mevalonolactone has been researched along with mevalonic acid in 181 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (33.70) | 18.7374 |
| 1990's | 69 (38.12) | 18.2507 |
| 2000's | 25 (13.81) | 29.6817 |
| 2010's | 23 (12.71) | 24.3611 |
| 2020's | 3 (1.66) | 2.80 |
| Authors | Studies |
|---|---|
| Edmond, J; Edwards, PA; Fogelman, AM; Popjak, G | 1 |
| Chen, Q; Florén, CH; Nilsson, A | 1 |
| Hashizume, H; Kumagai, H; Nagashima, H; Omura, S; Sunazuka, T; Tanaka, H; Tomoda, H; Tsuzuki, K | 1 |
| Haklai, R; Kloog, Y; Lerner, S | 1 |
| Anant, JS; Fung, BK | 1 |
| Dayananda, D; Jen, KL; Kasim, SE; Khilnani, S; LeBoeuf, RC; Tallapaka, L | 1 |
| Fellermann, K; Grosshans, I; Herold, G; Reimann, FM; Rogler, G; Stange, EF | 1 |
| Bernier, L; Braun, PE; De Angelis, D; Shtybel, WW | 1 |
| Heuman, DM; Hylemon, PB; Pandak, WM; Vlahcevic, ZR | 3 |
| Khor, HT; Ong, KK; Tan, DT | 1 |
| Chang, WS; Chao, YJ; Li, JL; Li, YJ; Lin, LX; Ouyang, MH; Peng, YB | 1 |
| Couillaud, F | 1 |
| Kawahara, Y; Momose, K; Shimizu, S; Sugawara, H; Yamamoto, T | 1 |
| Keller, RK; Ness, GC; Pendleton, LC | 1 |
| Farnsworth, CC; Gelb, MH; Glomset, JA; Kawata, M; Takai, Y; Yoshida, Y | 2 |
| Bell, C; Ip, DP; Lindemann, CJ; Ramjit, HG; Singh, MM | 1 |
| Batta, AK; Hauser, S; Ness, GC; Nguyen, LB; Rani, I; Salen, G; Shefer, S; Tint, GS | 1 |
| Chojnacki, T; Dallner, G; Löw, P; Thelin, A | 1 |
| Bansal, N; Houle, A; Melnykovych, G | 1 |
| Casey, PJ; Gilman, AG; Gutowski, S; Mumby, SM; Sternweis, PC | 1 |
| Albright, E; Field, FJ; Kam, NT; Mathur, S | 1 |
| Kong, DY; Lei, XH; Li, HT; Luo, SQ | 1 |
| Buddecke, E; Filipovic, I | 2 |
| Brady, SM; Erickson, SK; Havel, RJ; Jaeckle, S; Lear, SR | 1 |
| Buss, JE; Casey, PJ; Der, CJ; Solski, PA | 1 |
| Baulieu, EE; Hu, ZY; Jung-Testas, I; Robel, P | 1 |
| Drevon, CA; Nossen, JO; Osmundsen, H; Rustan, AC | 1 |
| Momose, K; Rudney, H; Shimizu, S; Sugawara, H; Yamamoto, T | 1 |
| Henneberg, R; Rodwell, VW | 1 |
| Avigan, J; Beg, ZH; Reznikov, DC | 1 |
| Burton, DN; Hurta, RA | 1 |
| Hindy, AM; Okuda, K; Takada, K; Yoshiga, K | 1 |
| Keller, RK | 1 |
| Farnsworth, DE; Feyereisen, R | 1 |
| Devor, KA; Nadeau, Y; Sauriol, F; Zamir, LO | 1 |
| Gupta, A; Rudney, H; Sexton, RC | 1 |
| Bilu, S; Herscovitz, H; Ronen, I; Tietz, A | 1 |
| Clarke, CF; Edwards, PA; Fogelman, AM | 2 |
| Haro, D; Hegardt, FG; Marrero, PF | 1 |
| Borgford, TJ; Burton, DN; Hurta, RA; Tough, DF | 1 |
| Herscovitz, H; Tietz, A | 1 |
| Axelsson, H; Bowallius, M; Holthuis, N; Molander, BM; Steen, G | 1 |
| Albers, JJ; Bierman, EL; Chait, A; Henze, K; Kudchodkar, BJ | 1 |
| Arebalo, RE; Hardgrave, JE; Noland, BJ; Scallen, TJ | 1 |
