midazolam has been researched along with haloperidol in 93 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.08) | 18.7374 |
1990's | 9 (9.68) | 18.2507 |
2000's | 24 (25.81) | 29.6817 |
2010's | 51 (54.84) | 24.3611 |
2020's | 8 (8.60) | 2.80 |
Authors | Studies |
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Topliss, JG; Yoshida, F | 1 |
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
Abraham, MH; Acree, WE; Ibrahim, A | 1 |
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahman, M; Holmén, AG; Wan, H | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
Dalvie, D; Loi, CM; Smith, DA | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Artursson, P; Mateus, A; Matsson, P | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Peng, Y; Welsh, WJ; Zhang, Q | 1 |
Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
Braun, U | 1 |
Kostowski, W; Pałejko, W; Plaznik, A; Stefański, R | 1 |
Borison, RL; Diamond, BI; O'Neal, E; Sloan, A; Wyant, M | 1 |
Barrett, JE; Mansbach, RS | 1 |
Fowler, SB; Hertzog, J; Wagner, BK | 1 |
Buhrich, N; Finlay-Jones, R; Nielssen, O | 1 |
Khan, LC; Lustik, SJ | 1 |
Remon, JP; Vermeire, A | 1 |
Rammsayer, TH | 1 |
Ryan, CJ | 1 |
Groh, D; Rammsayer, TH; Rodewald, S | 1 |
Hall, EJ; O'Doherty, CA; Schofield, L; Zeppetella, G | 1 |
Azuara, ML; Barcia, E; Negro, S; Reyes, R; Sánchez, Y | 1 |
Adams, CE; Coutinho, ES; Huf, G | 2 |
Dresden, GM; Levitt, MA; Nobay, F; Simon, BC | 1 |
Blitz-Lindeque, J; Bridge, D; Cameron, D | 1 |
Alexander, J; Allen, MH; Huf, G | 1 |
Almenar, CB; Arenas, VJ; Gómez, MA; Hernández, MJ; Sanjuán, MM; Torres, VJ | 1 |
Alexander, J; Allen, MH; Huf, G; Raveendran, NS | 1 |
Brakoulias, V; Mandali, R; Sammut, P; Seymour, J; Starcevic, V | 1 |
Baldaçara, L; Cordeiro, DC; Jackoswski, AP; Sanches, M | 1 |
Bak, M; Marcelis, M; van Os, J | 1 |
Goh, C; Poulose, VJ; Radha Krishna, LK | 1 |
Almeida, A; Edra, N; Gonçalves, F; Pereira, S; Teixeira, S | 1 |
Castelli, A; Colombo, R; Corona, A; Giannotti, C; Minari, C; Praga, F; Raimondi, F | 1 |
Kaminska, E; Leppert, W; Mikolajczak, P; Okulicz-Kozaryn, I | 1 |
Bükki, J; Dickman, A; Fürst, CJ; Hagelin, CL; Lindqvist, O; Lunder, U; Lundquist, G; Rasmussen, BH; Sauter, S; Tishelman, C | 1 |
Calver, L; Drinkwater, V; Isbister, GK | 1 |
Dickman, A; Ellershaw, JE; Gambles, M; Latten, R; Lowe, D; McGlinchey, T | 1 |
Kaminska, E; Leppert, W; Mikolajczak, P; Okulicz-Kozaryn, I; Szulc, M | 1 |
Azoulay, D; Ein-Mor, E; Eliyahu, E; Jacobs, JM; Shahal-Gassner, R; Weigert, N; Yehezkel, M | 1 |
Almeida, A; Gonçalves, F; Pereira, S | 1 |
Isenberg, DL; Jacobs, D | 1 |
Burns, K; Burry, L; Cook, D; Devlin, JW; Dodek, P; Ferguson, N; Fergusson, D; Fowler, RA; Granton, J; Jacka, M; Keenan, S; Luk, E; Mallick, R; Mehta, S; Olafson, K; Reynolds, S; Rose, L; Skrobik, Y; Steinberg, M; Tanios, M | 1 |
Miller, MW; Wolfe, LL | 1 |
Kamijo, Y | 1 |
Baar, FP; de Winter, BC; Franken, LG; Koch, BC; Mathôt, RA; Tibboel, D; van Esch, HJ; van Gelder, T; van Zuylen, L | 1 |
