Page last updated: 2024-08-23

mifepristone and lilopristone

mifepristone has been researched along with lilopristone in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19908 (26.67)18.7374
1990's18 (60.00)18.2507
2000's4 (13.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL1
Dansette, PM; Fontana, E; Poli, SM1
Healy, DL2
Bigsby, RM; Everett, LM1
Martin, L; Vinijsanun, A1
Emons, G; Hansemann, K; Knuppen, R; Ortmann, O1
Psychoyos, A1
Neef, G; Wiechert, R1
Chowdhury, SR; Elger, W; Kalra, V; Kamboj, VP; Maitra, SC; Singh, G; Singh, MM; Upadhyay, SN1
Baird, DT; Cameron, IT; Cameron, MJ; Healy, DL; Kelly, RW1
Kelly, RW; Smith, SK2
Beier, S; Chwalisz, K; Elger, W; Fähnrich, M; Qing, SS1
Chwalisz, K; Elger, W; Osawa, Y; Shimizu, Y; Yarborough, CP1
Altmann, M; Beck, CA; DeMarzo, A; Edwards, DP; Weigel, NL; Zhang, Y1
Croxatto, HB; Fuentealba, B; Salvatierra, AM1
Catt, KJ; Emons, G; Ortmann, O; Schulz, KD1
Forcelledo, ML; Poyser, NL1
Bigsby, RM1
Beck, S; Hackenberg, R; Hannig, K; Schmidt-Rhode, P; Scholz, A; Schulz, KD1
Forsyth, IA; Taylor, JA; Wang, MW1
Van Look, PF; von Hertzen, H1
Bygdeman, M; Danielsson, KG; Swahn, ML1
Benet, LZ; Jang, GR2
Calder, AA; Critchley, HO; Elliott, CL; Kelly, RW; Riley, SC1
Wang, JZ; Wu, ER; Xiao, BL; Zhao, JL1
Kelly, RW; King, AE; Morgan, K; Sallenave, JM1
Li, JJ; Li, MJ; Wang, W; Zhang, MJ; Zhao, XB1

Reviews

7 review(s) available for mifepristone and lilopristone

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review.
    Reproduction, fertility, and development, 1990, Volume: 2, Issue:5

    Topics: Abortifacient Agents, Steroidal; Animals; Estrenes; Female; Gonanes; Humans; Menstruation-Inducing Agents; Mifepristone; Pregnancy; Progesterone; Prostaglandins; Receptors, Progesterone

1990
Clinical status of antiprogesterone steroids.
    Clinical reproduction and fertility, 1985, Volume: 3, Issue:4

    Topics: Abortifacient Agents, Steroidal; Abortion, Induced; Animals; Biological Availability; Clinical Trials as Topic; Contraceptive Agents, Female; Corpus Luteum; Drug Evaluation; Endometrium; Estradiol; Estrenes; Ethics, Medical; Female; Humans; Hydrocortisone; Kinetics; Labor, Induced; Menopause; Menstruation; Menstruation-Inducing Agents; Mifepristone; Ovariectomy; Pituitary Hormones; Pregnancy; Progesterone; Prostaglandins; Receptors, Progesterone; Transcortin

1985
Synthesis of antiprogestational steroids.
    Journal of steroid biochemistry, 1987, Volume: 27, Issue:4-6

    Topics: Chemical Phenomena; Chemistry; Estrenes; Gonanes; Mifepristone; Progestins

1987
[Anti-progestins and contraception].
    Advances in contraception : the official journal of the Society for the Advancement of Contraception, 1994, Volume: 10 Suppl 1

    Topics: Contraceptives, Oral; Contraceptives, Postcoital, Hormonal; Embryo Implantation; Endometrium; Estrenes; Female; Glucocorticoids; Gonanes; Humans; Luteinizing Hormone; Mifepristone; Ovary; Ovulation; Progestins; Receptors, Progesterone

1994
Clinical uses of antiprogestogens.
    Human reproduction update, 1995, Volume: 1, Issue:1

    Topics: Abortion, Induced; Antineoplastic Agents; Breast Neoplasms; Contraception; Contraceptives, Oral, Synthetic; Endometrial Neoplasms; Endometriosis; Estrenes; Female; Gonanes; Humans; Labor, Induced; Mifepristone; Pregnancy; Pregnancy Trimester, Second; Progestins; Prostaglandins; Receptors, Progesterone

1995
Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use.
    Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:6

    Topics: Abortifacient Agents; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Contraceptives, Postcoital, Synthetic; Endometriosis; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Progestins

1997

Trials

1 trial(s) available for mifepristone and lilopristone

ArticleYear
Clinical status of antiprogesterone steroids.
    Clinical reproduction and fertility, 1985, Volume: 3, Issue:4