| Beg, ZH; Brewer, HB | 2 |
| Ledin, SF; Perkins, SL; Stubbs, JD | 1 |
| Gibbons, GF; Soutar, AK; Wade, DP | 1 |
| Paton, BC; Poulos, A | 1 |
| Cluette, JE; Doyle, K; Hojnacki, J; Mulligan, JJ; Noring, R | 1 |
| Aguilera, JA; Arce, V; Garcia-Peregrin, E; Linares, A | 1 |
| Randolph, RK; Smith, BP; St Clair, RW | 1 |
| Bergstrom, JD; Edmond, J; Edwards, PA; Wong, GA | 1 |
| Davis, RA; Highsmith, WE; Kuan, JC; McNeal, MM; Schexnayder, JA | 1 |
| Ditschuneit, H; Herold, G; Schneider, A; Stange, EF | 1 |
| Maxwell, RE; Nawrocki, JW; Uhlendorf, PD | 1 |
| Beg, ZH; Brewer, HB; Stonik, JA | 1 |
| Field, FJ; Mathur, SN | 1 |
| Dull, BJ; Kilara, A; McCarthy, RD | 1 |
| Agranoff, BW; Heacock, AM; Klinger, PD; Seguin, EB | 1 |
| Panini, SR; Rudney, H; Sexton, RC | 1 |
| Florén, CH; Nilsson, A | 1 |
| Brady, PS; Kumaran, K; Landau, BR; Margolis, JM; Ohgaku, S; Schumann, WC; Scofield, RF | 1 |
| Edwards, PA; Fogelman, AM; Lan, SF; Tanaka, RD | 1 |
| Dietschy, JM; Stange, EF; Suckling, KE | 1 |
| Arebalo, RE; Hardgrave, JE; Noland, BJ; Scallen, TJ; Tormanen, CD | 1 |
| Gibbons, GF; Pullinger, CR | 1 |
| Bard, M; Downing, JF | 1 |
| Obert, KA; Volpe, JJ | 1 |
| Morrow, CU; Scallen, TJ; Wilson, WK | 1 |
| Alavi, M; Ditschuneit, H; Preclik, G; Schneider, A; Stange, EF | 1 |
| Dick, HR; Gilbert, AB; Wells, JW | 1 |
| Nambudiri, AM; Ranganathan, S; Rudney, H | 1 |
| Cohen, BI; Raicht, RF; Sarwal, AN; Takahashi, M | 1 |
| Kaneko, I; Mitsui, S; Noguchi, H; Ogiso, A; Sato, A; Shimada, Y | 1 |
| Drevon, CA; Steinberg, D; Weinstein, DB | 1 |
| Cooper, AD; Erickson, SK; Gould, RG; Shrewsbury, MA | 1 |
| Brooks, C; Erickson, SK; Meyer, DJ; Shrewsbury, MA | 1 |
| Drevon, CA; Engelhorn, SC; Steinberg, D | 1 |
| Azzi, A; Boscoboinik, D; Latruffe, N | 1 |
| Bierman, EL; Hokland, BM; Oram, JF; Slotte, JP | 1 |
| Lackner, KJ; Rogler, G; Schmitz, G | 1 |
| Kwiterovich, PO; Motevalli, M | 2 |
| Johnson, EA; Schroeder, WA | 1 |
| Andres, DA; Crick, DC; Kluthe, CM; Suders, J; Waechter, CJ | 1 |
| Inglese, J | 1 |
| Doerner, KC; Gurley, EC; Hylemon, PB; Vlahcevic, ZR | 1 |
| Aspbury, RA; Fisher, MJ; Rees, HH | 1 |
| Andres, DA; Crick, DC; Waechter, CJ | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA; Palmoski, MJ; Wang-Iverson, D | 1 |
| Geerling, I; Herold, G; Jungwirth, R; Rogler, G; Stange, EF | 1 |
| Keller, RK; Ness, GC; Zhao, Z | 1 |
| Deschepper, CF; Mellon, SH | 1 |
| Botham, KM; Hoang, VQ; Pearce, NJ; Suckling, KE | 1 |
| Holcomb, S; McCarron, DA; Pappu, AS; Roullet, C; Roullet, JB; Xue, H | 1 |
| Fujiki, H; Komori, A; Okabe, S; Suganuma, M; Tius, MA; Zou, X | 1 |
| Li, G; Stahl, PD | 1 |
