpha-Fetoproteins; Animals; Base Sequence; Cell Line; Chickens; Chimera; Chromosome Deletion; Genes; Humans; Mifepristone; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Progesterone; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Restriction Mapping; Tamoxifen; Transfection | 1990 |
Ionic and ligand-specific effects on the DNA binding of progesterone receptor bound to the synthetic progestin R5020 and the antiprogestin RU486.
Topics: Animals; Base Sequence; Cations; Centrifugation, Density Gradient; DNA; Female; Ligands; Mifepristone; Molecular Sequence Data; Plasmids; Promegestone; Protein Binding; Rabbits; Receptors, Estrogen; Receptors, Progesterone; Uterus | 1991 |
Immunoanalysis of calf uterine progesterone receptor: modulation of receptor-associated 90 kDa heat-shock protein. f.
Topics: Animals; Binding Sites; Cattle; Female; Heat-Shock Proteins; Immunosorbent Techniques; Iodoacetamide; Mifepristone; Molecular Weight; Promegestone; Protein Conformation; Receptors, Progesterone; Uterus | 1991 |
Differences in the binding mechanism of RU486 and progesterone to the progesterone receptor.
Topics: Animals; Binding, Competitive; Cattle; Cytosol; Female; Kinetics; Mifepristone; Progesterone; Promegestone; Receptors, Progesterone; Uterus | 1991 |
Comparison of glucocorticoid receptors liganded with dexamethasone or progesterone.
Topics: Animals; Binding Sites; Binding, Competitive; Cortodoxone; Dexamethasone; Mice; Mifepristone; Progesterone; Promegestone; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ultraviolet Rays | 1991 |
Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines.
Topics: Breast Neoplasms; Estrogen Antagonists; Estrogens; Humans; Mifepristone; Neoplasms, Hormone-Dependent; Progestins; Prognosis; Promegestone; Proto-Oncogene Proteins; Pyrrolidines; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Thiophenes; Tumor Cells, Cultured | 1990 |
Progestin stimulation of thymidine kinase in the human breast cancer cell line T47D.
Topics: Breast Neoplasms; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Mifepristone; Progestins; Promegestone; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 1991 |
Effects of antiestrogen versus antiprogestin on transformed and nontransformed steroid receptors.
Topics: Animals; Centrifugation, Density Gradient; Estrogen Antagonists; Female; Mifepristone; Molybdenum; Promegestone; Rabbits; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Uterus | 1991 |
Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Cat Diseases; Cats; Cell Division; DNA Replication; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Female; Mammary Neoplasms, Animal; Mifepristone; Neoplasms, Hormone-Dependent; Phosphorylation; Progesterone; Progestins; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1991 |
Progesterone receptor stimulates transcription of mouse mammary tumour virus in a cell-free system.
Topics: Animals; Cell-Free System; Gene Expression Regulation; Mammary Tumor Virus, Mouse; Mice; Mifepristone; Promegestone; Promoter Regions, Genetic; Rabbits; Receptors, Progesterone; Regulatory Sequences, Nucleic Acid; Ribonucleases; RNA, Viral; Transcription Factors; Transcription, Genetic | 1990 |
Luteolytic effect of the antiprogestin and antiglucocorticoid agent RU486 in rats.
Topics: Algestone; Animals; Cells, Cultured; Chorionic Gonadotropin; Corpus Luteum; Dexamethasone; Female; Gestrinone; Glucocorticoids; Gonadotropins, Equine; Hypophysectomy; Mifepristone; Pregnancy; Progesterone; Progestins; Promegestone; Rats; Rats, Inbred Strains | 1990 |
Progesterone action in normal mouse mammary gland.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Estrogens; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Mifepristone; Osmolar Concentration; Progesterone; Promegestone; Receptors, Progesterone; Reference Values | 1990 |
Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells.
Topics: Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Drug Interactions; Estradiol; Flutamide; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Mifepristone; Neoplasm Proteins; Promegestone; Tumor Cells, Cultured | 1990 |
Sex steroid hormone modulation of NADPH pathways in MCF-7 cells.
Topics: Breast Neoplasms; Cell Division; Drug Interactions; Estradiol; Glucosephosphate Dehydrogenase; Humans; Mifepristone; NADP; Norpregnadienes; Premedication; Promegestone; Tamoxifen; Tumor Cells, Cultured | 1990 |
Normal breast cells in culture. Effect of estrogens, progestins, and antiestrogens.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast; Cell Division; Cells, Cultured; Epithelial Cells; Estradiol; Estrogens; Humans; In Vitro Techniques; Mifepristone; Progestins; Promegestone; Tamoxifen | 1990 |
Progestin effect on cell proliferation and 17 beta-hydroxysteroid dehydrogenase activity in normal human breast cells in culture.
