midazolam and cimetidine

midazolam has been researched along with cimetidine in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (16.67)	18.7374
1990's	6 (16.67)	18.2507
2000's	15 (41.67)	29.6817
2010's	8 (22.22)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Giacomini, KM; Schaner, ME; Zhang, L	1
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Arvela, P; Klotz, U; Rosenkranz, B	1
Blyden, GT; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Scavone, JM; Shader, RI	1
Aaltonen, L; Aantaa, E; Kanto, J; Salonen, M	1
Brown, GC	1
Collier, PS; Dundee, JW; Fee, JP; Howard, PJ	1
Collier, PS; Dundee, JW; Elliott, P; Elwood, RJ	1
Collier, PS; Hughes, CM; Swanton, JG	1
Ring, BJ; Wrighton, SA	1
Gildersleve, CD; Robinson, JO; Rosen, M; Sanders, LD; Whitehead, C	1
Iga, T; Matsuo, H; Sawada, Y; Takedomi, S; Yamamoto, K; Yamano, K	1
Agúndez, JA; Albet, C; Benítez, J; Carrillo, JA; Herrero, E; Márquez, M; Martínez, C; Ortiz, JA	1
Iga, T; Katashima, M; Kotaki, H; Matsuo, H; Ohtani, H; Sawada, Y; Takedomi, S; Yamamoto, K; Yamano, K	1
Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Honda, K; Inomata, S; Nakamura, T; Tanaka, E	1
Hayashi, Y; Helmi, AR; Khalil, WF; Motoyama, S; Sasaki, K; Shah, SS; Shimoda, M	1
Barth, A; Brimhall, DB; Dumont, EF; Nguyen, D; Perry, CR; Shabbir, S; Srinivasan, M; Swift, B; Thomas, S; Zamek-Gliszczynski, MJ	1

Reviews

1 review(s) available for midazolam and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

5 trial(s) available for midazolam and cimetidine

Article	Year
Effect of single doses of cimetidine and ranitidine on the steady-state plasma levels of midazolam. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:6 Topics: Adult; Benzodiazepines; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Humans; Infusions, Parenteral; Kinetics; Liver; Male; Midazolam; Middle Aged; Ranitidine; Reaction Time	1985
Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam. Anesthesia and analgesia, 1986, Volume: 65, Issue:2 Topics: Administration, Oral; Adult; Anesthetics; Benzodiazepines; Cimetidine; Drug Interactions; Female; Humans; Infusions, Parenteral; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Ranitidine	1986
The influence of H2 receptor antagonists on the plasma concentrations of midazolam and temazepam. European journal of anaesthesiology, 1984, Volume: 1, Issue:3 Topics: Administration, Oral; Adult; Antacids; Anti-Anxiety Agents; Benzodiazepines; Biological Availability; Cimetidine; Female; Histamine H2 Antagonists; Humans; Liver; Magnesium; Magnesium Silicates; Male; Microsomes, Liver; Midazolam; Middle Aged; Ranitidine; Silicic Acid; Temazepam	1984
Interaction of H2-receptor antagonists and benzodiazepine sedation. A double-blind placebo-controlled investigation of the effects of cimetidine and ranitidine on recovery after intravenous midazolam. Anaesthesia, 1993, Volume: 48, Issue:4 Topics: Adolescent; Adult; Cimetidine; Cognition; Double-Blind Method; Drug Interactions; Humans; Hypnotics and Sedatives; Male; Memory; Midazolam; Psychomotor Performance; Ranitidine; Time Factors	1993
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists. Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:4 Topics: Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Benzenesulfonates; Caffeine; Central Nervous System Stimulants; Cimetidine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Double-Blind Method; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Methylation; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Psychomotor Performance; Ranitidine; Thiazoles	1999

Other Studies

30 other study(ies) available for midazolam and cimetidine

Article	Year
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Importance of the interaction of midazolam and cimetidine. Acta pharmacologica et toxicologica, 1986, Volume: 58, Issue:2 Topics: Adult; Analysis of Variance; Benzodiazepines; Cimetidine; Drug Interactions; Eye Movements; Humans; Kinetics; Midazolam; Time Factors	1986
Midazolam and cimetidine: lack of interaction is unproven. Anesthesia and analgesia, 1987, Volume: 66, Issue:11 Topics: Cimetidine; Drug Interactions; Humans; Midazolam	1987
Cimetidine and ranitidine increase midazolam bioavailability. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:1 Topics: Absorption; Adult; Biological Availability; Cimetidine; Female; Humans; Kinetics; Male; Mathematics; Midazolam; Ranitidine	1987
The effect of three H2-receptor antagonists on the disposition of midazolam in the rat in-situ perfused liver model. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:12 Topics: Animals; Bile; Chromatography, Gas; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Famotidine; Histamine H2 Antagonists; Liver; Male; Midazolam; Perfusion; Ranitidine; Rats; Rats, Sprague-Dawley	1994
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. Pharmaceutical research, 1994, Volume: 11, Issue:6 Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine	1994
Quantitative prediction of the interaction of midazolam and histamine H2 receptor antagonists in rats. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:4 Topics: Animals; Area Under Curve; Cimetidine; Drug Interactions; Half-Life; Histamine H2 Antagonists; Liver; Male; Metabolic Clearance Rate; Midazolam; Models, Biological; Nizatidine; Rats; Rats, Wistar	1998
Prediction of midazolam-CYP3A inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:4 Pt 1 Topics: Anesthetics, Intravenous; Animals; Aryl Hydrocarbon Hydroxylases; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Erythromycin; Humans; Intestinal Absorption; Itraconazole; Kinetics; Liver; Male; Microsomes, Liver; Midazolam; Models, Biological; Oxidoreductases, N-Demethylating; Portal Vein; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution	2001
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors	2001
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide	2006
Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. The Journal of veterinary medical science, 2009, Volume: 71, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Area Under Curve; Cats; Cimetidine; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Female; Half-Life; Hypnotics and Sedatives; Ketoconazole; Microsomes, Liver; Midazolam	2009
Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug-drug interactions via CYP3A metabolism and transporters. Clinical and translational science, 2023, Volume: 16, Issue:4 Topics: Cimetidine; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Humans; Itraconazole; Membrane Transport Proteins; Midazolam; Models, Biological; Pharmaceutical Preparations; Rifampin	2023