Compounds > mevastatin
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mevastatin and simvastatin

mevastatin has been researched along with simvastatin in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.44)18.7374
1990's5 (12.20)18.2507
2000's21 (51.22)29.6817
2010's13 (31.71)24.3611
2020's1 (2.44)2.80

Authors

AuthorsStudies
Alberts, AW; Bostedor, R; Chao, YS; Duggan, ME; Fitzpatrick, SL; Halczenko, W; Hartman, GD; Imagire, JS; Pitzenberger, SM; Smith, RL1
Aparna, V; Chakraborti, AK; Gopalakrishnan, B; Kumar, R; Sobhia, ME; Thilagavathi, R1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Baret, E; Briolant, S; Fontaine, A; Fusai, T; Henry, M; Mosnier, J; Pradines, B; Rogier, C; Torrentino-Madamet, M1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Behnam, MA; Boldescu, V; Klein, CD; Nitsche, C1
Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L1
Mahoney, EM; Ranadive, SA; Serajuddin, AT1
Hasegawa, K; Koga, T; Kuroda, M; Shimada, Y; Tsujita, Y; Yamazaki, M1
Tobert, JA1
Carmena, R1
Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M1
Bastarda, A; Grahek, R; Kracun, M; Milivojevic, D1
Hamakubo, T; Inoue, K; Kitahara, M; Kodama, T; Morikawa, S; Nakagawa, S; Saito, Y; Suganami, H; Umetani, M; Yamazaki, H1
Altieri, PI; Crespo, MJ; Escobales, N; Furilla, RA1
Darvesh, S; Martin, E; Rockwood, K; Walsh, R1
Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H1
Dimmeler, S; Haendeler, J; Hoffmann, J; Zeiher, AM1
Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y1
Bastemir, M; Emral, R; Gullu, S; Lazarus, JH; Parkes, AB1
Chihara, K; Kaji, H; Kanatani, M; Sugimoto, T1
Boucher, K; Hauschka, PV; Sharma, P; Siegel, CS; Solomon, KR1
Crespo, MJ; Quidgley, JA1
Betta, PG; Bosia, A; Ghigo, D; Orecchia, S; Pescarmona, G; Riganti, C1
Gurbanov, E; Shiliang, X1
Antoun, TA; Badr, KF; Badreddine, R; Bertoglio, J; Habib, A; Nasrallah, MS; Nemer, G; Shamseddeen, I1
Sylvester, PW; Wali, VB1
Clynes, M; Eustace, AJ; Glynn, SA; O'Donovan, N; O'Sullivan, D1
Chihara, K; Inoue, Y; Kaji, H; Naito, J; Sowa, H; Sugimoto, T1
Fitzgerald, K; Kashanin, D; O'Dowd, F; Robinson, AJ; Walsh, GM; Williams, V1
Barrios-González, J; Miranda, RU1
Campbell, CD; Vederas, JC1
Barter, MJ; Catterall, JB; Cawston, TE; Hui, W; Lakey, RL; Young, DA1
Gander, H; Gruenbacher, G; Nussbaumer, O; Nussbaumer, W; Rahm, A; Thurnher, M1
Bosia, A; Couraud, P; Garzón, R; Ghigo, D; Pinzón-Daza, M; Riganti, C; Romero, Ia; Weksler, B1
Bosch, J; García-Cardeña, G; García-Pagán, JC; Gracia-Sancho, J; Hide, D; Marrone, G; Rosado, E; Russo, L1
Baumgarten, G; Frede, S; Hilbert, T; Hoeft, A; Klaschik, S; Knuefermann, P; Poth, J1
Bai, Y; Chan, C; Chang, X; Cheng, N; Cheng, Z; Lu, Y; Zhao, Y1
Battaglia, RA; Herrmann, H; Kabiraj, P; Madden, VJ; Snider, NT; Trogden, KP1
Du Plessis, J; Du Plessis, LH; Du Preez, JL; Gerber, M; Marais, S1
Beton, K; Brożek-Płuska, B1

Reviews

6 review(s) available for mevastatin and simvastatin

ArticleYear
The Medicinal Chemistry of Dengue Virus.
    Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12

    Topics: Antiviral Agents; Chemistry, Pharmaceutical; Dengue; Dengue Virus; Humans; Molecular Conformation; Structure-Activity Relationship

2016
[Cardiovascular pharmacology (VIII). The role of HMG CoA reductase inhibitors in the current treatment of hyperlipidemias].
    Revista espanola de cardiologia, 1995, Volume: 48, Issue:1

    Topics: Anticholesteremic Agents; Cardiovascular System; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lipoproteins; Lovastatin; Pravastatin; Simvastatin

1995
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2006, Volume: 30, Issue:3

    Topics: Apoptosis; Dichloroacetic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lovastatin; MAP Kinase Kinase Kinase 5; Microtubule-Associated Proteins; Muscle, Smooth, Vascular; Neoplasm Proteins; Pancreatic Elastase; PPAR gamma; Protein Serine-Threonine Kinases; Pulmonary Circulation; Receptor, Bradykinin B2; rho-Associated Kinases; Simvastatin; Survivin; Thrombosis; Vasoconstriction