Topics: 17-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Breast; Cell Division; Cells, Cultured; DNA; Estradiol; Estrenes; Female; Humans; Mifepristone; Progestins; Promegestone; Protein Biosynthesis; RNA | 1986 |
Progestin stimulation of lactate dehydrogenase in the human breast cancer cell line T-47D.
Topics: Breast Neoplasms; Cell Line; Estrenes; Female; Humans; L-Lactate Dehydrogenase; Mifepristone; Neoplasm Proteins; Progestins; Promegestone; RNA | 1987 |
RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins.
Topics: Binding, Competitive; Cell Division; Cellulose; Cytoplasm; DNA; Estrenes; Female; Glycogen; Humans; Mifepristone; Periodic Acid-Schiff Reaction; Progestins; Promegestone; Receptors, Progesterone; Staining and Labeling; Tumor Cells, Cultured; Uterine Neoplasms | 1988 |
Receptor binding of NBD-labeled fluorescent estrogens and progestins in whole cells and cell-free preparations.
Topics: Affinity Labels; Binding, Competitive; Breast Neoplasms; Cell Line; Cell Nucleus; Cytoplasm; Estradiol; Estrenes; Fluorescent Dyes; Hexestrol; Humans; Mifepristone; Nafoxidine; Oxadiazoles; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1989 |
Mapping contacts between unpurified human progesterone receptor and the hormone response element of mouse mammary tumor virus.
Topics: Base Sequence; Cell Nucleus; Deoxyribonuclease I; DNA-Binding Proteins; Humans; Mammary Tumor Virus, Mouse; Methylation; Mifepristone; Molecular Sequence Data; Precipitin Tests; Promegestone; Receptors, Progesterone; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Tumor Cells, Cultured | 1989 |
Progestins and androgens stimulate lipid accumulation in T47D breast cancer cells via their own receptors.
Topics: Acetates; Breast Neoplasms; Dihydrotestosterone; Dose-Response Relationship, Drug; Fatty Acids; Flutamide; Humans; In Vitro Techniques; Lipid Metabolism; Microscopy, Electron; Mifepristone; Norpregnadienes; Promegestone; Receptors, Androgen; Receptors, Progesterone; Triglycerides; Tumor Cells, Cultured | 1989 |
Effects of progestins, estrogens, and antihormones on growth and lactate dehydrogenase in the human breast cancer cell line T47D.
Topics: Breast Neoplasms; Cell Division; Estrenes; Estrogens; Hormone Antagonists; Humans; L-Lactate Dehydrogenase; Mifepristone; Progestins; Promegestone; Tumor Cells, Cultured | 1989 |
Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; Estradiol; Estrenes; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Mifepristone; Norpregnadienes; Promegestone; Protein Biosynthesis; Receptors, Estrogen; RNA, Messenger; Somatomedins; Tumor Cells, Cultured | 1989 |
Effect of potent antiglucocorticoids on dexamethasone induced enzymes in cultured hepatoma and rat liver cells.
Topics: Animals; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Estrenes; Glucocorticoids; Liver; Liver Neoplasms, Experimental; Male; Mifepristone; Norpregnadienes; Promegestone; Rats; Rats, Inbred Strains; Tryptophan Oxygenase; Tyrosine Transaminase | 1985 |
Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids.
Topics: Animals; Binding, Competitive; Cell Line; Dexamethasone; Estrenes; Glucocorticoids; Kinetics; Liver Neoplasms, Experimental; Mathematics; Mifepristone; Progesterone; Promegestone; Rats; Receptors, Glucocorticoid; Tyrosine Transaminase | 1986 |
Description and analysis of differential sensitivity to glucocorticoids in Fao cells.
Topics: Alanine Transaminase; Animals; Cell Line; Cortodoxone; Desoxycorticosterone; Dexamethasone; Enzyme Induction; Estrenes; gamma-Glutamyltransferase; Glucocorticoids; Hydroxyprogesterones; Liver Neoplasms, Experimental; Mifepristone; Pregnatrienes; Progesterone; Promegestone; Tyrosine Transaminase | 1988 |
Mammalian progesterone receptor shows differential sensitivity to sulfhydryl group modifying agents when bound to agonist and antagonist ligands.
