midazolam has been researched along with 6 beta-hydroxycortisol in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ | 1 |
| Watkins, PB | 1 |
| Desager, JP; Eeckhoudt, SL; Horsmans, Y; Leclercq, I; Robert, AR; Verbeeck, RK | 1 |
| Bertino, JS; Chen, YC; Gotzkowsky, SK; Kashuba, AD; Kulawy, RW; Nafziger, AN; Rocci, ML | 1 |
| Fenske, M | 1 |
| Cheng, ZN; Hu, ZY; Wu, D; Zhao, YS | 1 |
| Cheng, ZN; Hu, ZY; Li, XM; Luo, X | 1 |
| Inui, N; Morita, H; Nakamura, H; Takahashi, N; Takeuchi, K; Uchida, S; Watanabe, H | 1 |
| Alessi, F; Dingemanse, J; Hoch, M; Hoever, P; Theodor, R | 1 |
| Andersson, TB; Bäckström, T; Bertilsson, L; Björkhem-Bergman, L; Bredberg, E; Diczfalusy, U; Nylén, H; Rönquist-Nii, Y | 2 |
| Cho, JY; Choi, MH; Jang, IJ; Lim, KS; Shin, KH; Yu, KS | 1 |
| Beaton, MD; Choi, YH; Dresser, GK; Gryn, SE; Kim, RB; Tirona, RG; Woolsey, SJ | 1 |
| Ahn, LY; Cho, JY; Choi, MH; Jang, IJ; Lee, J; Moon, JY; Shin, KH; Yu, KS | 1 |
| Chan, SW; Chu, TT; Fok, BS; Hu, M; Lee, VH; Tomlinson, B; Xiao, Y; Yin, OQ | 1 |
| Chen, Y; Dean, B; Fan, P; Hop, CECA; Ismaili, MHA; Mao, J; Wang, J; Wong, S; Wright, M | 1 |
| Hasegawa, M; Tahara, H; Watanabe, M | 1 |
| Berger, B; Dingemanse, J; Kaufmann, P; Koch, A | 1 |
1 review(s) available for midazolam and 6 beta-hydroxycortisol
| Article | Year |
|---|---|
Noninvasive tests of CYP3A enzymes.
Topics: Animals; Breath Tests; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Hydrocortisone; Lidocaine; Liver; Midazolam; Nifedipine | 1994 |
9 trial(s) available for midazolam and 6 beta-hydroxycortisol
| Article | Year |
|---|---|
Midazolam and cortisol metabolism before and after CYP3A induction in humans.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; GABA Modulators; Humans; Hydrocortisone; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Predictive Value of Tests; Rifampin | 2001 |
Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism.
Topics: Clarithromycin; Cross-Over Studies; Cytochrome P-450 CYP3A; Female; Humans; Hydrocortisone; Male; Midazolam; Young Adult | 2009 |
Effect of thyroid hormone on the activity of CYP3A enzyme in humans.
Topics: Adult; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Hydrocortisone; Male; Midazolam; Middle Aged; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine | 2010 |
Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects.
Topics: Acetamides; Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Germany; Half-Life; Humans; Hydrocortisone; Hydroxylation; Isoquinolines; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Simvastatin; Substrate Specificity; Young Adult | 2013 |
Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.
Topics: Adult; Biomarkers; Cholesterol; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Humans; Hydrocortisone; Hydroxycholesterols; Male; Metabolic Clearance Rate; Midazolam; Rifampin | 2013 |
Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.
Topics: Adult; Biomarkers; Cortisone; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hydroxycholesterols; Ketoconazole; Liver; Male; Metabolomics; Midazolam; Pharmacogenetics; Rifampin; Young Adult | 2013 |
Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydrocortisone; Hydroxycholesterols; Midazolam; Quinidine; Quinine; Rifampin | 2014 |
Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.
Topics: Administration, Intravenous; Administration, Oral; Adult; Biomarkers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Induction; Female; Humans; Hydrocortisone; Ketoconazole; Liver; Metabolic Clearance Rate; Metabolomics; Midazolam; Middle Aged; Rifampin; Young Adult | 2016 |
Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects.
Topics: Adult; Area Under Curve; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Healthy Volunteers; Humans; Hydrocortisone; Male; Midazolam; Middle Aged; Orexin Receptor Antagonists; Orexin Receptors; Young Adult | 2020 |
8 other study(ies) available for midazolam and 6 beta-hydroxycortisol
| Article | Year |
|---|---|
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity | 1999 |
Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity.
Topics: Adult; Biomarkers; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Fluvoxamine; Humans; Hydrocortisone; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Midazolam; Phenotype | 2006 |
Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity: a comment.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Humans; Hydrocortisone; Liver; Midazolam; Phenotype | 2007 |
Endogenous cortisol 6 beta-hydroxylation clearance is not an accurate probe for overall cytochrome P450 3A phenotyping in humans.
Topics: Administration, Oral; Cytochrome P-450 CYP3A; Female; Humans; Hydrocortisone; Hydroxylation; Male; Midazolam; Phenotype; Time Factors | 2009 |
Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome P450 3A Activity and Single-Time-Point Oral Midazolam Microdose Phenotype in Healthy Subjects.
Topics: Administration, Oral; Adult; Biomarkers; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Humans; Hydrocortisone; Hydroxycholesterols; Linear Models; Male; Metabolic Clearance Rate; Midazolam; Polymorphism, Single Nucleotide | 2016 |
Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese.
Topics: Adult; Asian People; Biomarkers; Cross-Over Studies; Cytochrome P-450 CYP3A; Genotype; Humans; Hydrocortisone; Male; Midazolam; Polymorphism, Genetic; Tacrolimus; Young Adult | 2016 |
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Topics: Administration, Oral; Animals; Computer Simulation; Cytochrome P-450 CYP3A; Drug Discovery; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hydroxycholesterols; Liver; Macaca fascicularis; Midazolam; Models, Biological; Pharmacokinetics; Rifampin; RNA, Messenger | 2017 |
A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys.
Topics: Alprazolam; Animals; Area Under Curve; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Drug Interactions; Hydrocortisone; Hydroxycholesterols; Macaca fascicularis; Male; Midazolam; Rifampin; Triazolam | 2019 |