2006
Biotechnological production and applications of statins.
    Applied microbiology and biotechnology, 2010, Volume: 85, Issue:4

    Topics: Acyltransferases; Anticholesteremic Agents; Aspergillus; Biotechnology; Fermentation; Lovastatin; Pravastatin; Simvastatin

2010
Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes.
    Biopolymers, 2010, Volume: 93, Issue:9

    Topics: Cytochalasins; Lactones; Lovastatin; Polyketide Synthases; Pyrrolidinones; RNA, Catalytic; Simvastatin; Tetrahydronaphthalenes

2010
Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis.
    Atherosclerosis, 2016, Volume: 254

    Topics: Anticholesteremic Agents; Atorvastatin; Bayes Theorem; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney Diseases; Lipids; Lovastatin; Muscles; Network Meta-Analysis; Patient Safety; Pravastatin; Quinolines; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome

2016

Trials

2 trial(s) available for mevastatin and simvastatin

ArticleYear
New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
    Circulation, 1987, Volume: 76, Issue:3

    Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Clinical Trials as Topic; Dogs; Double-Blind Method; Drug Evaluation; Drug Tolerance; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, HDL; Lipoproteins, VLDL; Lovastatin; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Triglycerides

1987
In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis.
    European journal of endocrinology, 2005, Volume: 153, Issue:1

    Topics: Adult; Apoptosis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Lymphocytes; Male; Middle Aged; Pravastatin; Pyridines; Simvastatin; Thyroid Gland; Thyroiditis, Autoimmune

2005

Other Studies

33 other study(ies) available for mevastatin and simvastatin

ArticleYear
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.
    Journal of medicinal chemistry, 1992, Oct-16, Volume: 35, Issue:21

    Topics: Administration, Oral; Animals; Anticholesteremic Agents; Disease Models, Animal; Dogs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Magnetic Resonance Spectroscopy; Rats; Simvastatin; Structure-Activity Relationship

1992
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).
    Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4

    Topics: Binding Sites; Crystallography, X-Ray; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Pyrroles; Quantitative Structure-Activity Relationship

2005
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Animals; Antimalarials; Atorvastatin; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Inhibitory Concentration 50; Malaria, Falciparum; Microbial Sensitivity Tests; Plasmodium falciparum; Pyrroles; Structure-Activity Relationship

2007
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship

2016
Relative lipophilicities, solubilities, and structure-pharmacological considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin.
    Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:9

    Topics: Anticholesteremic Agents; Chromatography, High Pressure Liquid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Simvastatin; Solubility; Structure-Activity Relationship

1991
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
    Biochimica et biophysica acta, 1990, Jul-16, Volume: 1045, Issue:2

    Topics: Acetates; Acetic Acid; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; Kinetics; L Cells; Lens, Crystalline; Liver; Lovastatin; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Pravastatin; Rats; Simvastatin; Spleen

1990
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
    Biochemical and biophysical research communications, 2000, May-19, Volume: 271, Issue:3

    Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured

2000
Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
    Journal of chromatography. A, 2001, May-25, Volume: 918, Issue:2

    Topics: Chromatography, High Pressure Liquid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Simvastatin; Spectrophotometry, Ultraviolet

2001
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.
    Journal of atherosclerosis and thrombosis, 2000, Volume: 7, Issue:3

    Topics: Atorvastatin; Cell Line; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Pravastatin; Pyrroles; Quinolines; Receptors, LDL; RNA, Messenger; Simvastatin

2000
Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins.
    Journal of hypertension, 1996, Volume: 14, Issue:1

    Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Collagen Type VIII; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Lovastatin; Male; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstrictor Agents

1996
Differential effects of lipid-lowering agents on human cholinesterases.
    Clinical biochemistry, 2004, Volume: 37, Issue:1

    Topics: Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Dementia; Humans; Hypolipidemic Agents; Lovastatin; Molecular Structure; Pravastatin; Simvastatin

2004
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:8

    Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin

2004
Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins.
    Circulation, 2004, Aug-17, Volume: 110, Issue:7

    Topics: Amino Acid Substitution; Antioxidants; Atorvastatin; Cells, Cultured; Cysteine; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Pyrroles; Reactive Oxygen Species; Recombinant Fusion Proteins; S-Nitrosothiols; Simvastatin; Thioredoxins; Transfection; Umbilical Veins

2004
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
    The Journal of biological chemistry, 2004, Nov-12, Volume: 279, Issue:46

    Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha

2004
Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2005, Volume: 37, Issue:10

    Topics: Animals; Bone Resorption; Calcitriol; Carrier Proteins; Cell Differentiation; Cells, Cultured; Glycoproteins; Lovastatin; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Osteoclasts; Osteogenesis; Osteoprotegerin; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; RNA, Messenger; Simvastatin

