midazolam and digoxin

midazolam has been researched along with digoxin in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.13)	18.2507
2000's	15 (31.91)	29.6817
2010's	21 (44.68)	24.3611
2020's	10 (21.28)	2.80

Authors

Authors	Studies
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Bi, YA; Chupka, J; Duignan, DB; Kimoto, E; Xiao, Y	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S	1
Hu, J; Hu, Q; Kong, X; Liu, J; Luo, G; Shen, H; Wang, C; Wu, T; Wu, X; Xiang, Q; Xu, Y; Zhang, C; Zhang, Y; Zhuang, X; Zou, L	1
Augsburger, M; Giroud, C; Mangin, P; Rivier, L; Tracqui, A	1
Andersen, VC; Sonne, J	1
Achira, M; Crespi, CL; Ito, K; Kato, Y; Kawahara, I; Sugiyama, Y; Suzuki, H	1
Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T	1
Gilbert, D; Jolley, S; LeCluyse, EL; Milad, MA; Rose, KA; Sahi, J; Stern, RH; Stilgenbauer, L; Wang, H; Zheng, X	1
Becquemont, L; Burk, O; Drescher, S; Eichelbaum, M; Fromm, MF; Glaeser, H; Heinkele, G; Hitzl, M; Hofmann, U; Murdter, TE; Schaefer, C; Simon, N; Verstuyft, C	1
Hoffer, CJ; Kharasch, ED; Kirby, B; Narang, VS; Thummel, KT; Unadkat, JD	1
Cederberg, J; Dahl, ML; Karlsson, MO; Magnusson, MO; Sandström, R	1
Buchanan, ML; Carr, DB; Easterling, TR; Fishbein, DP; Hebert, MF; Kirby, B; Rutherford, T; Thummel, KE; Unadkat, JD	1
Baba, K; Hamahata, Y; Hayashi, M; Iwanaga, K; Kakemi, M; Miyazaki, M; Shibano, M; Taniguchi, M	1
Doroshyenko, O; Fätkenheuer, G; Frank, D; Fuhr, U; Hein, W; Jetter, A; Kirchheiner, J; Klaassen, T; Schömig, E; Seeringer, A; Wyen, C	1
Cai, X; Chu, X; Ding, Y; Evers, R; Gibson, C; Reitman, ML; Roupe, K; Stoch, A; Stone, JA; Venkatasubramanian, R; Wagner, JA; Witter, R; Yabut, J; Zajic, S	1
Bi, H; Huang, L; Huang, M; Qin, X; Xiao, H; Xue, X; Zhong, G	1
Bi, XL; Chen, LT; Di, LQ; Du, Q; Zhou, W	1
Alves, K; Chandorkar, G; Farmer, HF; Garg, V; Smith, F; van Heeswijk, RP	1
Barter, Z; Jamei, M; Neuhoff, S; Rostami-Hodjegan, A; Turner, DB; Yeo, KR	1
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM	1
Aspeslet, LJ; Foster, RT; Freitag, DG; Huizinga, RB; Larouche, R; Ling, SY; Mayo, PR	1
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD	1
Chavan, AB; Dubey, N; Gilmartin, GS; Higgins, M; Li, C; Luo, X; Mahnke, L; Robertson, SM	1
Johansson, S; Leese, PT; Li, Y; Lisbon, E; Martin, P; Mathews, D; Oliver, S; Read, J; Steinberg, M	1
Chan, LN; Flum, DR; Horn, JR; Lin, YS; Oelschlager, BK; Patton, KK; Shen, DD; Tay-Sontheimer, JC; Trawick, D	1
Jin, F; Moyer, C; Murray, B; Ramanathan, S; Robeson, M; Wilbert, S; Zhou, H	1
Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A	1
Britz, H; Eissing, T; Frechen, S; Hanke, N; Lehr, T; Moj, D; Wendl, T	1
Chan, LN; Chen, KF; Lin, YS	1
Kawaguchi, A; Nakamura, T; Shimizu, H	1
Balazki, P; Baumgart, J; Beelen, DW; Böhm, S; Hemmelmann, C; Hilger, RA; Martins, FS; Ring, A; Schaller, S	1
Henderson, LM; Ragueneau-Majlessi, I; Steinbronn, CE; Yeung, CK; Yu, J	1
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH	1
Abdulrasool, LI; Endres, CJ; Lee, A; Mayor, JG; Rustia, EL; Sun, H; Topletz-Erickson, A; Walker, L	1
Barth, A; Brimhall, DB; Dumont, EF; Nguyen, D; Perry, CR; Shabbir, S; Srinivasan, M; Swift, B; Thomas, S; Zamek-Gliszczynski, MJ	1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW	1