| Keller, RK; Vilsaint, F | 1 |
| Farrell, FX; Lapetina, EG; Yamamoto, K | 1 |
| Buss, JE; Cox, AD; Der, CJ; Graham, SM; Solski, PA | 1 |
| DeMattos, RB; Homan, R; Newton, RS; Pape, ME; Rea, TJ | 1 |
| Kikuchi, A; Nakanishi, H; Takai, Y | 1 |
| Brown, GR; Davidson, RG; Freeman, S; Holdgate, GA; Mallion, KB; McTaggart, F; Mirrlees, DJ; Smith, GJ; Ward, WH | 1 |
| Chambers, C; Keller, RK; Ness, GC; Zhao, Z | 1 |
| Buss, JE; Nantais, DE; Schwemmle, M; Stickney, JT; Vestal, DJ | 1 |
| Fellermann, K; Reimann, FM; Stange, EF; Winkelmann, F | 1 |
| Busch-Petersen, J; Fujiki, H; Kannangara, GS; Kerr, MA; Komori, A; Oh, LM; Okabe, S; Suganuma, M; Tius, MA; Zhuo, J; Zou, X | 1 |
| Batta, AK; Honda, A; Honda, M; Salen, G; Shefer, S; Tint, GS | 1 |
| Bellés, X; Martín, D; Piulachs, MD | 1 |
| Blench, I; Croft, S; Field, H; Field, MC | 1 |
| Clark, DS; Curtiss, LK; Erickson, SK; Johnson, GA; Spencer, TA | 1 |
| Elson, CE; Gould, MN; Ren, Z | 1 |
| Ghosh, S; Grogan, WM; Natarajan, R | 1 |
| Cenedella, RJ; Sexton, PS | 1 |
| Aspbury, RA; Fisher, MJ; Prescott, MC; Rees, HH | 1 |
| Gould, MN; Ren, Z | 1 |
| Bansal, VS; Bergstrom, JD; Bostedor, R; Kurtz, MM; Vaidya, S | 1 |
| Kanaki, T; Kitahara, M; Miyakoshi, C; Saito, Y; Tamaki, T; Tanaka, S; Toyoda, K | 1 |
| Benford, HL; Coxon, FP; Rogers, MJ; Russell, RG | 1 |
| Haikara, A; Laitila, A; Mattila-Sandholm, T; Niku-Paavola, ML | 1 |
| Cenedella, RJ; Sexton, PS; Zhu, XL | 1 |
| Becke, D; Bruchelt, G; Girgert, R; Schweizer, P; Vogt, Y | 1 |
| Bui, ND; Lambert, M | 1 |
| Archelas, A; Furstoss, R | 1 |
| Kinghorn, AD; Lantvit, DD; Lee, D; Park, EJ; Pezzuto, JM; Shin, YG; van Breemen, RB | 1 |
| Lichtenthaler, HK; Zeidler, J | 1 |
| Chen, T; Gubina, E; Kozlowski, S; Lizzio, EF; Zhang, L | 1 |
| Andreatta, C; Cole, WC; Edwards-Prasad, J; Koustas, WT; Kumar, B; Prasad, KN | 1 |
| Alla, S; Cassel, S; Frérot, B; Malosse, C; Rollin, P | 1 |
| Kreck, M; Mosandl, A; Püschel, S; Wüst, M | 1 |
| Awad, AB; Fink, CS; Williams, H | 1 |
| FUMAGALLI, R; GARATTINI, S; GROSSI, E; PAOLETTI, P; POGGI, M | 1 |
| Miziorko, HM; Wang, CZ | 1 |
| Coso, OA; Giráldez, AN; Giulianelli, S; Jimenez de Asua, L; Rudland, PS; Sauane, M | 1 |
| Clark, DS; Gerber, R; Ryan, JD | 1 |
| Lehner, R; Rasouli, M; Trischuk, TC | 1 |
| Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H | 1 |
| Kim, J; Matsuyama, S; Suzuki, T | 1 |
| Etemadmoghadam, D; Fraser, SA; Kandane, RK; Kanellis, J; Kemp, BE; Levidiotis, V; Mount, PF; Power, DA | 1 |
| de Bravo, MG; Polo, MP | 1 |
| Hampel, D; Mosandl, A; Wüst, M | 1 |
| Doy, M; Honda, A; Ikegami, T; Matsuzaki, Y; Miyazaki, H; Mizokami, Y | 1 |