2005
HMG-CoA reductase inhibitors induce apoptosis in pericytes.
    Microvascular research, 2006, Volume: 71, Issue:2

    Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lung; Male; Mice; Mice, Inbred BALB C; Morpholines; Pericytes; Simvastatin; Time Factors

2006
Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro.
    Pharmacology, 2006, Volume: 76, Issue:3

    Topics: Animals; Atorvastatin; Coronary Vessels; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Male; Pravastatin; Pyrroles; Serotonin; Simvastatin; Swine; Time Factors; Vasoconstriction

2006
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.
    International journal of cancer, 2006, Jul-01, Volume: 119, Issue:1

    Topics: Amides; Antibiotics, Antineoplastic; Bacterial Proteins; Bacterial Toxins; Blotting, Western; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mesothelioma; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pyridines; Simvastatin

2006
Modulation of COX-2 expression by statins in human monocytic cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:8

    Topics: Cyclooxygenase 2; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Membrane Proteins; Mevalonic Acid; Monocytes; NF-kappa B; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Simvastatin; U937 Cells

2007
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.
    Lipids, 2007, Volume: 42, Issue:12

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mammary Neoplasms, Animal; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Proto-Oncogene Proteins c-akt; Simvastatin; Vitamin E

2007
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.
    BMC cancer, 2008, Jan-16, Volume: 8

    Topics: Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Lung Neoplasms; Male; Melanoma; Neoplasm Invasiveness; Simvastatin; Skin Neoplasms

2008
Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:11

    Topics: Alendronate; Animals; Apoptosis; Cell Line; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Osteoblasts; Quinolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Smad3 Protein; Transforming Growth Factor beta

2008
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:12

    Topics: Antibodies, Monoclonal; Apoptosis; Cell Adhesion; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Eosinophils; Fatty Acids, Monounsaturated; Fluvastatin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Microfluidic Analytical Techniques; Microfluidics; Pravastatin; Recombinant Proteins; Simvastatin; Vascular Cell Adhesion Molecule-1

2009
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
    Annals of the rheumatic diseases, 2010, Volume: 69, Issue:12

    Topics: Animals; Cartilage, Articular; Cattle; Cells, Cultured; Collagen; Collagenases; Down-Regulation; Gelatinases; Gene Expression Regulation, Enzymologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1alpha; Lovastatin; Matrix Metalloproteinases; Mevalonic Acid; Nasal Cartilages; Oncostatin M; Signal Transduction; Simvastatin; Terpenes; Tissue Culture Techniques

2010
IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells.
    Cancer research, 2010, Dec-01, Volume: 70, Issue:23

    Topics: Apoptosis; Caspase 1; CD56 Antigen; Cell Line, Tumor; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Humans; Interferon-gamma; Interleukin-18; Interleukin-1beta; Interleukin-2; Killer Cells, Natural; Leukocytes, Mononuclear; Lovastatin; Lymphocyte Activation; Molecular Structure; Simvastatin; Time Factors

2010
The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.
    British journal of pharmacology, 2012, Volume: 167, Issue:7

    Topics: ATP-Binding Cassette Transporters; Blood-Brain Barrier; Cell Line; Cell Line, Tumor; Doxorubicin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liposomes; Lovastatin; NF-kappa B; Nitric Oxide Synthase; Nitrites; Receptors, LDL; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin

2012
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
    Journal of hepatology, 2013, Volume: 58, Issue:1

    Topics: Animals; Atorvastatin; Cell Communication; Disease Models, Animal; Endothelial Cells; Gene Expression; Hepatic Stellate Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Kruppel-Like Transcription Factors; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Lovastatin; Male; Paracrine Communication; Pyrroles; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical

2013
Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells.
    Biochemical pharmacology, 2013, Nov-15, Volume: 86, Issue:10

    Topics: Acyl Coenzyme A; Angiopoietin-2; Atherosclerosis; Cell Survival; Cells, Cultured; Endothelial Cells; Exocytosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Simvastatin; Weibel-Palade Bodies

2013
An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:5

    Topics: Adrenal Gland Neoplasms; Breast Neoplasms; Cell Death; Female; Humans; Lovastatin; MCF-7 Cells; Microscopy, Fluorescence; Neoplasm Proteins; Simvastatin; Vimentin

2018
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution.
    Die Pharmazie, 2019, 11-01, Volume: 74, Issue:11

    Topics: Chromatography, High Pressure Liquid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Rosuvastatin Calcium; Simvastatin; Skin Absorption

2019
Biochemistry and Nanomechanical Properties of Human Colon Cells upon Simvastatin, Lovastatin, and Mevastatin Supplementations: Raman Imaging and AFM Studies.
    The journal of physical chemistry. B, 2022, 09-22, Volume: 126, Issue:37

    Topics: Biomarkers, Tumor; Caco-2 Cells; Colon; Dietary Supplements; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Microscopy, Atomic Force; Simvastatin

2022