Reviews

3 review(s) available for midazolam and digoxin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Drug metabolism in the small intestine--the significance for biological availability]. Ugeskrift for laeger, 2000, May-29, Volume: 162, Issue:22 Topics: Animals; Biological Availability; Cyclosporins; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; GABA Modulators; Glycoproteins; Humans; Intestinal Absorption; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Midazolam; Models, Biological; Pharmaceutical Preparations	2000
Analysis of Drug-Drug Interaction Labeling Language and Clinical Recommendations for Newly Approved Drugs Evaluated With Digoxin, Midazolam, and S-Warfarin. Clinical therapeutics, 2021, Volume: 43, Issue:11 Topics: Digoxin; Drug Interactions; Humans; Language; Midazolam; Pharmaceutical Preparations; Product Labeling; Warfarin	2021

Trials

12 trial(s) available for midazolam and digoxin

Article	Year
Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:5 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Activators; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Leukocytes; Male; Midazolam; RNA, Messenger; Ursodeoxycholic Acid	2006
Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. Journal of clinical pharmacology, 2006, Volume: 46, Issue:11 Topics: Adolescent; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Female; Humans; Male; Midazolam	2006
Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2 Topics: Adult; Anesthetics, Intravenous; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiotonic Agents; Creatinine; Cytochrome P-450 CYP3A; Digoxin; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Genotype; Humans; Hypnotics and Sedatives; Midazolam; Postpartum Period; Pregnancy; Pregnancy Trimester, Third	2008
Effect of telaprevir on the pharmacokinetics of midazolam and digoxin. Journal of clinical pharmacology, 2012, Volume: 52, Issue:10 Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Oligopeptides; Protease Inhibitors; Young Adult	2012
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects. Journal of clinical pharmacology, 2014, Volume: 54, Issue:4 Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult	2014
Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin. British journal of clinical pharmacology, 2014, Volume: 77, Issue:6 Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Verapamil	2014
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European journal of clinical pharmacology, 2014, Volume: 70, Issue:9 Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult	2014
Clinical drug-drug interaction assessment of ivacaftor as a potential inhibitor of cytochrome P450 and P-glycoprotein. Journal of clinical pharmacology, 2015, Volume: 55, Issue:1 Topics: Adolescent; Adult; Aminophenols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Contraceptives, Oral, Combined; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Digoxin; Double-Blind Method; Drug Interactions; Ethinyl Estradiol; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Midazolam; Middle Aged; Norethindrone; Progesterone; Quinolones; Rosiglitazone; Thiazolidinediones; Young Adult	2015
Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine. Clinical pharmacokinetics, 2014, Volume: 53, Issue:9 Topics: Adolescent; Adult; Area Under Curve; Digoxin; Drug Interactions; Female; Humans; Male; Metformin; Midazolam; Middle Aged; Omeprazole; Piperidines; Quinazolines; Ranitidine; Young Adult	2014
Clinical drug interaction profile of idelalisib in healthy subjects. Journal of clinical pharmacology, 2015, Volume: 55, Issue:8 Topics: Adult; Antineoplastic Agents; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Phosphoinositide-3 Kinase Inhibitors; Purines; Quinazolinones; Rifampin; Rosuvastatin Calcium; Young Adult	2015
Drug-Drug Interactions of the Nonsteroidal Mineralocorticoid Receptor Antagonist Apararenone With Midazolam, Warfarin, and Digoxin: A Phase 1 Studies in Healthy Volunteers. Clinical therapeutics, 2020, Volume: 42, Issue:11 Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Mineralocorticoid Receptor Antagonists; Warfarin; Young Adult	2020
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers. Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7 Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide	2022

