Page last updated: 2024-08-24

mibefradil and flunarizine

mibefradil has been researched along with flunarizine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Back, SK; Choo, HY; Kam, YL; Na, HS; Rhee, HK; Rhim, H1
Baek, du J; Cho, YS; Choi, YH; Lee, JK; Min, SJ; Pae, AN; Seo, SH1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN1
Haynes, J; Li, M; Obiako, BO; Stevens, T; Stubbs, JR; Taylor, JT; Wu, S1
Akaike, N; Kim, CJ; Min, BI; Ogawa, S; Shin, MC; Tanaka, E1
Amobi, N; Guillebaud, J; Smith, CH1
Capuano, V; Ferron, L; Renaud, JF; Ruchon, Y; Sankhe, S1

Other Studies

9 other study(ies) available for mibefradil and flunarizine

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Analgesics; Animals; Calcium Channels, T-Type; Humans; Neuralgia; Pain Measurement; Piperazines; Rats

2010
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Benzhydryl Compounds; Calcium Channel Blockers; Calcium Channels, T-Type; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Piperazines; Structure-Activity Relationship

2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
    Chemical biology & drug design, 2016, Volume: 88, Issue:6

    Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain

2016
Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation.
    Circulation research, 2003, Aug-22, Volume: 93, Issue:4

    Topics: Amino Acid Sequence; Anemia, Sickle Cell; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Erythrocytes, Abnormal; Flunarizine; Lung; Membrane Potentials; Mibefradil; Microcirculation; Molecular Sequence Data; Neurotoxins; Nickel; Pimozide; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Scorpion Venoms; Sequence Homology, Amino Acid

2003
A selective T-type Ca2+ channel blocker R(-) efonidipine.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:4-6

    Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, T-Type; Dihydropyridines; Dose-Response Relationship, Drug; Flunarizine; Mibefradil; Nitrophenols; Nystatin; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Pyramidal Cells; Rats; Rats, Wistar; Sodium Channels

2008
Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens.
    BJU international, 2010, Volume: 106, Issue:4

    Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Flunarizine; Humans; Male; Mibefradil; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Pyrroles; Vas Deferens

2010
T-type Ca²⁺ signalling downregulates MEK1/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes.
    Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:2

    Topics: Animals; Calcium Signaling; Flunarizine; Fluoxetine; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mibefradil; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Nifedipine; Phosphorylation; Rats; Rats, Wistar; Receptors, Glucocorticoid; Renin-Angiotensin System; Spironolactone

2012