midazolam has been researched along with efavirenz in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C | 1 |
| Gehrig, AK; Heinrich, T; Mikus, G; Röder, CS | 1 |
| Burhenne, J; Haefeli, WE; Keubler, A; Mikus, G; Weiss, J | 1 |
| Kosugi, Y; Takahashi, J | 1 |
| Berger, B; Derungs, A; Donzelli, M; Haschke, M; Krähenbühl, S; Noppen, C | 1 |
| Bödigheimer, J; Burhenne, J; Haefeli, WE; Heinrich, T; Matthee, AK; Mikus, G; Röder, C; Weiss, J | 1 |
| Ichikawa, T; Kobayashi, M; Matsubara, C; Miki, T; Miyata, S; Takeshita, K; Tsujino, H; Uno, T; Yamashita, T; Yonezawa, Y | 1 |
| Burhenne, J; Gottwalt, K; Haefeli, WE; Hohmann, N; Huisinga, W; Kloft, C; Meid, AD; Michelet, R; Mikus, G; Nassar, YM | 1 |
1 review(s) available for midazolam and efavirenz
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
3 trial(s) available for midazolam and efavirenz
| Article | Year |
|---|---|
Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.
Topics: Adult; Alkynes; Benzoxazines; Caffeine; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Genotype; Humans; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Phenotype; Young Adult | 2016 |
Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.
Topics: Administration, Oral; Adult; Alkynes; Area Under Curve; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Midazolam; Reverse Transcriptase Inhibitors; Young Adult | 2017 |
Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion.
Topics: Administration, Oral; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Midazolam; Pharmaceutical Preparations; Rifampin; Voriconazole | 2022 |
9 other study(ies) available for midazolam and efavirenz
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2022 |
Misleading results of screening for illicit drugs during efavirenz treatment.
Topics: Alkynes; Benzodiazepines; Benzoxazines; Cyclopropanes; Dronabinol; Drug Administration Schedule; Humans; Immunoassay; Midazolam; Reverse Transcriptase Inhibitors; Substance Abuse Detection | 2007 |
Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro.
Topics: Alkynes; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Activation; Humans; Hydroxylation; Microsomes, Liver; Midazolam | 2012 |
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.
Topics: Administration, Oral; Alkynes; Animals; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Drug Interactions; Haplorhini; Humans; Hydroxylation; Male; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Species Specificity; Substrate Specificity; Testosterone | 2015 |
Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.
Topics: Alkynes; Allosteric Regulation; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Humans; Midazolam; Molecular Dynamics Simulation; Protein Binding | 2018 |