Page last updated: 2024-08-24

mibefradil and pimozide

mibefradil has been researched along with pimozide in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (10.34)	18.2507
2000's	17 (58.62)	29.6817
2010's	9 (31.03)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Keserü, GM	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Caron, G; Ermondi, G; Visentin, S	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Back, SK; Choo, HY; Kam, YL; Na, HS; Rhee, HK; Rhim, H	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Baek, du J; Cho, YS; Choi, YH; Lee, JK; Min, SJ; Pae, AN; Seo, SH	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN	1
Arnoult, C; Florman, HM; Villaz, M	1
Garcia, MA; Meizel, S	1
Capponi, AM; Ertel, EA; Rossier, MF; Vallotton, MB	1
Ceric, F; Kerr, B; Kong, M; Morales, P; Pizarro, E; Vigil, P	1
Baldi, E; Bonaccorsi, L; Forti, G	1
Barnes, S; Bertolesi, GE; Elbaum, L; Jollimore, C; Kelly, ME; Rozenberg, G; Shi, C	1
Haynes, J; Li, M; Obiako, BO; Stevens, T; Stubbs, JR; Taylor, JT; Wu, S	1
Feng, MG; Li, M; Navar, LG	1
Connolly, TM; Figueroa, DJ; Lawlor, AM; Liang, HA; Liu, Y; Salata, JJ; Xia, M	1
Holstein-Rathlou, NH; Jensen, BL; Jensen, LJ; Salomonsson, M	1
Bancila, M; Bijlenga, P; Copin, JC; Daali, Y; Gasche, Y; Schatlo, B	1

Other Studies

29 other study(ies) available for mibefradil and pimozide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity. Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16 Topics: Analgesics; Animals; Calcium Channels, T-Type; Humans; Neuralgia; Pain Measurement; Piperazines; Rats	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers. Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 Topics: Benzhydryl Compounds; Calcium Channel Blockers; Calcium Channels, T-Type; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Piperazines; Structure-Activity Relationship	2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chemical biology & drug design, 2016, Volume: 88, Issue:6 Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain	2016
Pharmacological properties of the T-type Ca2+ current of mouse spermatogenic cells. Molecular pharmacology, 1998, Volume: 53, Issue:6 Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels; Male; Mibefradil; Mice; Nickel; Pimozide; Spermatozoa; Tetrahydronaphthalenes	1998
Progesterone-mediated calcium influx and acrosome reaction of human spermatozoa: pharmacological investigation of T-type calcium channels. Biology of reproduction, 1999, Volume: 60, Issue:1 Topics: Acrosome Reaction; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calmodulin; Dopamine Antagonists; Fluorescent Dyes; Fura-2; Humans; Imidazoles; Male; Mibefradil; Pimozide; Progesterone; Sperm Capacitation; Sperm Motility; Spermatozoa; Tetrahydronaphthalenes	1999
Inhibitory action of mibefradil on calcium signaling and aldosterone synthesis in bovine adrenal glomerulosa cells. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3 Topics: Aldosterone; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Cytosol; Mibefradil; Nicardipine; Patch-Clamp Techniques; Pimozide; Potassium Chloride; Signal Transduction; Tetrahydronaphthalenes; Zona Glomerulosa	1998
Gonadotropin-releasing hormone-stimulated sperm binding to the human zona is mediated by a calcium influx. Biology of reproduction, 2000, Volume: 63, Issue:2 Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Egtazic Acid; Female; Gonadotropin-Releasing Hormone; Humans; Male; Mibefradil; Nifedipine; Pimozide; Sperm-Ovum Interactions; Spermatozoa; Verapamil; Zona Pellucida	2000
Low-voltage-activated calcium channels are not involved in capacitation and biological response to progesterone in human sperm. International journal of andrology, 2001, Volume: 24, Issue:6 Topics: Amiloride; Calcium Channel Blockers; Calcium Channels; Fluoresceins; Humans; Ion Channel Gating; Male; Mibefradil; Phosphorylation; Pimozide; Progesterone; Sperm Capacitation; Tyrosine	2001
The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Molecular pharmacology, 2002, Volume: 62, Issue:2 Topics: Antineoplastic Agents; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Cycle; Cell Division; Drug Interactions; Humans; Mibefradil; Pimozide; Tumor Cells, Cultured	2002
Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation. Circulation research, 2003, Aug-22, Volume: 93, Issue:4 Topics: Amino Acid Sequence; Anemia, Sickle Cell; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Erythrocytes, Abnormal; Flunarizine; Lung; Membrane Potentials; Mibefradil; Microcirculation; Molecular Sequence Data; Neurotoxins; Nickel; Pimozide; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Scorpion Venoms; Sequence Homology, Amino Acid	2003
T-type calcium channels in the regulation of afferent and efferent arterioles in rats. American journal of physiology. Renal physiology, 2004, Volume: 286, Issue:2 Topics: Animals; Arterioles; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Diltiazem; Dopamine Antagonists; Homeostasis; In Vitro Techniques; Male; Mibefradil; Pimozide; Potassium Chloride; Rats; Rats, Sprague-Dawley; Renal Circulation	2004
Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells. Journal of molecular and cellular cardiology, 2004, Volume: 36, Issue:1 Topics: Animals; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line; Electric Conductivity; Heart Atria; Ion Transport; Mibefradil; Mice; Myocytes, Cardiac; Nimodipine; Patch-Clamp Techniques; Pimozide; Potassium; Verapamil	2004
Depolarization-induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels. British journal of pharmacology, 2004, Volume: 142, Issue:4 Topics: Animals; Arterioles; Blotting, Southern; Calcium; Calcium Channels; Denmark; Elapid Venoms; Fluorescence; Fura-2; Gene Expression; Lanthanum; Male; Membrane Potentials; Mesenteric Arteries; Mibefradil; Muscle, Smooth, Vascular; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Phentolamine; Pimozide; Potassium Chloride; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Calcium Exchanger; Solutions; Spider Venoms; Tetrodotoxin	2004
Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats. Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:4 Topics: Animals; Brain; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Death; Cell Survival; Electrophysiological Phenomena; Glucose; HEK293 Cells; Humans; Hypoxia; Ischemic Attack, Transient; Lactic Acid; Male; Membrane Potentials; Mibefradil; Neurons; Neuroprotective Agents; Pimozide; Rats; Rats, Sprague-Dawley; Survival Analysis; Tissue Culture Techniques; Transfection	2011