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mevastatin and geranylgeranyl pyrophosphate

mevastatin has been researched along with geranylgeranyl pyrophosphate in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's8 (80.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Laufs, U; Liao, JK1
Kasai, S; Nagai, K; Stern, PH; Woo, JT1
Fujita, T; Izumo, N; Koida, M; Nakamuta, H1
Catalano, R; Cordell, B; Naidu, A; Xu, Q1
Andela, VB; O'Keefe, RJ; Pirri, M; Puzas, EJ; Rosenblatt, JD; Rosier, RN; Schwarz, EM1
Azuma, Y; Fujita, T; Fukuyama, R; Hirano, A; Koida, M; Komori, T; Nakamuta, H1
Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y1
Fujii, Y; Iwaki, M; Matsuoka, H; Nishida, S; Tanimori, Y; Tsubaki, M; Yanae, M1
Harris, KW; Lehenkari, PP; Merrell, MA; Selander, KS; Wakchoure, S1
Alarcon, VB; Marikawa, Y1

Reviews

1 review(s) available for mevastatin and geranylgeranyl pyrophosphate

ArticleYear
The mevalonate synthesis pathway as a therapeutic target in cancer.
    Clinical orthopaedics and related research, 2003, Issue:415 Suppl

    Topics: Acute-Phase Proteins; Alendronate; Alkyl and Aryl Transferases; Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Polyisoprenyl Phosphates; Tumor Cells, Cultured

2003

Other Studies

9 other study(ies) available for mevastatin and geranylgeranyl pyrophosphate

ArticleYear
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
    The Journal of biological chemistry, 1998, Sep-11, Volume: 273, Issue:37

    Topics: ADP Ribose Transferases; Bacterial Toxins; Botulinum Toxins; Cells, Cultured; Cytosol; Cytotoxins; Endothelium, Vascular; Escherichia coli Proteins; Gene Expression Regulation, Enzymologic; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Lovastatin; Membrane Proteins; Mevalonic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polyisoprenyl Phosphates; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA Processing, Post-Transcriptional; RNA, Messenger; Sesquiterpenes

1998
Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:4

    Topics: Actins; Animals; Apoptosis; Bone Resorption; Calcitriol; Calcium; Coculture Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lovastatin; Male; Membrane Fusion; Mevalonic Acid; Mice; Osteoclasts; Parathyroid Hormone; Polyisoprenyl Phosphates; Sesquiterpenes

2000
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
    Methods and findings in experimental and clinical pharmacology, 2001, Volume: 23, Issue:7

    Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Calcium; Cell Line; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Fatty Acids, Monounsaturated; Fluvastatin; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Osteoblasts; Osteogenesis; Phosphates; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured

2001
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins.
    Brain research, 2002, Dec-20, Volume: 958, Issue:1

    Topics: Alkyl and Aryl Transferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Farnesyltranstransferase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Microglia; Neuroglia; Polyisoprenyl Phosphates; Protein Prenylation

2002
Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.
    Biochemical and biophysical research communications, 2004, Mar-12, Volume: 315, Issue:3

    Topics: Animals; Cell Line; Chemotaxis; Chromones; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Insulin-Like Growth Factor I; Lovastatin; Mice; Morpholines; Osteoblasts; Phosphorylation; Platelet-Derived Growth Factor; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Recombinant Proteins; rho GTP-Binding Proteins; Sesquiterpenes; Signal Transduction; Toxins, Biological; Vascular Endothelial Growth Factor A

2004
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
    The Journal of biological chemistry, 2004, Nov-12, Volume: 279, Issue:46

    Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha

2004
Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK.
    Molecular and cellular biochemistry, 2005, Volume: 269, Issue:1-2

    Topics: Antineoplastic Agents; Apoptosis; Butadienes; Caspase 3; Caspases; Cell Nucleus; Extracellular Signal-Regulated MAP Kinases; HL-60 Cells; Humans; Lovastatin; Nitriles; Phosphorylation; Polyisoprenyl Phosphates; Protein Kinase Inhibitors

2005
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.
    European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; DNA; Humans; Lovastatin; Mevalonic Acid; Nitrogen; p38 Mitogen-Activated Protein Kinases; Polyisoprenyl Phosphates; rap1 GTP-Binding Proteins

2007
Statins inhibit blastocyst formation by preventing geranylgeranylation.
    Molecular human reproduction, 2016, Volume: 22, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Blastocyst; Cell Cycle Proteins; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Phosphoproteins; Polyisoprenyl Phosphates; Pravastatin; Prenylation; Quinuclidines; Sesquiterpenes; YAP-Signaling Proteins

2016