mevastatin has been researched along with pravastatin in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.88) | 18.7374 |
| 1990's | 10 (24.39) | 18.2507 |
| 2000's | 19 (46.34) | 29.6817 |
| 2010's | 10 (24.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L | 1 |
| Mahoney, EM; Ranadive, SA; Serajuddin, AT | 1 |
| Matsuoka, T; Serizawa, N | 1 |
| Endo, A | 1 |
| Hasegawa, K; Koga, T; Kuroda, M; Shimada, Y; Tsujita, Y; Yamazaki, M | 1 |
| Matsuoka, T; Nakahara, K; Serizawa, N | 1 |
| Hosobuchi, M; Matsuoka, T; Miyakoshi, S; Nakahara, K; Serizawa, N; Tanzawa, K | 1 |
| Tobert, JA | 1 |
| Carmena, R | 1 |
| Badimon, L; Martínez-González, J | 1 |
| Demain, AL; Peng, Y; Yashphe, J | 1 |
| Serizawa, N; Watanabe, I | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
| Honda, H; Kobayashi, T | 1 |
| Naito, A | 1 |
| Bastarda, A; Grahek, R; Kracun, M; Milivojevic, D | 1 |
| Hamakubo, T; Inoue, K; Kitahara, M; Kodama, T; Morikawa, S; Nakagawa, S; Saito, Y; Suganami, H; Umetani, M; Yamazaki, H | 1 |
| Cole, WC; Kumar, B; Prasad, KN | 1 |
| Fujita, T; Izumo, N; Koida, M; Nakamuta, H | 1 |
| Altieri, PI; Crespo, MJ; Escobales, N; Furilla, RA | 1 |
| Andreatta, C; Cole, WC; Edwards-Prasad, J; Koustas, WT; Kumar, B; Prasad, KN | 1 |
| Darvesh, S; Martin, E; Rockwood, K; Walsh, R | 1 |
| Kang, SM; Kim, YJ; Kwon, TJ; Lee, JK; Moon, SH; Park, JW; Park, YI; Suh, HH; Yi, DH | 1 |
| Baurand, A; Bergmann, MW; Dietz, R; El Jamali, A; Freund, C; Rechner, C | 1 |
| Bastemir, M; Emral, R; Gullu, S; Lazarus, JH; Parkes, AB | 1 |
| Crespo, MJ; Quidgley, JA | 1 |
| Chen, CH; Cho, YC; Hsu, WH; Hu, HY | 1 |
| Sylvester, PW; Wali, VB | 1 |
| George, J; Keren, G; Luboshits, G; Mausner-Fainberg, K; Maysel-Auslender, S; Mor, A; Rubinstein, A | 1 |
| Fujii, T; Fujii, Y; Ito, M; Machida, K; Ochiai, A | 1 |
| Fitzgerald, K; Kashanin, D; O'Dowd, F; Robinson, AJ; Walsh, GM; Williams, V | 1 |
| Barrios-González, J; Miranda, RU | 1 |
| Arisawa, A; Aritoku, Y; Fujii, T; Fujii, Y; Johdo, O; Kagawa, Y; Norihisa, K; Sallam, KI; Tamura, T | 1 |
| Lin, CL; Lin, SM; Tang, YL | 1 |
| Ba, L; Duan, Y; Li, P; Lin, Z; Zhang, H | 1 |
| Baumgarten, G; Frede, S; Hilbert, T; Hoeft, A; Klaschik, S; Knuefermann, P; Poth, J | 1 |
| Alarcon, VB; Marikawa, Y | 1 |
| Bai, Y; Chan, C; Chang, X; Cheng, N; Cheng, Z; Lu, Y; Zhao, Y | 1 |
| Abdulmughni, A; Bernhardt, R; Hartz, P; Kern, F; Milhim, M; Putkaradze, N | 1 |
| Hayashi, K; Ikushiro, S; Kamakura, M; Ohta, M; Sakaki, T; Shiro, Y; Sugimoto, H; Takita, T; Yasuda, K; Yasukawa, K | 1 |
6 review(s) available for mevastatin and pravastatin
| Article | Year |
|---|---|
[Cardiovascular pharmacology (VIII). The role of HMG CoA reductase inhibitors in the current treatment of hyperlipidemias].
Topics: Anticholesteremic Agents; Cardiovascular System; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lipoproteins; Lovastatin; Pravastatin; Simvastatin | 1995 |
Fuzzy control of bioprocess in Japan.
Topics: Alcoholic Beverages; Automation; Biotechnology; Fuzzy Logic; Japan; Lovastatin; Models, Theoretical; Pravastatin; Protein Precursors; Quality Control; Temperature | 2000 |
[Tracing the past half century of my microbial transformation studies].
Topics: History, 20th Century; Lovastatin; Microbiology; Pravastatin; Prednisolone; Streptomyces; Transformation, Bacterial; Xanthenes | 2000 |
Biotechnological production and applications of statins.
