mifepristone has been researched along with phenobarbital in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kliewer, SA; Lehmann, JM; McKee, DD; Moore, JT; Watson, MA; Willson, TM | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Beck, G; Chasserot-Golaz, S | 1 |
| Beck, G; Chasserot-Golaz, S; Genot, G; Lechner, MC; Ribeiro, V | 1 |
| Adesnik, M; Corcos, L; Shaw, PM; Weiss, MC | 1 |
| Beck, G; Chasserot-Golaz, S; Venetianer, A | 1 |
| Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM | 1 |
| Jarukamjorn, K; Nemoto, N; Ohara, A; Sakuma, T; Yamamoto, M | 1 |
| Davidson, BP; Dogra, SC; May, BK | 1 |
| Harada, E; Ikeda, U; Ise, H; Katsuyama, Y; Maruyama, M; Matsunaga, T; Negishi, N; Ohmori, S; Sugihara, N | 1 |
| Hollenberg, PF; Lin, HL; Zhang, H | 1 |
1 review(s) available for mifepristone and phenobarbital
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
13 other study(ies) available for mifepristone and phenobarbital
| Article | Year |
|---|---|
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Genes, Reporter; Histone Acetyltransferases; Humans; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Nuclear Receptor Coactivator 1; Pharmaceutical Preparations; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transcription Factors; Transfection | 1998 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells.
Topics: Aminopyrine; Animals; Biotransformation; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Kinetics; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Mifepristone; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases.
Topics: Aging; Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mifepristone; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1990 |
The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.
Topics: Animals; Base Sequence; Cytochrome P-450 Enzyme System; Enzyme Activation; Gene Expression; Gene Expression Regulation, Enzymologic; Glucocorticoids; Liver Neoplasms, Experimental; Mifepristone; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotide Probes; Phenobarbital; Polymerase Chain Reaction; Progesterone; Promoter Regions, Genetic; Rats; RNA Splicing; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Biotransformation of 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) in rat hepatoma variants.
Topics: Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Mifepristone; Phenobarbital; Rats; Troleandomycin; Tumor Cells, Cultured | 1993 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1999 |
Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis; Female; Gene Expression; Glucocorticoids; Hormone Antagonists; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mifepristone; Oxidoreductases, N-Demethylating; Phenobarbital; RNA, Messenger; Sex Characteristics | 2001 |
The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.
Topics: Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enhancer Elements, Genetic; Excitatory Amino Acid Antagonists; Glucocorticoids; Hepatocytes; Hormone Antagonists; Medroxyprogesterone Acetate; Mifepristone; Phenobarbital; Pregnane X Receptor; Progesterone Congeners; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; RNA, Messenger; Transcription Factors | 2001 |
Expression and induction of CYP3As in human fetal hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Fetus; Hepatocytes; Humans; Insecta; Microsomes; Mifepristone; Phenobarbital; Receptors, Glucocorticoid; Rifampin; RNA, Messenger; Tretinoin | 2004 |
Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
Topics: Animals; Apoproteins; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Crystallization; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Glutathione; Heme; Hormone Antagonists; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; Mifepristone; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry | 2009 |