Topics: Animals; Cattle; Cytosol; Dithiothreitol; Estrenes; Female; Kinetics; Ligands; Mifepristone; Progestins; Promegestone; Receptors, Progesterone; Sulfhydryl Reagents; Uterus | 1989 |
Comparative effects of 17 beta-estradiol, progestin R5020, tamoxifen and RU38486 on lactate dehydrogenase activity in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Dexamethasone; Dihydrotestosterone; Estradiol; Estrenes; Female; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Mifepristone; Norpregnadienes; Promegestone; Tamoxifen | 1989 |
Modulation of aromatase activity in human endometrial stromal cells by steroids, tamoxifen and RU 486.
Topics: Adult; Aromatase; Dexamethasone; Dose-Response Relationship, Drug; Endometrium; Estrenes; Female; Humans; Hydrocortisone; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Mifepristone; Norethindrone; Progesterone; Progestins; Promegestone; Steroids; Tamoxifen; Testosterone; Time Factors | 1986 |
Progestin and antiprogestin effects on progesterone receptor transformation.
Topics: Animals; Desoxycorticosterone; Estrenes; Female; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Mifepristone; Molybdenum; Progestins; Promegestone; Protein Conformation; Rabbits; Receptors, Progesterone | 1986 |
Effect of the antiprogestin RU486 on progesterone production by cultured human granulosa cells: inhibition of the ovarian 3B-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Cells, Cultured; Dehydroepiandrosterone; Estrenes; Female; Humans; Kinetics; Mifepristone; Progesterone; Promegestone | 1986 |
Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Carcinoma; Cell Nucleus; Cytosol; Estrenes; Female; Humans; Immunohistochemistry; Mifepristone; Molecular Weight; Promegestone; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone | 1988 |
Comment on 'Difference between R5020 and the anti progestin RU486 in antiproliferative effects on human breast cancer cells'.
Topics: Breast Neoplasms; Cell Division; Estrenes; Humans; Mifepristone; Norpregnadienes; Promegestone | 1988 |
Effects of progestins on sexual behaviour in castrated lizards (Cnemidophorus inornatus).
Topics: Animals; Estrenes; Female; Lizards; Male; Mifepristone; Orchiectomy; Ovariectomy; Progesterone; Progestins; Promegestone; Sexual Behavior, Animal | 1988 |
Transformation of human progesterone receptor in the presence of the progestin (R5020) and the antiprogestin (RU486).
Topics: Binding, Competitive; Cytosol; Estrenes; Female; Humans; Mifepristone; Norpregnadienes; Progesterone; Promegestone; Receptors, Progesterone; Uterus | 1988 |
Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element.
Topics: Breast Neoplasms; Cell Line; Enhancer Elements, Genetic; Estradiol; Estrenes; Female; Humans; Hydrocortisone; Mifepristone; Progesterone; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1988 |
Effects of progesterone, promegestone and RU 486 on glucocorticoid receptor levels in primary cultures of mouse mammary epithelial cells.
Topics: Animals; Cells, Cultured; Epithelium; Estrenes; Female; Glucocorticoids; Kinetics; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Mifepristone; Norpregnadienes; Pregnancy; Progesterone; Promegestone; Receptors, Glucocorticoid; Reference Values | 1988 |
Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines.
Topics: Breast Neoplasms; Estrenes; Estrogen Antagonists; Estrogens; Female; Humans; Ligands; Mifepristone; Promegestone; Receptors, Progesterone; RNA, Messenger; Tumor Cells, Cultured | 1988 |
Characterization of R5020 and RU486 binding to progesterone receptor from calf uterus.
Topics: Animals; Cattle; Cytosol; Estrenes; Female; Glycerol; Kinetics; Mifepristone; Molybdenum; Norpregnadienes; Progestins; Promegestone; Receptors, Progesterone; Thermodynamics; Uterus | 1988 |
Pharmacokinetic properties of the antiglucocorticoid and antiprogesterone steroid RU 486 in man.
Topics: Adult; Animals; Cushing Syndrome; Dexamethasone; Estrenes; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Mifepristone; Progesterone; Promegestone; Radioligand Assay; Rats; Receptors, Progesterone; Thymus Gland; Uterus | 1987 |
Early glycogenesis in the uterine glandular cells of the rabbit induced by progestins: a quantitative investigation.
