Page last updated: 2024-08-23

mifepristone and onapristone

mifepristone has been researched along with onapristone in 117 studies

Research

Studies (117)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (5.98)	18.7374
1990's	80 (68.38)	18.2507
2000's	21 (17.95)	29.6817
2010's	9 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bender, SL; Crombie, D; Farmer, LJ; Goldman, ME; Hamann, LG; Johnson, MG; Jones, TK; Mais, DE; Wang, MW	1
Crombie, DL; Edwards, JP; Goldman, ME; Jones, TK; Marschke, KB; Pooley, CL; Wang, MW	1
Edwards, JP; Jones, TK; Mais, DE; Marschke, KB; Motamedi, M; Pio, B; Ringgenberg, JD; Schrader, WT; Tegley, CM; West, SJ; Zhi, L	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Dansette, PM; Fontana, E; Poli, SM	1
Peplow, PV	2
Gehring, S; Kühnel, W; Michna, H; Nishino, Y; Schneider, MR	1
Blennerhassett, MG; Garfield, RE; Sakai, N	1
Chwalisz, K; Elger, W; Fahrenholz, F; Garfield, R; Hackenberg, M	1
el Etreby, MF; Louton, T; Michna, H; Nishino, Y; Schneider, MR	1
Bhakta, A; Moudgil, VK; Nakao, M; Nath, R	1
Muskiet, FA; Slappendel, EJ; van der Schoot, P; Zeegers, TA	1
Healy, DL	1
Cato, AC; Henderson, D; Klein-Hitpass, L; Ryffel, GU	1
Uilenbroek, JT	1
Bigsby, RM; Everett, LM	1
el Etreby, MF; McGuire, WL; Michna, H; Nishino, Y; Schneider, M	1
Slappendel, EJ; Uilenbroek, JT; van der Schoot, P	2
Emons, G; Hansemann, K; Knuppen, R; Ortmann, O	1
el Etreby, MF; Michna, H; Nishino, Y; Schneider, MR	4
Brooks, J; Holland, P; Kelly, R	1
Neef, G; Wiechert, R	1
Beier, S; Chwalisz, K; Elger, W; Fähnrich, M; Qing, SS	1
Elger, WG; Pongubala, JM; Puri, CP	1
Chwalisz, K; Elger, W; Osawa, Y; Shimizu, Y; Yarborough, CP	1
de Gooyer, ME; Deckers, GH; Dijkema, R; Kloosterboer, HJ; Orlemans, EO; Schoonen, WG	1
Chwalisz, K; Einspanier, A; Fritzemeier, KH; Fuhrmann, U; Garfield, RE; Stöckemann, K	1
Altmann, M; Beck, CA; DeMarzo, A; Edwards, DP; Weigel, NL; Zhang, Y	1
Danielsen, M; Zhang, S	1
Archer, TK; Mymryk, JS	2
Croxatto, HB; Fuentealba, B; Salvatierra, AM	1
Allen, JM; Blaustein, JD; Clark, JH; Law, SW; Mani, SK; O'Malley, BW	1
Alkhalaf, M; Coutts, A; Dotzlaw, H; Haddad-Alkhalaf, B; Murphy, LC	1
Deckers, GH; Kloosterboer, HJ; Schoonen, WG	1
Catt, KJ; Emons, G; Ortmann, O; Schulz, KD	1
Bartsch, J; Beato, M; Truss, M	1
Groshong, SD; Horwitz, KB; Miller, LA; Powell, RL; Sartorius, CA; Takimoto, GS; Tung, L	1
Cato, AC; Gast, A; Heck, S; Herrlich, P; Kullmann, M; Ponta, H; Rahmsdorf, HJ	1
Kawamoto, K; Kiya, K; Kurisu, K; Matsuda, Y; Sugiyama, K; Uozumi, T	1
Hoeffler, JP; Horwitz, KB; Mohamed, MK; Takimoto, GS; Tung, L	1
Goldman, ME; McDonnell, DP; Shahbaz, MM; Vegeto, E	1
Delabre, K; Guiochon-Mantel, A; Lescop, P; Milgrom, E; Perrot-Applanat, M	1
Horwitz, KB; Sartorius, CA; Takimoto, GS; Tung, L	1
Lynch, M; Martin, JH; van den Berg, HW	1
Kühnel, W; Michna, H; Rumpel, E	1
Benhamou, B; Bocquel, MT; Chambon, P; Gronemeyer, H; Ji, J; Vergezac, A; Ylikomi, T	1
Delabre, K; Guiochon-Mantel, A; Milgrom, E	1
Hinko, A; Jeng, YJ; Soloff, MS	1
Beck, CA; Edwards, DP; Weigel, NL; Zhang, Y	1
Crombie, DL; Hayes, JS; Heap, RB; Parandoosh, Z; Tetzke, TA; Wang, MW	1
Delabre, K; Guiochon-Mantel, A; Lescop, P; Milgrom, E	1
Bender, SL; Farmer, LJ; Goldman, ME; Hamann, LG; Ianiro, T; Johnson, MG; Jones, TK; Mais, DE; Pathirana, C; Stein, RB	1
Baulieu, EE; Breckwoldt, M; Chwalisz, K; Hodgen, GD; Neulen, J; Williams, RF	1
Beck, S; Hackenberg, R; Hannig, K; Schmidt-Rhode, P; Scholz, A; Schulz, KD	1
Casulari, LA; Maggi, R; Martini, L; Pimpinelli, F; Piva, F	1
Fritzemeier, KH; Michna, H; Nishino, Y; Parczyk, K; Schneider, MR	1
Baker, C; Hawkins, P; Norris, B; Quinn, PG; Sheridan, PL; Wei, LL	1
Auger, AP; Blaustein, JD; Moffatt, CA	1
Bardin, CW; Dao, B; Koide, SS; Li, XJ; Vanage, G	1
Koper, JW; Lamberts, SW; Molijn, GJ; Stigter, E; van Uffelen, CJ	1
Van Look, PF; von Hertzen, H	1
Kilen, SM; Knox, KL; Ringstrom, SJ; Saberi, S; Schwartz, NB; Szabo, M	1
Baird, DT; Buckley, CH; Cameron, ST; Critchley, HO; Kelly, RW	1
Bygdeman, M; Danielsson, KG; Swahn, ML	1
Gurpide, E; Markiewicz, L	1
Delaunay, F; Gustafsson, J; Liden, J; Okret, S; Rafter, I	1
Grimison, B; Groshong, SD; Horwitz, KB; Langan, TA; Lange, CA; Owen, GI; Schauer, IE; Sclafani, RA; Todd, MC	1
Einspanier, A; Ivell, R; Kascheike, B; Lioutas, C; Walther, N	1
Dinda, S; Herman, M; Hurd, C; Iwasaki, K; Kloosterboer, HJ; Moudgil, VK; Underwood, B	1
Rao, AJ; Shanker, YG	1
Edwards, DP; Gass, EK; Leonhardt, SA; Nordeen, SK	1
Benet, LZ; Jang, GR	2
Brouwer, A; Kuil, CW; van der Burg, B; van der Saag, PT	1
Kilen, SM; Ringstrom, SJ; Saberi, S; Schwartz, NB; Szabo, M	1
Borras, M; Lacroix, M; Leclercq, G; Legros, N	1
El Etreby, MF; Liang, Y	1
Calder, AA; Critchley, HO; Elliott, CL; Kelly, RW; Riley, SC	1
Bellido, C; Gaytán, F; Morales, C; Sánchez-Criado, JE	1
Schubert, AK	1
Gonzalez, D; Sánchez-Criado, JE; Tébar, M	1
Charreau, E; Lamb, C; Lanari, C; Luthy, IA; Molinolo, AA; Montecchia, MF; Pazos, P; Vanzulli, S	1
Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK; Nag, K	1
Kilen, SM; Nho, SJ; Schwartz, NB; Szabo, M	1
Davis, JS; Hendry III, WJ; Hendry, IR; Rueda, BR; Slayden, OD; Stormshak, F	1
Aguilar, R; Bellido, C; Gonzalez, D; Sánchez-Criado, JE	1
Bellido, C; de Jong, FH; Sánchez-Criado, JE; Tébar, M	1
Chiappetta, C; Hyder, SM; Stancel, GM	1
Hill, JW; Levine, JE; Urban, JH; Xu, M	1
Chwalisz, K; Cleve, A; Fritzemeier, KH; Fuhrmann, U; Hess-Stumpp, H; Hoffmann, J; Neef, G; Schwede, W	1
Husted, RF; Itani, OA; Loftus, RW; Mick, VE; Schmidt, TJ; Thomas, CP	1
Atkin, SL; Bilko, D; Newton, CJ; Pappa, S	1
Alban, P; Dinda, S; Hurd, C; Khattree, N; Moudgil, VK	1
Aw, SE; Lin, VC; Ng, EH; Tan, MG	1
Auboeuf, D; Chen, JD; Liu, Z; O'Malley, BW; Tsai, MJ; Tsai, SY; Wong, J	1
Chegini, N; Ma, C; Tang, XM; Williams, RS	1
Cidlowski, JA; Schaaf, MJ	1
Engström, C; Jaeger, R; Sager, G; Ørbo, A	1
Hirsová, D; Kadlecová, L; Kolínská, J; Kraml, J; Nosková, L; Sinkora, J; Zákostelecká, M	1
Curry, TE; Jo, M	1
Edwards, DP; Elbi, C; Fletcher, TM; Hager, GL; Rayasam, GV; Walker, DA; Wolford, R	1
Allan, GF; Clancy, J; Lai, MT; Musto, A; Palmer, E; Palmer, S	1
Edwards, DP; Narayanan, R; Wardell, SE; Weigel, NL	1
Chang, CY; Edwards, DP; Kazmin, D; Kimbrel, EA; Kobayashi, S; McDonnell, DP; Stice, JP; Wittmann, BM	1
Sarkar, NN	1
Amazit, L; Bellance, C; Guiochon-Mantel, A; Khan, JA; Lombès, M; Loosfelt, H	1
Guil-Luna, S; Hellmén, E; Martín de las Mulas, J; Millán, Y; Sánchez-Céspedes, R	1
Hayashi, N; Hirata, R; Hojo, T; Okuda, K; Sano, M	1
Kotwica, J; Kowalik, MK; Rekawiecki, R	1
Bolt, MJ; Edwards, DP; Grimm, SL; Mancini, MA; Treviño, LS; Weigel, NL	1
Cooperrider, J; Custer, M; Dobyns, AE; Elsissy, JG; Heuerman, AC; Kirby, MA; Strilaeff, R; Stutz, KN; Yellon, SM	1

Reviews

12 review(s) available for mifepristone and onapristone