| Anayama, H; Hamajyo, H; Hirakata, M; Ishikawa, E; Nagai, H; Nishimoto, T; Tozawa, R | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Kamiya, Y; Kasahara, H; Kawaide, H; Nojiri, H; Okada, K; Yamaguchi, S; Yamane, H | 1 |
| Flenker, U; Lüdke, SM; Schänzer, W; Schomburg, D | 1 |
| Bode, HB; Lorenzen, W; Ring, MW; Schwär, G | 1 |
| Liu, J; Zhao, S; Zhou, W | 1 |
| Banas, A; Berna, A; Bouvier-Navé, P; Carlsson, AS; Compagnon, V; Noiriel, A; Schaller, H; Stymne, S | 1 |
| Dushkin, MI; Feofanova, NA; Khoshchenko, OM; Schwartz, YSh | 1 |
| Waldron, J; Webster, C | 1 |
| Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H | 1 |
| Brock, NL; Dickschat, JS; Tudzynski, B | 1 |
| Fuhrmeister, J; Kromer, A; Moosmann, B; Tews, M | 1 |
| Brock, NL; Citron, CA; Dickschat, JS; Tudzynski, B | 1 |
| Citron, CA; Dickschat, JS | 1 |
| Abraham, WR; Antunes, AL; Henriques, AT; Macedo, AJ; Scopel, M | 1 |
| Jacobsen, LL; Johansen, HT; Rustan, AC; Smith, R; Solberg, R; Thoresen, GH; Voreland, AL | 1 |
| Baranska, M; Chruszcz-Lipska, K; Jaworska, A; Szczurek, E | 1 |
| Finley, D; Franco, B; Katsanis, N; Lee, BH; Leitch, CC; Liu, YP; Massa, F; Morleo, M; Oh, EC; Parker, DS; Tsai, IC; Zaghloul, NA | 1 |
| Barra, L; Dickschat, JS; Schulz, B | 1 |
| Adachi, O; Fukushige, S; Horii, A; Kawamoto, S; Matsuo, S; Saiki, Y | 1 |
| Bernhardt, R; Günnewich, N; Hannemann, F; Khatri, Y; Ly, TT; Schifrin, A; Schulz, S; Thiel, V; Zapp, J | 1 |
| Hyde, KD; Kuhnert, E; Stadler, M; Sudarman, E; Surup, F; Thongbai, B | 1 |
| Barra, L; Dickschat, JS; Ibrom, K | 1 |
| Amaral, AU; Cecatto, C; da Silva, JC; Godoy, KDS; Gonçalves, AM; Ribeiro, RT; Vargas, CR; Wajner, A; Wajner, M | 1 |
| Chojnacki, T; Danikiewicz, W; Jozwiak, A; Kania, M; Lipko, A; Pączkowski, C; Poznanski, J; Surmacz, L; Swiezewska, E; Witek, A; Wojcik, J; Zdanowski, K | 1 |
| Berthelet, J; Bruttger, J; Kalt, B; Lacher, SM; Rajalingam, K; Waisman, A; Wörtge, S | 1 |
| Kim, JW; Kwon, SJ; Lee, BY; Lee, PC; Yoon, HC | 1 |
| Celsi, F; Crovella, S; Gratton, R; Tricarico, PM | 1 |
| Haq Muhammad, ZU; Wu, Y; Yang, D; Yang, Y; Yu, J; Zhang, G; Zhang, J | 1 |
| Bida, M; Kiabilua, O; Pillay, TS; Satekge, TM; Terblanche, AJ | 1 |
| Bao, YY; Chen, MH; Ge, MX; He, HW; Li, Y; Li, YM; Lu, ZN; Niu, WX; Zhang, N | 1 |
| Chen, B; Hasegawa, C; Lee, K; Lu, N; Maeda, K; Ye, L | 1 |
| Birk, OS; Davidov, G; Dolgin, V; Drabkin, M; Hadar, N; Halperin, D; Koifman, A; Nudelman, H; Perez, Y; Proskorovski-Ohayon, R; Shelef, I; Shorer, Z; Wormser, O; Yogev, Y; Zarivach, R | 1 |
2 review(s) available for mevalonolactone and mevalonic acid
| Article | Year |
|---|---|
Regulation of liver 3-hydroxy-3-methylglutaryl-CoA reductase.
