midazolam has been researched along with hypericum in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorski, JC; Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z | 1 |
| Dresser, GK; Kim, RB; Schwarz, UI; Wilkinson, GR | 1 |
| Adigun, AQ; Gorski, JC; Hall, SD; Hamman, MA; Hilligoss, JK; Huang, SM; Miller, M; Vasavada, N; Wang, Z | 1 |
| Antal, EJ; Arakawa, T; Gordi, T; Hong, C; Knuth, DW; Nickens, DJ; Polasek, EC; Sharma, A; Tan, LH; Teillol-Foo, M; Xie, R | 1 |
| Ang, CY; Cui, Y; Gardner, SF; Gentry, WB; Gurley, BJ; Hubbard, MA; Williams, DK | 1 |
| Horiuchi, R; Hosokawa, S; Nakamura, K; Okada, Y; Qi, JW; Yamamoto, K | 1 |
| Dostalek, M; Hadasova, E; Jurica, J; Linhart, I; Pistovcakova, J; Sulcová, A; Tomandl, J | 1 |
| Bauer, S; Drewelow, B; Frank, B; Klammt, S; Kundt, G; Majcher-Peszynska, J; Miekisch, W; Mueller, SC; Mundkowski, RG; Sievers, H; Uehleke, B | 1 |
| Eshima, N; Imai, H; Kotegawa, T; Morimoto, T; Nakano, S; Ohashi, K; Tsutsumi, K | 1 |
| Drewelow, B; Frank, B; Klammt, S; Kundt, G; Lehnfeld, R; Majcher-Peszynska, J; Mueller, SC; Mundkowski, RG; Sievers, H; Thurow, K; Uehleke, B | 1 |
| Anthony, MN; Dinchuk, JE; Dulac, HA; Grace, JE; Kim, S; Mosure, KW; Orcutt, T; Pizzano, J; Sauer, MB; Simmermacher, J; Sinz, M; Vuppugalla, R; Zoeckler, ME | 1 |
| Burhenne, J; Ding, R; Haefeli, WE; Hafner, V; Jäger, M; Matthée, AK; Mikus, G | 1 |
| Burhenne, J; Fuchs, I; Haefeli, WE; Hafner-Blumenstiel, V; Markert, C; Mikus, G; Weiss, J | 1 |
| Burhenne, J; Haefeli, WE; Hellwig, R; Hoffmann, MM; Kalafut, P; Kastner, IM; Markert, C; Mikus, G; Schweizer, Y; Weiss, J | 1 |
| Hammann, F; Haschke, M; Krähenbühl, S; Kummer, O | 1 |
| Awortwe, C; Bruckmueller, H; Cascorbi, I | 1 |
| Adiwidjaja, J; Boddy, AV; McLachlan, AJ | 1 |
1 review(s) available for midazolam and hypericum
| Article | Year |
|---|---|
Interaction of herbal products with prescribed medications: A systematic review and meta-analysis.
Topics: Animals; Biological Transport; Cytochrome P-450 Enzyme System; Echinacea; Herb-Drug Interactions; Humans; Hypericum; Hypnotics and Sedatives; Midazolam; Oximes; Plant Preparations; Tea | 2019 |
10 trial(s) available for midazolam and hypericum
| Article | Year |
|---|---|
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Injections, Intravenous; Isoenzymes; Male; Midazolam; Oxidoreductases, N-Demethylating; Plant Extracts; Tolbutamide | 2001 |
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Enzyme Induction; Female; Gene Expression Regulation; Genes, MDR; Humans; Hypericum; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Plant Preparations; Reference Values; Terfenadine | 2003 |
The interaction between St John's wort and an oral contraceptive.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Contraceptives, Oral, Combined; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Enzyme Induction; Female; Follicle Stimulating Hormone; Half-Life; Humans; Hypericum; Hypnotics and Sedatives; Injections, Intravenous; Menstrual Cycle; Mestranol; Metabolic Clearance Rate; Midazolam; Norethindrone; Oxidoreductases, N-Demethylating; Plant Preparations | 2003 |
CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations.
Topics: Adult; Asian People; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black or African American; Cytochrome P-450 CYP3A; Female; Genotype; Herb-Drug Interactions; Hispanic or Latino; Humans; Hypericum; Male; Midazolam; Middle Aged; Phenotype; Plant Preparations; Terfenadine; White People | 2005 |
Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.
Topics: Administration, Oral; Aged; Allyl Compounds; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dietary Supplements; Drug Administration Schedule; Female; Ginkgo biloba; Herb-Drug Interactions; Humans; Hypericum; Isoenzymes; Male; Midazolam; Panax; Phenotype; Plant Preparations; Sulfides | 2005 |
The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.
Topics: Adult; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Extracts; Tablets; Terpenes | 2006 |
No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.
Topics: Administration, Oral; Adult; Bridged Bicyclo Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Preparations; Powders; Substrate Specificity; Terpenes; Young Adult | 2009 |
Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity.
Topics: Administration, Oral; Adult; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; HIV Protease Inhibitors; Humans; Hypericum; Infusions, Intravenous; Male; Midazolam; Plant Extracts; Ritonavir; Substance Withdrawal Syndrome; Young Adult | 2010 |
Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity.
Topics: Adult; Area Under Curve; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Germany; Humans; Hydroxylation; Hypericum; Ketoconazole; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Plant Extracts; Plants, Medicinal; Pregnane X Receptor; Receptors, Steroid; Substrate Specificity; Transcription, Genetic; Young Adult | 2013 |
The effect of induction of CYP3A4 by St John's wort on ambrisentan plasma pharmacokinetics in volunteers of known CYP2C19 genotype.
Topics: Administration, Oral; Adult; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Administration Schedule; Enzyme Induction; Female; Genotype; Germany; Healthy Volunteers; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Pharmacogenetics; Phenotype; Phenylpropionates; Plant Extracts; Pyridazines | 2015 |
6 other study(ies) available for midazolam and hypericum
| Article | Year |
|---|---|
Time-dependent induction of midazolam-1-hydroxylation enzymes in rats treated with St. John's wort.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Enzyme Induction; Hydroxylation; Hypericum; Kinetics; Male; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Rats; Rats, Wistar | 2005 |
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver.
Topics: Animals; Antidepressive Agents; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Hypericum; Injections, Intraperitoneal; Liver; Male; Midazolam; Perfusion; Plant Extracts; Rats; Rats, Wistar; Tolbutamide | 2005 |
The recovery time-course of CYP3A after induction by St John's wort administration.
Topics: Adult; Cytochrome P-450 CYP3A; GABA Modulators; Humans; Hypericum; Male; Midazolam; Plant Extracts; Time Factors | 2008 |
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Topics: Adult; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds; Cell Line; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Gene Expression; Hepatocytes; Humans; Hypericum; Macaca fascicularis; Macaca mulatta; Male; Midazolam; Middle Aged; Models, Animal; Molecular Sequence Data; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Rifampin; Sequence Homology, Amino Acid; Terpenes; Transcriptional Activation; Transfection; Xenobiotics | 2010 |
Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II.
Topics: Adult; Area Under Curve; Bilirubin; Crigler-Najjar Syndrome; Cytochrome P-450 CYP3A; Enzyme Induction; Female; GABA Modulators; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Hypericum; Midazolam; Phenobarbital; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Young Adult | 2016 |
Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort.
Topics: Adult; Alprazolam; Antineoplastic Agents; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hypericum; Imatinib Mesylate; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Models, Biological; Phloroglucinol; Terpenes | 2019 |