Topics: Animals; Dexamethasone; Endocrine Glands; Estradiol; Estrenes; Female; Glycogen; Mifepristone; Progesterone; Promegestone; Rabbits; Uterus | 1987 |
Antiprogesterone and antiglucocorticoid actions of RU 486 on rabbit mammary gland explant cultures. Evidence for a persistent inhibitory action of residual progesterone upon the mammary tissue.
Topics: Animals; Caseins; Culture Techniques; Dexamethasone; DNA; Estrenes; Female; Glucocorticoids; Mammary Glands, Animal; Mifepristone; Pregnancy; Progesterone; Prolactin; Promegestone; Rabbits; Receptors, Glucocorticoid; Receptors, Progesterone | 1987 |
Actions of progestins on estrous behaviour in female rats.
Topics: Animals; Dose-Response Relationship, Drug; Estrenes; Estrus; Female; Mifepristone; Norpregnadienes; Progesterone; Promegestone; Rats; Sexual Behavior, Animal | 1987 |
Difference between R5020 and the antiprogestin RU486 in antiproliferative effects on human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Estradiol; Estrenes; Glucocorticoids; Humans; Mifepristone; Norpregnadienes; Phenolsulfonphthalein; Promegestone; Protein Biosynthesis; Receptors, Estrogen; Tumor Cells, Cultured | 1987 |
Evidence for separate binding sites for progesterone and RU486 in the chick oviduct.
Topics: Animals; Centrifugation, Density Gradient; Chickens; Cytosol; Estrenes; Female; Hot Temperature; Mifepristone; Oviducts; Progesterone; Promegestone; Receptors, Progesterone | 1986 |
Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation.
Topics: Animals; Base Sequence; Cytosol; Deoxyribonuclease I; DNA; Estrenes; Female; Genes; Glycoproteins; Kinetics; Mifepristone; Phosphorylation; Promegestone; Rabbits; Receptors, Progesterone; Uteroglobin; Uterus | 1986 |
Antiprogestin-receptor complexes: differences in the interaction of the antiprogestin RU38,486 and the progestin R5020 with the progesterone receptor of human breast cancer cells.
Topics: Binding, Competitive; Breast Neoplasms; Cell Line; Centrifugation, Density Gradient; Deoxyribonucleases; Estrenes; Female; Humans; Mifepristone; Norpregnadienes; Promegestone; Receptors, Progesterone; Ribonucleases; Sulfhydryl Compounds; Urea | 1986 |
Studies of a plasma membrane steroid receptor in Xenopus oocytes using the synthetic progestin RU 486.
Topics: Affinity Labels; Animals; Cell Membrane; Estrenes; Female; Mifepristone; Molecular Weight; Oocytes; Photochemistry; Promegestone; Receptors, Steroid; Xenopus laevis | 1985 |
The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.
Topics: Affinity Labels; Breast Neoplasms; Cells, Cultured; Estrenes; Estrogens; Female; Humans; Mifepristone; Progestins; Promegestone; Receptor, Insulin; Receptors, Glucocorticoid; Receptors, Progesterone | 1985 |
Effects of progestins and antiprogestins on mitochondria in uterine glandular cells in the rat. A quantitative investigation.
Topics: Animals; Castration; Estrenes; Female; Gestrinone; Microscopy, Electron; Mifepristone; Mitochondria; Progestins; Promegestone; Rats; Rats, Inbred Strains; Uterus | 1984 |
Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.
Topics: Amino Acid Sequence; Base Sequence; Cyclic AMP Response Element-Binding Protein; Gene Expression; HeLa Cells; Histone Acetyltransferases; Hormone Antagonists; Humans; Mifepristone; Molecular Sequence Data; Nuclear Receptor Coactivator 1; Promegestone; Receptors, Progesterone; Receptors, Steroid; Recombinant Fusion Proteins; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection | 1995 |
Hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line.
Topics: Base Sequence; Blood; Breast Neoplasms; Cell Division; Charcoal; Culture Media; DNA-Binding Proteins; Down-Regulation; Estradiol; Hormone Antagonists; Humans; Mifepristone; Molecular Sequence Data; Oligodeoxyribonucleotides; Progesterone Congeners; Promegestone; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Reptilian (Chrysemys picta) hepatic progesterone receptors: relationship to plasma steroids and the vitellogenic cycle.
