mevastatin has been researched along with mevalonic acid in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (37.62) | 18.7374 |
| 1990's | 27 (26.73) | 18.2507 |
| 2000's | 30 (29.70) | 29.6817 |
| 2010's | 6 (5.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doi, O; Endo, A | 1 |
| Endo, A; Kuroda, M; Tanzawa, K; Tsujita, Y | 1 |
| Galick, H; Silber, JR; Siperstein, MD; Wu, JM | 1 |
| Bokoch, GM; Prossnitz, V | 1 |
| Chen, Q; Florén, CH; Nilsson, A | 1 |
| Cox, AD; Der, CJ; Kato, K; Khosravi-Far, R | 1 |
| Brown, MS; Goldstein, JL; Kim, CM | 1 |
| Bradfute, DL; Silva, CJ; Simoni, RD | 1 |
| Archer, BT; Jahn, R; Johnston, PA; Mignery, GA; Robinson, K; Südhof, TC | 1 |
| Gebhardt, R | 1 |
| Kumagai, H; Omura, S; Tomoda, H | 1 |
| Bourne, JR; Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Solski, PA | 1 |
| Bar-Nun, S; Chun, KT; Simoni, RD | 1 |
| Hoefle, ML; Newton, RS; Roth, BD; Sliskovic, DR; Wilson, MW | 1 |
| Buddecke, E; Filipovic, I | 1 |
| Cohen, LH; Griffioen, M; van Miert, E | 1 |
| Bankhurst, AD; Cutts, JL; Scallen, TJ; Watson, J | 1 |
| Cohen, LH; Griffioen, M | 1 |
| Kumagai, H; Omura, S; Tanaka, H; Tomoda, H | 1 |
| Boogaard, A; Cohen, LH; Griffioen, M | 1 |
| Endo, A; Ikeura, R; Murakawa, S | 1 |
| Brown, MS; Goldstein, JL; Nakanishi, M | 1 |
| Brown, D; Simoni, RD | 1 |
| Endo, A; Hasumi, K; Shimizu, Y; Yamada, A | 1 |
| Mizuno, M; Shimamura, M; Takaku, F; Urabe, A | 1 |
| Florén, CH; Jensen, E; Nilsson, A | 1 |
| Braithwaite, AW; Palni, LM | 1 |
| Cohen, LH; Griffioen, M; Havekes, L; Kempen, HJ; Schouten, D; van Hinsbergh, V | 1 |
| Ledin, SF; Perkins, SL; Stubbs, JD | 1 |
| Hatton, J; Middleton, B; White, DA | 1 |
| Krieger, M | 1 |
| Ditschuneit, H; Herold, G; Schneider, A; Stange, EF | 1 |
| Maxwell, RE; Nawrocki, JW; Uhlendorf, PD | 1 |
| Golomb, HM; Saffold, C; West, EJ; Yachnin, S | 1 |
| Fairbanks, KP; Goodman, DS; Witte, LD | 1 |
| Glomset, JA; Habenicht, AJ; Ross, R | 1 |
| Hoffman, PC; Larson, RA; Richman, CM; Yachnin, S | 1 |
| Kimber, SJ; Osborn, JC; Surani, MA | 1 |
| Huneeus, VQ; Siperstein, MD; Wiley, MH | 1 |
| Gibbons, GF; Pullinger, CR | 1 |
| Cuthbert, JA; Lipsky, PE | 1 |
| Brown, MS; Goldstein, JL | 1 |
| Endo, A | 1 |
| Cohen, DC; Gospodarowicz, D; Massoglia, SL | 1 |
| Yachnin, S | 1 |
| Glomset, JA; Habenicht, AJ; Ross, R; Schmidt, RA; Wight, TN | 1 |
| Akiyama, S; Kuwano, M; Masuda, A | 1 |
| Alavi, M; Ditschuneit, H; Preclik, G; Schneider, A; Stange, EF | 1 |
| Endo, A; Hardeman, EC; Ryan, J; Simoni, RD | 1 |
| Humphries, GM | 1 |
| Azzi, A; Boscoboinik, D; Latruffe, N | 1 |
| Barry, M; Bokoch, GM; Santoro, D; Solan, J; Terkeltaub, R | 1 |
| Ansorge, S; Bühling, F; Schulz, S | 1 |
| Bennis, F; Favre, G; Le Gaillard, F; Soula, G | 1 |
| Chen, GZ; Luján, HD; Mowatt, MR; Nash, TE | 1 |
| Andersson, T; Grönroos, E; Schippert, A; Sjölander, A; Zheng, L | 1 |
| Blench, I; Croft, S; Field, H; Field, MC | 1 |
| Badimon, L; Martínez-González, J | 1 |
| Coxon, FP; Graham, R; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, G | 1 |
| Laufs, U; Liao, JK | 1 |