    Topics: Abortifacient Agents, Steroidal; Abortion, Induced; Animals; Biological Availability; Clinical Trials as Topic; Contraceptive Agents, Female; Corpus Luteum; Drug Evaluation; Endometrium; Estradiol; Estrenes; Ethics, Medical; Female; Humans; Hydrocortisone; Kinetics; Labor, Induced; Menopause; Menstruation; Menstruation-Inducing Agents; Mifepristone; Ovariectomy; Pituitary Hormones; Pregnancy; Progesterone; Prostaglandins; Receptors, Progesterone; Transcortin

1985

Other Studies

23 other study(ies) available for mifepristone and lilopristone

ArticleYear
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
    Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18

    Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride

2005
Effects of progestin antagonists, glucocorticoids and estrogen on progesterone-induced protein secreted by rabbit endometrial stromal cells in culture.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:1

    Topics: Animals; Cells, Cultured; Endometrium; Estrenes; Estrogens; Extracellular Matrix Proteins; Female; Glucocorticoids; Gonanes; Mifepristone; Progesterone; Progestins; Proteins; Rabbits

1991
Effects of progesterone antagonists RU486 and ZK98734 on embryo transport, development and implantation in laboratory mice.
    Reproduction, fertility, and development, 1990, Volume: 2, Issue:6

    Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Epithelium; Estradiol; Estrenes; Female; Fetal Viability; Luteolysis; Mice; Mifepristone; Organ Size; Pregnancy; Progesterone; Progestins; Thymus Gland; Uterus

1990
Modulatory actions of the new antiprogestins ZK 98.299 and ZK 98.734 and of RU 486 on luteinizing hormone secretion and progesterone effects in pituitary gonadotrophs.
    Journal of steroid biochemistry, 1990, Aug-14, Volume: 36, Issue:5

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Estrenes; Female; Gonanes; Kinetics; Luteinizing Hormone; Mifepristone; Pituitary Gland, Anterior; Progesterone; Progestins; Rats; Rats, Inbred Strains

1990
Antiprogestins and egg-implantation.
    Progress in clinical and biological research, 1989, Volume: 294

    Topics: Animals; Embryo Implantation; Estrenes; Female; Mifepristone; Ovariectomy; Pregnancy; Progestins; Rats; Reference Values

1989
Luteolytic action of two antiprogestational agents (RU-38486 and ZK-98734) in the rat.
    Journal of reproduction and fertility, 1988, Volume: 83, Issue:1

    Topics: Animals; Corpus Luteum; Estrenes; Female; Hysterectomy; Luteolysis; Microscopy, Electron; Mifepristone; Organ Size; Ovary; Progesterone; Progestins; Rats; Rats, Inbred Strains

1988
The stimulation of prostaglandin production by two antiprogesterone steroids in human endometrial cells.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 62, Issue:6

    Topics: Dinoprost; Dinoprostone; Endometrium; Estrenes; Fatty Acids; Female; Humans; In Vitro Techniques; Mifepristone; Progesterone; Prostaglandins; Prostaglandins E; Prostaglandins F

1986
The effect of the antiprogestins RU 486 and ZK 98734 on the synthesis and metabolism of prostaglandins F2 alpha and E2 in separated cells from early human decidua.
    The Journal of clinical endocrinology and metabolism, 1987, Volume: 65, Issue:3

    Topics: Cells, Cultured; Decidua; Dinoprost; Dinoprostone; Estrenes; Female; Humans; Mifepristone; Pregnancy; Progestins; Prostaglandins E; Prostaglandins F

1987
Endometrial and myometrial effects of progesterone antagonists in pregnant guinea pigs.
    American journal of obstetrics and gynecology, 1987, Volume: 157, Issue:4 Pt 2

    Topics: Abortion, Induced; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Embryo Implantation; Endometrium; Estrenes; Female; Gonanes; Guinea Pigs; Mifepristone; Myometrium; Pregnancy; Pregnancy, Animal; Progesterone; Prostaglandins E, Synthetic; Prostaglandins F; Uterine Contraction

1987
Progesterone and antiprogestins, a comparison of their effect on prostaglandin production by human secretory phase endometrium and decidua.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:2-3

    Topics: Adult; Decidua; Dinoprost; Endometrium; Estrenes; Female; Humans; Mifepristone; Progesterone; Progestins; Prostaglandins; Prostaglandins F

1987
Inhibition of aromatase activity in human placental microsomes by 13-retro-antiprogestins.
    Steroids, 1995, Volume: 60, Issue:2

    Topics: Aromatase Inhibitors; Estrenes; Estrone; Female; Gonanes; Humans; Microsomes; Mifepristone; Placenta; Pregnancy; Progestins

1995
Progesterone receptor and the mechanism of action of progesterone antagonists.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; DNA-Binding Proteins; Estrenes; Gonanes; Humans; In Vitro Techniques; Mifepristone; Progesterone; Promegestone; Protein Binding; Protein Conformation; Receptors, Progesterone; Signal Transduction; Transcription Factors; Transcription, Genetic

