Compounds > mibefradil
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mibefradil and nnc 55-0396

mibefradil has been researched along with nnc 55-0396 in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.11)29.6817
2010's15 (83.33)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Hansen, JB; Huang, L; Keyser, BM; Li, M; Ragsdale, DS; Tagmose, TM; Taylor, JT; Zhang, M; Zhuang, H1
Hansen, JB; Huang, L; Keyser, BM; Li, M; Taylor, JT1
Docherty, JR; Seto, SW1
Bui, PH; Handforth, A; Hankinson, O; Homanics, GE; Quesada, A1
Brenker, C; Goodwin, N; Kashikar, ND; Kaupp, UB; Seifert, R; Strünker, T; Weyand, I1
Li, M; Li, W; Wang, N; Zhang, BB; Zhang, SL1
Huang, CS; Kuo, CC; Pan, MK; Tai, CH; Yang, YC1
Brenker, C; Goodwin, N; Kashikar, ND; Kaupp, UB; Krähling, M; Müller, A; Naruse, M; Strünker, T; Weyand, I1
Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T1
Akerman, KE; Castrén, ML; Hakala, E; Jansson, LC; Louhivuori, LM; Louhivuori, V; Nordström, T; Wigren, HK1
Barratt, CL; Mansell, S; Publicover, SJ; Ramalho-Santos, J; Tavares, RS; Wilson, SM1
de Diego, AM; Fernández-Morales, JC; Fernando Padín, J; García, AG; Musial, DC; Vestring, S1
Kumamoto, N; Shibata, Y; Shimada, S; Ueda, T; Ugawa, S; Watanabe, M1
Chen, Y; Huang, W; Lu, C; Ouyang, S; Wu, Y1
Álvarez-Rodríguez, M; Rodríguez-Martínez, H; Vicente-Carrillo, A1
Chávez, JC; Darszon, A; De la Vega-Beltrán, JL; José, O; Nishigaki, T; Torres, P; Treviño, CL1
Cronin, S; Donnellan, E; Fair, S; Romero-Aguirregomezcorta, J1
Chen, Z; Edwards, A; Lee, GY; Li, M; Lu, Y; Zhang, K; Zhao, N1

Other Studies

18 other study(ies) available for mibefradil and nnc 55-0396

ArticleYear
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1

    Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Cells, Cultured; Cyclopropanes; Electrophysiology; Humans; Mass Spectrometry; Mibefradil; Naphthalenes; Rats

2004
Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396.
    Cardiovascular drug reviews, 2005,Summer, Volume: 23, Issue:2

    Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Cyclopropanes; Drug Design; Humans; Mibefradil; Naphthalenes

2005
Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens.
    British journal of pharmacology, 2010, Volume: 159, Issue:6

    Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Electric Stimulation; Epididymis; Isometric Contraction; Male; Mibefradil; Mice; Mice, Inbred C57BL; Muscle, Smooth; Naphthalenes; Prostate; Rats; Rats, Wistar; Thalidomide; Vas Deferens

2010
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
    European journal of pharmacology, 2011, May-20, Volume: 659, Issue:1

    Topics: Animals; Behavior, Animal; Benzimidazoles; Cyclopropanes; Cytochrome P-450 Enzyme System; Disease Models, Animal; Essential Tremor; Gene Deletion; Harmaline; Hydroxylation; Methylation; Mibefradil; Mice; Naphthalenes; Receptors, GABA-A; Structure-Activity Relationship; Testosterone

2011
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.
    Nature, 2011, Mar-17, Volume: 471, Issue:7338

    Topics: Alprostadil; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclopropanes; Electric Conductivity; Humans; Hydrogen-Ion Concentration; Male; Mibefradil; Naphthalenes; Patch-Clamp Techniques; Progesterone; Spermatozoa

2011
Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.
    Cancer investigation, 2011, Volume: 29, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line, Tumor; Cell Proliferation; Chi-Square Distribution; Cyclopropanes; Female; Humans; Mibefradil; Mice; Mice, Nude; Naphthalenes; Ovarian Neoplasms; RNA Interference; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2011
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:8