| Benford, HL; Coxon, FP; Rogers, MJ; Russell, RG | 1 |
| Michikawa, M; Yanagisawa, K | 2 |
| Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM | 1 |
| Löwik, C; Papapoulos, S; van beek, E; van der Pluijm, G | 1 |
| Kasai, S; Nagai, K; Stern, PH; Woo, JT | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
| Joseph, SB; Kast, HR; Laffitte, BA; Mangelsdorf, DJ; Repa, JJ; Tontonoz, P; Wilpitz, DC | 1 |
| Belles, X; Buesa, C; Casals, N; Hegardt, FG; Marrero, PF | 1 |
| Bertoglio, J; Blaie, S; Bolla, M; Boquet, P; Créminon, C; Degraeve, F; Habib, A; Lévy-Toledano, S; Quéré, I | 1 |
| Hansen, PR; Kristiansen, MT; Ledet, T; Nabipour, MT; Olesen, P; Rasmussen, LM | 1 |
| Fujita, T; Izumo, N; Koida, M; Nakamuta, H | 1 |
| Chen, T; Gubina, E; Kozlowski, S; Lizzio, EF; Zhang, L | 1 |
| Getz, B; Ingle, JN; Karpeisky, MY; Mikhailov, SN; Padyukova, NSh; Reinholz, GG; Sanders, ES; Spelsberg, TC | 1 |
| Andreatta, C; Cole, WC; Edwards-Prasad, J; Koustas, WT; Kumar, B; Prasad, KN | 1 |
| Duriez, P; Fruchart, JC; Hazzan, M; Kandoussi, A; Martin, F; Noël, C; Staels, B | 1 |
| Hanada, A; Kamiya, Y; Kasahara, H; Kuzuyama, T; Takagi, M; Yamaguchi, S | 1 |
| Ballard, AJ; Demer, LL; Gharavi, N; Mody, N; Parhami, F; Tintut, Y | 1 |
| Catalano, R; Cordell, B; Naidu, A; Xu, Q | 1 |
| Andela, VB; O'Keefe, RJ; Pirri, M; Puzas, EJ; Rosenblatt, JD; Rosier, RN; Schwarz, EM | 1 |
| Dong, J; Fujii, S; Furumoto, T; Goto, D; Imagawa, S; Kaneko, T; Kitabatake, A; Mishima, T; Nakai, Y; Zaman, TA | 1 |
| Dello Russo, C; Navarra, P; Preziosi, P; Tringali, G; Vairano, M | 1 |
| Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H | 1 |
| Anthony, MD; Edwards, RH; Fortin, DL; Kubo, S; Nakamura, K; Troyer, MD | 1 |
| Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y | 1 |
| Coxon, FP; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, GG | 1 |
| Rogers, MJ; Rojas-Navea, J; Thompson, K | 1 |
| Kim, J; Matsuyama, S; Suzuki, T | 1 |
| Etemadmoghadam, D; Fraser, SA; Kandane, RK; Kanellis, J; Kemp, BE; Levidiotis, V; Mount, PF; Power, DA | 1 |
| Duleba, AJ; Foyouzi, N; Kwintkiewicz, J; Piotrowski, P; Rzepczynska, I | 1 |
| Hamblin, MW; Sjögren, B; Svenningsson, P | 1 |
| Antoun, TA; Badr, KF; Badreddine, R; Bertoglio, J; Habib, A; Nasrallah, MS; Nemer, G; Shamseddeen, I | 1 |
| Aldieri, E; Betta, PG; Bosia, A; Gazzano, E; Ghigo, D; Orecchia, S; Pescarmona, G; Riganti, C; Silvagno, F | 1 |
| Harris, KW; Lehenkari, PP; Merrell, MA; Selander, KS; Wakchoure, S | 1 |
| Fitzgerald, K; Kashanin, D; O'Dowd, F; Robinson, AJ; Walsh, GM; Williams, V | 1 |
| Costanzo, A; Cruz, J; Ennis, FA; Jameson, JM; Terajima, M | 1 |
| Barter, MJ; Catterall, JB; Cawston, TE; Hui, W; Lakey, RL; Young, DA | 1 |
| Hiasa, J; Ibrahim, HM; Kameyama, K; Nishikawa, Y; Shiga, I; Xuan, X | 1 |
| Gartner, U; McLean, WH; Smith, FJ; Zhao, Y | 1 |
| Barszczyk, A; Charlton, MP; Feng, ZP; Quan, Y; Sun, HS; Zheng, W | 1 |
| Alarcon, VB; Marikawa, Y | 1 |
4 review(s) available for mevastatin and mevalonic acid
| Article | Year |
|---|---|
Protein prenylation: key to ras function and cancer intervention?
