mf-438 and pyridazine

mf-438 has been researched along with pyridazine* in 1 studies

Other Studies

1 other study(ies) available for mf-438 and pyridazine

Article	Year
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2 A series of stearoyl-CoA desaturase 1 (SCD1) inhibitors were developed. Investigations of enzyme potency and metabolism led to the identification of the thiadiazole-pyridazine derivative MF-438 as a potent SCD1 inhibitor. MF-438 exhibits good pharmacokinetics and metabolic stability, thereby serving as a valuable tool for further understanding the role of SCD inhibition in biological and pharmacological models of diseases related to metabolic disorders. Topics: Administration, Oral; Animals; Enzyme Inhibitors; Mice; Microsomes, Liver; Pyridazines; Rats; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Thiadiazoles	2010

Article

Year

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2

A series of stearoyl-CoA desaturase 1 (SCD1) inhibitors were developed. Investigations of enzyme potency and metabolism led to the identification of the thiadiazole-pyridazine derivative MF-438 as a potent SCD1 inhibitor. MF-438 exhibits good pharmacokinetics and metabolic stability, thereby serving as a valuable tool for further understanding the role of SCD inhibition in biological and pharmacological models of diseases related to metabolic disorders.

Topics: Administration, Oral; Animals; Enzyme Inhibitors; Mice; Microsomes, Liver; Pyridazines; Rats; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Thiadiazoles

2010