Compounds > midazolam

midazolam and quinazolines

midazolam has been researched along with quinazolines in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's4 (23.53)29.6817
2010's9 (52.94)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Holtzman, SG; Mumford, GK1
Andersin, R; Mesilaakso, M1
Ando, Y; Araki, K; Endo, H; Fujita, K; Kodama, K; Miya, T; Nagashima, F; Narabayashi, M; Sasaki, Y; Yamamoto, W1
Cantarini, MV; Fuhr, R; Holt, A; Swaisland, HC1
Baker, SD; He, P; Hidalgo, M; Li, J; Zhao, M1
Chupka, J; Feng, B; Fenner, KS; Frederick, KS; Kalgutkar, AS; Kempshall, S; Mireles, RJ; Troutman, MD1
Chan, EC; Chua, TB; Ho, HK; Nelson, SD; New, LS; Yap, CW1
Calvert, H; Fettner, S; Hamilton, M; Ling, J; Lum, BL; Pantze, M; Plummer, R; Rakhit, A; Ranson, M; Twelves, C1
Johansson, S; Leese, PT; Li, Y; Lisbon, E; Martin, P; Mathews, D; Oliver, S; Read, J; Steinberg, M1
Chaplain, MAJ; Hill, L; Kapelyukh, Y; Wolf, R1
Chen, RJ; Ge, NY; Hao, C; Zhang, DF; Zhang, Y; Zhang, YT; Zhu, GH1
Che, J; Li, H; Li, Z; Lu, C; Luo, H; Wang, J; Yang, H; Yue, S; Zhang, T; Zhang, Y; Zhu, M; Zhuang, X1
Arya, N; Beelen, AP; Coker, SA; Dees, EC; Gainer, SD; Koch, KM; Lewis, LD; Reddy, NJ1
Abe, K; Ando, O; Imaoka, T; Karibe, T1
Chen, D; Cho, CR; Hartmann, G; Menzel, K; Wang, YH1
Erb-Zohar, K; Kropeit, D; McCormick, D; Rübsamen-Schaeff, H; Stobernack, HP; Zimmermann, H1
Abdulrasool, LI; Endres, CJ; Lee, A; Mayor, JG; Rustia, EL; Sun, H; Topletz-Erickson, A; Walker, L1

Trials

4 trial(s) available for midazolam and quinazolines

ArticleYear
Exploring the relationship between expression of cytochrome P450 enzymes and gefitinib pharmacokinetics.
    Clinical pharmacokinetics, 2006, Volume: 45, Issue:6

    Topics: Adolescent; Adult; Aged; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gefitinib; Genotype; Humans; Male; Midazolam; Middle Aged; Phenotype; Quinazolines

2006
Effect of erlotinib on CYP3A activity, evaluated in vitro and by dual probes in patients with cancer.
    Anti-cancer drugs, 2014, Volume: 25, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Breath Tests; Cytochrome P-450 CYP3A; Drug Interactions; Erlotinib Hydrochloride; Erythromycin; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Midazolam; Middle Aged; Neoplasms; Quinazolines

2014
Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine.
    Clinical pharmacokinetics, 2014, Volume: 53, Issue:9

    Topics: Adolescent; Adult; Area Under Curve; Digoxin; Drug Interactions; Female; Humans; Male; Metformin; Midazolam; Middle Aged; Omeprazole; Piperidines; Quinazolines; Ranitidine; Young Adult

2014
Pharmacokinetics and Safety of Letermovir and Midazolam Coadministration in Healthy Subjects.
    Clinical pharmacology in drug development, 2022, Volume: 11, Issue:1

    Topics: Acetates; Area Under Curve; Drug Interactions; Female; Healthy Volunteers; Humans; Midazolam; Quinazolines

2022

Other Studies

13 other study(ies) available for midazolam and quinazolines

ArticleYear
Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat?
    Brain research, 1991, May-31, Volume: 550, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Carbolines; Chlordiazepoxide; Electric Stimulation; Hypothalamic Area, Lateral; Male; Midazolam; Phenylisopropyladenosine; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reinforcement, Psychology; Self Stimulation; Sensory Thresholds; Theophylline; Triazoles