Topics: Allosteric Regulation; AMP-Activated Protein Kinases; Animals; Chickens; Cholesterol; Chromatography, Affinity; Cyclic AMP; Electrophoresis; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucagon; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; In Vitro Techniques; Mevalonic Acid; Microsomes, Liver; Models, Biological; Multienzyme Complexes; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Structure-Activity Relationship | 1981 |
Synthetic applications of epoxide hydrolases.
Topics: Aspergillus niger; Biomass; Biotechnology; Cloning, Molecular; Epoxide Hydrolases; Epoxy Compounds; Hydrolysis; Mevalonic Acid; Mutagenesis, Site-Directed; Rhizobium; Stereoisomerism; Substrate Specificity | 2001 |
1 trial(s) available for mevalonolactone and mevalonic acid
| Article | Year |
|---|---|
Application of mevalonolactone prevents deterioration of epidermal barrier function by accelerating the lamellar granule lipid transport system.
Topics: Adult; ATP-Binding Cassette Transporters; Biological Transport; Epidermis; Fatty Acids; Female; Humans; Keratinocytes; Lamellar Bodies; Mevalonic Acid; Middle Aged; PPAR-beta; RNA, Messenger | 2022 |
178 other study(ies) available for mevalonolactone and mevalonic acid
| Article | Year |
|---|---|
Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes.
Topics: Animals; Biological Transport; Kinetics; Lactones; Liver; Mevalonic Acid; Molecular Conformation; Rats; Sterols; Structure-Activity Relationship | 1977 |
Lipoprotein receptor mediated metabolism of [14C]arachidonic acid labeled chylomicron remnants by Hep G2 cells.
Topics: Arachidonic Acid; Biological Transport; Cholesterol Esters; Chylomicrons; Glycerides; Humans; Lovastatin; Mevalonic Acid; Phospholipids; Receptors, Cell Surface; Receptors, Lipoprotein; Tumor Cells, Cultured | 1992 |
Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.
Topics: Animals; Fatty Acids, Unsaturated; Hydroxymethylglutaryl-CoA Synthase; Lactones; Mevalonic Acid; Microbial Sensitivity Tests; Vero Cells | 1992 |
Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; GTP-Binding Proteins; Lovastatin; Methylation; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Pheochromocytoma; Protein Prenylation; Protein Processing, Post-Translational; Rats; Tumor Cells, Cultured | 1992 |
In vivo farnesylation of rat rhodopsin kinase.
Topics: Animals; Eye Proteins; Farnesol; G-Protein-Coupled Receptor Kinase 1; Light; Membranes; Mevalonic Acid; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Rats; Rod Cell Outer Segment | 1992 |
Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat.
Topics: Adipose Tissue; Animals; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Kinetics; Lipid Metabolism; Lipids; Lipoproteins, VLDL; Liver; Lovastatin; Male; Mevalonic Acid; Polyethylene Glycols; Rats; Rats, Zucker; Triglycerides | 1992 |
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells.
Topics: Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Intestinal Mucosa; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Radioligand Assay; Sterol O-Acyltransferase; Tumor Cells, Cultured | 1992 |
Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cytosol; Glioma; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Protein Binding; Protein Processing, Post-Translational | 1991 |
Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis.
Topics: Acyl Coenzyme A; Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Dehydrocholesterols; Down-Regulation; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
Assay of 3-hydroxy-3-methylglutaryl CoA reductase activity using anionic-exchange column chromatography.
Topics: Anions; Chromatography, Ion Exchange; Chromatography, Thin Layer; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid | 1991 |
Cholesterol requirement for growth of IR983F and P3X63-Ag8-U1 myeloma cells in serum-free medium.
Topics: Animals; Cell Division; Cholesterol; Culture Media, Serum-Free; Hybridomas; Kinetics; Mevalonic Acid; Mice; Multiple Myeloma; Rats; Tumor Cells, Cultured | 1991 |
Evidence for regulation of juvenile hormone biosynthesis operating before mevalonate in locust corpora allata.
Topics: Animals; Corpora Allata; Female; Grasshoppers; Hydrogen-Ion Concentration; In Vitro Techniques; Juvenile Hormones; Kinetics; Mevalonic Acid; Osmotic Pressure | 1991 |
Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart.
Topics: Animals; Diphosphates; Hemiterpenes; Hydroxymethylglutaryl CoA Reductases; Iodoacetamide; Isoproterenol; Mevalonic Acid; Mitochondria, Heart; Myocardium; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Terpenes; Ubiquinone | 1991 |
Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels.