Topics: Acyltransferases; Anticholesteremic Agents; Aspergillus; Biotechnology; Fermentation; Lovastatin; Pravastatin; Simvastatin | 2010 |
Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis.
Topics: Anticholesteremic Agents; Atorvastatin; Bayes Theorem; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney Diseases; Lipids; Lovastatin; Muscles; Network Meta-Analysis; Patient Safety; Pravastatin; Quinolines; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome | 2016 |
Protein engineering of CYP105s for their industrial uses.
Topics: Actinobacteria; Amino Acid Substitution; Bacterial Proteins; Cholecalciferol; Conserved Sequence; Cytochrome P-450 Enzyme System; Ferredoxins; Gene Expression; Hydroxylation; Isoenzymes; Lovastatin; Molecular Docking Simulation; Mutation; Pravastatin; Protein Engineering; Streptomyces; Substrate Specificity | 2018 |
2 trial(s) available for mevastatin and pravastatin
| Article | Year |
|---|---|
New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Clinical Trials as Topic; Dogs; Double-Blind Method; Drug Evaluation; Drug Tolerance; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, HDL; Lipoproteins, VLDL; Lovastatin; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Triglycerides | 1987 |
In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis.
Topics: Adult; Apoptosis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Lymphocytes; Male; Middle Aged; Pravastatin; Pyridines; Simvastatin; Thyroid Gland; Thyroiditis, Autoimmune | 2005 |
33 other study(ies) available for mevastatin and pravastatin
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship | 2016 |
Relative lipophilicities, solubilities, and structure-pharmacological considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin.
Topics: Anticholesteremic Agents; Chromatography, High Pressure Liquid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Simvastatin; Solubility; Structure-Activity Relationship | 1991 |
A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Cytochrome P-450 Enzyme System; Enzyme Stability; Flavoproteins; Heptanoic Acids; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mixed Function Oxygenases; Models, Biological; NADH, NADPH Oxidoreductases; Naphthalenes; Nucleotides; Oxygenases; Pravastatin; Streptomyces | 1991 |
[HMG-CoA reductase inhibitors].
Topics: Animals; Anticholesteremic Agents; Bile; Cell Division; Cholesterol; Depression, Chemical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Liver; Lovastatin; Pravastatin | 1991 |
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Topics: Acetates; Acetic Acid; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; Kinetics; L Cells; Lens, Crystalline; Liver; Lovastatin; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Pravastatin; Rats; Simvastatin; Spleen | 1990 |
Formation of dihydroxy derivative of ML-236B from ML-236B (compactin) by lipid peroxidation.
Topics: Anti-Bacterial Agents; Anticholesteremic Agents; Heptanoic Acids; Lipid Peroxidation; Lovastatin; Molecular Structure; Naphthalenes; Pravastatin | 1990 |
Purification and characterization of cytochrome P-450sca from Streptomyces carbophilus. ML-236B (compactin) induces a cytochrome P-450sca in Streptomyces carbophilus that hydroxylates ML-236B to pravastatin sodium (CS-514), a tissue-selective inhibitor of
Topics: Amino Acids; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Heptanoic Acids; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Naphthalenes; Pravastatin; Spectrophotometry; Streptomyces | 1989 |
Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model.
Topics: Animals; Anticholesteremic Agents; Cell Division; Cell Survival; DNA; Humans; Lovastatin; Mevalonic Acid; Muscle, Smooth; Pravastatin | 1996 |
Biotransformation of compactin to pravastatin by Actinomadura sp. 2966.
Topics: Actinomycetaceae; Antifungal Agents; Biotransformation; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin | 1997 |
Molecular approaches for production of pravastatin, a HMG-CoA reductase inhibitor: transcriptional regulation of the cytochrome p450sca gene from Streptomyces carbophilus by ML-236B sodium salt and phenobarbital.
Topics: Amino Acid Sequence; Anticholesteremic Agents; Antifungal Agents; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Pravastatin; Repressor Proteins; RNA, Messenger; Sequence Analysis, DNA; Streptomyces; Up-Regulation | 1998 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Chromatography, High Pressure Liquid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Simvastatin; Spectrophotometry, Ultraviolet | 2001 |
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.
Topics: Atorvastatin; Cell Line; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Pravastatin; Pyrroles; Quinolines; Receptors, LDL; RNA, Messenger; Simvastatin | 2000 |
Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Antioxidants; Carotenoids; Cell Line, Transformed; Cells, Cultured; Chromatography, High Pressure Liquid; Lovastatin; Mice; Neurons; Pravastatin; Rats; Tocopherols; Tretinoin; Vitamin E | 2001 |
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Calcium; Cell Line; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Fatty Acids, Monounsaturated; Fluvastatin; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Osteoblasts; Osteogenesis; Phosphates; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins.
Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Collagen Type VIII; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Lovastatin; Male; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstrictor Agents | 1996 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Topics: Animals; Anticholesteremic Agents; Cell Differentiation; Cell Survival; Culture Media; Cyclic AMP; Cysteine Endopeptidases; Lovastatin; Mevalonic Acid; Multienzyme Complexes; Nerve Degeneration; Neuroblastoma; Neurons; Pravastatin; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
Differential effects of lipid-lowering agents on human cholinesterases.
Topics: Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Dementia; Humans; Hypolipidemic Agents; Lovastatin; Molecular Structure; Pravastatin; Simvastatin | 2004 |
Bioconversion of compactin into pravastatin by Streptomyces sp.
Topics: Bioreactors; Biotransformation; Cell Culture Techniques; Cell Division; Cytochrome P-450 Enzyme System; Lovastatin; Pravastatin; Streptomyces | 2003 |
Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin.
Topics: Animals; Apoptosis; beta Catenin; Caspase 3; Caspases; Cell Hypoxia; Cell Line; Cytoskeletal Proteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lovastatin; Male; Myocardial Infarction; Myocytes, Cardiac; Pravastatin; Rats; Rats, Wistar; Trans-Activators; Ventricular Remodeling | 2004 |
Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro.
Topics: Animals; Atorvastatin; Coronary Vessels; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Male; Pravastatin; Pyrroles; Serotonin; Simvastatin; Swine; Time Factors; Vasoconstriction | 2006 |
Screening of compactin-resistant microorganisms capable of converting compactin to pravastatin.
Topics: Bacteria; Chromatography, High Pressure Liquid; Culture Media; Hydroxylation; Lovastatin; Microbial Sensitivity Tests; Pravastatin | 2006 |
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mammary Neoplasms, Animal; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Proto-Oncogene Proteins c-akt; Simvastatin; Vitamin E | 2007 |
The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.
Topics: Adult; Animals; Atorvastatin; Forkhead Transcription Factors; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Mice; Mice, Inbred C57BL; Pravastatin; Pyrroles; T-Lymphocytes, Regulatory; Up-Regulation | 2008 |
Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes.
Topics: Bacterial Outer Membrane Proteins; Calcifediol; Cholecalciferol; Cholestenones; Cytochrome P-450 Enzyme System; Escherichia coli; Escherichia coli Proteins; Hydrophobic and Hydrophilic Interactions; Intracellular Space; Lovastatin; Membrane Transport Proteins; Mutation; Oxidation-Reduction; Pravastatin; Spectrum Analysis; Stereoisomerism; Substrate Specificity | 2009 |
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.
Topics: Antibodies, Monoclonal; Apoptosis; Cell Adhesion; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Eosinophils; Fatty Acids, Monounsaturated; Fluvastatin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Microfluidic Analytical Techniques; Microfluidics; Pravastatin; Recombinant Proteins; Simvastatin; Vascular Cell Adhesion Molecule-1 | 2009 |
Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.
Topics: Acetone; Base Sequence; Biotransformation; Cloning, Molecular; Cytochrome P-450 Enzyme System; Gene Expression; Genetic Engineering; Genetic Vectors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Industrial Microbiology; Lovastatin; Molecular Sequence Data; Plasmids; Pravastatin; Promoter Regions, Genetic; Replication Origin; Streptomyces | 2011 |
Efficient bioconversion of compactin to pravastatin by the quinoline-degrading microorganism Pseudonocardia carboxydivorans isolated from petroleum-contaminated soil.
Topics: Actinomycetales; Base Sequence; Biodegradation, Environmental; Culture Media; DNA, Ribosomal; Lovastatin; Molecular Sequence Data; Petroleum Pollution; Phylogeny; Pravastatin; Quinolines; Soil Microbiology | 2011 |
Engineering of a hybrid biotransformation system for cytochrome P450sca-2 in Escherichia coli.
Topics: Biodegradation, Environmental; Bioengineering; Circular Dichroism; Cytochrome P-450 Enzyme System; Escherichia coli; Ferredoxins; Hydroxylation; Industrial Microbiology; Lovastatin; Models, Molecular; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Pravastatin; Pseudomonas putida; Recombinant Proteins | 2013 |
Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells.
Topics: Acyl Coenzyme A; Angiopoietin-2; Atherosclerosis; Cell Survival; Cells, Cultured; Endothelial Cells; Exocytosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Simvastatin; Weibel-Palade Bodies | 2013 |
Statins inhibit blastocyst formation by preventing geranylgeranylation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Blastocyst; Cell Cycle Proteins; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Phosphoproteins; Polyisoprenyl Phosphates; Pravastatin; Prenylation; Quinuclidines; Sesquiterpenes; YAP-Signaling Proteins | 2016 |
Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin.
Topics: Bacillus megaterium; Biotransformation; Cytochrome P-450 Enzyme System; Escherichia coli; Hydroxylation; Lovastatin; Plasmids; Pravastatin; Substrate Specificity | 2016 |