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Fungal Proteins; GTP-Binding Proteins; Humans; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); ras Proteins; Saccharomyces cerevisiae; Transferases | 1992 |
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.
Topics: Animals; Cell Division; Cell Line; Cholesterol; Cricetinae; Cricetulus; Feedback; Female; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Naphthalenes; Ovary | 1980 |
[Regulation of cholesterol synthesis, as focused on the regulation of HMG-CoA reductase (author's transl)].
Topics: Animals; Cholesterol; Glucagon; Humans; Hydroxymethylglutaryl CoA Reductases; Insulin; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Microsomes, Liver; Naphthalenes; Phosphorylation; Rats | 1980 |
The mevalonate synthesis pathway as a therapeutic target in cancer.
Topics: Acute-Phase Proteins; Alendronate; Alkyl and Aryl Transferases; Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Polyisoprenyl Phosphates; Tumor Cells, Cultured | 2003 |
97 other study(ies) available for mevastatin and mevalonic acid
| Article | Year |
|---|---|
Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium.
Topics: Animals; Cells, Cultured; Depression, Chemical; Desmosterol; Fatty Acids; Growth Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Nucleic Acids; Phospholipids; Triglycerides | 1978 |
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Acetates; Animals; Binding, Competitive; Caprylates; Cholesterol; Fatty Acids; Gallbladder; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kidney; Kinetics; Lactones; Liver; Lovastatin; Male; Mevalonic Acid; Mice; Naphthalenes; Naphthols; Organ Specificity; Pyrans; Rats; Sterols | 1977 |
The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence.
Topics: Amino Acids; Animals; Cell Nucleus; DNA; DNA Replication; DNA-Directed DNA Polymerase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Ornithine Decarboxylase; Protein Biosynthesis; Rats; Resting Phase, Cell Cycle; RNA; Tetrahydrofolate Dehydrogenase; Time Factors; Tumor Cells, Cultured | 1992 |
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
Topics: Butadienes; Enzyme Activation; GTP-Binding Proteins; Hemiterpenes; Humans; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; NADH, NADPH Oxidoreductases; NADPH Oxidases; Pentanes; Respiratory Burst; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Lipoprotein receptor mediated metabolism of [14C]arachidonic acid labeled chylomicron remnants by Hep G2 cells.
Topics: Arachidonic Acid; Biological Transport; Cholesterol Esters; Chylomicrons; Glycerides; Humans; Lovastatin; Mevalonic Acid; Phospholipids; Receptors, Cell Surface; Receptors, Lipoprotein; Tumor Cells, Cultured | 1992 |
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Gene Library; Genes, Dominant; Humans; Lovastatin; Membrane Proteins; Membrane Transport Proteins; Mesocricetus; Mevalonic Acid; Molecular Sequence Data; Oligodeoxyribonucleotides; Point Mutation; Polymerase Chain Reaction; Protein Conformation; Proteins; Rats; RNA, Messenger; Transfection | 1992 |
Squalene synthase-deficient mutant of Chinese hamster ovary cells.
Topics: Acetates; Animals; CHO Cells; Cholesterol; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Flow Cytometry; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Mutagenesis | 1992 |
rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Drosophila melanogaster; GTP-Binding Proteins; Humans; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Nerve Tissue Proteins; Protein Biosynthesis; rab3 GTP-Binding Proteins; Sequence Homology, Nucleic Acid; Synaptic Vesicles | 1991 |
Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes.
Topics: Acetates; Animals; Anticholesteremic Agents; Cell Survival; Cells, Cultured; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Fatty Acid Synthases; Garlic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Liver; Lovastatin; Male; Mevalonic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase | 1991 |
Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells.
Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Cell Division; Fatty Acids, Unsaturated; Fungi; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Lactones; Lovastatin; Mevalonic Acid; Molecular Structure; Naphthalenes; Oxo-Acid-Lyases; Soil Microbiology; Vero Cells | 1990 |
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Exons; Farnesol; Genetic Vectors; Humans; Lovastatin; Mevalonic Acid; Mice; Mutation; Oligonucleotide Probes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Transfection | 1990 |
The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Female; Hydroxymethylglutaryl CoA Reductases; Intracellular Membranes; Lovastatin; Mevalonic Acid; Ovary; Proteins; Recombinant Fusion Proteins; Transfection | 1990 |
Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.
Topics: Animals; Chemical Phenomena; Chemistry; Cholesterol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Liver; Lovastatin; Mevalonic Acid; Molecular Conformation; Molecular Structure; Pyrazoles; Rats; Structure-Activity Relationship | 1990 |
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine | 1986 |
Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols.
Topics: Androstenes; Carcinoma, Hepatocellular; Cholesterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Isomerases; Lipoproteins, HDL; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Sterols; Tumor Cells, Cultured | 1989 |
Role of mevalonic acid in the regulation of natural killer cell cytotoxicity.
Topics: Cell Line; Cell Survival; Cells, Cultured; Cholesterol; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Dolichols; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Sterols | 1989 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites.
Topics: Androstenes; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Enzyme Activation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Immunoblotting; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; RNA, Messenger; Tumor Cells, Cultured | 1988 |
F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Topics: Acetates; Acetic Acid; Acetyl Coenzyme A; Acetyl-CoA C-Acetyltransferase; Animals; Carbohydrate Sequence; Cell Line; Fatty Acids, Unsaturated; Hydroxymethylglutaryl-CoA Synthase; Lactones; Liver; Lovastatin; Mevalonic Acid; Oxo-Acid-Lyases; Rats; Sterols | 1987 |
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity.
Topics: Androstenes; Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Imidoesters; Lipid Metabolism; Liver Neoplasms; Lovastatin; Mevalonic Acid; Naphthalenes; Triparanol | 1987 |
Growth inhibition of yeast by compactin (ML-236B) analogues.
Topics: Anti-Bacterial Agents; Culture Media; Lovastatin; Mevalonic Acid; Mitosporic Fungi; Saccharomycetales | 1988 |
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.
Topics: Animals; Cell Division; Cell Line; Homeostasis; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Protein Biosynthesis; Protein Processing, Post-Translational; RNA, Messenger; Transfection | 1988 |
Mevalonate deprivation leads to aneuploidy in Chinese hamster ovary cells.
Topics: Aneuploidy; Animals; Cell Line; Chromosomes; Cricetinae; DNA; Drug Resistance; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mutation; Ovary | 1988 |
Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Naphthalenes; Phenotype; Receptors, LDL | 1987 |
Partial prevention of compactin (ML-236B) inhibition of in vitro hematopoiesis by dolichol and dolichyl phosphate.
Topics: Animals; Bone Marrow Cells; Cell Cycle; Cell Differentiation; Cells, Cultured; Diterpenes; Dolichol Phosphates; Dolichols; Erythropoiesis; Granulocytes; Hematopoiesis; Liver; Lovastatin; Macrophages; Mevalonic Acid; Mice; Naphthalenes | 1986 |
Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid.
Topics: Animals; Cells, Cultured; Cholesterol; Chylomicrons; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Linoleic Acid; Linoleic Acids; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rats; Rats, Inbred Strains | 1987 |
Inhibition of mevalonate synthesis with compactin does not prevent DNA replication in cultured animal cells.
Topics: Animals; Cells, Cultured; Cricetinae; DNA Replication; HeLa Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes | 1986 |
Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2.
Topics: Animals; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lipoproteins, LDL; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Naphthalenes; Receptors, Cell Surface; Receptors, LDL | 1984 |
Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium.
Topics: Animals; Bucladesine; Cholesterol; Concanavalin A; Cricetinae; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mice; Naphthalenes | 1982 |
A mevalonate requirement for maintenance of fatty acid and protein synthesis during hormonally stimulated development of mammary gland in vitro.
Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Fatty Acids; Female; Hydroxymethylglutaryl CoA Reductases; Insulin; Leucine; Lovastatin; Mammary Glands, Animal; Mevalonic Acid; Microsomes; Naphthalenes; Organ Culture Techniques; Pregnancy; Prolactin; Protein Biosynthesis; Rabbits; Tritium | 1984 |
The use of amphotericin B to detect inhibitors of cellular cholesterol biosynthesis.
Topics: Acyl Coenzyme A; Amphotericin B; Animals; Cell Line; Cell Survival; Cholesterol; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Mevalonic Acid; Naphthalenes | 1983 |
Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation.
Topics: Animals; Anticholesteremic Agents; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol Esters; Ileum; Intestinal Mucosa; Jejunum; Kinetics; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Organ Culture Techniques; Rabbits; Tritium | 1984 |
Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Pentanoic Acids; Rats; Rats, Inbred F344; Sterols; Valerates | 1983 |
Increased cholesterol biosynthesis in leukemic cells from patients with hairy cell leukemia.
Topics: Acetates; Adult; B-Lymphocytes; Cells, Cultured; Cholesterol; Concanavalin A; DNA; Female; Humans; Hydroxycholesterols; Leukemia, Hairy Cell; Lovastatin; Male; Mevalonic Acid; Middle Aged; Naphthalenes | 1983 |
Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.
Topics: Anticholesteremic Agents; Cells, Cultured; Cholesterol; DNA Replication; Fibroblasts; Humans; Infant, Newborn; Kinetics; Lovastatin; Male; Mevalonic Acid; Mitogens; Naphthalenes; Platelet-Derived Growth Factor; Skin Physiological Phenomena | 1984 |
Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.
Topics: Acetates; Animals; Cell Cycle; Cell Line; Cells, Cultured; Cholesterol; DNA; Growth Substances; Haplorhini; Hydroxycholesterols; Kinetics; Lovastatin; Macaca; Mevalonic Acid; Mice; Mitogens; Muscle, Smooth, Vascular; Naphthalenes; Platelet-Derived Growth Factor; Thymidine | 1980 |
Cholesterol and mevalonic acid are independent requirements for the in vitro proliferation of human bone marrow granulocyte progenitor cells: studies using ML-236B.
Topics: Acetates; Cell Division; Cholesterol; DNA; Hematopoietic Stem Cells; Humans; Hydroxycholesterols; Lovastatin; Mevalonic Acid; Naphthalenes; Optical Rotation | 1983 |
Mevalonate reverses the developmental arrest of preimplantation mouse embryos by Compactin, an inhibitor of HMG Co A reductase.
Topics: Animals; Blastocyst; Cell Division; Cholesterol; Diosgenin; Electrophoresis, Polyacrylamide Gel; Glycopeptides; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Peptide Biosynthesis | 1983 |
Isopentenyladenine as a mediator of mevalonate-regulated DNA replication.
Topics: Adenine; Animals; Cells, Cultured; Cricetinae; DNA Replication; Isopentenyladenosine; Kidney; Lovastatin; Mevalonic Acid; Nalidixic Acid; Naphthalenes; Structure-Activity Relationship | 1980 |
Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol Esters; Cholesterol, VLDL; Kinetics; Lipoproteins, VLDL; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Oleic Acid; Oleic Acids; Rats | 1982 |
Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation.
Topics: Cholesterol; Concanavalin A; Humans; Ketocholesterols; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mitogens; Naphthalenes; Phytohemagglutinins; Pokeweed Mitogens; Sterols; T-Lymphocytes; Time Factors | 1980 |
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components.
Topics: Animals; Aorta; Cattle; Endothelium; Feedback; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, HDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Naphthalenes; Sterols | 1982 |
Mevalonic acid as an initiator of cell growth. Studies using human lymphocytes and inhibitors of endogenous mevalonate biosynthesis.
Topics: Concanavalin A; DNA; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Naphthalenes | 1982 |
A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.
Topics: Animals; Cell Adhesion; Cell Division; Cells, Cultured; Cholesterol; DNA; Dolichols; Growth Substances; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Peptides; Platelet-Derived Growth Factor; Protein Biosynthesis | 1982 |
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein.
Topics: Acetates; Animals; Cell Line; Clone Cells; Cricetinae; Drug Resistance; Endocytosis; Genes, Regulator; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketocholesterols; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Sterols | 1982 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa.
