Compounds > midazolam

midazolam and dextromethorphan

midazolam has been researched along with dextromethorphan in 98 studies

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (5.10)18.2507
2000's26 (26.53)29.6817
2010's51 (52.04)24.3611
2020's16 (16.33)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Obach, RS; Orozco, CC; Strelevitz, TJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Kanebratt, KP; Sjögren, E; Svanberg, P1
Dalvie, D; Loi, CM; Smith, DA1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chen, D; Goh, WH; Soh, CK; Wang, H1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J1
Peng, Y; Welsh, WJ; Zhang, Q1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL1
Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C1
Dun-Ren, P; Ladona, MG; Lindström, B; Rane, A; Thyr, C1
Bonnabry, P; Dayer, P; Leemann, T1
Beaune, P; Dayer, P; Lecoeur, S; Leemann, T; Transon, C1
Beck, DJ; Bertino, JS; Gotschall, R; Kashuba, AD; Kearns, GL; Kulawy, RW; Leeder, JS; Nafziger, AN; Rocci, ML1
Agúndez, JA; Albet, C; Benítez, J; Carrillo, JA; Herrero, E; Márquez, M; Martínez, C; Ortiz, JA1
Bertino, JS; Bleakley, JF; Gaedigk, A; Gotschall, R; Kearns, GL; Kim, JS; Leeder, JS; Nafziger, AN; Streetman, DS1
Bu, HZ; Knuth, K; Magis, L; Teitelbaum, P1
Gorski, JC; Hall, SD; Hamman, MA; Huang, SM; Lesko, LJ; Wang, Z1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K1
Hagiwara, M; Inoue, Y; Kawashima, Y; Someya, T1
Abd-Ellah, MF; Andrews, J; Carlile, DJ; Friedberg, T; Houston, JB; Kenworthy, KE; Randolph, NL1
Adedoyin, A; Caserta, KA; Jones, SS; Laws, K; Saraswat, LD; Wei, D1
Bertino, JS; Chainuvati, S; Gaedigk, A; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Zhang, Y1
Desai, M; Gorski, JC; Hall, SD; Hamman, MA; Hilligoss, JK; Huang, SM; Miller, M; Pinto, A; Zaheer, NA1
Cherkaoui, S; Daali, Y; Dayer, P; Jerdi, MC; Oestreicher, MK1
Bhoopathy, S; Karnes, HT; Unger, SE; Xin, B1
Dostalek, M; Hadasova, E; Jurica, J; Linhart, I; Pistovcakova, J; Sulcová, A; Tomandl, J1
Bertino, JS; Gaedigk, A; Kashuba, AD; Kearns, G; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Shelepova, T; Victory, J; Zhang, Y1
Adkison, KK; Berrey, MM; Bertino, JS; Borland, J; Fang, L; Johnson, BM; Lou, Y; Nafziger, AN; Piscitelli, SC; Song, IH1
Greif, J; Lurie, O; Schwarz, Y; Tarrasch, R; Weinbroum, AA1
Cha, IJ; Liu, KH; Ryu, JY; Shin, JG; Shon, JH; Song, IS; Sunwoo, YE1
Kumar, A; Mann, HJ; Remmel, RP1
Brown, HS; Chadwick, A; Houston, JB1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J1
Felmlee, MA; Gonzalez, FJ; Lon, HK; Yu, AM1
Becker, S; Calandra, GB; Chee, P; Everts, S; Hendrix, CW; MacFarland, RT; Nyunt, MM; Scarborough, R1
Jones, BC; Lyons, R; Payne, L; Saunders, K; Youdim, KA1
Asl, BH; Hassanzadeh, K; Khezri, E; Mohammadi, S1
Iqbal, MZ; Lagundoye, O; Lennard, MS; Rostami-Hodjegan, A; Seivewright, N; Shiran, MR; Tucker, GT1
Chem, MC; Chetty, M; Ghassabian, S; Glen, J; McLachlan, AJ; Murray, M; Rahme, J; Ramzan, I; Stankovic, Z; Tattam, BN1
Cho, JY; Hong, JH; Jang, IJ; Kim, BH; Kim, J; Kim, KP; Lim, KS; Shin, SG; Yi, S; Yu, KS1
Blake, M; Brown, KC; Gaedigk, A; Gotzkowsky, K; Hein, DW; Jones, AE; Kashuba, AD; van der Horst, C; Werner, RE1
Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H1
Beilman, GJ; Kumar, A; Mann, HJ; Remmel, RP1
Doroshyenko, O; Fätkenheuer, G; Frank, D; Fuhr, U; Hein, W; Jetter, A; Kirchheiner, J; Klaassen, T; Schömig, E; Seeringer, A; Wyen, C1
Arellano, C; Belkhelfa, H; Bonnefille, P; Gandia, P; Houin, G; Sezgin-Bayindir, Z; Woodley, J1
