Compounds > midazolam

midazolam and debrisoquin

midazolam has been researched along with debrisoquin in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's5 (62.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Dayer, P; Gascon, MP1
Lewis, IA; Palmer, J; Pleasance, S; Scott, RJ1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ1
Aherne, Z; Blakey, GE; Lockton, JA; Norwood, P; Perrett, J; Plume, J; Russell, M1
Carrier, J; Edwards, DJ; Gardner, SF; Gentry, WB; Gurley, BJ; Hubbard, MA; Khan, IA; Shah, A; Williams, DK1
Booker, BM; Brazeau, D; Cloen, D; Frerichs, V; Frye, RF; Haas, CE; Kufel, T; Zaranek, C1

Trials

4 trial(s) available for midazolam and debrisoquin

ArticleYear
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:5

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating

2001
Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:2

    Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Combinations; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Plasma; Tolbutamide

2004
In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.
    Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:5

    Topics: Adrenergic Agents; Adult; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Citrus; Cytochrome P-450 Enzyme System; Debrisoquin; Dietary Supplements; Drug Interactions; Echinacea; Female; GABA Modulators; Humans; Isoenzymes; Kinetics; Male; Midazolam; Phenotype; Plant Extracts; Serenoa; Silybum marianum; Solubility

2004
Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:8

    Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Gene Expression Regulation, Enzymologic; Humans; Leukocytes, Mononuclear; Male; Midazolam; Omeprazole; Rifampin; RNA, Messenger

2005

Other Studies

4 other study(ies) available for midazolam and debrisoquin

ArticleYear
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
    Pharmaceutical research, 1999, Volume: 16, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity

1999
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
In vitro forecasting of drugs which may interfere with the biotransformation of midazolam.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:6

    Topics: Biotransformation; Debrisoquin; Humans; Hydroxylation; Male; Microsomes, Liver; Midazolam; Middle Aged; Time Factors

1991
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:23

    Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline

1999