Topics: Animals; Binding, Competitive; Cell Extracts; Cell Nucleus; Cytosol; Desoxycorticosterone; Estradiol; Female; Liver; Mifepristone; Pregnenolone; Progesterone; Progesterone Congeners; Promegestone; Receptors, Progesterone; Seasons; Turtles; Vitellogenesis | 1995 |
Effects of steroid hormones on fibrinolytic system in cultured human endometrial cells.
Topics: Cells, Cultured; Endometrium; Estradiol; Female; Fibrinolysis; Humans; Middle Aged; Mifepristone; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Progesterone; Promegestone | 1995 |
Progesterone receptor and the mechanism of action of progesterone antagonists.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; DNA-Binding Proteins; Estrenes; Gonanes; Humans; In Vitro Techniques; Mifepristone; Progesterone; Promegestone; Protein Binding; Protein Conformation; Receptors, Progesterone; Signal Transduction; Transcription Factors; Transcription, Genetic | 1995 |
8-Br-cAMP does not convert antagonists of the glucocorticoid receptor into agonists.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; CHO Cells; Cricetinae; Gonanes; Mice; Mifepristone; Progesterone; Promegestone; Receptors, Glucocorticoid; Transfection | 1995 |
The leucine zippers of c-fos and c-jun for progesterone receptor dimerization: A-dominance in the A/B heterodimer.
Topics: Base Sequence; Binding, Competitive; Biopolymers; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; HeLa Cells; Humans; Leucine Zippers; Mifepristone; Molecular Sequence Data; Promegestone; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Progesterone; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Transcription, Genetic | 1994 |
Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo.
Topics: Base Sequence; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Gonanes; Humans; In Vitro Techniques; Mammary Tumor Virus, Mouse; Mifepristone; Molecular Sequence Data; Oligodeoxyribonucleotides; Progestins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; RNA, Messenger; Transcription, Genetic | 1994 |
Development of specific bioluminescent in vitro assays for selecting potential antimineralocorticoids.
Topics: Animals; Base Sequence; Biological Assay; Cell Line; Dexamethasone; HeLa Cells; Hormone Antagonists; Humans; Luciferases; Luminescent Measurements; Mifepristone; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Molecular Sequence Data; Pregnenediones; Promegestone; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Recombinant Fusion Proteins; Spironolactone; Testosterone; Transfection | 1994 |
Effects of molecular crowding on protein self-association: a potential source of error in sedimentation coefficients obtained by zonal ultracentrifugation in a sucrose gradient.
Topics: Centrifugation, Zonal; Chemical Phenomena; Chemistry, Physical; Macromolecular Substances; Mifepristone; Phosphopyruvate Hydratase; Promegestone; Proteins; Receptors, Progesterone; Saccharomyces cerevisiae; Sucrose | 1994 |
Binding studies of RU486 in different Reuber hepatoma variants.
Topics: Animals; Binding, Competitive; Cell Division; Dexamethasone; Genetic Variation; Liver Neoplasms, Experimental; Mifepristone; Pregnatrienes; Promegestone; Rats; Receptors, Steroid; Testosterone; Tumor Cells, Cultured | 1993 |
Differential regulation of human progesterone receptor A and B form-mediated trans-activation by phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Base Sequence; Blotting, Western; Cell Line; Drug Synergism; Ethers, Cyclic; Gene Expression; Humans; Mifepristone; Molecular Sequence Data; Okadaic Acid; Phosphoproteins; Phosphorylation; Promegestone; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Receptors, Progesterone; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 1993 |
Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Base Sequence; beta-Galactosidase; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclic AMP; DNA-Binding Proteins; Female; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphates; Progesterone; Promegestone; Receptors, Progesterone; Recombinant Proteins; Transcription Factors; Transfection; Tumor Cells, Cultured | 1993 |
The constitution of a progesterone response element.
Topics: Baculoviridae; Base Composition; Base Sequence; Binding Sites; Breast Neoplasms; DNA; DNA, Viral; Gene Expression; Humans; Mammary Tumor Virus, Mouse; Mifepristone; Molecular Sequence Data; Mutation; Progestins; Promegestone; Receptors, Progesterone; Transfection; Tumor Cells, Cultured | 1993 |
Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/antiprogestin RU486.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Chlorocebus aethiops; Dexamethasone; DNA-Binding Proteins; Gene Expression Regulation; In Vitro Techniques; Mifepristone; Molecular Sequence Data; Prolactin; Promegestone; Promoter Regions, Genetic; Receptors, Glucocorticoid; Receptors, Progesterone; Transcription, Genetic | 1993 |
Expression of 67 kDa laminin receptor in human breast cancer cells: regulation by progestins.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Basement Membrane; Blotting, Western; Breast Neoplasms; Cell Adhesion; Female; Fibronectins; Humans; Laminin; Mice; Mice, Nude; Mifepristone; Neoplasm Metastasis; Promegestone; Receptors, Laminin; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation | 1993 |
Progesterone modulation of gonadotropin secretion by dispersed rat pituitary cells in culture. IV. Follicle-stimulating hormone synthesis and release.