Flaherty, KT; Frye, RF; Lathia, C; O'Dwyer, PJ; Redlinger, M; Rosen, M; Schuchter, L1
Chen, Y; Guo, Y; Klaassen, CD; Tan, ZR; Zhou, HH1
Auwärter, V; Dresen, S; Lutz-Bonengel, S; Naue, J; Wohlfarth, A1
Chen, Y; Kang, Z; Ouyang, DS; Tan, ZR; Yan, J; Yang, GP; Zhou, G1
Bekersky, I; Blum, RA; Tolbert, D; Walzer, M1
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I1
Chalasani, N; Hall, SD; Jones, DR; Mattar, S; Tandra, S; Vuppalanchi, R1
Chen, JL; Cui, HM; Dong, Y; Gong, JY; Zhang, YL1
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM1
Ge, RS; Xu, RA; Xu, ZS1
Namiki, N; Tanaka, S; Uchida, S1
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Staub, C; Walder, B1
Davis, C; Foti, RS; Isoherranen, N; Kunze, KL; Lutz, JD; Sager, JE1
Bosilkovska, M; Daali, Y; Dayer, P; Déglon, J; Desmeules, JA; Rebsamen, M; Samer, CF; Staub, C; Walder, B1
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ1
Corcoran, M; Ermer, J; Martin, P1
Murayama, N; Shida, S; Shimizu, M; Uno, Y; Utoh, M; Yamazaki, H1
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ1
Bénech, H; Lenuzza, N; Nguyen, TT; Pruvost, A1
Hellum, B; Nilsen, OG; Spigset, O; Thu, OK1
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Thomas, A; Walder, B1
Allegaert, K; Annaert, P; Boussery, K; De Bock, L; Mannens, G; Snoeys, J; T'jollyn, H; Van Bocxlaer, J; Van Peer, A; Vermeulen, A1
Casteleyn, C; Jacobs, F; Pijpers, I; Snoeys, J; Van Cruchten, S; Van Ginneken, C; Van Houdt, J; Van Peer, E1
Armani, S; Chun, DY; Darstein, C; Einolf, HJ; Gu, H; Kulkarni, S; Sauter, N; Ting, L; Tripathi, AP; Wang, L; Zhu, B1
Jilek, JL; Tian, Y; Yu, AM1
Apers, S; Bijttebier, S; Casteleyn, C; Cos, P; Maes, L; Matheeussen, A; Pype, C; Saad, M; Van Cruchten, S; Van Ginneken, C; Verbueken, E1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ1
Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A1
Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B1
Mangoni, AA; Rowland, A; Sorich, MJ; van Dyk, M; Warncken, D1
Jo, JH; Jo, JJ; Kim, S; Lee, JM; Lee, S1
Bailey-Smith, C; Bodrug, I; Cheng, A; Glasgow, XS; Hussain, A; Iwamoto, M; Khalilieh, S; Levine, V; Martinho, M; Mekokishvili, L; Montgomery, D; Shaw, PM1
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ1
Choi, MK; Choi, WG; Han, YH; Heo, JK; Jo, J; Kang, WY; Lee, HS; Lee, HW; Lee, S; Liu, KH; Ohk, B; Seong, SJ; Song, IS; Yoon, YR1
Collins, C; Ernault, E; Fuhr, R; Gangaram-Panday, S; Passier, P; Treijtel, N; van Bruijnsvoort, M1
Ducray, PS; Endo-Tsukude, C; Gardner, I; Gill, KL; Hatley, OJ; Machavaram, KK; Parrott, N; Terao, K1
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J1
Enejosa, JV; Feng, T; Fisniku, O; Mohamed, MF; Othman, AA1
Eagles, SK; Gross, AS; McLachlan, AJ; Wang, X1
Cho, P; Jo, JJ; Ki, SH; Kim, JH; Kim, KM; Kim, Y; Lee, JM; Lee, S; Liu, KH; Shrestha, R; Song, IS; Song, KS1
Cech, NB; Oberlies, NH; Paine, MF; Rettie, AE; Tanna, RS; Thummel, KE; Tian, DD1
Fahmy, A; Johnson, JG; Kapetas, AJ; Mounzer, R; Newman, LA; Rodrigues, AD; Rowland, A; Sorich, MJ; Useckaite, Z; van Dyk, M; Wood, LS1
Doogue, MP; Epton, MJ; McNeill, RP; Zhang, M1
Hakamata, A; Inui, N; Kamiya, C; Katayama, N; Kawakami, J; Miura, M; Namiki, N; Odagiri, K; Tanaka, S; Uchida, S; Watanabe, H1
Brantley, SJ; Dai, X; Goulet, MT; Hard, ML; Hitron, M; Karol, MD; McLaughlin, CF1
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH1
Newman, EM; Rowland, A1
Cech, NB; Hadi, DL; Layton, ME; Nguyen, JT; Oberlies, NH; Paine, MF; Rettie, AE; Tanna, RS; Thummel, KE; White, JR1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW1