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review. Reproduction, fertility, and development, 1990, Volume: 2, Issue:5 Topics: Abortifacient Agents, Steroidal; Animals; Estrenes; Female; Gonanes; Humans; Menstruation-Inducing Agents; Mifepristone; Pregnancy; Progesterone; Prostaglandins; Receptors, Progesterone	1990
Antitumor activity and mechanism of action of different antiprogestins in experimental breast cancer models. The Journal of steroid biochemistry and molecular biology, 1990, Dec-20, Volume: 37, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Cycle; Gonanes; Kinetics; Mammary Neoplasms, Experimental; Mifepristone; Progesterone	1990
Synthesis of antiprogestational steroids. Journal of steroid biochemistry, 1987, Volume: 27, Issue:4-6 Topics: Chemical Phenomena; Chemistry; Estrenes; Gonanes; Mifepristone; Progestins	1987
Mechanism of action of antiprogestins in the pregnant uterus. Annals of the New York Academy of Sciences, 1995, Jun-12, Volume: 761 Topics: Animals; Embryo Implantation; Female; Gonanes; Humans; In Vitro Techniques; Labor, Obstetric; Mifepristone; Models, Biological; Pregnancy; Primates; Progestins; Prostaglandins; Uterus	1995
[Anti-progestins and contraception]. Advances in contraception : the official journal of the Society for the Advancement of Contraception, 1994, Volume: 10 Suppl 1 Topics: Contraceptives, Oral; Contraceptives, Postcoital, Hormonal; Embryo Implantation; Endometrium; Estrenes; Female; Glucocorticoids; Gonanes; Humans; Luteinizing Hormone; Mifepristone; Ovary; Ovulation; Progestins; Receptors, Progesterone	1994
Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins. Human reproduction (Oxford, England), 1994, Volume: 9 Suppl 1 Topics: Breast Neoplasms; Cell Division; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, myc; Gonanes; Humans; Medroxyprogesterone Acetate; Mifepristone; Neoplasm Proteins; Progestins; Transforming Growth Factors; Tumor Cells, Cultured	1994
The Ernst Schering Poster Award. Intracellular traffic of steroid hormone receptors. The Journal of steroid biochemistry and molecular biology, 1996, Volume: 56, Issue:1-6 Spec N Topics: Amino Acid Sequence; Animals; beta-Galactosidase; Biological Transport; Cell Line; Cell Nucleus; Cricetinae; Cytoplasm; Gene Expression Regulation; Gonanes; Hormone Antagonists; Humans; Mice; Mifepristone; Molecular Sequence Data; Nuclear Envelope; Protein Sorting Signals; Receptors, Progesterone; Receptors, Steroid; Recombinant Fusion Proteins; Signal Transduction; Zinc Fingers	1996
Discovery of novel intracellular receptor modulating drugs. The Journal of steroid biochemistry and molecular biology, 1996, Volume: 56, Issue:1-6 Spec N Topics: Animals; Anisoles; Chlorocebus aethiops; Chlorophyta; Cyclohexanes; Drug Design; Estrogen Replacement Therapy; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Molecular Structure; Progesterone Congeners; Receptors, GABA; Receptors, Progesterone; Receptors, Steroid; Recombinant Proteins; Sleep Stages; Structure-Activity Relationship; Transfection	1996
Antiprogestin-progesterone interactions. Cancer treatment and research, 1996, Volume: 83 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Gonanes; Hormone Antagonists; Humans; Mice; Mifepristone; Progesterone	1996
Clinical uses of antiprogestogens. Human reproduction update, 1995, Volume: 1, Issue:1 Topics: Abortion, Induced; Antineoplastic Agents; Breast Neoplasms; Contraception; Contraceptives, Oral, Synthetic; Endometrial Neoplasms; Endometriosis; Estrenes; Female; Gonanes; Humans; Labor, Induced; Mifepristone; Pregnancy; Pregnancy Trimester, Second; Progestins; Prostaglandins; Receptors, Progesterone	1995
Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:6 Topics: Abortifacient Agents; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Contraceptives, Postcoital, Synthetic; Endometriosis; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Progestins	1997

Other Studies

105 other study(ies) available for mifepristone and onapristone

Article	Year
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether. Journal of medicinal chemistry, 1996, Apr-26, Volume: 39, Issue:9 Topics: Animals; Anisoles; Cell Line; Cyclohexanes; Cyclohexenes; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Receptors, Progesterone; Structure-Activity Relationship; Tumor Cells, Cultured	1996
Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore. Journal of medicinal chemistry, 1998, Aug-27, Volume: 41, Issue:18 Topics: Administration, Oral; Animals; Cell Line; Cercopithecus; Embryo Implantation; Female; Gonanes; Hormone Antagonists; Humans; Mice; Pregnancy; Quinolines; Receptors, Progesterone; Structure-Activity Relationship	1998
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore. Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12 Topics: Animals; Cell Line; Chlorocebus aethiops; Humans; Inhibitory Concentration 50; Progesterone; Quinolines; Receptors, Progesterone; Receptors, Steroid; Structure-Activity Relationship; Transcription, Genetic; Transfection	2003
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Prostaglandin E production by uteri of ovariectomized pregnant rats receiving antiprogesterone steroid or in which progesterone has been withdrawn. Prostaglandins, leukotrienes, and essential fatty acids, 1992, Volume: 47, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Female; Gonanes; In Vitro Techniques; Mifepristone; Ovariectomy; Pregnancy; Progesterone; Prostaglandins E; Rats; Uterus	1992
The antitumor potency of progesterone antagonists is due to their differentiation potential. The Journal of steroid biochemistry and molecular biology, 1992, Volume: 43, Issue:1-3 Topics: Animals; Antineoplastic Agents; Cell Differentiation; Gonanes; Mammary Neoplasms, Experimental; Mice; Mifepristone; Progesterone; Rats	1992
Effects of antiprogesterones on myometrial cell-to-cell coupling in pregnant guinea pigs. Biology of reproduction, 1992, Volume: 46, Issue:3 Topics: Animals; Cell Communication; Electric Conductivity; Electrophysiology; Female; Fluorescent Dyes; Gonanes; Guinea Pigs; Hormone Antagonists; Isoquinolines; Microelectrodes; Mifepristone; Myometrium; Pregnancy; Progesterone; Time Factors	1992
The progesterone antagonist onapristone increases the effectiveness of oxytocin to produce delivery without changing the myometrial oxytocin receptor concentrations. American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:6 Pt 1 Topics: Animals; Connexins; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Female; Gestational Age; Gonanes; Guinea Pigs; Intercellular Junctions; Labor, Induced; Membrane Proteins; Mifepristone; Myometrium; Oxytocin; Progesterone; Receptors, Angiotensin; Receptors, Oxytocin; Uterine Contraction	1991