1991
Structure elucidation of 6-chloro-2-methyl-4(1H)-quinazolinone, a photodecomposition product of midazolam.
    Journal of pharmaceutical and biomedical analysis, 1995, Volume: 13, Issue:4-5

    Topics: Chromatography, Thin Layer; Magnetic Resonance Spectroscopy; Mass Spectrometry; Midazolam; Photochemistry; Quinazolines; Quinazolinones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

1995
Gefitinib (Iressa) inhibits the CYP3A4-mediated formation of 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin but activates that of 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin from irinotecan.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:12

    Topics: Camptothecin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Gefitinib; Humans; Irinotecan; Microsomes, Liver; Midazolam; Quinazolines

2005
Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jun-15, Volume: 13, Issue:12

    Topics: Anesthetics, Intravenous; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Gefitinib; Humans; Microsomes, Liver; Midazolam; Protein Kinase Inhibitors; Quinazolines; Recombinant Proteins

2007
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:12

    Topics: Animals; Anti-Allergic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estradiol; Hypnotics and Sedatives; Intestinal Absorption; Isoquinolines; Male; Midazolam; Pharmaceutical Preparations; Prazosin; Quinazolines; Rats; Rats, Sprague-Dawley; Sympatholytics; Terfenadine

2009
Interaction of lapatinib with cytochrome P450 3A5.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7

    Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dealkylation; Humans; Hydroxylation; Lapatinib; Midazolam; NADP; Protein Kinase Inhibitors; Quinazolines; Testosterone

2012
The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.
    Mathematical medicine and biology : a journal of the IMA, 2017, 03-01, Volume: 34, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; GABA Modulators; Gefitinib; Liver; Mice; Mice, Transgenic; Midazolam; Models, Biological; NADPH-Ferrihemoprotein Reductase; Protein Kinase Inhibitors; Quinazolines; Thalidomide

2017
Effect of Evodiamine on CYP Enzymes in Rats by a Cocktail Method.
    Pharmacology, 2016, Volume: 97, Issue:5-6

    Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Liver; Male; Metoprolol; Midazolam; Omeprazole; Phenacetin; Quinazolines; Rats, Sprague-Dawley; Tolbutamide

2016
Allosteric activation of midazolam CYP3A5 hydroxylase activity by icotinib - Enhancement by ketoconazole.
    Biochemical pharmacology, 2016, Dec-01, Volume: 121

    Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Crown Ethers; Cytochrome P-450 CYP3A; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Haplorhini; Humans; In Vitro Techniques; Ketoconazole; Mice; Microsomes, Liver; Midazolam; Quinazolines; Rats; Species Specificity; Substrate Specificity

2016
The effects of lapatinib on CYP3A metabolism of midazolam in patients with advanced cancer.
    Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Cross-Over Studies; Cytochrome P-450 CYP3A; Female; Humans; Lapatinib; Male; Midazolam; Middle Aged; Neoplasms; Quinazolines

2017
Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Curcumin; Cytochrome P-450 CYP3A; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Lapatinib; Macaca fascicularis; Male; Midazolam; Neoplasm Proteins; Pantoprazole; Quinazolines; Rosuvastatin Calcium; Sulfasalazine; Terfenadine

2018
PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling.
    Clinical pharmacology and therapeutics, 2019, Volume: 105, Issue:2

    Topics: Acetates; Adult; Antiviral Agents; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytomegalovirus Infections; Drug Interactions; Drug Labeling; Female; Hematopoietic Stem Cell Transplantation; Humans; Hypnotics and Sedatives; Liver-Specific Organic Anion Transporter 1; Male; Midazolam; Models, Biological; Quinazolines; Young Adult

2019
Evaluation of Safety and Clinically Relevant Drug-Drug Interactions with Tucatinib in Healthy Volunteers.
    Clinical pharmacokinetics, 2022, Volume: 61, Issue:10

    Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Digoxin; Drug Interactions; Gemfibrozil; Healthy Volunteers; Humans; Itraconazole; Midazolam; Oxazoles; Pyridines; Quinazolines; Rifampin; Tolbutamide

2022