Reviews

2 review(s) available for midazolam and dextromethorphan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure.
    International journal of molecular sciences, 2022, Oct-04, Volume: 23, Issue:19

    Topics: Animals; Caffeine; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dextromethorphan; Metoprolol; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Rosiglitazone; Warfarin

2022

Trials

28 trial(s) available for midazolam and dextromethorphan

ArticleYear
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
    Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Benzenesulfonates; Caffeine; Central Nervous System Stimulants; Cimetidine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Double-Blind Method; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Methylation; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Psychomotor Performance; Ranitidine; Thiazoles

1999
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Injections, Intravenous; Isoenzymes; Male; Midazolam; Oxidoreductases, N-Demethylating; Plant Extracts; Tolbutamide

2001
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:5

    Topics: Acetyltransferases; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Genotype; Humans; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Phosphodiesterase Inhibitors; Reproducibility of Results; Vitamins; Warfarin; Xanthine Oxidase

2003
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:12

    Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Genotype; Humans; Midazolam; Norgestrel; Omeprazole; Therapeutic Equivalency; Vitamin K; Warfarin; Xanthine Oxidase

2005
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:5

    Topics: Adult; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; Benzoates; Caffeine; CCR5 Receptor Antagonists; Dextromethorphan; Diketopiperazines; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Omeprazole; Piperazines; Spiro Compounds; Warfarin

2006
Dextromethorphan premedication reduces midazolam requirement: objective and subjective parameters in peribronchoscopy.
    Respiration; international review of thoracic diseases, 2007, Volume: 74, Issue:3

    Topics: Adult; Aged; Anti-Anxiety Agents; Antitussive Agents; Bronchoscopy; Cohort Studies; Conscious Sedation; Dextromethorphan; Double-Blind Method; Female; Humans; Male; Midazolam; Middle Aged; Monitoring, Physiologic; Premedication

2007
Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5

    Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Genotype; Humans; Isoenzymes; Linear Models; Losartan; Male; Midazolam; Mixed Function Oxygenases; Omeprazole; Phenotype; Polymerase Chain Reaction; Reference Values; Time Factors

2007
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Antineoplastic Agents; Area Under Curve; Benzenesulfonates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Isoenzymes; Melanoma; Midazolam; Niacinamide; Omeprazole; Phenylurea Compounds; Pyridines; Sorafenib