Topics: Animals; Calcimycin; Cells, Cultured; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Mifepristone; Pituitary Gland, Anterior; Progesterone; Promegestone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.
Topics: Breast Neoplasms; Carcinoma; Cell Division; Desogestrel; Dose-Response Relationship, Drug; Estradiol; Estrenes; Estrogen Antagonists; Female; Furans; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Mifepristone; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Tumor Cells, Cultured | 1995 |
An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Enhancer Elements, Genetic; Gonanes; HeLa Cells; Hormone Antagonists; Humans; Methionine; Mifepristone; Progesterone Congeners; Progestins; Promegestone; Protein Biosynthesis; Receptors, Progesterone; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Progestins prevent apoptosis in a rat endometrial cell line and increase the ratio of bcl-XL to bcl-XS.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Line; Dexamethasone; Endometrium; Epithelial Cells; Epithelium; Female; Kinetics; Microscopy, Electron; Mifepristone; Pregnancy; Progesterone Congeners; Promegestone; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rabbits; Rats; Receptors, Progesterone; Recombinant Proteins; Transcription, Genetic | 1997 |
Ligand specificity of uterine oestrogen and progesterone receptors in the subadult African elephant, Loxodonta africana.
Topics: Animals; Binding, Competitive; Elephants; Female; Hormone Antagonists; Ligands; Mifepristone; Norethindrone; Progesterone; Progesterone Congeners; Promegestone; Protein Binding; Radioligand Assay; Receptors, Estrogen; Receptors, Progesterone; Sexual Maturation; Tritium | 1997 |
Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1).
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Gene Expression Regulation; Gonanes; Hormone Antagonists; Humans; Microtubule-Associated Proteins; Mifepristone; Progesterone; Promegestone; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands.
Topics: Binding, Competitive; Blotting, Western; DNA; Electrophoresis, Polyacrylamide Gel; Estrenes; Furans; Gonanes; Hormone Antagonists; Humans; Ligands; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Sodium Dodecyl Sulfate; Tumor Cells, Cultured | 1997 |
Synergistic enhancement of PRB-mediated RU486 and R5020 agonist activities through cyclic adenosine 3',5'-monophosphate represents a delayed primary response.
Topics: Chromosomes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Genes, Reporter; HeLa Cells; Humans; Mammary Tumor Virus, Mouse; Mifepristone; Promegestone; Receptors, Progesterone; Subcellular Fractions | 1998 |
A 361 base pair region of the rat FSH-beta promoter contains multiple progesterone receptor-binding sequences and confers progesterone responsiveness.
Topics: Animals; Base Sequence; Binding Sites; Cells, Cultured; Cloning, Molecular; DNA; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; High Mobility Group Proteins; Humans; Mifepristone; Molecular Sequence Data; Pituitary Gland, Anterior; Progesterone; Progesterone Congeners; Promegestone; Promoter Regions, Genetic; Rats; Receptors, Progesterone; Recombinant Fusion Proteins; Transfection | 1997 |
Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.
Topics: Drug Evaluation, Preclinical; Endometrium; Epithelial Cells; Female; Gene Expression Regulation; Glycodelin; Glycoproteins; HeLa Cells; Humans; Mifepristone; Pregnancy Proteins; Progesterone Congeners; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Transfection | 1998 |
Agonist and antagonists induce homodimerization and mixed ligand heterodimerization of human progesterone receptors in vivo by a mammalian two-hybrid assay.
Topics: Animals; Binding Sites; COS Cells; Dimerization; DNA; DNA-Binding Proteins; Genes, Reporter; Herpes Simplex Virus Protein Vmw65; Hormone Antagonists; Humans; Mifepristone; Progesterone; Progesterone Congeners; Promegestone; Receptors, Progesterone; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Transfection | 1998 |
Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cytoplasm; Green Fluorescent Proteins; Hormone Antagonists; Humans; Luciferases; Luminescent Proteins; Mammary Tumor Virus, Mouse; Mice; Mifepristone; Progesterone Congeners; Promegestone; Protein Isoforms; Receptors, Progesterone; Recombinant Fusion Proteins; Recombinant Proteins; Subcellular Fractions; Terminal Repeat Sequences; Transcriptional Activation | 1999 |
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.