A bioassay for the evaluation of antiproliferative potencies of progesterone antagonists. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:3 Topics: Animals; DNA; Female; Gonanes; Mammary Glands, Animal; Mifepristone; Organ Size; Progesterone; Rats; Rats, Inbred Strains; RNA	1991
Uterine production of prostaglandins F2 alpha and 6-keto-F1 alpha by ovariectomized pregnant rats receiving antiprogesterone steroid or in which progesterone has been withdrawn. Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 44, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Drug Implants; Epoprostenol; Estradiol; Female; Gonanes; Mifepristone; Organ Size; Ovariectomy; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Rats, Inbred Strains; Uterus	1991
ZK98299, a novel antiprogesterone that does not interact with chicken oviduct progesterone receptor. Biochimica et biophysica acta, 1991, Sep-03, Volume: 1094, Issue:2 Topics: Animals; Antibodies, Monoclonal; Cattle; Chickens; Cytosol; Female; Gonanes; In Vitro Techniques; Mifepristone; Molecular Structure; Oviducts; Phosphorylation; Progesterone; Receptors, Progesterone; Uterus	1991
Reduction of the intake of food and water is responsible for reduction of litter growth when dams are treated with a progesterone antagonist. The British journal of nutrition, 1991, Volume: 66, Issue:1 Topics: Animals; Animals, Newborn; Body Weight; Drinking; Eating; Female; Gonanes; Lactation; Male; Mifepristone; Milk; Ovariectomy; Pregnancy; Progesterone; Rats; Rats, Inbred Strains	1991
Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic acids research, 1991, Mar-25, Volume: 19, Issue:6 Topics: Base Sequence; Binding, Competitive; DNA; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Plasmids; Progesterone; Receptors, Progesterone; TATA Box; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured	1991
Hormone concentrations and ovulatory response in rats treated with antiprogestagens. The Journal of endocrinology, 1991, Volume: 129, Issue:3 Topics: Animals; Chorionic Gonadotropin; Female; Gonadotropins, Pituitary; Gonanes; Luteinizing Hormone; Mifepristone; Ovary; Ovulation; Progesterone; Prolactin; Rats; Rats, Inbred Strains	1991
Effects of progestin antagonists, glucocorticoids and estrogen on progesterone-induced protein secreted by rabbit endometrial stromal cells in culture. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:1 Topics: Animals; Cells, Cultured; Endometrium; Estrenes; Estrogens; Extracellular Matrix Proteins; Female; Glucocorticoids; Gonanes; Mifepristone; Progesterone; Progestins; Proteins; Rabbits	1991
Progesterone antagonists block the growth of experimental mammary tumors in G0/G1. Breast cancer research and treatment, 1990, Volume: 17, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Division; Female; G1 Phase; Gonanes; Mammary Neoplasms, Experimental; Mifepristone; Progesterone; Rats; Rats, Inbred Strains; Resting Phase, Cell Cycle	1990
Effect of the progesterone antagonist mifepristone on the hypothalamo-hypophysial-ovarian axis in rats. The Journal of endocrinology, 1990, Volume: 124, Issue:3 Topics: 20-alpha-Dihydroprogesterone; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Body Weight; Bromocriptine; Delayed-Action Preparations; Female; Gonanes; Hypothalamo-Hypophyseal System; Mifepristone; Organ Size; Ovary; Pituitary Gland; Progesterone; Prolactin; Rats; Uterus	1990
Modulatory actions of the new antiprogestins ZK 98.299 and ZK 98.734 and of RU 486 on luteinizing hormone secretion and progesterone effects in pituitary gonadotrophs. Journal of steroid biochemistry, 1990, Aug-14, Volume: 36, Issue:5 Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Estrenes; Female; Gonanes; Kinetics; Luteinizing Hormone; Mifepristone; Pituitary Gland, Anterior; Progesterone; Progestins; Rats; Rats, Inbred Strains	1990
Comparison of antiprogestin stimulation of uterine prostaglandin synthesis in vitro. Prostaglandins, leukotrienes, and essential fatty acids, 1990, Volume: 40, Issue:3 Topics: Animals; Female; Fertility Agents, Female; Gonanes; Guinea Pigs; In Vitro Techniques; Male; Mifepristone; Perfusion; Pregnancy; Prostaglandin Antagonists; Prostaglandins; Uterus	1990
Antitumor activity of the progesterone antagonists ZK 98.299 and RU 38.486 in the hormone-dependent MXT mammary tumor model of the mouse and the DMBA- and the MNU-induced mammary tumor models of the rat. European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:4 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estrenes; Female; Gonanes; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mifepristone; Neoplasms, Hormone-Dependent; Progesterone; Rats; Rats, Inbred Strains	1989
Failure of two progesterone antagonists, mifepristone and onapristone, to affect luteal activity in lactating rats. Journal of reproduction and fertility, 1989, Volume: 87, Issue:2 Topics: Algestone; Animals; Corpus Luteum; Female; Gonanes; Lactation; Luteolysis; Mifepristone; Ovulation; Pregnancy; Progesterone; Prolactin; Rats; Rats, Inbred Strains	1989
Antitumor activity of the antiprogestins ZK 98.299 and RU 38.486 in hormone dependent rat and mouse mammary tumors: mechanistic studies. Breast cancer research and treatment, 1989, Volume: 14, Issue:3 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Female; Gonanes; Mammary Neoplasms, Experimental; Methylnitrosourea; Mifepristone; Neoplasm Transplantation; Organ Size; Ovariectomy; Ovary; Rats; Rats, Inbred Strains; Uterus; Vagina	1989
The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death. Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Estradiol; Female; Gonanes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mifepristone; Ovariectomy; Progesterone; Tumor Cells, Cultured	1989
Endometrial and myometrial effects of progesterone antagonists in pregnant guinea pigs. American journal of obstetrics and gynecology, 1987, Volume: 157, Issue:4 Pt 2 Topics: Abortion, Induced; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Embryo Implantation; Endometrium; Estrenes; Female; Gonanes; Guinea Pigs; Mifepristone; Myometrium; Pregnancy; Pregnancy, Animal; Progesterone; Prostaglandins E, Synthetic; Prostaglandins F; Uterine Contraction	1987
Induction of menstruation by antiprogesterone ZK 98.299 in cycling bonnet monkeys. Contraception, 1987, Volume: 35, Issue:4 Topics: Animals; Corpus Luteum; Estradiol; Estrenes; Female; Gonanes; Macaca radiata; Menstrual Cycle; Mifepristone; Progesterone	1987
Inhibition of aromatase activity in human placental microsomes by 13-retro-antiprogestins. Steroids, 1995, Volume: 60, Issue:2 Topics: Aromatase Inhibitors; Estrenes; Estrone; Female; Gonanes; Humans; Microsomes; Mifepristone; Placenta; Pregnancy; Progestins	1995