2011
Repeated administration of berberine inhibits cytochromes P450 in humans.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:2

    Topics: Adult; Berberine; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult

2012
Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:6

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; China; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Drugs, Chinese Herbal; Genotype; Herb-Drug Interactions; Humans; Male; Midazolam; Omeprazole; Placebos

2012
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes.
    Pharmacotherapy, 2012, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Clinical Trials, Phase I as Topic; Clobazam; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Isoenzymes; Lamotrigine; Male; Midazolam; Middle Aged; Models, Statistical; Pharmacokinetics; Prospective Studies; Tolbutamide; Triazines; Valproic Acid; Young Adult

2012
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.
    Annals of surgery, 2013, Volume: 258, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Biotransformation; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dextromethorphan; Diuretics; Excitatory Amino Acid Antagonists; Female; Furosemide; GABA Modulators; Gastric Bypass; Humans; Hypoglycemic Agents; Male; Midazolam; Middle Aged; Omeprazole; Pharmacokinetics; Tandem Mass Spectrometry; Tolbutamide; Young Adult

2013
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult

2014
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:9

    Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult

2014
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10

    Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult

2014
Lisdexamfetamine Dimesylate Effects on the Pharmacokinetics of Cytochrome P450 Substrates in Healthy Adults in an Open-Label, Randomized, Crossover Study.
    Drugs in R&D, 2015, Volume: 15, Issue:2

    Topics: Adult; Area Under Curve; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Lisdexamfetamine Dimesylate; Male; Midazolam; Omeprazole

2015
A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:1

    Topics: Bayes Theorem; Caffeine; Computer Simulation; Dextromethorphan; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Phenotype; Pilot Projects; Tolbutamide

2016
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:3

    Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Plant Extracts; Rhodiola; Young Adult

2016
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:3

    Topics: Adolescent; Adult; Bupropion; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Dried Blood Spot Testing; Drug Interactions; Female; Flurbiprofen; Genotyping Techniques; Humans; Male; Midazolam; Omeprazole; Phenotype; Terfenadine; Young Adult

2016
Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults.
    Clinical drug investigation, 2017, Volume: 37, Issue:5

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Imidazoles; Male; Midazolam; Middle Aged; Omeprazole; Pituitary ACTH Hypersecretion; Pyridines

2017
The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial.
    Journal of bronchology & interventional pulmonology, 2017, Volume: 24, Issue:4

    Topics: Analgesics; Anesthetics, Local; Anti-Anxiety Agents; Antitussive Agents; Anxiety; Bronchoscopy; Cough; Dextromethorphan; Female; Humans; Hypnotics and Sedatives; Lidocaine; Male; Midazolam; Middle Aged; Patient Satisfaction; Premedication; Prospective Studies

2017
Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:3

    Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Losartan; Male; Midazolam; Modafinil; Omeprazole; Phenotype; Time Factors; Young Adult

2018
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Administration, Oral; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Injections, Subcutaneous; Interleukin-23 Subunit p19; Male; Midazolam; Middle Aged; Omeprazole; Psoriasis; Severity of Illness Index; Treatment Outcome; Warfarin; Young Adult

2018
A Cocktail Interaction Study Evaluating the Drug-Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels.
    Clinical pharmacology in drug development, 2019, Volume: 8, Issue:4

    Topics: Administration, Oral; Adult; Area Under Curve; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Losartan; Male; Midazolam; Middle Aged; Omeprazole; Piperidines; Pyridines; Young Adult

2019
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:1

    Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Midazolam; Middle Aged; Omeprazole; Phenotype; Vitamin K; Warfarin

2020
Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:6

    Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Male; Midazolam; Models, Biological; Omeprazole; Young Adult

2021
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
    Clinical pharmacology in drug development, 2021, Volume: 10, Issue:8

    Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzofurans; Bupropion; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Flurbiprofen; Gene Expression Regulation; Half-Life; Healthy Volunteers; Humans; Male; Midazolam; Naphthoquinones; Neoplasm Proteins; Omeprazole; Rosuvastatin Calcium; Young Adult

2021
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.
    Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7

    Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide

2022

Other Studies

68 other study(ies) available for midazolam and dextromethorphan

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7

    Topics: Acetamides; Aldehyde Oxidase; Cryopreservation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Activation; Hepatocytes; Humans; Hydralazine; Liver; Microsomes, Liver; Pyrimidines

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry

2012
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
    Journal of medicinal chemistry, 2018, 02-22, Volume: 61, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2018
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
    Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13

    Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays

2020
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
    Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1

    Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles

2021
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship

2021
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
    European journal of medicinal chemistry, 2022, Aug-05, Volume: 238

    Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2022
Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:3

    Topics: Antibodies, Monoclonal; Blotting, Western; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dextromethorphan; Embryonic and Fetal Development; Humans; Methylation; Microsomes, Liver; Midazolam; Mixed Function Oxygenases

1991
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.
    Life sciences, 1994, Volume: 54, Issue:14

    Topics: Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating

1994
Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes.
    European journal of clinical pharmacology, 1996, Volume: 51, Issue:1

    Topics: Adult; Age Factors; Anesthetics, Intravenous; Animals; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Female; Humans; Hydroxylation; Isoenzymes; Male; Methylation; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Rabbits; Regression Analysis; Sex Factors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; White People

1996
Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
    Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:3

    Topics: Acetyltransferases; Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Female; Fluvoxamine; Genotype; Humans; Hypnotics and Sedatives; Male; Midazolam; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Selective Serotonin Reuptake Inhibitors; Time Factors; Xanthine Oxidase

1998
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4

    Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Polymerase Chain Reaction; Xanthine Oxidase

2000
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.
    Rapid communications in mass spectrometry : RCM, 2001, Volume: 15, Issue:10

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Single-Blind Method; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide

2001
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
    Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured

2002
Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Dextromethorphan; Humans; Male; Metabolic Clearance Rate; Methylation; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Sensitivity and Specificity

2002
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.
    Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:11

    Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diazepam; Dose-Response Relationship, Drug; Escherichia coli; Excitatory Amino Acid Antagonists; Female; GABA Modulators; Humans; Kinetics; Liver; Lymphocytes; Male; Microsomes, Liver; Midazolam; Middle Aged; Protein Binding; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Temazepam

2002
A high-throughput method for enzyme kinetic studies.
    Journal of biomolecular screening, 2003, Volume: 8, Issue:5

    Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzymes; Half-Life; Humans; Kinetics; Mass Spectrometry; Midazolam; Molecular Biology; Sensitivity and Specificity; Testosterone; Warfarin

2003
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.
    Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:1

    Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Echinacea; Female; Herb-Drug Interactions; Humans; Infusions, Intravenous; Male; Midazolam; Phytotherapy; Plant Extracts; Plant Roots; Reference Values; Tolbutamide

2004
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.
    Journal of pharmaceutical and biomedical analysis, 2004, Sep-03, Volume: 35, Issue:5

    Topics: Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Flurbiprofen; Humans; Isoenzymes; Midazolam; Omeprazole; Phenotype; Reproducibility of Results; Sensitivity and Specificity

2004
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
    Journal of pharmaceutical and biomedical analysis, 2005, Apr-01, Volume: 37, Issue:4

    Topics: Algorithms; Animals; Antitussive Agents; Chlorpromazine; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Half-Life; Humans; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Microsomes, Liver; Midazolam; Pharmaceutical Preparations; Primaquine; Quinidine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2005
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver.
    Life sciences, 2005, Dec-05, Volume: 78, Issue:3

    Topics: Animals; Antidepressive Agents; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Hypericum; Injections, Intraperitoneal; Liver; Male; Midazolam; Perfusion; Plant Extracts; Rats; Rats, Wistar; Tolbutamide

2005
Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Jun-15, Volume: 853, Issue:1-2

    Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Flurbiprofen; Mass Spectrometry; Midazolam; Molecular Structure; Reproducibility of Results; Spectrometry, Fluorescence; Swine