Choi, JY; Gwak, MS; Joh, JW; Kim, GS; Kim, JM; Kim, SJ; Ko, JS; Kwon, CH; Lee, S; Lee, SK; Park, JB | 1 |
Cameron, R | 1 |
Almeida, A; Carneiro, R; Costa, I; Ferraz Gonçalves, JA; Silva, P | 1 |
Alexander, J; Allen, MH; Gandhi, P; Huf, G | 1 |
Khokhar, MA; Rathbone, J | 1 |
Benowitz, NL; Horng, H; Smollin, CG; Vo, KT | 1 |
Afzalimoghaddam, M; Edalatifard, M; Isavi, N; Karimialavijeh, E; Momeni, M; Nejati, A | 1 |
Bailey, AM; Baum, RA; Horn, K; Justice, SN; Lewis, T; Morizio, K; Schultz, A; Weant, K | 1 |
Hu, B; Li, JG; Peng, ZY; Rao, X; Wang, J; Zhou, WH | 1 |
Cole, JB; Collins, JD; Driver, BE; Fagerstrom, E; Hessel, M; Horton, GB; Klein, LR; Martel, ML; Miner, JR; Satpathy, R | 1 |
Dickert, NW; Sugarman, J | 2 |
Cancelli, F; Garetto, F; Maltoni, M; Rossi, R | 1 |
Grześkowiak, T; Jeszka-Skowron, M; Rusińska-Roszak, D; Zaporowska-Stachowiak, I; Zgoła-Grześkowiak, A | 1 |
Andolfatto, G; Barbic, D; Barbic, SP; Grunau, B; Honer, WG; MacEwan, W; Scheuermeyer, FX; Wong, H | 1 |
Abdolrazaghnejad, A; Akhlaghi, AA; Akhlaghi, N; Payandemehr, P; Yaseri, M | 1 |
Bak, E; Bak, M; Bervoets, C; Bienkowski, P; De Fruyt, J; Dom, G; Drukker, M; Fiorillo, A; Frydecka, D; Misiak, B; Preuss, WU; Samochowiec, A; Samochowiec, J; Sampogna, G; Weltens, I | 1 |
Cole, JB; Driver, BE; Horton, G; Klein, LR; Martel, ML; Scharber, S | 1 |
Casini, C; de Nooijer, K; Ingravallo, F; Miccinesi, G; Morino, P; Pucci, V; Rietjens, JAC | 1 |
Nordstrom, K; Wilson, M; Zeller, S | 1 |
Cole, JB; Driver, BE; Klein, LR; Martel, ML; Miner, JR | 2 |
Lee, P; Murray, H | 1 |
April, MD; De Lorenzo, RA; Schauer, SG; Wheeler, AR | 1 |
Andolfatto, G; Barbic, D; Barbic, SP; Grunau, B; Honer, WG; Macewan, B; Qian, H; Scheuermeyer, FX; Wong, H | 1 |
Conrardy, MJ; Cruz, DS; Fant, AL; Kim, HS; Lank, PM; Malik, S; Tyler, DJ | 1 |
Austin, E; Kent, J; Nolan, B | 1 |
Chan, EW; Haendler, M; Knapp, MRJ; Lao, KSJ; Lau, H; Li, X; Tsui, SH; Yan, VKC; Yap, CYL | 1 |
Huecker, M; Javed, J; Roy, D; Senn, J; Shaw, I; Shreffler, J; Thiemann, P; Thomas, A | 1 |
Allen, PJ; Johanson, KE; Lock, AE; Neff, LA; Reveles, KR | 1 |
13 review(s) available for midazolam and haloperidol
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Pharmacological interventions for agitation in head-injured patients in the acute care setting.
Topics: Adult; Brain Injuries; Critical Care; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Humans; Lorazepam; Male; Midazolam; Multiple Trauma; Neurologic Examination; Nursing Assessment; Propofol; Psychomotor Agitation | 1995 |
Haloperidol plus promethazine for psychosis induced aggression.
Topics: Aggression; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Promethazine; Psychomotor Agitation; Psychotic Disorders; Randomized Controlled Trials as Topic | 2005 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Olanzapine; Promethazine; Psychomotor Agitation; Psychotic Disorders; Randomized Controlled Trials as Topic | 2009 |
[Haloperidol plus promethazine for agitated patients--a systematic review].
