Page last updated: 2024-08-23

mifepristone and ketoconazole

mifepristone has been researched along with ketoconazole in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's4 (14.29)18.2507
2000's10 (35.71)29.6817
2010's13 (46.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Fischkoff, SA; Howe, RS; Lee, YH; Lyttle, CR; Teuscher, C1
Svec, F1
Crapo, L; Miller, JW1
Dluhy, RG; Solomon, CG1
Khalil, MW; Killinger, DW; Strutt, B; Vachon, D1
Haehner, T; Müller-Enoch, D; Refaie, MO1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T1
Kearns, GL; Leeder, JS; Pearce, RE1
Ligtenberg, JJ; Meertens, JH; Monteban-Kooistra, WE; Oosterhuis, JK; Tulleken, JE; van den Berg, G; Zijlstra, JG1
Dang, CN; Trainer, P1
Coleman, VH; Kling, MA; Schulkin, J1
Adomat, HH; Gleave, ME; Guns, ES; Hendy, SC; Locke, JA; Nelson, CC1
Alexandraki, KI; Grossman, AB1
Biller, BM; Tritos, NA1
Barahona Constanzo, MJ; del Pozo Picó, C1
Hamrahian, AH; Hoffman, AR; Yuen, KC1
Colleoni, S; Crotti, G; Franciosi, F; Galli, C; Lazzari, G; Lodde, V; Luciano, AM; Modina, SC; Tessaro, I1
Bendall, S; Garner, B; Hetrick, SE; Phillips, LJ1
Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS1
Athimulam, S; Bancos, I; Delivanis, DA1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1

Reviews

8 review(s) available for mifepristone and ketoconazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The medical treatment of Cushing's syndrome.
    Endocrine reviews, 1993, Volume: 14, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dogs; Horses; Humans; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Octreotide; Palliative Care; Pituitary Gland; Radiography; Valproic Acid

1993
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
    Depression and anxiety, 2009, Volume: 26, Issue:7

    Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depressive Disorder, Major; Double-Blind Method; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Ketoconazole; Metyrapone; Mifepristone; Severity of Illness Index

2009
Medical therapy of Cushing's disease: where are we now?
    Frontiers of hormone research, 2010, Volume: 38

    Topics: Dopamine Agonists; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Pituitary ACTH Hypersecretion; Somatostatin

2010
Advances in medical therapies for Cushing's syndrome.
    Discovery medicine, 2012, Volume: 13, Issue:69

    Topics: Animals; Bexarotene; Cushing Syndrome; Etomidate; Humans; Ketoconazole; Lapatinib; Metyrapone; Mifepristone; Mitotane; Quinazolines; Somatostatin; Tetrahydronaphthalenes

2012
New prospects for drug treatment in Cushing disease.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:10

    Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Ergolines; Etomidate; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Metyrapone; Mice; Mifepristone; Mitotane; Multicenter Studies as Topic; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; PPAR gamma; Pyridines; Rats; Somatostatin; Therapies, Investigational; Tretinoin

2012
AACE/ACE Disease State Clinical Review: Medical Management of Cushing Disease.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2014, Volume: 20, Issue:7

    Topics: Adrenocorticotropic Hormone; Cabergoline; Drug Therapy, Combination; Ergolines; Humans; Ketoconazole; Mifepristone; Pituitary ACTH Hypersecretion; Somatostatin

2014
Antiglucocorticoid and related treatments for psychosis.
    The Cochrane database of systematic reviews, 2016, Jan-04, Issue:1

    Topics: Dehydroepiandrosterone; Dexamethasone; Glucocorticoids; Humans; Hypothalamo-Hypophyseal System; Ketoconazole; Mifepristone; Pituitary-Adrenal System; Psychotic Disorders; Randomized Controlled Trials as Topic

2016

Other Studies

20 other study(ies) available for mifepristone and ketoconazole

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Glucocorticoid and progestin regulation of eosinophil chemotactic factor and complement C3 in the estrogen-treated rat uterus.
    Endocrinology, 1990, Volume: 126, Issue:6

    Topics: Animals; Biological Assay; Chemotaxis, Leukocyte; Complement C3; Dexamethasone; Eosinophils; Estradiol; Female; Humans; Ketoconazole; Lymphokines; Mifepristone; Progesterone; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Uterus

1990
Differences in the interaction of RU 486 and ketoconazole with the second binding site of the glucocorticoid receptor.
    Endocrinology, 1988, Volume: 123, Issue:4