Topics: Animals; Blotting, Northern; Catalase; Cholesterol, Dietary; Dimethylallyltranstransferase; Feedback; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; RNA, Messenger | 1991 |
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Antibodies; Brain Chemistry; Cattle; Cell Line; Cysteine; Diterpenes; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; GTP-Binding Proteins; Mevalonic Acid; Molecular Sequence Data; Peptides; Pheochromocytoma; rab3 GTP-Binding Proteins; Rats; Spectrometry, Mass, Fast Atom Bombardment | 1991 |
Determination of mevalonolactone in capsules by capillary gas-liquid chromatography.
Topics: Capsules; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Mass Spectrometry; Mevalonic Acid; Reference Standards | 1991 |
Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply.
Topics: Animals; Bile Acids and Salts; Blotting, Western; Catalysis; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxylation; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains; Taurochenodeoxycholic Acid; Taurocholic Acid | 1991 |
Covalent binding of dolichyl phosphate to proteins in rat liver.
Topics: Animals; Cell Fractionation; Chromatography, Ion Exchange; Dolichol Phosphates; Electrophoresis, Polyacrylamide Gel; Lipid Metabolism; Lipids; Lysosomes; Male; Mevalonic Acid; Microsomes, Liver; Mitochondria, Liver; Protein Binding; Proteins; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Subcellular Fractions; Tritium; Ultracentrifugation | 1991 |
Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.
Topics: Cell Division; Cell Survival; Cycloheximide; Dactinomycin; Deoxyribonucleases; Dexamethasone; DNA Damage; Humans; Hydroxycholesterols; In Vitro Techniques; Leukemia, T-Cell; Lovastatin; Mevalonic Acid; Mifepristone; Nuclear Proteins; Tumor Cells, Cultured | 1991 |
G protein gamma subunits contain a 20-carbon isoprenoid.
Topics: Adrenal Gland Neoplasms; Animals; Brain Chemistry; Cattle; Cell Line; Chromatography, Affinity; Chromatography, High Pressure Liquid; Diterpenes; GTP-Binding Proteins; Macromolecular Substances; Mevalonic Acid; Pheochromocytoma; Rats | 1990 |
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
Topics: Blood Platelets; Cysteine; Gas Chromatography-Mass Spectrometry; GTP-Binding Proteins; Humans; In Vitro Techniques; Methylation; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; rap GTP-Binding Proteins | 1990 |
Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Colonic Neoplasms; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Sterol O-Acyltransferase; Triglycerides | 1990 |
[Studies on the chemical components of Viscum coloratum. VI. Chirality of the acyl group of viscumneoside IV].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Glycosides; Mevalonic Acid; Molecular Conformation | 1990 |
Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains | 1990 |
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine | 1986 |
Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Circadian Rhythm; Ethinyl Estradiol; Hydroxymethylglutaryl CoA Reductases; Lipoproteins; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; Receptors, LDL; Sterol O-Acyltransferase | 1989 |
p21ras is modified by a farnesyl isoprenoid.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Farnesol; Genes, ras; Mevalonic Acid; Mice; Molecular Sequence Data; Oncogene Protein p21(ras); Transfection | 1989 |
Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells.
Topics: Animals; Cells, Cultured; Cholesterol; Mevalonic Acid; Neuroglia; Phosphorus; Pregnenolone; Progesterone; Rats | 1989 |
Eicosapentaenoic acid inhibits cholesterol esterification in cultured parenchymal cells and isolated microsomes from rat liver.
Topics: Animals; Cholesterol Esters; Dose-Response Relationship, Drug; Eicosapentaenoic Acid; Hydroxycholesterols; Liver; Male; Mevalonic Acid; Microsomes, Liver; Oleic Acid; Oleic Acids; Rats; Sterol O-Acyltransferase | 1988 |
Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart.
Topics: Animals; Enzyme Precursors; In Vitro Techniques; Lipids; Male; Methylation; Mevalonic Acid; Mitochondria, Heart; Myocardium; Parabens; Perfusion; Rats; Rats, Inbred Strains; Ubiquinone | 1989 |
Glucocorticoid-stimulated biosynthesis of low density lipoprotein receptor in cultured fibroblasts.