Topics: Alkaline Phosphatase; Animals; Cells, Cultured; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lactones; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rabbits | 1981 |
Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Genetic Variation; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Ovary | 1981 |
Difference in the ability of compactin and oxidized cholesterol, both known inhibitors of cholesterol biosynthesis, to suppress in vitro immune responses.
Topics: Animals; Cell Division; Cells, Cultured; Cholesterol; DNA; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Immunocompetence; Lovastatin; Lymphocytes; Mevalonic Acid; Naphthalenes | 1981 |
Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Hypolipidemic Agents; Lovastatin; Marine Toxins; Mevalonic Acid; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 1995 |
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.
Topics: Cell Division; Cell Line; Cell Survival; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; GTP-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-8; Lovastatin; Mevalonic Acid; Monocytes; Protein Prenylation; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate | 1994 |
Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes.
Topics: Cell Cycle; Cyclohexenes; DNA; Humans; In Vitro Techniques; Limonene; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Monoterpenes; Protein Prenylation; Terpenes | 1994 |
Importance of mevalonate-derived products in the control of HMG-CoA reductase activity and growth of human lung adenocarcinoma cell line A549.
Topics: Adenocarcinoma; Cholesterol, LDL; Feedback; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Lung Neoplasms; Mevalonic Acid | 1993 |
Isoprenylation of proteins in the protozoan Giardia lamblia.
Topics: Acetylcysteine; Animals; Cholesterol; Cyclohexenes; Dolichols; Giardia lamblia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Limonene; Lipid Metabolism; Lovastatin; Mevalonic Acid; Monoterpenes; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Protozoan Proteins; Terpenes; Ubiquinone | 1995 |
Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho.
Topics: ADP Ribose Transferases; Botulinum Toxins; Calcium; Cell Line; Cytochalasin D; Cytosol; Enzyme Inhibitors; Epithelium; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Intestines; Isoenzymes; Kinetics; Leukotriene D4; Lovastatin; Membrane Proteins; Mevalonic Acid; Protein Prenylation; rhoB GTP-Binding Protein; Signal Transduction; Type C Phospholipases | 1996 |
Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei.
Topics: Animals; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Microscopy, Electron; Protein Prenylation; Protozoan Proteins; Trypanosoma brucei brucei | 1996 |
Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model.
Topics: Animals; Anticholesteremic Agents; Cell Division; Cell Survival; DNA; Humans; Lovastatin; Mevalonic Acid; Muscle, Smooth; Pravastatin | 1996 |
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
Topics: Alendronate; Animals; Apoptosis; Bone Resorption; Cells, Cultured; Clodronic Acid; Diphosphonates; Enzyme Inhibitors; Etidronic Acid; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Macrophages; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; Protein Processing, Post-Translational; ras Proteins; Risedronic Acid; Structure-Activity Relationship | 1998 |
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
Topics: ADP Ribose Transferases; Bacterial Toxins; Botulinum Toxins; Cells, Cultured; Cytosol; Cytotoxins; Endothelium, Vascular; Escherichia coli Proteins; Gene Expression Regulation, Enzymologic; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Lovastatin; Membrane Proteins; Mevalonic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polyisoprenyl Phosphates; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA Processing, Post-Transcriptional; RNA, Messenger; Sesquiterpenes | 1998 |
Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
Topics: Alendronate; Animals; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line; Cycloheximide; Diphosphonates; Enzyme Activation; Enzyme Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Protein Biosynthesis; Protein Synthesis Inhibitors | 1998 |
Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.
Topics: Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Apoptosis; Cells, Cultured; Cerebral Cortex; Cholesterol; Cholesterol, VLDL; DNA Fragmentation; In Situ Nick-End Labeling; Lovastatin; Mevalonic Acid; Neurons; Rats; Rats, Sprague-Dawley; Squalene | 1998 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured | 1998 |
The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates.
Topics: Animals; Bone and Bones; Bone Resorption; Culture Techniques; Diphosphonates; Dose-Response Relationship, Drug; Female; Ibandronic Acid; Lovastatin; Mevalonic Acid; Mice; Models, Chemical; Nitrogen; Pregnancy; Protein Prenylation | 1999 |
Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death.
Topics: 3T3 Cells; Acetates; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cerebral Cortex; Cholesterol; Embryo, Mammalian; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, VLDL; Lovastatin; Mevalonic Acid; Mice; Neurons; PC12 Cells; Rabbits; Rats; Rats, Sprague-Dawley; Squalene; Tricarboxylic Acids | 1999 |
Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts.