    Topics: Animals; Binding, Competitive; Cell Line; Cytosol; Dexamethasone; Estrenes; Glucocorticoids; Ketoconazole; Kinetics; Liver; Male; Mifepristone; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Reference Values

1988
Paraneoplastic endocrine syndromes.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndrome; Diazoxide; Diphosphonates; Estrogens; Fluid Therapy; Hemangiopericytoma; Humans; Hypercalcemia; Hyperthyroidism; Hypoglycemia; Inappropriate ADH Syndrome; Ketoconazole; Mifepristone; Mineralocorticoids; Mitotane; Octreotide; Osteomalacia; Pamidronate; Paraneoplastic Endocrine Syndromes; Phosphorus; Plicamycin; Propylthiouracil; Saline Solution, Hypertonic; Somatostatin; Thyroid Neoplasms

1994
Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells.
    The Journal of steroid biochemistry and molecular biology, 1994, Volume: 48, Issue:5-6

    Topics: Adipose Tissue; Aminoglutethimide; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dehydroepiandrosterone; Dexamethasone; Humans; Ketoconazole; Metyrapone; Mifepristone; Stromal Cells

1994
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:1

    Topics: Antifungal Agents; Antimalarials; Catalysis; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Estrogen Antagonists; Ethinyl Estradiol; Flavanones; Hormone Antagonists; Humans; Immunosuppressive Agents; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mifepristone; NADPH-Ferrihemoprotein Reductase; Phospholipids; Quinidine; Quinine; Tacrolimus

2004
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin

2005
Biotransformation of fluticasone: in vitro characterization.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:6

    Topics: Androstadienes; Anti-Inflammatory Agents; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluticasone; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Lung; Microsomes, Liver; Mifepristone; Recombinant Proteins

2006
Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome.
    The Netherlands journal of medicine, 2007, Volume: 65, Issue:6

    Topics: Cushing Syndrome; Disease Progression; Fatal Outcome; Female; Humans; Ketoconazole; Middle Aged; Mifepristone; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Risk Factors; Spironolactone

2007
Pharmacological management of Cushing's syndrome: an update.
    Arquivos brasileiros de endocrinologia e metabologia, 2007, Volume: 51, Issue:8

    Topics: Cushing Syndrome; Dopamine Antagonists; Hormone Antagonists; Humans; Hypothalamo-Hypophyseal System; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Pituitary-Adrenal System; PPAR gamma; Somatostatin; Steroids

2007
Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 115, Issue:3-5

    Topics: Androgen Antagonists; Androgens; Anilides; Animals; Castration; Cell Line, Tumor; Cinnamates; Disease Progression; Drug Combinations; Enzyme Inhibitors; Finasteride; Gene Expression Regulation, Neoplastic; Humans; Ketoconazole; Male; Mice; Mice, Nude; Mifepristone; Molecular Structure; Neoplasm Transplantation; Nitriles; Progesterone; Prostatic Neoplasms; Steroids; Tosyl Compounds; Transplantation, Heterologous

2009
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte fertilization test.
    Reproductive toxicology (Elmsford, N.Y.), 2015, Volume: 51

    Topics: Acetoacetates; Animals; Benzo(a)pyrene; Busulfan; Cadmium Chloride; Cattle; Cycloheximide; Diethylstilbestrol; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Ketoconazole; Laboratories; Mifepristone; Oocytes; Reproducibility of Results

2015
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Aged; Antineoplastic Agents; Cabergoline; Comorbidity; Enzyme Inhibitors; Ergolines; Female; Follow-Up Studies; Hirsutism; Hormone Antagonists; Hormones; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Ketoconazole; Male; Metyrapone; Middle Aged; Mifepristone; Muscle Weakness; Muscular Atrophy; Neurosurgical Procedures; Obesity, Abdominal; Pituitary ACTH Hypersecretion; Pituitary Irradiation; Polycystic Ovary Syndrome; Retrospective Studies; Rosiglitazone; Somatostatin; Striae Distensae; Thiazolidinediones; Treatment Outcome; Tumor Burden; Young Adult

2017
Modern Management of Mild Autonomous Cortisol Secretion.
    Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocortical Adenoma; Adrenocorticotropic Hormone; Dehydroepiandrosterone Sulfate; Diabetes Mellitus, Type 2; Disease Management; Dyslipidemias; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Humans; Hydrocortisone; Hypertension; Incidental Findings; Ketoconazole; Metyrapone; Mifepristone; Mortality; Obesity; Osteoporosis; Postoperative Hemorrhage; Risk; Saliva; Severity of Illness Index

2019
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016