Pharmacological properties of a new selective antiprogestagen: Org 33628. Annals of the New York Academy of Sciences, 1995, Jun-12, Volume: 761 Topics: Adrenal Glands; Animals; Cell Line; Estrenes; Female; Furans; Gonanes; Guinea Pigs; Humans; In Vitro Techniques; Mifepristone; Ovulation; Pregnancy; Progestins; Receptors, Cell Surface; Receptors, Progesterone; Structure-Activity Relationship	1995
Progesterone receptor and the mechanism of action of progesterone antagonists. The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; DNA-Binding Proteins; Estrenes; Gonanes; Humans; In Vitro Techniques; Mifepristone; Progesterone; Promegestone; Protein Binding; Protein Conformation; Receptors, Progesterone; Signal Transduction; Transcription Factors; Transcription, Genetic	1995
8-Br-cAMP does not convert antagonists of the glucocorticoid receptor into agonists. Recent progress in hormone research, 1995, Volume: 50 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; CHO Cells; Cricetinae; Gonanes; Mice; Mifepristone; Progesterone; Promegestone; Receptors, Glucocorticoid; Transfection	1995
Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo. Genes & development, 1995, Jun-01, Volume: 9, Issue:11 Topics: Animals; Breast Neoplasms; Cell Line, Transformed; Cell Transformation, Viral; Chromatin; Female; Gonanes; Humans; Mammary Tumor Virus, Mouse; Mice; Mifepristone; Promoter Regions, Genetic; Receptors, Progesterone; Signal Transduction; Transcriptional Activation	1995
Inhibition of rat sexual behavior by antisense oligonucleotides to the progesterone receptor. Endocrinology, 1994, Volume: 135, Issue:4 Topics: Animals; Base Sequence; DNA; Dose-Response Relationship, Drug; Female; Gonanes; Hypothalamus; Mifepristone; Molecular Sequence Data; Oligonucleotides, Antisense; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Sexual Behavior, Animal	1994
Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806. Human reproduction (Oxford, England), 1994, Volume: 9 Suppl 1 Topics: 9,10-Dimethyl-1,2-benzanthracene; Abortifacient Agents, Steroidal; Abortion, Induced; Androgen Antagonists; Animals; Estrenes; Female; Furans; Gonanes; Macaca; Male; Mammary Neoplasms, Experimental; Menstruation-Inducing Agents; Mifepristone; Pregnancy; Progestins; Rats; Receptors, Glucocorticoid; Receptors, Progesterone	1994
Modulatory action of progesterone and progesterone antagonists on hypothalamic-pituitary function. Human reproduction (Oxford, England), 1994, Volume: 9 Suppl 1 Topics: Animals; Cells, Cultured; Estrenes; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonanes; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Mifepristone; Ovariectomy; Pituitary Gland, Anterior; Progesterone; Rats; Rats, Sprague-Dawley; Rats, Wistar	1994
Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo. Proceedings of the National Academy of Sciences of the United States of America, 1994, Nov-22, Volume: 91, Issue:24 Topics: Base Sequence; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Gonanes; Humans; In Vitro Techniques; Mammary Tumor Virus, Mouse; Mifepristone; Molecular Sequence Data; Oligodeoxyribonucleotides; Progestins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; RNA, Messenger; Transcription, Genetic	1994
New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer research, 1994, Jul-15, Volume: 54, Issue:14 Topics: Base Sequence; Breast Neoplasms; Cyclic AMP; Female; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Progestins; Receptors, Progesterone; Transcription, Genetic; Tumor Cells, Cultured	1994
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. The EMBO journal, 1994, Sep-01, Volume: 13, Issue:17 Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cells, Cultured; DNA; DNA Mutational Analysis; Gene Expression Regulation; Glucocorticoids; Gonanes; Mifepristone; Molecular Sequence Data; Point Mutation; Promoter Regions, Genetic; Protein Conformation; Proto-Oncogene Proteins c-jun; Receptors, Glucocorticoid; Structure-Activity Relationship	1994
Antitumor effects of antiprogesterones on human meningioma cells in vitro and in vivo. Journal of neurosurgery, 1994, Volume: 80, Issue:3 Topics: Adult; Aged; Animals; Antineoplastic Agents; Female; Gonanes; Humans; Male; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude; Middle Aged; Mifepristone; Progesterone; Receptors, Progesterone; Tumor Cells, Cultured	1994
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Molecular endocrinology (Baltimore, Md.), 1993, Volume: 7, Issue:10 Topics: Binding Sites; DNA; Genes, fos; Genes, jun; Genes, Reporter; Gonanes; HeLa Cells; Humans; Leucine Zippers; Mifepristone; Phenotype; Progesterone; Promoter Regions, Genetic; Receptors, Progesterone; Recombinant Fusion Proteins; Transcription, Genetic; Transfection	1993
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. The Journal of steroid biochemistry and molecular biology, 1994, Volume: 48, Issue:5-6 Topics: Animals; Cells, Cultured; Gonanes; Haplorhini; Humans; Mifepristone; Mineralocorticoid Receptor Antagonists; Molecular Conformation; Progestins; Receptors, Mineralocorticoid; Receptors, Progesterone; Repressor Proteins; Transcription, Genetic	1994
Cytoplasmic-nuclear trafficking of progesterone receptor. In vivo study of the mechanism of action of antiprogestins. Biochemical pharmacology, 1994, Jan-13, Volume: 47, Issue:1 Topics: Animals; Cell Nucleus; Cytoplasm; Gonanes; Mifepristone; Nuclear Localization Signals; Nuclear Proteins; Progestins; Protein Sorting Signals; Rabbits; Receptors, Progesterone	1994
Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. The Journal of biological chemistry, 1993, May-05, Volume: 268, Issue:13 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Base Sequence; beta-Galactosidase; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclic AMP; DNA-Binding Proteins; Female; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphates; Progesterone; Promegestone; Receptors, Progesterone; Recombinant Proteins; Transcription Factors; Transfection; Tumor Cells, Cultured	1993
The relationship between affinity of progestins and antiprogestins for the progesterone receptor in breast cancer cells (ZR-PR-LT) and ability to down-regulate the receptor: evidence for heterospecific receptor modulation via the glucocorticoid receptor. European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:12 Topics: Binding, Competitive; Breast Neoplasms; Dexamethasone; Down-Regulation; Female; Gonanes; Humans; Medroxyprogesterone Acetate; Mifepristone; Mitosis; Pregnenediones; Progesterone Congeners; Progestins; Receptors, Glucocorticoid; Receptors, Progesterone; Tumor Cells, Cultured	1993