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Olanzapine; Promethazine; Psychomotor Agitation; Randomized Controlled Trials as Topic | 2009 |
[Rapid tranquillisation; review of the literature and recommendations].
Topics: Aggression; Benzodiazepines; Conscious Sedation; Drug Therapy, Combination; Haloperidol; Humans; Hypnotics and Sedatives; Lorazepam; Midazolam; Olanzapine; Practice Guidelines as Topic; Promethazine; Psychotic Disorders; Time Factors; Treatment Outcome | 2011 |
[Dangerous drugs: products containing synthetic chemicals].
Topics: Alkaloids; Antipsychotic Agents; Cannabinoids; Central Nervous System Diseases; Consciousness Disorders; Delusions; Diazepam; Fluid Therapy; Hallucinations; Haloperidol; Humans; Illicit Drugs; Midazolam; Prognosis; Renal Dialysis; Respiration, Artificial; Rhabdomyolysis; Risperidone | 2016 |
Pharmacokinetic considerations and recommendations in palliative care, with focus on morphine, midazolam and haloperidol.
Topics: Analgesics, Opioid; Animals; Antipsychotic Agents; Haloperidol; Humans; Hypnotics and Sedatives; Midazolam; Morphine; Palliative Care; Quality of Life; Terminal Care | 2016 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Promethazine; Psychomotor Agitation; Psychotic Disorders; Randomized Controlled Trials as Topic; Restraint, Physical | 2016 |
Droperidol for psychosis-induced aggression or agitation.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Benzodiazepines; Droperidol; Haloperidol; Humans; Midazolam; Olanzapine; Psychomotor Agitation; Psychotic Disorders; Randomized Controlled Trials as Topic | 2016 |
Review of Intranasally Administered Medications for Use in the Emergency Department.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Anticonvulsants; Antidotes; Antipsychotic Agents; Dexmedetomidine; Emergency Service, Hospital; Fentanyl; Flumazenil; Haloperidol; Humans; Hydromorphone; Hypnotics and Sedatives; Ketamine; Lorazepam; Midazolam; Naloxone; Narcotic Antagonists; Narcotics | 2017 |
Palliative Sedation for the Terminally Ill Patient.
Topics: Decision Making; Deep Sedation; Delirium; Haloperidol; Humans; Hypnotics and Sedatives; Midazolam; Terminally Ill | 2018 |
The pharmacological management of agitated and aggressive behaviour: A systematic review and meta-analysis.
Topics: Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Hypnotics and Sedatives; Lorazepam; Midazolam; Olanzapine; Promethazine; Psychomotor Agitation; Psychotic Disorders; Treatment Outcome | 2019 |
16 trial(s) available for midazolam and haloperidol
Article | Year |
---|---|
The use of midazolam in acutely agitated psychiatric patients.
Topics: Adult; Amobarbital; Haloperidol; Humans; Male; Midazolam; Middle Aged; Schizophrenia | 1990 |
Intravenous sedation of involuntary psychiatric patients in New South Wales.
Topics: Adult; Benztropine; Commitment of Mentally Ill; Diazepam; Drug Utilization; Emergency Services, Psychiatric; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Mental Disorders; Midazolam; Retrospective Studies; Violence | 1997 |
Neuropharmacological evidence for different timing mechanisms in humans.
Topics: Adult; Arousal; Attention; Awareness; Basal Ganglia; Double-Blind Method; Haloperidol; Humans; Male; Mental Recall; Midazolam; Neurotransmitter Agents; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA-A; Scopolamine; Time Perception | 1999 |
Dopamine-antagonistic, anticholinergic, and GABAergic effects on declarative and procedural memory functions.
Topics: Acetylcholine; Acoustic Stimulation; Adult; Arousal; Brain Chemistry; Cerebral Cortex; Dopamine; Dopamine Antagonists; Double-Blind Method; Face; GABA Modulators; gamma-Aminobutyric Acid; Haloperidol; Humans; Male; Mental Recall; Midazolam; Motor Skills; Muscarinic Antagonists; Pattern Recognition, Visual; Photic Stimulation; Psychomotor Performance; Reaction Time; Scopolamine; Verbal Learning | 2000 |
Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine.
