Compounds > midazolam

midazolam and hyperforin

midazolam has been researched along with hyperforin in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauer, S; Drewelow, B; Frank, B; Klammt, S; Kundt, G; Majcher-Peszynska, J; Miekisch, W; Mueller, SC; Mundkowski, RG; Sievers, H; Uehleke, B1
Drewelow, B; Frank, B; Klammt, S; Kundt, G; Lehnfeld, R; Majcher-Peszynska, J; Mueller, SC; Mundkowski, RG; Sievers, H; Thurow, K; Uehleke, B1
Anthony, MN; Dinchuk, JE; Dulac, HA; Grace, JE; Kim, S; Mosure, KW; Orcutt, T; Pizzano, J; Sauer, MB; Simmermacher, J; Sinz, M; Vuppugalla, R; Zoeckler, ME1
Adiwidjaja, J; Boddy, AV; McLachlan, AJ1

Trials

2 trial(s) available for midazolam and hyperforin

ArticleYear
The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:1

    Topics: Adult; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Extracts; Tablets; Terpenes

2006
No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:1

    Topics: Administration, Oral; Adult; Bridged Bicyclo Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Preparations; Powders; Substrate Specificity; Terpenes; Young Adult

2009

Other Studies

2 other study(ies) available for midazolam and hyperforin

ArticleYear
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1

    Topics: Adult; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds; Cell Line; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Gene Expression; Hepatocytes; Humans; Hypericum; Macaca fascicularis; Macaca mulatta; Male; Midazolam; Middle Aged; Models, Animal; Molecular Sequence Data; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Rifampin; Sequence Homology, Amino Acid; Terpenes; Transcriptional Activation; Transfection; Xenobiotics

2010
Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort.
    Clinical pharmacokinetics, 2019, Volume: 58, Issue:7

    Topics: Adult; Alprazolam; Antineoplastic Agents; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hypericum; Imatinib Mesylate; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Models, Biological; Phloroglucinol; Terpenes

2019