Topics: Acetates; Cathepsin D; Cells, Cultured; Cholesterol; Dexamethasone; Fibroblasts; Humans; Lipoproteins, LDL; Methionine; Mevalonic Acid; Receptors, Cell Surface; Receptors, Lipoprotein; Skin; Time Factors | 1985 |
Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cyclic AMP or cyclic GMP.
Topics: Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Glucagon; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Insulin; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains | 1985 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.
Topics: Acetates; AMP-Activated Protein Kinases; Cells, Cultured; Fibroblasts; Fluorides; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Ketocholesterols; Lipid Metabolism; Lipoproteins, LDL; Mevalonic Acid; Multienzyme Complexes; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Complex; Sterols; Water | 1986 |
Relief of temperature sensitivity in a concanavalin A resistant Chinese hamster ovary cell line auxotrophic for cholesterol.
Topics: Animals; Cell Division; Cell Line; Cholesterol; Concanavalin A; Dolichols; Drug Resistance; Kinetics; Mevalonic Acid; Temperature | 1987 |
Sterol composition and biosynthesis in mouse salivary glands.
Topics: Animals; Azacosterol; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; In Vitro Techniques; Liver; Male; Mevalonic Acid; Mice; Mice, Inbred Strains; Salivary Glands; Skin; Sterols | 1986 |
The mechanism and regulation of dolichyl phosphate biosynthesis in rat liver.
Topics: Acetates; Acetic Acid; Animals; Cholesterol; Cholestyramine Resin; Chromatography, High Pressure Liquid; Circadian Rhythm; Dolichol Phosphates; Farnesyl-Diphosphate Farnesyltransferase; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Polyisoprenyl Phosphates; Rats; Time Factors | 1986 |
Characterization and regulation of HMG-CoA reductase during a cycle of juvenile hormone synthesis.
Topics: Animals; Cockroaches; Corpora Allata; Cycloheximide; Enzyme Activation; Farnesol; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; Lovastatin; Mevalonic Acid; Microsomes; Sesquiterpenes; Stereoisomerism | 1987 |
Structure determination and biosynthesis of a novel metabolite of Fusarium culmorum, apotrichodiol.
Topics: Chromatography, High Pressure Liquid; Fusarium; Magnetic Resonance Spectroscopy; Mevalonic Acid; Sesquiterpenes; Trichothecenes | 1987 |
Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole. A role for cytochrome P-450 in the regulation of HMG-CoA reductase in rat intestina
Topics: Animals; Cholesterol; Cholesterol Esters; Cytochrome P-450 Enzyme System; Epithelium; Hydroxymethylglutaryl CoA Reductases; Intestines; Ketoconazole; Lipoproteins, LDL; Mevalonic Acid; Models, Chemical; Oleic Acid; Oleic Acids; Rats; Sterol O-Acyltransferase; Sterols | 1986 |
Bile acid synthesis from HDL cholesterol and cholesterol ester by cultured chick embryo hepatocytes.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chick Embryo; Chloroquine; Cholesterol; Cholesterol Esters; Cholesterol, HDL; Lipoproteins, HDL; Liver; Mevalonic Acid | 1986 |
Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver.
Topics: Amanitins; Animals; Cell Nucleus; Cholestyramine Resin; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Naphthalenes; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 1985 |
Rat liver HMG CoA reductase, a glycoprotein of the endoplasmic reticulum, is in equilibrium between monomeric and dimeric forms.
Topics: Acetylglucosaminidase; Animals; Depression, Chemical; Endoplasmic Reticulum; Enzyme Induction; Glycoproteins; Hydroxymethylglutaryl CoA Reductases; Intracellular Membranes; Isoenzymes; Liver; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Membrane Proteins; Mevalonic Acid; Peptides; Protein Conformation; Rats; Rats, Inbred Strains | 1985 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and lipid metabolism in a concanavalin A-resistant Chinese hamster ovary cell line.
Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Cell Line; Cholesterol; Concanavalin A; Cricetinae; Cricetulus; Culture Media; Dolichols; Drug Resistance; Fatty Acids; Female; Hydroxymethylglutaryl CoA Reductases; Iodine Radioisotopes; Lipid Metabolism; Lipids; Lipoproteins, LDL; Mannose; Mevalonic Acid; Mutation; Ovary; Tunicamycin | 1986 |
The availability of different sources of cholesterol for bile acid synthesis by cultured chick embryo hepatocytes.