2007
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11

    Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide

2007
Effect of methamphetamine on cytochrome P450 activity.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12

    Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide

2007
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2

    Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Male; Mice; Mice, Transgenic; Microsomes; Midazolam; Pregnenolone Carbonitrile; Pyridines; Testosterone

2008
Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers.
    Journal of acquired immune deficiency syndromes (1999), 2008, Apr-15, Volume: 47, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aminoquinolines; Benzimidazoles; Butylamines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Drug Interactions; Excitatory Amino Acid Antagonists; Female; GABA Modulators; Heterocyclic Compounds, 1-Ring; Humans; Leukocytosis; Male; Midazolam; Middle Aged; Receptors, CXCR4

2008
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
    Journal of pharmaceutical and biomedical analysis, 2008, Sep-10, Volume: 48, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Midazolam; Miniaturization; Oxidoreductases, N-Demethylating; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Tacrine; Tandem Mass Spectrometry; Time Factors

2008
Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice.
    Pakistan journal of biological sciences : PJBS, 2008, Jul-01, Volume: 11, Issue:13

    Topics: Animals; Dextromethorphan; Drug Tolerance; Male; Mice; Midazolam; Morphine; Naloxone; Substance-Related Disorders

2008
Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:1

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; Female; Humans; Isomerism; Male; Methadone; Midazolam; Middle Aged; Narcotics; Opioid-Related Disorders; Saliva; Young Adult

2009
A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:2

    Topics: Biotransformation; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Midazolam; Omeprazole; Phenotype; Tandem Mass Spectrometry

2009
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:4

    Topics: Adult; Angelica; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Phytotherapy; Republic of Korea; Scutellaria baicalensis; Tandem Mass Spectrometry; Young Adult

2009
Variability in drug metabolizing enzyme activity in HIV-infected patients.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:5

    Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; HIV Infections; Humans; Interleukin-6; Male; Midazolam; Phenotype; Tumor Necrosis Factor-alpha; Xanthine Oxidase

2010
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, May-01, Volume: 878, Issue:15-16

    Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Interactions; Drug Stability; High-Throughput Screening Assays; Humans; Midazolam; Omeprazole; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Tolbutamide

2010
Drug metabolism in hemorrhagic shock: pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: Animals; Biomarkers; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Flurbiprofen; Injections, Intravenous; Midazolam; Models, Animal; Resuscitation; Shock, Hemorrhagic; Swine

2011
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
    Antiviral therapy, 2010, Volume: 15, Issue:7

    Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Digoxin; Down-Regulation; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Midazolam; Middle Aged; Pyrimidinones; Ritonavir; Young Adult

2010
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bupropion; Chromatography, Liquid; Dextromethorphan; Enterocytes; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Isoenzymes; L-Lactate Dehydrogenase; Male; Mass Spectrometry; Microsomes; Midazolam; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Swine

2011
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:8

    Topics: Adult; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Phenotype; Pilot Projects; Tandem Mass Spectrometry; Tolbutamide; Young Adult

2012
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
    Biomedical research (Tokyo, Japan), 2012, Volume: 33, Issue:4

    Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide

2012
[CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:12

    Topics: Berberine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Microsomes, Liver; Midazolam; Phenacetin; Tolbutamide

2013
Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats.
    Journal of ethnopharmacology, 2014, Feb-12, Volume: 151, Issue:3

    Topics: Animals; Chalcone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Herb-Drug Interactions; Isoenzymes; Liver; Male; Midazolam; Phenacetin; Quinones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tolbutamide

2014
Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats.
    Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:4

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Drug Interactions; Fluconazole; Fluvoxamine; Ketoconazole; Losartan; Male; Midazolam; Omeprazole; Rats, Sprague-Dawley

2014
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.
    Bioanalysis, 2014, Volume: 6, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Flurbiprofen; Half-Life; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2014
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
    Clinical pharmacology and therapeutics, 2014, Volume: 95, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Drug Interactions; Female; Fluoxetine; Half-Life; Hepatocytes; Humans; Lovastatin; Male; Midazolam; Models, Statistical; Omeprazole; Stereoisomerism

2014
Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.
    Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:3

    Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Capsules; Carbonated Beverages; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Enzyme Inhibitors; Feasibility Studies; Flurbiprofen; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenotype; Pilot Projects; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult

2014
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:10

    Topics: Administration, Intravenous; Administration, Oral; Animals; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Biological; Omeprazole; Pharmacokinetics; Warfarin

2015
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:3

    Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide

2015
Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.
    European journal of drug metabolism and pharmacokinetics, 2017, Volume: 42, Issue:3

    Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Humans; Kinetics; Liver; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Tramadol

2017
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs.
    Pharmaceutical research, 2017, Volume: 34, Issue:4

    Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Fetus; Glucuronosyltransferase; Humans; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Midazolam; Phenacetin; Swine; Swine, Miniature; Tolbutamide

2017
Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5

    Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Drug Interactions; Male; Mice; MicroRNAs; Midazolam; Pharmacokinetics; Phenacetin

2017
In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 42

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Embryo, Nonmammalian; Female; Humans; Male; Microsomes, Liver; Midazolam; Testosterone; Zebrafish

2017
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9

    Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin

2017
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.
    Advances in therapy, 2017, Volume: 34, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin

2017
Development of a simultaneous LC-MS/MS method to predict in vivo drug-drug interaction in mice.
    Archives of pharmacal research, 2018, Volume: 41, Issue:4

    Topics: Animals; Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inducers; Dextromethorphan; Drug Interactions; Forecasting; Male; Mice; Mice, Inbred ICR; Midazolam; Tandem Mass Spectrometry

2018
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2

    Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency

2017
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng.
    Clinical therapeutics, 2018, Volume: 40, Issue:8

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Liver-Specific Organic Anion Transporter 1; Losartan; Male; Midazolam; Omeprazole; Panax; Plant Preparations; Random Allocation; Young Adult

2018
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations.
    The AAPS journal, 2019, 03-18, Volume: 21, Issue:3

    Topics: Administration, Oral; Adult; Caffeine; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 Enzyme System; Dextromethorphan; Down-Regulation; Drug Development; Drug Interactions; Female; Humans; Interleukin-6; Male; Midazolam; Middle Aged; Models, Biological; Neuromyelitis Optica; Omeprazole; Rare Diseases; Serum Albumin, Human; Simvastatin; Warfarin

2019
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
    Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6

    Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha

2019
An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Mar-01, Volume: 1140

    Topics: Biosensing Techniques; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Limit of Detection; Losartan; Midazolam; Omeprazole; Phenotype; Sensitivity and Specificity; Tandem Mass Spectrometry

2020
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice.
    Biopharmaceutics & drug disposition, 2020, Volume: 41, Issue:7

    Topics: Administration, Oral; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Dose-Response Relationship, Drug; Herb-Drug Interactions; Male; Mice; Midazolam; Panax; Plant Extracts; Time Factors

2020
Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations.
    The Journal of pharmacology and experimental therapeutics, 2021, Volume: 376, Issue:1

    Topics: Cytochrome P450 Family 2; Dextromethorphan; Drug Interactions; Humans; Intestinal Mucosa; Microsomes, Liver; Midazolam; Secologanin Tryptamine Alkaloids

2021
Exploring the Use of Serum-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Hepatic Cytochromes P450 and Organic Anion Transporting Polypeptides.
    Clinical pharmacology and therapeutics, 2021, Volume: 110, Issue:1

    Topics: Adult; Area Under Curve; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Induction; Extracellular Vesicles; Female; Genotype; Humans; Liquid Biopsy; Liver; Male; Midazolam; Organic Anion Transporters; Pregnancy; Proteomics; Rifampin; Young Adult

2021
Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study.
    British journal of clinical pharmacology, 2021, Volume: 87, Issue:11

    Topics: Dextromethorphan; Drug Interactions; Humans; Midazolam; Pharmaceutical Preparations; Pulmonary Disease, Chronic Obstructive

2021
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom.
    Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:6

    Topics: Adult; Analgesics, Opioid; Biological Products; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Drug Interactions; Humans; Midazolam; Mitragyna; Psychotropic Drugs

2023
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
    Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary

2023