Other Studies

32 other study(ies) available for midazolam and digoxin

Article	Year
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Characterization of digoxin uptake in sandwich-cultured human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biological Transport; Cells, Cultured; Digoxin; HEK293 Cells; Hepatocytes; Humans; Liver; Membrane Transport Proteins; Oocytes; Organic Anion Transporters; Transfection; Xenopus laevis	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives. European journal of medicinal chemistry, 2021, Nov-05, Volume: 223 Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones	2021
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. Journal of medicinal chemistry, 2022, 01-13, Volume: 65, Issue:1 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; CREB-Binding Protein; Drug Design; Humans; Indolizidines; Male; Mice; Mice, SCID; Microsomes, Liver; Models, Molecular; Molecular Docking Simulation; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays	2022
Car crash after massive ingestion of digoxin and midazolam. International journal of legal medicine, 1998, Volume: 111, Issue:4 Topics: Accidents, Traffic; Adult; Alcohol Drinking; Autopsy; Cardiotonic Agents; Digoxin; Humans; Hypnotics and Sedatives; Male; Midazolam; Substance-Related Disorders	1998
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Dose-Response Relationship, Drug; Humans; Hydroxylation; Indans; Microsomes; Midazolam; Mixed Function Oxygenases; Piperazines; Recombinant Proteins; Transfection	2000
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2001, Volume: 12, Issue:4 Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Enzyme Inhibitors; GABA Modulators; Gonadal Steroid Hormones; Humans; LLC-PK1 Cells; Midazolam; Mixed Function Oxygenases; Nifedipine; Phthalazines; Swine; Testosterone	2001
Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3 Topics: Acetamides; Acetates; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Hepatocytes; Humans; Microsomes, Liver; Midazolam; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sulfonamides; Sulfonic Acids	2003
Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Carbamazepine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Digoxin; Enzyme Induction; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Substrate Specificity	2008
Furanocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:8 Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Furocoumarins; Humans; Medicine, Kampo; Midazolam; Quinidine	2010
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? Antiviral therapy, 2010, Volume: 15, Issue:7 Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Digoxin; Down-Regulation; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Midazolam; Middle Aged; Pyrimidinones; Ritonavir; Young Adult	2010
Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design. Clinical pharmacology and therapeutics, 2011, Volume: 89, Issue:2 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Digoxin; Drug Interactions; Humans; Male; Midazolam; Middle Aged; Models, Biological; Organic Anion Transporters, Sodium-Independent; Research Design; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3	2011
Rapid and simultaneous measurement of midazolam, 1'-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity. Journal of pharmaceutical and biomedical analysis, 2011, Apr-28, Volume: 55, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Calibration; Cardiotonic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Drug Stability; Limit of Detection; Male; Midazolam; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2011
[Intestinal absorption of forsythoside A by rat circulation in situ]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:11 Topics: Animals; Colon; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Duodenum; Edetic Acid; Glycosides; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Jejunum; Male; Mannitol; Midazolam; Rats; Rats, Sprague-Dawley	2010
Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:9 Topics: Adjuvants, Anesthesia; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B; Computer Simulation; Digoxin; Drug Interactions; Enzyme Inhibitors; Humans; Midazolam; Models, Biological; Permeability; Rifampin; Verapamil	2013
Proximal Roux-en-Y gastric bypass alters drug absorption pattern but not systemic exposure of CYP3A4 and P-glycoprotein substrates. Pharmacotherapy, 2015, Volume: 35, Issue:4 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Digoxin; Female; Gastric Bypass; Gastrointestinal Absorption; Humans; Longitudinal Studies; Male; Midazolam; Middle Aged; Obesity; Pilot Projects; Prospective Studies	2015
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects. Advances in therapy, 2017, Volume: 34, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin	2017
PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin. CPT: pharmacometrics & systems pharmacology, 2018, Volume: 7, Issue:10 Topics: Alfentanil; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clarithromycin; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Humans; Itraconazole; Midazolam; Models, Biological; Rifampin	2018
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery. Journal of pharmacokinetics and pharmacodynamics, 2020, Volume: 47, Issue:5 Topics: Acetaminophen; Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Gastric Bypass; Gastrointestinal Absorption; Hepatobiliary Elimination; Humans; Intestinal Elimination; Metabolic Clearance Rate; Midazolam; Models, Biological; Obesity, Morbid; Postoperative Period; Triazoles; Verapamil	2020
Evaluation of the drug-drug interaction potential of treosulfan using a physiologically-based pharmacokinetic modelling approach. British journal of clinical pharmacology, 2022, Volume: 88, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Busulfan; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Pharmaceutical Preparations	2022
Evaluation of Safety and Clinically Relevant Drug-Drug Interactions with Tucatinib in Healthy Volunteers. Clinical pharmacokinetics, 2022, Volume: 61, Issue:10 Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Digoxin; Drug Interactions; Gemfibrozil; Healthy Volunteers; Humans; Itraconazole; Midazolam; Oxazoles; Pyridines; Quinazolines; Rifampin; Tolbutamide	2022
Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug-drug interactions via CYP3A metabolism and transporters. Clinical and translational science, 2023, Volume: 16, Issue:4 Topics: Cimetidine; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Humans; Itraconazole; Membrane Transport Proteins; Midazolam; Models, Biological; Pharmaceutical Preparations; Rifampin	2023
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary	2023

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