1995
Modulatory action of progesterone and progesterone antagonists on hypothalamic-pituitary function.
    Human reproduction (Oxford, England), 1994, Volume: 9 Suppl 1

    Topics: Animals; Cells, Cultured; Estrenes; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonanes; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Mifepristone; Ovariectomy; Pituitary Gland, Anterior; Progesterone; Rats; Rats, Sprague-Dawley; Rats, Wistar

1994
A comparison of the pregnancy-terminating potencies of three anti-progestins in guinea-pigs, and the effects of sulprostone.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 50, Issue:5

    Topics: Abortifacient Agents; Abortifacient Agents, Steroidal; Abortion, Induced; Animals; Dinoprostone; Drug Evaluation, Preclinical; Drug Synergism; Estrenes; Female; Guinea Pigs; Mifepristone; Norpregnadienes; Pregnancy; Pregnenediones; Progestins

1994
Progesterone and dexamethasone inhibition of estrogen-induced synthesis of DNA and complement in rat uterine epithelium: effects of antiprogesterone compounds.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 45, Issue:4

    Topics: Animals; Cell Division; Complement C3c; Dexamethasone; DNA; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Epithelium; Estradiol; Estrenes; Female; Mifepristone; Progesterone; Progestins; Rats; Receptors, Glucocorticoid; Uterus

1993
Androgen-like and anti-androgen-like effects of antiprogestins in human mammary cancer cells.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:4

    Topics: Androgen Antagonists; Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cell Division; Dihydrotestosterone; Estrenes; Flutamide; Gonanes; Humans; Mifepristone; Models, Biological; Progestins; Receptors, Androgen; Transfection; Tumor Cells, Cultured

1996
Activity of progesterone and anti-progestins in a rat mammary primary cell culture system.
    The Journal of steroid biochemistry and molecular biology, 1996, Volume: 58, Issue:1

    Topics: Animals; Cell Culture Techniques; Cells, Cultured; Collagen; Culture Media; DNA; Drug Evaluation, Preclinical; Epithelial Cells; Epithelium; Estrenes; Female; Gels; Hormone Antagonists; Mammary Glands, Animal; Mifepristone; Progesterone; Prolactin; Rats; Rats, Wistar; Sheep

1996
The possible use of antiprogestins for contraception.
    Acta obstetricia et gynecologica Scandinavica. Supplement, 1997, Volume: 164

    Topics: Contraceptives, Oral, Synthetic; Endometrium; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Mifepristone; Pregnancy; Progesterone

1997
Antiprogestin-mediated inactivation of cytochrome P450 3A4.
    Pharmacology, 1998, Volume: 56, Issue:3

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gonanes; Hormone Antagonists; Humans; Microsomes, Liver; Midazolam; Mifepristone; Mixed Function Oxygenases; NADP; Spectrophotometry; Tissue Donors

1998
Regulation of interleukin 8 production in the term human placenta during labor and by antigestagens.
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:1

    Topics: Culture Techniques; Estrenes; Female; Gonanes; Hormone Antagonists; Humans; Immunohistochemistry; Interleukin-8; Labor, Obstetric; Mifepristone; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Progestins

1998
Flow cytometry of porcine ovarian cells: antiprogestins play an important role in progesterone receptor upregulation.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13, Issue:5

    Topics: Amnion; Animals; Estradiol; Estrenes; Female; Flow Cytometry; Granulosa Cells; Hormone Antagonists; Humans; Mifepristone; Ovary; Progesterone; Radioimmunoassay; Receptors, Estrogen; Receptors, Progesterone; Swine; Theca Cells; Up-Regulation

1999
Differential regulation of secretory leukocyte protease inhibitor and elafin by progesterone.
    Biochemical and biophysical research communications, 2003, Oct-17, Volume: 310, Issue:2

    Topics: Base Sequence; Cell Line; Epithelial Cells; Estrenes; Gene Expression Regulation; Hormone Antagonists; Humans; Interleukin-1; Mifepristone; Progesterone; Promoter Regions, Genetic; Proteinase Inhibitory Proteins, Secretory; Proteins; Response Elements; RNA, Messenger; Secretory Leukocyte Peptidase Inhibitor; Tumor Necrosis Factor-alpha

2003
[Influence of mifepristone and lilopristone on proliferation and expression of nuclear factor-kappa B of ectopic stromal cells in vitro].
    Zhonghua fu chan ke za zhi, 2005, Volume: 40, Issue:1

    Topics: Adult; Cell Proliferation; Cells, Cultured; Endometriosis; Endometrium; Estrenes; Female; Hormone Antagonists; Humans; Mifepristone; RNA, Messenger; Stromal Cells; Transcription Factor RelA

2005