Morphology of the rat uterus after long-term treatment with progesterone antagonists. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 1993, Volume: 175, Issue:2 Topics: Animals; Cytoplasmic Granules; Endometrium; Epithelial Cells; Epithelium; Female; Gonanes; Microscopy, Electron; Mifepristone; Progesterone; Rats; Rats, Sprague-Dawley; Uterus	1993
Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization. The Journal of steroid biochemistry and molecular biology, 1993, Volume: 45, Issue:4 Topics: Animals; Binding, Competitive; DNA; Furans; Gene Expression; Gonanes; HeLa Cells; Humans; Mice; Mifepristone; Phosphorylation; Progesterone; Receptors, Glucocorticoid; Receptors, Progesterone; Transfection	1993
In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. Proceedings of the National Academy of Sciences of the United States of America, 1993, May-15, Volume: 90, Issue:10 Topics: Animals; Cell Line; Chlorocebus aethiops; DNA-Binding Proteins; Gene Expression Regulation; Gonanes; In Vitro Techniques; Mifepristone; Protein Binding; Rabbits; Receptors, Progesterone; Recombinant Proteins; RNA, Messenger; Transcription, Genetic	1993
Effectors of cyclic adenosine 5'-monophosphate up-regulating-oxytocin receptors in rabbit amnion cells: isoproterenol, parathyroid hormone-related protein, and potentiation by cortisol. Biology of reproduction, 1995, Volume: 53, Issue:5 Topics: Adenylyl Cyclases; Amnion; Animals; Colforsin; Cyclic AMP; DNA; Drug Synergism; Female; Gonanes; Hormone Antagonists; Hydrocortisone; Isoproterenol; Mifepristone; Parathyroid Hormone-Related Protein; Pregnancy; Proteins; Rabbits; Receptors, Glucocorticoid; Receptors, Oxytocin	1995
Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor. The Journal of biological chemistry, 1996, Jan-12, Volume: 271, Issue:2 Topics: Amino Acid Sequence; Breast Neoplasms; Female; Gonanes; Humans; Mifepristone; Molecular Sequence Data; Phosphorylation; Progestins; Receptors, Progesterone; Signal Transduction; Tumor Cells, Cultured	1996
Progesterone and oestrogen receptors in the decidualized mouse uterus and effects of different types of anti-progesterone treatment. Journal of reproduction and fertility, 1995, Volume: 105, Issue:2 Topics: Animals; Antibodies, Monoclonal; Decidua; Female; Gonanes; Mice; Mice, Inbred Strains; Mifepristone; Progesterone; Pseudopregnancy; Receptors, Estrogen; Receptors, Progesterone	1995
Influence of hormone antagonists on chromatin remodeling and transcription factor binding to the mouse mammary tumor virus promoter in vivo. Molecular endocrinology (Baltimore, Md.), 1995, Volume: 9, Issue:12 Topics: Animals; Binding, Competitive; Chromatin; Dexamethasone; Glucocorticoids; Gonanes; Hormone Antagonists; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mifepristone; Promoter Regions, Genetic; Receptors, Glucocorticoid; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured	1995
Non-competitive anti-oestrogenic actions of progesterone antagonists in primate endometrium: enhancement of oestrogen and progesterone receptors with blockade of post-receptor proliferative mechanisms. Human reproduction (Oxford, England), 1996, Volume: 11, Issue:7 Topics: Animals; Cell Division; Endometrium; Estrogen Antagonists; Female; Gonanes; Hormone Antagonists; Macaca fascicularis; Mifepristone; Progesterone; Receptors, Estrogen; Receptors, Progesterone	1996
Androgen-like and anti-androgen-like effects of antiprogestins in human mammary cancer cells. European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:4 Topics: Androgen Antagonists; Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cell Division; Dihydrotestosterone; Estrenes; Flutamide; Gonanes; Humans; Mifepristone; Models, Biological; Progestins; Receptors, Androgen; Transfection; Tumor Cells, Cultured	1996
Antiprogestins inhibit the binding of opioids to mu-opioid receptors in nervous membrane preparations. European journal of pharmacology, 1996, Apr-22, Volume: 301, Issue:1-3 Topics: Analgesics; Animals; Dihydromorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonanes; Hormone Antagonists; Humans; In Vitro Techniques; Male; Membranes; Mice; Mifepristone; Narcotic Antagonists; Narcotics; Nerve Tissue; Nervous System Neoplasms; Neuroblastoma; Progestins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium; Tumor Cells, Cultured	1996
An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:11 Topics: Antineoplastic Agents; Breast Neoplasms; Enhancer Elements, Genetic; Gonanes; HeLa Cells; Hormone Antagonists; Humans; Methionine; Mifepristone; Progesterone Congeners; Progestins; Promegestone; Protein Biosynthesis; Receptors, Progesterone; Transcription, Genetic; Transfection; Tumor Cells, Cultured	1996
Progesterone-independent activation of rat brain progestin receptors by reproductive stimuli. Endocrinology, 1997, Volume: 138, Issue:1 Topics: Animals; Female; Genes, fos; Gonanes; Mifepristone; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Sexual Behavior, Animal	1997
Comparative effectiveness of three antiprogestins alone and in combination with anordiol in terminating pregnancy in the rat. Contraception, 1997, Volume: 55, Issue:1 Topics: Abortion, Induced; Administration, Oral; Animals; Cohort Studies; Contraceptives, Postcoital; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Estradiol; Estrenes; Female; Furans; Gonanes; Hormone Antagonists; Male; Mifepristone; Norandrostanes; Pregnancy; Progesterone; Rats; Rats, Sprague-Dawley	1997
Antiprogestins and iatrogenic glucocorticoid resistance. Life sciences, 1997, Volume: 60, Issue:9 Topics: Binding, Competitive; Dexamethasone; Drug Resistance; Estrenes; Furans; Glucocorticoids; Gonanes; Hormone Antagonists; Humans; Hydrocortisone; In Vitro Techniques; Lymphocyte Activation; Meningeal Neoplasms; Meningioma; Mifepristone; Progestins; Receptors, Glucocorticoid	1997
The antiprogestins RU486 and ZK98299 affect follicle-stimulating hormone secretion differentially on estrus, but not on proestrus. Endocrinology, 1997, Volume: 138, Issue:6 Topics: Animals; Estrus; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Gonanes; Hormone Antagonists; Luteinizing Hormone; Mifepristone; Pituitary Gland, Anterior; Proestrus; Progestins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Uterus	1997
Effect of two antiprogestins (mifepristone and onapristone) on endometrial factors of potential importance for implantation. Fertility and sterility, 1997, Volume: 67, Issue:6 Topics: Abortifacient Agents, Steroidal; Biomarkers; Biopsy; Cell Division; Embryo Implantation; Endometrium; Female; Fertility Agents, Female; Glycodelin; Glycoproteins; Gonanes; Growth Inhibitors; Hormone Antagonists; Humans; Hydroxyprostaglandin Dehydrogenases; Interleukin-6; Ki-67 Antigen; Leukemia Inhibitory Factor; Luteinizing Hormone; Lymphokines; Menstrual Cycle; Mifepristone; Pregnancy Proteins	1997