Topics: Actins; Animals; Apoptosis; Bone Resorption; Calcitriol; Calcium; Coculture Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lovastatin; Male; Membrane Fusion; Mevalonic Acid; Mice; Osteoclasts; Parathyroid Hormone; Polyisoprenyl Phosphates; Sesquiterpenes | 2000 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anticholesteremic Agents; Apolipoproteins E; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Differentiation; Cells, Cultured; Cholesterol; Diet, Atherogenic; Dimerization; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Lipids; Liver Neoplasms; Liver X Receptors; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Knockout; Organic Chemicals; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene.
Topics: Animals; Base Sequence; Cockroaches; Gene Expression Regulation, Enzymologic; Genes, Insect; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Insect Proteins; Introns; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Retroelements; Species Specificity | 2001 |
Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.
Topics: Amides; Aorta; Apoptosis; Bacterial Proteins; Bacterial Toxins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dactinomycin; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Interleukin-1; Isoenzymes; Leucine; Lovastatin; Membrane Proteins; Mevalonic Acid; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein Prenylation; Pyridines; rho GTP-Binding Proteins; Time Factors | 2001 |
Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.
Topics: Cell Membrane; Cells, Cultured; Cytokines; E-Selectin; Endothelium, Vascular; Half-Life; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Membrane Proteins; Mevalonic Acid; NF-kappa B; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2001 |
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Calcium; Cell Line; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Fatty Acids, Monounsaturated; Fluvastatin; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Osteoblasts; Osteogenesis; Phosphates; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Topics: Animals; Antigens, CD; Cell Polarity; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukosialin; Lovastatin; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Pyrimidines; Sialoglycoproteins; Spleen; src-Family Kinases; T-Lymphocytes | 2002 |
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.
Topics: Bone and Bones; Breast Neoplasms; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Female; Humans; Imidazoles; Lovastatin; Mevalonic Acid; Osteoblasts; Pregnancy; Structure-Activity Relationship; Tumor Cells, Cultured; Zoledronic Acid | 2002 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Topics: Animals; Anticholesteremic Agents; Cell Differentiation; Cell Survival; Culture Media; Cyclic AMP; Cysteine Endopeptidases; Lovastatin; Mevalonic Acid; Multienzyme Complexes; Nerve Degeneration; Neuroblastoma; Neurons; Pravastatin; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Clofibric Acid; Cyclosporine; Endothelin-1; Endothelium, Vascular; Fibric Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lovastatin; Mevalonic Acid; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis.
Topics: Arabidopsis; Carbon Isotopes; Erythritol; Gibberellins; Lovastatin; Mevalonic Acid; Molecular Structure; Pentosephosphates; Plant Growth Regulators; Seedlings; Xylulose | 2002 |
Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred Strains; Osteoblasts; Osteocalcin; Pluripotent Stem Cells; Promoter Regions, Genetic; Stromal Cells | 2002 |
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins.
Topics: Alkyl and Aryl Transferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Farnesyltranstransferase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Microglia; Neuroglia; Polyisoprenyl Phosphates; Protein Prenylation | 2002 |
Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives.
Topics: Acute-Phase Reaction; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Interleukin-1; Interleukin-6; Liver Neoplasms; Lovastatin; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Up-Regulation | 2003 |
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Autoimmune Diseases of the Nervous System; Cells, Cultured; Coculture Techniques; Cytokines; Dinoprostone; Down-Regulation; Drug Synergism; Encephalitis; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Prostaglandins; Rats; Sesquiterpenes | 2004 |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin | 2004 |
Lipid rafts mediate the synaptic localization of alpha-synuclein.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; beta-Cyclodextrins; Brain Chemistry; Cell Compartmentation; Cell Membrane Permeability; Cells, Cultured; Cholesterol; Detergents; Digitonin; Fumonisins; HeLa Cells; Hippocampus; Humans; Kidney; Lovastatin; Membrane Lipids; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Nystatin; Protein Binding; Rats; Recombinant Fusion Proteins; Sphingolipids; Synucleins; Transfection | 2004 |
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha | 2004 |
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).
Topics: Animals; Bone Resorption; Cells, Cultured; Diphosphonates; GTP-Binding Proteins; History, 20th Century; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; ras Proteins | 2005 |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.