Topics: Animals; Binding Sites; CREB-Binding Protein; HeLa Cells; Histone Acetyltransferases; Hormone Antagonists; Humans; Insecta; Mammals; Mifepristone; Nuclear Proteins; Nuclear Receptor Coactivator 1; Peptide Fragments; Progesterone; Progesterone Congeners; Promegestone; Receptors, Progesterone; Recombinant Proteins; Trans-Activators; Transcription Factors | 1999 |
Agonist and antagonist-induced qualitative and quantitative alterations of progesterone receptor from breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Division; Charcoal; Culture Media; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1999 |
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
Topics: Amino Acid Sequence; DNA-Binding Proteins; Dose-Response Relationship, Drug; HeLa Cells; Hormone Antagonists; Humans; Kinetics; Mifepristone; Molecular Sequence Data; Nuclear Receptor Co-Repressor 2; Peptides; Plasmids; Progesterone Congeners; Promegestone; Protein Binding; Protein Isoforms; Receptors, Progesterone; Recombinant Proteins; Repressor Proteins; Transcription, Genetic | 2000 |
Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Furylfuramide; Glucocorticoids; Hormone Antagonists; Humans; Hydroxycorticosteroids; Mifepristone; Models, Molecular; Molecular Sequence Data; Progestins; Promegestone; Protein Conformation; Receptors, Glucocorticoid; Receptors, Progesterone; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transcriptional Activation | 2000 |
Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro.
Topics: Animals; Drug Combinations; Electric Stimulation; Epilepsy; Female; Hippocampus; Hormone Antagonists; In Vitro Techniques; Mifepristone; Pregnanolone; Progesterone; Progesterone Congeners; Promegestone; Rats; Rats, Wistar; Reaction Time; Receptors, Progesterone | 2000 |
Differential regulation of retinoblastoma protein by hormonal and antihormonal agents in T47D breast cancer cells.
Topics: Breast Neoplasms; Estradiol; Estrogen Receptor Modulators; Estrogens; Fulvestrant; Gonanes; Humans; Mifepristone; Phosphorylation; Progesterone; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Retinoblastoma Protein; Tumor Cells, Cultured | 2001 |
Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African Green Monkey Kidney CV1 cells.
Topics: Animals; Binding, Competitive; Cell Line; Chloramphenicol O-Acetyltransferase; Chlorocebus aethiops; Estrogens; Gene Expression; Genes, Reporter; Genetic Vectors; Kidney; Levonorgestrel; Mifepristone; Norethindrone; Norpregnenes; Progestins; Promegestone; Promoter Regions, Genetic; Rabbits; Receptors, Progesterone; Response Elements; Transcriptional Activation; Transfection | 2001 |
Progestins activate vascular endothelial growth factor gene transcription in endometrial adenocarcinoma cells.
Topics: Adenocarcinoma; Endometrial Neoplasms; Endothelial Growth Factors; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Medroxyprogesterone; Mifepristone; Promegestone; Receptors, Progesterone; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Stimulatory effect of progesterone on the expression of steroidogenic acute regulatory protein in MA-10 Leydig cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoglutethimide; Animals; Blotting, Northern; Dexamethasone; Enzyme Inhibitors; Female; Gene Expression Regulation; Glucocorticoids; Leydig Cell Tumor; Mice; Mifepristone; Phosphoproteins; Progesterone; Progesterone Congeners; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Nongenomic inhibition of oxytocin binding by progesterone in the ovine uterus.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Endometrium; Female; Hormone Antagonists; In Vitro Techniques; Mifepristone; Oxytocin; Progesterone; Promegestone; Receptors, Oxytocin; Sheep | 2004 |
Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2.
Topics: Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Hormone Antagonists; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mifepristone; Phosphoproteins; Progesterone; Progestins; Promegestone; Protein Isoforms; Receptor, Insulin; Receptors, Progesterone; RNA, Messenger; Signal Transduction; Somatomedins; Up-Regulation | 2003 |
Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitro.
Topics: Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Assembly and Disassembly; DNA Helicases; Fluorescence Recovery After Photobleaching; Gonanes; Green Fluorescent Proteins; Humans; Ligands; Mammary Tumor Virus, Mouse; Mifepristone; Nuclear Proteins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Transcription Factors | 2005 |
Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell.