The possible use of antiprogestins for contraception. Acta obstetricia et gynecologica Scandinavica. Supplement, 1997, Volume: 164 Topics: Contraceptives, Oral, Synthetic; Endometrium; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Pregnancy; Progesterone	1997
Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays. Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:4 Topics: Adenocarcinoma; Alkaline Phosphatase; Androgen Antagonists; Androgens; Breast Neoplasms; Cyproterone Acetate; Endometrial Neoplasms; Estradiol; Estrogen Antagonists; Female; Flutamide; Gonanes; Humans; Mifepristone; Polyunsaturated Alkamides; Progestins; Tamoxifen; Testosterone; Testosterone Congeners; Tumor Cells, Cultured	1997
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation. The Journal of biological chemistry, 1997, Aug-22, Volume: 272, Issue:34 Topics: Amino Acid Sequence; Animals; Arginine; COS Cells; Dexamethasone; Dimerization; Glucocorticoids; Gonanes; Lysine; Mifepristone; Molecular Sequence Data; NF-kappa B; Rats; Receptors, Glucocorticoid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Repressor Proteins; Structure-Activity Relationship; Transcription Factor RelA; Transcriptional Activation; Zinc Fingers	1997
Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Molecular endocrinology (Baltimore, Md.), 1997, Volume: 11, Issue:11 Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Gene Expression Regulation; Gonanes; Hormone Antagonists; Humans; Microtubule-Associated Proteins; Mifepristone; Progesterone; Promegestone; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins	1997
An autocrine progesterone positive feedback loop mediates oxytocin upregulation in bovine granulosa cells during luteinization. Endocrinology, 1997, Volume: 138, Issue:11 Topics: Animals; Blotting, Northern; Cattle; Corpus Luteum; Dexamethasone; Feedback; Female; Glucocorticoids; Gonanes; Granulosa Cells; Hormone Antagonists; Medroxyprogesterone Acetate; Mifepristone; Oxytocin; Progesterone; Progestins; RNA, Messenger	1997
Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands. Molecular and cellular biochemistry, 1997, Volume: 175, Issue:1-2 Topics: Binding, Competitive; Blotting, Western; DNA; Electrophoresis, Polyacrylamide Gel; Estrenes; Furans; Gonanes; Hormone Antagonists; Humans; Ligands; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Sodium Dodecyl Sulfate; Tumor Cells, Cultured	1997
Regulation of progesterone biosynthesis in the human placenta by estradiol 17 beta and progesterone. Biochemistry and molecular biology international, 1997, Volume: 43, Issue:3 Topics: Estradiol; Fadrozole; Female; Fulvestrant; Gonanes; Homeostasis; Hormone Antagonists; Humans; Mifepristone; Placenta; Pregnancy; Progesterone	1997
The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation. Endocrinology, 1998, Volume: 139, Issue:4 Topics: Animals; Binding Sites; Binding, Competitive; COS Cells; DNA; Gonanes; Hormone Antagonists; Humans; Mice; Mifepristone; Progesterone; Promoter Regions, Genetic; Protein Conformation; Receptors, Glucocorticoid; Receptors, Progesterone; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; TATA Box; Transfection	1998
Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology, 1998, Volume: 56, Issue:3 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gonanes; Hormone Antagonists; Humans; Microsomes, Liver; Midazolam; Mifepristone; Mixed Function Oxygenases; NADP; Spectrophotometry; Tissue Donors	1998
Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms. The Journal of biological chemistry, 1998, Apr-10, Volume: 273, Issue:15 Topics: Breast Neoplasms; Cytochrome P-450 CYP1A1; Female; Gene Expression Regulation, Enzymologic; Gonanes; Hormone Antagonists; Humans; Mifepristone; Polychlorinated Dibenzodioxins; Pregnenediones; Progesterone Congeners; Receptors, Aryl Hydrocarbon; Receptors, Progesterone; Recombinant Proteins; Signal Transduction; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation	1998
Antiprogestins suppress basal and activin-stimulated follicle-stimulating hormone secretion in an estrogen-dependent manner. Endocrinology, 1998, Volume: 139, Issue:5 Topics: Activins; Animals; Cells, Cultured; Estradiol; Female; Follicle Stimulating Hormone; Gonanes; Hormone Antagonists; Inhibins; Luteinizing Hormone; Metestrus; Mifepristone; Pituitary Gland, Anterior; Proestrus; Progestins; Rats; Rats, Sprague-Dawley	1998
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers. Cancer letters, 1997, Nov-25, Volume: 120, Issue:1 Topics: Breast Neoplasms; Cell Division; Cytosol; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Gonanes; Hormone Antagonists; Humans; Mifepristone; Pregnenediones; Progestins; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured	1997
Effect of antiprogestins and tamoxifen on growth inhibition of MCF-7 human breast cancer cells in nude mice. Breast cancer research and treatment, 1998, Volume: 49, Issue:2 Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Gonanes; Hormone Antagonists; Humans; Mice; Mice, Nude; Mifepristone; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Tumor Cells, Cultured	1998
Regulation of interleukin 8 production in the term human placenta during labor and by antigestagens. American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:1 Topics: Culture Techniques; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Immunohistochemistry; Interleukin-8; Labor, Obstetric; Mifepristone; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Progestins	1998
Both prolactin and progesterone in proestrus are necessary for the induction of apoptosis in the regressing corpus luteum of the rat. Biology of reproduction, 1998, Volume: 59, Issue:5 Topics: Animals; Apoptosis; Bromocriptine; Corpus Luteum; Dopamine Agonists; Female; Gonanes; Hormone Antagonists; Luteolysis; Macrophages; Mifepristone; Proestrus; Progesterone; Prolactin; Rats; Rats, Wistar	1998
[Effects of progesterone antagonists on the eosinophilic granulocytes in the rat uterus]. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 1998, Volume: 180, Issue:5 Topics: Animals; Endometrium; Eosinophils; Estrogens; Estrone; Female; Gonanes; Hormone Antagonists; Mifepristone; Myometrium; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sexual Maturation; Uterus	1998