Topics: Adult; Aggression; Drug Therapy, Combination; Emergency Service, Hospital; Emergency Services, Psychiatric; Emergency Treatment; Female; Haloperidol; Hospitals, Psychiatric; Humans; Injections, Intramuscular; Male; Mental Disorders; Midazolam; Promethazine; Psychomotor Agitation; Restraint, Physical; Sleep; Tranquilizing Agents; Treatment Outcome | 2003 |
A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients.
Topics: Adult; Arousal; Blood Pressure; Double-Blind Method; Haloperidol; Heart Rate; Humans; Lorazepam; Midazolam; Prospective Studies; Psychomotor Agitation; Respiratory Mechanics; Tranquilizing Agents; Treatment Outcome; Violence | 2004 |
Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Emergency Services, Psychiatric; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Male; Midazolam; Olanzapine; Piperazines; Promethazine; Psychomotor Agitation; Psychotic Disorders; Thiazoles; Tranquilizing Agents | 2011 |
A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study.
Topics: Acoustic Stimulation; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Critical Care; Critical Illness; Delirium; Female; Haloperidol; Humans; Hypnotics and Sedatives; Internal Medicine; Male; Medical Audit; Midazolam; Middle Aged; Narcotics; Olanzapine; Orientation; Photic Stimulation; Postoperative Complications; Propofol; Proportional Hazards Models; Risk Factors; Surveys and Questionnaires; Wounds and Injuries | 2012 |
Prehospital Agitation and Sedation Trial (PhAST): A Randomized Control Trial of Intramuscular Haloperidol versus Intramuscular Midazolam for the Sedation of the Agitated or Violent Patient in the Prehospital Environment.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Conscious Sedation; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Male; Midazolam; Middle Aged; Prospective Studies; Psychomotor Agitation; Treatment Outcome; Violence | 2015 |
Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults.
Topics: Adult; Aged; Alcohol Drinking; Analgesics, Opioid; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Device Removal; Female; Fentanyl; Haloperidol; Humans; Hydromorphone; Intensive Care Units; Lorazepam; Male; Midazolam; Middle Aged; Morphine; Multivariate Analysis; Prevalence; Proportional Hazards Models; Respiration, Artificial; Restraint, Physical; Risk Factors; Ventilators, Mechanical | 2016 |
Comparison of Haloperidol Alone and in Combination with Midazolam for the Treatment of Acute Agitation in an Inpatient Palliative Care Service.
Topics: Aged; Antipsychotic Agents; Drug Therapy, Combination; Female; Haloperidol; Humans; Hypnotics and Sedatives; Inpatients; Male; Midazolam; Middle Aged; Palliative Care; Psychomotor Agitation; Time Factors; Treatment Outcome | 2016 |
Midazolam Plus Haloperidol as Adjuvant Analgesics to Morphine in Opium Dependent Patients: A Randomized Clinical Trial.
Topics: Adult; Analgesics; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Emergency Service, Hospital; Female; Haloperidol; Humans; Injections, Intramuscular; Male; Midazolam; Middle Aged; Morphine; Opioid-Related Disorders; Pain; Pain Measurement; Pilot Projects; Severity of Illness Index; Treatment Outcome | 2016 |
Rapid agitation control with ketamine in the emergency department (RACKED): a randomized controlled trial protocol.
Topics: Adult; Anesthetics, Dissociative; British Columbia; Emergency Service, Hospital; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Ketamine; Male; Midazolam; Middle Aged; Prospective Studies; Psychomotor Agitation; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Violence; Young Adult | 2018 |
Premedication With Midazolam or Haloperidol to Prevent Recovery Agitation in Adults Undergoing Procedural Sedation With Ketamine: A Randomized Double-Blind Clinical Trial.
Topics: Administration, Intravenous; Adult; Anxiety; Conscious Sedation; Double-Blind Method; Emergency Service, Hospital; Female; Haloperidol; Humans; Ketamine; Male; Midazolam; Middle Aged; Premedication; Treatment Outcome; Young Adult | 2019 |
Rapid Agitation Control With Ketamine in the Emergency Department: A Blinded, Randomized Controlled Trial.
Topics: Adult; Anesthetics, Dissociative; Canada; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Ketamine; Male; Midazolam; Middle Aged; Psychomotor Agitation | 2021 |
Cost-Effectiveness of Midazolam Versus Haloperidol Versus Olanzapine for the Management of Acute Agitation in the Accident and Emergency Department.