    Topics: Animals; Benzimidazoles; Cadmium; Calcium; Calcium Channels, T-Type; Cyclopropanes; Dihydropyridines; Disease Models, Animal; Electrophysiology; Male; Mibefradil; Movement; Naphthalenes; Neurons; Nickel; Nitrophenols; Organophosphorus Compounds; Parkinson Disease; Rats; Rats, Wistar

2011
The CatSper channel: a polymodal chemosensor in human sperm.
    The EMBO journal, 2012, Apr-04, Volume: 31, Issue:7

    Topics: Aldehydes; Benzimidazoles; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclopropanes; Humans; Male; Mibefradil; Naphthalenes; Pheromones; Receptors, G-Protein-Coupled; Spermatozoa

2012
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
    British journal of pharmacology, 2012, Volume: 167, Issue:4

    Topics: Acetanilides; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclophosphamide; Cyclopropanes; Cystathionine gamma-Lyase; Cystitis; Disease Models, Animal; Female; Ganglia, Spinal; Hydrogen Sulfide; Mibefradil; Mice; Naphthalenes; Organ Size; Pain; Purines; Transient Receptor Potential Channels; TRPA1 Cation Channel; Urinary Bladder; Verapamil

2012
Role of low voltage activated calcium channels in neuritogenesis and active migration of embryonic neural progenitor cells.
    Stem cells and development, 2013, Apr-15, Volume: 22, Issue:8

    Topics: Animals; Barium; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Cell Movement; Cells, Cultured; Cyclopropanes; Embryonic Stem Cells; Fura-2; Membrane Potentials; Mibefradil; Mice; Microscopy, Confocal; Naphthalenes; Neural Stem Cells; Neurites; Neurons; Nifedipine; Patch-Clamp Techniques; Time-Lapse Imaging

2013
p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:12

    Topics: Benzimidazoles; Calcium; Calcium Channels; Calcium Signaling; Cell Survival; Cyclopropanes; Dichlorodiphenyl Dichloroethylene; Endocrine Disruptors; Humans; In Vitro Techniques; Male; Mibefradil; Naphthalenes; Spermatozoa

2013
Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life.
    European journal of pharmacology, 2015, Mar-15, Volume: 751

    Topics: Animals; Animals, Newborn; Barium; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Cell Hypoxia; Chromaffin Cells; Cyclopropanes; Cytosol; Dose-Response Relationship, Drug; Exocytosis; Membrane Potentials; Mibefradil; Naphthalenes; Nickel; Potassium; Rats; Signal Transduction

2015
Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Analgesics; Animals; Benzimidazoles; Calcium Channels, T-Type; Cyclopropanes; Ganglia, Spinal; Hyperalgesia; Inflammation; Mibefradil; Mice; Naphthalenes; Neuralgia; Neurons

2015
T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.
    Journal of experimental & clinical cancer research : CR, 2015, May-21, Volume: 34

    Topics: Apoptosis; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopropanes; Endoplasmic Reticulum; Humans; Leukemia; Leukocytes, Mononuclear; MAP Kinase Signaling System; Mibefradil; Naphthalenes

2015
The CatSper channel modulates boar sperm motility during capacitation.
    Reproductive biology, 2017, Volume: 17, Issue:1

    Topics: Acrosome; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclopropanes; Hydrolases; Intracellular Membranes; Male; Mibefradil; Microscopy, Confocal; Naphthalenes; Progesterone; Protein Subunits; Protein Transport; Sodium Bicarbonate; Sperm Capacitation; Sperm Motility; Spermatozoa; Sus scrofa; Sweden

2017
Acrosomal alkalization triggers Ca
    Journal of cellular physiology, 2018, Volume: 233, Issue:6

    Topics: Acrosome; Acrosome Reaction; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclopropanes; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Male; Mibefradil; Mice; Naphthalenes

2018
Progesterone induces the release of bull spermatozoa from oviductal epithelial cells.
    Reproduction, fertility, and development, 2019, Volume: 31, Issue:9

    Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Signaling; Cattle; Cyclopropanes; Epithelial Cells; Female; Hormone Antagonists; Male; Mibefradil; Mifepristone; Naphthalenes; Oviducts; Progesterone; Receptors, Progesterone; Sperm Capacitation; Sperm Motility; Spermatozoa

2019
Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:3

    Topics: Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Humans; Mibefradil; Models, Molecular; Naphthalenes

2021