Mechanism of the stimulatory action of antisteroid RU486 on follicle-stimulating hormone secretion in the cyclic Rat. Hormone research, 1999, Volume: 51, Issue:1 Topics: Animals; Estrenes; Estrus; Female; Follicle Stimulating Hormone; Furans; Gonadotropin-Releasing Hormone; Gonanes; Hormone Antagonists; Luteinizing Hormone; Mifepristone; Pentobarbital; Progesterone; Rats; Rats, Wistar	1999
Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas. The Journal of steroid biochemistry and molecular biology, 1999, Volume: 68, Issue:1-2 Topics: Adenocarcinoma; Androgens; Animals; Binding Sites; Estradiol; Female; Flutamide; Glucocorticoids; Gonanes; Hormone Antagonists; Mammary Neoplasms, Experimental; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Mifepristone; Neoplasms, Hormone-Dependent; Oligonucleotides, Antisense; Ovariectomy; Receptors, Estrogen; Receptors, Progesterone; Thymidine; Tumor Cells, Cultured	1999
Agonist and antagonist-induced qualitative and quantitative alterations of progesterone receptor from breast cancer cells. Molecular and cellular biochemistry, 1999, Volume: 199, Issue:1-2 Topics: Blotting, Western; Breast Neoplasms; Cell Division; Charcoal; Culture Media; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured	1999
Progesterone receptor A and B messenger ribonucleic acid levels in the anterior pituitary of rats are regulated by estrogen. Biology of reproduction, 2000, Volume: 62, Issue:1 Topics: Animals; Estrogens; Estrus; Female; Gene Expression Regulation; Gonanes; Hormone Antagonists; Metestrus; Mifepristone; Ovariectomy; Pituitary Gland, Anterior; Proestrus; Progesterone; Rats; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2000
Decreased progesterone levels and progesterone receptor antagonists promote apoptotic cell death in bovine luteal cells. Biology of reproduction, 2000, Volume: 62, Issue:2 Topics: Aminoglutethimide; Animals; Apoptosis; Cattle; Corpus Luteum; Cytochrome P-450 Enzyme Inhibitors; DNA, Complementary; Enzyme Inhibitors; Female; Gonanes; Hormone Antagonists; Immunohistochemistry; Mifepristone; Progesterone; Radioimmunoassay; Receptors, Progesterone; RNA, Messenger; Steroids	2000
Antiprogestins RU486 and ZK299 suppress basal and LHRH-stimulated FSH and LH secretion at pituitary level in the rat in an oestrous cycle stage-dependent manner. The Journal of endocrinology, 1999, Volume: 163, Issue:1 Topics: Analysis of Variance; Animals; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Gonanes; Hormone Antagonists; Luteinizing Hormone; Median Eminence; Mifepristone; Ovariectomy; Pituitary Gland; Proestrus; Rats; Rats, Wistar	1999
Comparison of the effects of antiprogestins RU38486, ZK98299 and ORG31710 on periovulatory hypophysial, ovarian and adrenal hormone secretion in the rat. Journal of endocrinological investigation, 2000, Volume: 23, Issue:3 Topics: Adrenal Glands; Animals; Corticosterone; Estrenes; Female; Follicle Stimulating Hormone; Furans; Gonanes; Hormone Antagonists; Inhibins; Luteinizing Hormone; Mifepristone; Ovary; Ovulation; Pituitary Gland, Posterior; Progesterone; Rats; Rats, Wistar	2000
Induction of the angiogenic factor VEGF in the uterus by the antiprogestin onapristone. Cancer letters, 2000, Aug-01, Volume: 156, Issue:1 Topics: Animals; Endothelial Growth Factors; Estradiol; Female; Fulvestrant; Gonanes; Hormone Antagonists; Lymphokines; Mifepristone; Progestins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Uterus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Regulation of hypothalamic neuropeptide Y Y1 receptor gene expression during the estrous cycle: role of progesterone receptors. Endocrinology, 2000, Volume: 141, Issue:9 Topics: Animals; Estrus; Exons; Female; Gonadal Steroid Hormones; Gonanes; Hormone Antagonists; Hypothalamus; Indicators and Reagents; Mice; Mice, Knockout; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Receptors, Progesterone	2000
Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. Journal of medicinal chemistry, 2000, Dec-28, Volume: 43, Issue:26 Topics: Abortifacient Agents; Adrenalectomy; Androgen Antagonists; Animals; Antineoplastic Agents; Binding, Competitive; Castration; Cell Line; Estrenes; Female; Glucocorticoids; Gonanes; Hormone Antagonists; Ligands; Male; Mammary Neoplasms, Experimental; Mifepristone; Progesterone; Protein Isoforms; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Transcriptional Activation	2000
The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5'-flanking region of the gene. Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:4 Topics: Aldosterone; Animals; Base Sequence; Binding Sites; Cells, Cultured; Cloning, Molecular; Dactinomycin; Dexamethasone; Dogs; Epithelial Sodium Channels; Gonanes; Humans; Kidney Tubules, Collecting; Mice; Mifepristone; Molecular Sequence Data; Promoter Regions, Genetic; Protein Subunits; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Regulatory Sequences, Nucleic Acid; Response Elements; Sodium Channels; Transcription, Genetic	2001
Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells. The Journal of endocrinology, 2001, Volume: 169, Issue:2 Topics: Adenosine Triphosphate; Cell Death; Dexamethasone; Estradiol; Estrogen Receptor Modulators; Estrone; Flow Cytometry; Flutamide; Fulvestrant; Glucocorticoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Gonanes; Humans; Hydrogen Peroxide; Microscopy, Fluorescence; Mifepristone; Pituitary Neoplasms; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured	2001
Differential regulation of retinoblastoma protein by hormonal and antihormonal agents in T47D breast cancer cells. The Journal of steroid biochemistry and molecular biology, 2001, Volume: 77, Issue:2-3 Topics: Breast Neoplasms; Estradiol; Estrogen Receptor Modulators; Estrogens; Fulvestrant; Gonanes; Humans; Mifepristone; Phosphorylation; Progesterone; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Retinoblastoma Protein; Tumor Cells, Cultured	2001
Demonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analogues. British journal of cancer, 2001, Dec-14, Volume: 85, Issue:12 Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Size; Enzyme Activation; Female; Focal Adhesions; Gonanes; Hormone Antagonists; Humans; MAP Kinase Signaling System; Mifepristone; Progesterone; Receptors, Progesterone; Recombinant Fusion Proteins; Stress Fibers; Transfection; Tumor Cells, Cultured	2001
Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jun-11, Volume: 99, Issue:12 Topics: Gonanes; HeLa Cells; Hormone Antagonists; Humans; Ligands; Mifepristone; Mutagenesis, Site-Directed; Receptors, Progesterone; Recombinant Proteins; Repressor Proteins; Trans-Activators; Transcription, Genetic; Transfection	2002