Topics: Antipsychotic Agents; Benzodiazepines; Cost-Benefit Analysis; Emergency Service, Hospital; Haloperidol; Humans; Injections, Intramuscular; Midazolam; Olanzapine; Psychomotor Agitation | 2022 |
64 other study(ies) available for midazolam and haloperidol
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles | 2021 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
[Treatment of perioperative alcoholic delirium].
Topics: Alcohol Withdrawal Delirium; Biperiden; Chlormethiazole; Critical Care; Droperidol; Drug Therapy, Combination; Haloperidol; Humans; Infusions, Parenteral; Midazolam; Surgical Procedures, Operative | 1991 |
Myorelaxant effect of baclofen injected to the nucleus accumbens septi.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Haloperidol; Injections, Intraperitoneal; Male; Microinjections; Midazolam; Muscimol; Muscle Relaxation; Nicardipine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Task Performance and Analysis | 1990 |
Discriminative stimulus properties of buspirone in the pigeon.
Topics: Animals; Apomorphine; Buspirone; Clozapine; Columbidae; Discrimination Learning; Haloperidol; Methysergide; Midazolam; Pyrimidines; Serotonin | 1987 |
Treatment of a paradoxical reaction to midazolam with haloperidol.
Topics: Akathisia, Drug-Induced; Anti-Anxiety Agents; Antipsychotic Agents; Haloperidol; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Preanesthetic Medication | 1997 |
Compatibility and stability of ternary admixtures of morphine with haloperidol or midazolam and dexamethasone or methylprednisolone.
Topics: Chromatography, High Pressure Liquid; Dexamethasone; Drug Incompatibility; Drug Stability; Haloperidol; Hydrogen-Ion Concentration; Methylprednisolone; Midazolam; Morphine; Osmolar Concentration; Solubility; Temperature | 1999 |
Haloperidol, midazolam and intravenous sedation.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Conscious Sedation; Dose-Response Relationship, Drug; Emergency Services, Psychiatric; Haloperidol; Humans; Infusions, Intravenous; Midazolam; Psychotic Disorders; Risk Factors; Torsades de Pointes | 1999 |
Drugs and syringe drivers: a survey of adult specialist palliative care practice in the United Kingdom and Eire.
Topics: Adult; Analgesics; Cyclizine; Drug Delivery Systems; Drug Therapy, Combination; Haloperidol; Heroin; Humans; Injections, Subcutaneous; Ireland; Methotrimeprazine; Midazolam; Palliative Care; Syringes; United Kingdom | 2001 |
Physical compatibility and in vivo evaluation of drug mixtures for subcutaneous infusion to cancer patients in palliative care.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Butylscopolammonium Bromide; Dexamethasone; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Haloperidol; Humans; Infusion Pumps; Male; Metoclopramide; Midazolam; Middle Aged; Morphine; Neoplasms; Palliative Care; Spain; Tramadol; Treatment Outcome | 2002 |
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].
Topics: Brazil; Clinical Protocols; Drug Combinations; Emergency Services, Psychiatric; Ethics, Research; Haloperidol; Humans; Mental Disorders; Midazolam; Patient Selection; Placebos; Promethazine; Psychomotor Agitation; Randomized Controlled Trials as Topic; Research Design | 2002 |
Use of sedation to relieve refractory symptoms in dying patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Aged, 80 and over; Communication; Conscious Sedation; Dopamine Antagonists; Dyspnea; Ethics, Medical; Female; Haloperidol; Humans; Hypnotics and Sedatives; Intestinal Obstruction; Male; Midazolam; Middle Aged; Neoplasms; Pain, Intractable; Palliative Care; Prospective Studies; South Africa; Survival Analysis; Terminally Ill; Treatment Outcome | 2004 |
Stability studies of binary mixtures of haloperidol and/or midazolam with other drugs for parenteral administration.
