midazolam and ranitidine

midazolam has been researched along with ranitidine in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (20.00)	18.7374
1990's	3 (10.00)	18.2507
2000's	13 (43.33)	29.6817
2010's	8 (26.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abd Rabo Moustafa, MM; Abdelghany, TM; Eissa, IH; Elshafeey, A; Mayhoub, AS; Mohammad, H; Qassem, OA; Seleem, MN; Younis, W	1
Arvela, P; Klotz, U; Rosenkranz, B	1
Blyden, GT; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Scavone, JM; Shader, RI	1
Dundee, JW; Elliott, P; Robinson, FP; Thompson, EM; Wilson, CM	1
Collier, PS; Dundee, JW; Fee, JP; Howard, PJ	1
Collier, PS; Dundee, JW; Elwood, RJ; Hildebrand, PJ	1
Collier, PS; Dundee, JW; Elliott, P; Elwood, RJ	1
Collier, PS; Hughes, CM; Swanton, JG	1
Gildersleve, CD; Robinson, JO; Rosen, M; Sanders, LD; Whitehead, C	1
Agúndez, JA; Albet, C; Benítez, J; Carrillo, JA; Herrero, E; Márquez, M; Martínez, C; Ortiz, JA	1
Bueno Torres, A; García Enguita, MA; Girón Monbiela, JA; Ortega Lahuerta, P; Pardillos Calatayud, C; Rasal Miguel, S	1
Iwaki, M; Kawase, A; Tanino, T; Tsuji, A; Uno, S	1
Johansson, S; Leese, PT; Li, Y; Lisbon, E; Martin, P; Mathews, D; Oliver, S; Read, J; Steinberg, M	1

Reviews

1 review(s) available for midazolam and ranitidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

7 trial(s) available for midazolam and ranitidine

Article	Year
Effect of single doses of cimetidine and ranitidine on the steady-state plasma levels of midazolam. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:6 Topics: Adult; Benzodiazepines; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Humans; Infusions, Parenteral; Kinetics; Liver; Male; Midazolam; Middle Aged; Ranitidine; Reaction Time	1985
Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam. Anesthesia and analgesia, 1986, Volume: 65, Issue:2 Topics: Administration, Oral; Adult; Anesthetics; Benzodiazepines; Cimetidine; Drug Interactions; Female; Humans; Infusions, Parenteral; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Ranitidine	1986
Ranitidine influences the uptake of oral midazolam. British journal of clinical pharmacology, 1983, Volume: 15, Issue:6 Topics: Benzodiazepines; Biological Availability; Drug Interactions; Furans; Histamine H2 Antagonists; Humans; Male; Midazolam; Ranitidine; Time Factors	1983
The influence of H2 receptor antagonists on the plasma concentrations of midazolam and temazepam. European journal of anaesthesiology, 1984, Volume: 1, Issue:3 Topics: Administration, Oral; Adult; Antacids; Anti-Anxiety Agents; Benzodiazepines; Biological Availability; Cimetidine; Female; Histamine H2 Antagonists; Humans; Liver; Magnesium; Magnesium Silicates; Male; Microsomes, Liver; Midazolam; Middle Aged; Ranitidine; Silicic Acid; Temazepam	1984
Interaction of H2-receptor antagonists and benzodiazepine sedation. A double-blind placebo-controlled investigation of the effects of cimetidine and ranitidine on recovery after intravenous midazolam. Anaesthesia, 1993, Volume: 48, Issue:4 Topics: Adolescent; Adult; Cimetidine; Cognition; Double-Blind Method; Drug Interactions; Humans; Hypnotics and Sedatives; Male; Memory; Midazolam; Psychomotor Performance; Ranitidine; Time Factors	1993
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists. Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:4 Topics: Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Benzenesulfonates; Caffeine; Central Nervous System Stimulants; Cimetidine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Double-Blind Method; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Methylation; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Psychomotor Performance; Ranitidine; Thiazoles	1999
Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine. Clinical pharmacokinetics, 2014, Volume: 53, Issue:9 Topics: Adolescent; Adult; Area Under Curve; Digoxin; Drug Interactions; Female; Humans; Male; Metformin; Midazolam; Middle Aged; Omeprazole; Piperidines; Quinazolines; Ranitidine; Young Adult	2014

Other Studies

22 other study(ies) available for midazolam and ranitidine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Carbanilides; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance	2017
Effect of pretreatment with ranitidine on the hypnotic action of single doses of midazolam, temazepam and zopiclone. A clinical study. British journal of anaesthesia, 1986, Volume: 58, Issue:5 Topics: Adolescent; Adult; Azabicyclo Compounds; Benzodiazepines; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Midazolam; Middle Aged; Piperazines; Preanesthetic Medication; Ranitidine; Temazepam; Time Factors	1986
Cimetidine and ranitidine increase midazolam bioavailability. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:1 Topics: Absorption; Adult; Biological Availability; Cimetidine; Female; Humans; Kinetics; Male; Mathematics; Midazolam; Ranitidine	1987
The effect of three H2-receptor antagonists on the disposition of midazolam in the rat in-situ perfused liver model. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:12 Topics: Animals; Bile; Chromatography, Gas; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Famotidine; Histamine H2 Antagonists; Liver; Male; Midazolam; Perfusion; Ranitidine; Rats; Rats, Sprague-Dawley	1994
[Discovery of an intra-arterial hydatid cyst during a diagnostic thoracotomy]. Revista espanola de anestesiologia y reanimacion, 2000, Volume: 47, Issue:8 Topics: Adjuvants, Anesthesia; Adult; Anaphylaxis; Anti-Inflammatory Agents; Chlorpheniramine; Echinococcosis; Hemoptysis; Histamine Antagonists; Humans; Intraoperative Complications; Male; Methylprednisolone; Midazolam; Occupational Diseases; Preanesthetic Medication; Pulmonary Artery; Ranitidine; Thoracotomy	2000
Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:4 Topics: Animals; Antipyrine; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Diffusion Chambers, Culture; Female; Fluorescent Dyes; In Vitro Techniques; Intestinal Mucosa; Intestines; Microsomes; Midazolam; Ranitidine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger	2007