Effects of GnRH analogues, 'add-back' steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression. Molecular human reproduction, 2002, Volume: 8, Issue:12 Topics: Estradiol; Estrogen Receptor Modulators; Female; Gonadotropin-Releasing Hormone; Gonanes; Humans; Leiomyoma; Leuprolide; Medroxyprogesterone Acetate; Mifepristone; Muscle Development; Myocytes, Smooth Muscle; Myometrium; Oligopeptides; Progestins; Steroids; Transforming Growth Factors	2002
Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Molecular and cellular biology, 2003, Volume: 23, Issue:6 Topics: Active Transport, Cell Nucleus; Animals; Bacterial Proteins; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Chlorocebus aethiops; Corticosterone; Cortodoxone; COS Cells; Cysteine Endopeptidases; Cytoplasm; Dexamethasone; Fluorescent Dyes; Genes, Reporter; Gonanes; HeLa Cells; Humans; Hydrocortisone; Kidney; Leupeptins; Ligands; Luminescent Proteins; Microscopy, Confocal; Mifepristone; Multienzyme Complexes; Mutagenesis, Site-Directed; Photochemistry; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Sequence Deletion; Transfection; Triamcinolone Acetonide	2003
Non-genomic effects of progestins--inhibition of cell growth and increased intracellular levels of cyclic nucleotides. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:1 Topics: Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Gonanes; Hormone Antagonists; Humans; Mifepristone; Progestins; Radioimmunoassay; Receptors, Steroid; Time Factors	2003
Glucocorticoid agonistic and antagonistic effects of mifepristone and onapristone on thymocyte subset composition and CD26/dipeptidyl peptidase IV activity in infant male rats. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 87, Issue:1 Topics: Animals; Animals, Newborn; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; CD8-Positive T-Lymphocytes; Cell Count; Dipeptidyl Peptidase 4; Glucocorticoids; Gonanes; Hydrocortisone; Male; Mifepristone; Organ Size; Rats; Rats, Wistar; Thymus Gland	2003
Regulation of matrix metalloproteinase-19 messenger RNA expression in the rat ovary. Biology of reproduction, 2004, Volume: 71, Issue:6 Topics: Animals; Cells, Cultured; Cycloheximide; Cyclooxygenase Inhibitors; Female; Follicular Phase; Gene Expression Regulation; Gonanes; Granulosa Cells; Hormone Antagonists; Indomethacin; Luteal Phase; Luteinizing Hormone; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mifepristone; Ovary; Ovulation; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Theca Cells; Tissue Distribution	2004
Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitro. Molecular and cellular biology, 2005, Volume: 25, Issue:6 Topics: Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Assembly and Disassembly; DNA Helicases; Fluorescence Recovery After Photobleaching; Gonanes; Green Fluorescent Proteins; Humans; Ligands; Mammary Tumor Virus, Mouse; Mifepristone; Nuclear Proteins; Promegestone; Promoter Regions, Genetic; Receptors, Progesterone; Transcription Factors	2005
Molecular properties and preclinical pharmacology of JNJ-1250132, a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro. Steroids, 2006, Volume: 71, Issue:7 Topics: Animals; DNA; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gonanes; Hormone Antagonists; Humans; In Vitro Techniques; Male; Mifepristone; Progestins; Protein Binding; Rabbits; Rats; Receptors, Progesterone; Steroids; Tumor Cells, Cultured	2006
Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400. Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:2 Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclin A; Cyclin-Dependent Kinase 2; Gonanes; HeLa Cells; Hormone Antagonists; Humans; Mifepristone; Nuclear Receptor Coactivator 1; Phosphorylation; Promegestone; Protein Interaction Domains and Motifs; Rats; Receptors, Progesterone; Repressor Proteins; Serine; Transcriptional Activation	2010
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:12 Topics: Amino Acid Sequence; Cell Line; Cell Line, Tumor; Enhancer Elements, Genetic; Epithelial Cells; Female; Gonanes; Humans; Inflammatory Breast Neoplasms; Interleukin-1beta; Mifepristone; Molecular Sequence Data; NF-kappa B; Progesterone; Progestins; Promoter Regions, Genetic; Protein Isoforms; Receptors, Progesterone; RNA, Messenger; Signal Transduction; Transcriptional Activation; Translocation, Genetic	2010
The state-of-the-art of emergency contraception with the cutting edge drug. German medical science : GMS e-journal, 2011, Volume: 9 Topics: Contraception, Postcoital; Contraceptive Agents, Female; Estrenes; Female; Gonanes; Humans; Mifepristone; Norpregnadienes; Oximes; Pregnancy; Receptors, Progesterone	2011
p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization. Molecular endocrinology (Baltimore, Md.), 2011, Volume: 25, Issue:10 Topics: Breast Neoplasms; Cell Line, Tumor; Endometrial Neoplasms; Female; Gonanes; Humans; Ligands; MAP Kinase Kinase Kinase 1; Mifepristone; Mitogen-Activated Protein Kinase 1; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Stability; Receptors, Progesterone; Transcription, Genetic	2011
The antiprogestins mifepristone and onapristone reduce cell proliferation in the canine mammary carcinoma cell line CMT-U27. Histology and histopathology, 2014, Volume: 29, Issue:7 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dogs; Gonanes; Hormone Antagonists; Mammary Neoplasms, Animal; Mifepristone	2014
Potential role of hCG in apoptosis of human luteinized granulosa cells. The Journal of reproduction and development, 2015, Volume: 61, Issue:1 Topics: Adult; Apoptosis; Caspase 3; Cell Survival; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Female; Fertilization in Vitro; Gonanes; Granulosa Cells; Humans; Immunoenzyme Techniques; Luteinizing Hormone; Luteolysis; Mifepristone; Progesterone	2015
Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium. Theriogenology, 2015, Volume: 84, Issue:3 Topics: Animals; Cattle; Endometrium; Female; Gene Expression Regulation; Gonanes; Hormone Antagonists; Mifepristone; Progesterone; Prostaglandins; Receptors, Progesterone; RNA, Messenger	2015
Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Molecular endocrinology (Baltimore, Md.), 2016, Volume: 30, Issue:2 Topics: Chromones; Cyclin-Dependent Kinase 2; DNA-Activated Protein Kinase; Gonanes; HeLa Cells; Humans; Mediator Complex; Mifepristone; Models, Biological; Morpholines; Promegestone; Purines; Receptors, Progesterone; Recombinant Proteins; Transcription, Genetic	2016
Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reproductive sciences (Thousand Oaks, Calif.), 2016, Volume: 23, Issue:11 Topics: Animals; Cell Count; Cervical Ripening; Cervix Uteri; Female; Gonanes; Macrophages; Mice; Mifepristone; Neutrophils; Ovariectomy; Pregnancy; Premature Birth; Receptors, Progesterone	2016