Topics: Drug Combinations; Drug Incompatibility; Drug Stability; Drug Storage; Haloperidol; Humans; Infusions, Parenteral; Midazolam; Spain | 2007 |
Characteristics of admissions to a recently opened Psychiatric Emergency Care Centre.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Antipsychotic Agents; Australia; Drug Prescriptions; Emergency Service, Hospital; Emergency Services, Psychiatric; Female; Haloperidol; Humans; Hypnotics and Sedatives; Male; Mental Disorders; Midazolam; Middle Aged; Patient Admission; Poisoning; Prevalence; Restraint, Physical; Suicidal Ideation; Young Adult | 2010 |
The use of midazolam and haloperidol in cancer patients at the end of life.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Haloperidol; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Neoplasms; Palliative Care; Retrospective Studies; Terminal Care; Terminally Ill; Time Factors; Treatment Outcome | 2012 |
A protocol for the acute control of agitation in palliative care: a preliminary report.
Topics: Antipsychotic Agents; Clinical Protocols; Drug Therapy, Combination; Haloperidol; Humans; Hypnotics and Sedatives; Midazolam; Palliative Care; Psychomotor Agitation | 2012 |
Analgesic effects of tramadol in combination with adjuvant drugs: an experimental study in rats.
Topics: Adjuvants, Pharmaceutic; Analgesia; Analgesics; Animals; Anti-Anxiety Agents; Antiemetics; Antipsychotic Agents; Drug Therapy, Combination; Haloperidol; Male; Midazolam; Pain; Rats; Rats, Wistar; Tramadol | 2013 |
Four essential drugs needed for quality care of the dying: a Delphi-study based international expert consensus opinion.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Antipsychotic Agents; Delphi Technique; Drugs, Essential; European Union; Female; Glycopyrrolate; Haloperidol; Humans; Male; Midazolam; Middle Aged; Morphine; Muscarinic Antagonists; Palliative Care; Psychomotor Agitation; Scopolamine | 2013 |
A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit.
Topics: Adult; Droperidol; Drug Therapy, Combination; Female; Haloperidol; Humans; Hypnotics and Sedatives; Immobilization; Male; Mental Disorders; Midazolam; Middle Aged; Prospective Studies; Psychiatric Department, Hospital; Time Factors; Treatment Outcome | 2013 |
How is agitation and restlessness managed in the last 24 h of life in patients whose care is supported by the Liverpool care pathway for the dying patient?
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Critical Pathways; Female; Haloperidol; Hospitals; Humans; Hypnotics and Sedatives; Infusions, Subcutaneous; Male; Methotrimeprazine; Midazolam; Patient-Centered Care; Psychomotor Agitation; Retrospective Studies; Terminal Care; Terminally Ill | 2011 |
Analgesic effects of morphine in combination with adjuvant drugs in rats.
Topics: Adjuvants, Pharmaceutic; Analgesics, Opioid; Animals; Butylscopolammonium Bromide; Drug Interactions; Drug Therapy, Combination; Haloperidol; Male; Methotrimeprazine; Metoclopramide; Midazolam; Morphine; Pain; Rats, Wistar | 2014 |
Palliative Sedation at the End of Life: Patterns of Use in an Israeli Hospice.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; Female; Haloperidol; Hospices; Humans; Hypnotics and Sedatives; Israel; Male; Midazolam; Middle Aged; Morphine; Pain; Palliative Care; Retrospective Studies; Terminal Care | 2016 |
A Protocol for the Control of Agitation in Palliative Care.
Topics: Aged; Aged, 80 and over; Clinical Protocols; Drug Administration Routes; Drug Administration Schedule; Drug Therapy, Combination; Female; Haloperidol; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Pain Management; Palliative Care; Psychomotor Agitation | 2016 |
USING TAILORED TRANQUILIZER COMBINATIONS TO REDUCE STRESS ASSOCIATED WITH LARGE UNGULATE CAPTURE AND TRANSLOCATION.
Topics: Animals; Azaperone; Colorado; Deer; Delayed-Action Preparations; Drug Combinations; Female; Haloperidol; Male; Midazolam; Sheep; Sheep Diseases; Sheep, Bighorn; Stress, Physiological; Stress, Psychological; Tranquilizing Agents; Transportation | 2016 |
Use of Dexmedetomidine in Liver Transplant Recipients With Postoperative Agitated Delirium.
Topics: Adult; Aged; Antipsychotic Agents; Delirium; Dexmedetomidine; Female; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of Stay; Liver Transplantation; Male; Midazolam; Middle Aged; Postoperative Complications; Postoperative Period; Retrospective Studies | 2016 |
Look again at psychedelic drugs.