Topics: Animals; Butylamines; Cell Proliferation; Geranyltranstransferase; Hemiterpenes; Lovastatin; Lymphocyte Activation; Macrophages; Mevalonic Acid; Mice; Organophosphorus Compounds; Propylamines; Protein Prenylation; rap1 GTP-Binding Proteins; Signal Transduction; T-Lymphocyte Subsets; T-Lymphocytes | 2006 |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
Topics: Acetates; Aldehydes; Animals; Carbon Radioisotopes; Deuterium; Esters; Fatty Acids; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Lovastatin; Male; Mevalonic Acid; Pheromones; Propionates; Sesquiterpenes; Tribolium; Volatilization | 2005 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Cell Movement; Chemokine CCL2; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Activators; Humans; Lovastatin; Mevalonic Acid; Protein Kinases; rho GTP-Binding Proteins; Ribonucleotides; U937 Cells | 2006 |
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway.
Topics: Animals; Blood; Cell Proliferation; Cells, Cultured; Drug Synergism; Enzyme Activation; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Lovastatin; Mevalonic Acid; Mitogen-Activated Protein Kinases; Progesterone; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Testosterone; Theca Cells | 2006 |
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors.
Topics: 5-Methoxytryptamine; Activating Transcription Factor 1; beta-Cyclodextrins; Binding, Competitive; Blotting, Western; Cholesterol; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fumonisins; HeLa Cells; Humans; Lovastatin; Mevalonic Acid; Phenols; Phosphorylation; Radioligand Assay; Receptors, Serotonin; Serine; Serotonin; Signal Transduction; Sulfonamides; Transfection; Tritium | 2006 |
Modulation of COX-2 expression by statins in human monocytic cells.
Topics: Cyclooxygenase 2; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Membrane Proteins; Mevalonic Acid; Monocytes; NF-kappa B; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Simvastatin; U937 Cells | 2007 |
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Asbestos, Crocidolite; Cattle; Cell Line, Tumor; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Humans; I-kappa B Kinase; Isoenzymes; Lovastatin; Mesothelioma; Mevalonic Acid; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Proto-Oncogene Proteins c-akt; Pyridines; rho GTP-Binding Proteins; Second Messenger Systems; Terpenes | 2007 |
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; DNA; Humans; Lovastatin; Mevalonic Acid; Nitrogen; p38 Mitogen-Activated Protein Kinases; Polyisoprenyl Phosphates; rap1 GTP-Binding Proteins | 2007 |
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.
Topics: Antibodies, Monoclonal; Apoptosis; Cell Adhesion; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Eosinophils; Fatty Acids, Monounsaturated; Fluvastatin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Microfluidic Analytical Techniques; Microfluidics; Pravastatin; Recombinant Proteins; Simvastatin; Vascular Cell Adhesion Molecule-1 | 2009 |
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antigens, Viral; Cross Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Influenza A virus; Influenza, Human; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Receptors, Antigen, T-Cell, gamma-delta; Species Specificity; T-Lymphocytes | 2010 |
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
Topics: Animals; Cartilage, Articular; Cattle; Cells, Cultured; Collagen; Collagenases; Down-Regulation; Gelatinases; Gene Expression Regulation, Enzymologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1alpha; Lovastatin; Matrix Metalloproteinases; Mevalonic Acid; Nasal Cartilages; Oncostatin M; Signal Transduction; Simvastatin; Terpenes; Tissue Culture Techniques | 2010 |
Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages.
Topics: Animals; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Mice, Inbred C57BL; Receptors, LDL; Toxoplasma | 2011 |
Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita.
Topics: Anticholesteremic Agents; Cell Line; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Keratin-6; Lovastatin; Mevalonic Acid; Pachyonychia Congenita; Promoter Regions, Genetic; STAT1 Transcription Factor | 2011 |
Differential roles of the mevalonate pathway in the development and survival of mouse Purkinje cells in culture.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Female; Lovastatin; Mevalonic Acid; Mice; Pregnancy; Purkinje Cells; Signal Transduction | 2015 |
Statins inhibit blastocyst formation by preventing geranylgeranylation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Blastocyst; Cell Cycle Proteins; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Phosphoproteins; Polyisoprenyl Phosphates; Pravastatin; Prenylation; Quinuclidines; Sesquiterpenes; YAP-Signaling Proteins | 2016 |