Topics: Adult; Cells, Cultured; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Humans; Immunohistochemistry; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Menstruation; Middle Aged; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells | 2006 |
[Functional study of progesterone receptor isoforms in endometrial cancer cell lines].
Topics: Adenocarcinoma; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Estradiol; Female; Humans; Mifepristone; Oligodeoxyribonucleotides, Antisense; Promegestone; Receptors, Progesterone; Transfection | 2006 |
R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanism.
Topics: Carrier Proteins; Contraceptives, Oral, Synthetic; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; Ligands; Mifepristone; Progesterone Congeners; Promegestone; Promoter Regions, Genetic; Protein Biosynthesis; Receptors, Cell Surface; Receptors, Progesterone; Sp1 Transcription Factor; Sp4 Transcription Factor; Transcriptional Activation | 2007 |
Progestins activate the AKT pathway in leiomyoma cells and promote survival.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Female; Fluorescent Antibody Technique; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Leiomyoma; Mifepristone; Oncogene Protein v-akt; Phosphorylation; Progestins; Promegestone; Signal Transduction; Uterine Neoplasms | 2009 |
Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells.
Topics: Base Sequence; Breast Neoplasms; Butadienes; Cell Line, Tumor; DNA Primers; Female; Hormone Antagonists; Humans; MAP Kinase Signaling System; Mifepristone; Neoplasm Invasiveness; Nitriles; Progesterone Congeners; Promegestone; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Superoxide Dismutase | 2009 |
Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures.
Topics: Adenoviridae; Animals; Apolipoprotein A-I; Apoptosis Regulatory Proteins; Cells, Cultured; Endothelin-1; Female; Gene Expression; Gene Expression Regulation; Genetic Vectors; Granulosa Cells; Humans; Luteinizing Hormone; Mice; Mice, Inbred C57BL; Mifepristone; Mutation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Promegestone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Trans-Activators; Transfection | 2010 |
Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclin A; Cyclin-Dependent Kinase 2; Gonanes; HeLa Cells; Hormone Antagonists; Humans; Mifepristone; Nuclear Receptor Coactivator 1; Phosphorylation; Promegestone; Protein Interaction Domains and Motifs; Rats; Receptors, Progesterone; Repressor Proteins; Serine; Transcriptional Activation | 2010 |
Aromatase promoter I.f is regulated by progesterone receptor in mouse hypothalamic neuronal cell lines.
Topics: Animals; Aromatase; Base Sequence; Cell Line; Chromatin Immunoprecipitation; Enzyme Assays; Estrogen Receptor alpha; Estrogens; Feedback, Physiological; Genes, Reporter; Hypothalamus; Luciferases, Renilla; Mice; Mifepristone; Molecular Sequence Data; Neurons; Progestins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Transcription, Genetic | 2011 |
p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.
Topics: Breast Neoplasms; Cell Line, Tumor; Endometrial Neoplasms; Female; Gonanes; Humans; Ligands; MAP Kinase Kinase Kinase 1; Mifepristone; Mitogen-Activated Protein Kinase 1; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Stability; Receptors, Progesterone; Transcription, Genetic | 2011 |
Progesterone impairs social recognition in male rats.
Topics: Amygdala; Animals; Discrimination, Psychological; Feeding Behavior; Hormone Antagonists; Male; Mifepristone; Progesterone; Progesterone Congeners; Promegestone; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Septal Nuclei; Smell; Social Behavior; Vasopressins | 2012 |
Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.
Topics: Amino Acid Sequence; Animals; Deuterium Exchange Measurement; Humans; Ligands; Mass Spectrometry; Mifepristone; Models, Molecular; Molecular Sequence Data; Promegestone; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Receptors, Progesterone; Sf9 Cells; TATA-Box Binding Protein | 2014 |
Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK.
Topics: Chromones; Cyclin-Dependent Kinase 2; DNA-Activated Protein Kinase; Gonanes; HeLa Cells; Humans; Mediator Complex; Mifepristone; Models, Biological; Morpholines; Promegestone; Purines; Receptors, Progesterone; Recombinant Proteins; Transcription, Genetic | 2016 |
Mifepristone inhibits extracellular matrix formation in uterine leiomyoma.
Topics: Cell Line, Transformed; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Hormone Antagonists; Humans; Leiomyoma; Mifepristone; Promegestone; Tumor Cells, Cultured; Uterine Neoplasms | 2016 |