Topics: Anxiety; Delirium; Depression; Diazepam; Hallucinogens; Haloperidol; Humans; Lorazepam; Midazolam; Pharmaceutical Research; Psychomotor Agitation; United Kingdom | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Ketamine; Lorazepam; Male; Midazolam; Propofol; Quetiapine Fumarate; Respiration, Artificial; Substance Withdrawal Syndrome; Substance-Related Disorders | 2017 |
A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China.
Topics: Delirium; Dexmedetomidine; Fentanyl; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Pain; Pain Management; Pain Measurement; Surveys and Questionnaires | 2017 |
Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Emergency Medical Services; Female; Haloperidol; Humans; Injections, Intramuscular; Male; Mental Status and Dementia Tests; Midazolam; Middle Aged; Olanzapine; Piperazines; Prospective Studies; Psychomotor Agitation; Thiazoles; Treatment Outcome; Young Adult | 2018 |
Ethics and Regulatory Barriers to Research in Emergency Settings.
Topics: Emergency Service, Hospital; Haloperidol; Midazolam; Olanzapine; Piperazines; Thiazoles | 2018 |
Fragmentation studies of selected drugs utilized in palliative care.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anticonvulsants; Antiemetics; Antipsychotic Agents; Clonazepam; Fentanyl; Haloperidol; Humans; Methotrimeprazine; Metoclopramide; Midazolam; Palliative Care; Pharmaceutical Preparations; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tramadol | 2018 |
Rescue Sedation When Treating Acute Agitation in the Emergency Department With Intramuscular Antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Droperidol; Emergency Service, Hospital; Female; Haloperidol; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Male; Midazolam; Middle Aged; Minnesota; Olanzapine; Psychomotor Agitation; Retrospective Studies | 2019 |
Discussions about palliative sedation in hospice: Frequency, timing and factors associated with patient involvement.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; Decision Making, Shared; Delirium; Dyspnea; Family; Female; Haloperidol; Hospices; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Morphine; Pain; Palliative Care; Patient Participation; Psychomotor Agitation; Terminal Care | 2019 |
Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation.
Topics: Emergency Service, Hospital; Haloperidol; Midazolam; Olanzapine; Piperazines; Thiazoles | 2019 |
In reply.
Topics: Emergency Service, Hospital; Haloperidol; Midazolam; Olanzapine; Piperazines; Thiazoles | 2019 |
Midazolam or haloperidol premedication reduced ketamine-induced recovery agitation and increased ED recovery time.
Topics: Adult; Double-Blind Method; Haloperidol; Humans; Ketamine; Midazolam; Premedication | 2019 |
Acute Agitation and the Exception From Informed Consent Requirements.
Topics: Emergency Service, Hospital; Haloperidol; Informed Consent; Midazolam; Olanzapine; Piperazines; Thiazoles | 2019 |
In reply.
Topics: Emergency Service, Hospital; Haloperidol; Midazolam; Olanzapine; Piperazines; Thiazoles | 2019 |
In reply.
Topics: Emergency Service, Hospital; Haloperidol; Midazolam; Olanzapine; Piperazines; Thiazoles | 2019 |
Midazolam with haloperidol versus lorazepam with haloperidol for agitation: Effect on emergency department lengths of stay.
Topics: Antipsychotic Agents; Drug Therapy, Combination; Emergency Service, Hospital; Haloperidol; Humans; Lorazepam; Midazolam; Psychomotor Agitation | 2022 |
Does ketamine provide a shorter time to sedation when compared to haloperidol and midazolam in the agitated ED patient?
Topics: Anesthetics, Dissociative; Haloperidol; Humans; Hypnotics and Sedatives; Ketamine; Midazolam | 2022 |
Prospective study of haloperidol plus lorazepam versus droperidol plus midazolam for the treatment of acute agitation in the emergency department.
Topics: Antipsychotic Agents; Droperidol; Emergency Service, Hospital; Haloperidol; Humans; Lorazepam; Midazolam; Prospective Studies; Psychomotor Agitation | 2022 |
Comparison of Droperidol and Midazolam Versus Haloperidol and Lorazepam for Acute Agitation Management in the Emergency Department.
Topics: Antipsychotic Agents; Droperidol; Emergency Service, Hospital; Haloperidol; Humans; Injections, Intramuscular; Lorazepam; Midazolam; Psychomotor Agitation; Retrospective Studies | 2023 |