Topics: Acetates; Animals; Bile Acids and Salts; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Cholesterol; Cholesterol, HDL; Kinetics; Liposomes; Liver; Mevalonic Acid; Phosphatidylcholines | 1985 |
Isoprenoid biosynthesis in multiple sclerosis.
Topics: Adult; Brain Chemistry; Butadienes; Cholesterol; Diterpenes; Hemiterpenes; Humans; Hydroxymethylglutaryl CoA Reductases; Lymphocytes; Mevalonic Acid; Multiple Sclerosis; Pentanes; Ubiquinone | 1985 |
The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts.
Topics: Acetates; Caprylates; Cells, Cultured; Cholesterol; Fibroblasts; Humans; Hydrocortisone; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Skin | 1981 |
In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone.
Topics: Animals; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Mevalonic Acid; Microsomes, Liver; Phosphoprotein Phosphatases; Phosphorylation; Rats | 1980 |
Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium.
Topics: Animals; Bucladesine; Cholesterol; Concanavalin A; Cricetinae; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mice; Naphthalenes | 1982 |
Modulation of rat liver 3-hydroxy-3-methylglutaryl-CoA reductase activity by reversible phosphorylation.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cholesterol; Cyclic AMP; Glucagon; Hydroxymethylglutaryl CoA Reductases; Liver; Mevalonic Acid; Multienzyme Complexes; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats | 1982 |
Independent regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and chylomicron remnant receptor activities in rat liver.
Topics: Animals; Cell Membrane; Cholesterol; Chylomicrons; Ethinyl Estradiol; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Lipoprotein | 1984 |
Dolichol metabolism in cultured skin fibroblasts from patients with "neuronal" ceroid lipofuscinosis (Batten's disease).
Topics: Acetates; Acetic Acid; Carbon Radioisotopes; Cells, Cultured; Diterpenes; Dolichols; Fibroblasts; Humans; Mevalonic Acid; Neuronal Ceroid-Lipofuscinoses; Reference Values; Skin; Tritium | 1984 |
Ethanol enhances de novo synthesis of high density lipoprotein cholesterol.
Topics: Animals; Cholesterol; Cholesterol, HDL; Diet; Ethanol; Humans; Kinetics; Lipoproteins, HDL; Male; Mevalonic Acid; Saimiri; Tritium | 1984 |
Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways.
Topics: Animals; Chickens; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Kidney; Kinetics; Lipids; Liver; Male; Mevalonic Acid | 1984 |
Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway.
Topics: Animals; Cholesterol; Columbidae; Culture Media; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lipoproteins, LDL; Macaca mulatta; Mevalonic Acid; Muscle, Smooth, Vascular; Receptors, LDL; Sterol O-Acyltransferase; Thymidine; Time Factors | 1984 |
The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis.
Topics: Acetoacetates; Adrenal Glands; Animals; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Coenzyme A Ligases; Cytosol; Kinetics; Liver; Mevalonic Acid; Microsomes; Microsomes, Liver; Rats; Rats, Inbred Strains; Tritium | 1984 |
Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein.
Topics: Animals; Cholestyramine Resin; Circadian Rhythm; Diet; Hydroxymethylglutaryl CoA Reductases; Kinetics; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains; RNA, Messenger | 1984 |
Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cells, Cultured; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rats; Rats, Inbred Strains | 1983 |
Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation.
Topics: Animals; Anticholesteremic Agents; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol Esters; Ileum; Intestinal Mucosa; Jejunum; Kinetics; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Organ Culture Techniques; Rabbits; Tritium | 1984 |
Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Pentanoic Acids; Rats; Rats, Inbred F344; Sterols; Valerates | 1983 |
In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone.
Topics: AMP-Activated Protein Kinases; Animals; Cytosol; Hydroxymethylglutaryl CoA Reductases; Kinetics; Liver; Male; Mevalonic Acid; Models, Biological; Multienzyme Complexes; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Inbred Strains | 1984 |
Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells.
Topics: Acyltransferases; Animals; Cholesterol Esters; Hydroxycholesterols; Intestines; Lipid Metabolism; Male; Mevalonic Acid; Microsomes; Oleic Acid; Oleic Acids; Rabbits; Sterol O-Acyltransferase | 1983 |
The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone.
Topics: Acetates; Acetic Acid; Animals; Anticholesteremic Agents; Cattle; Cholesterol; Cholesterol, LDL; Diterpenes; Dolichols; In Vitro Techniques; Lanosterol; Lipoproteins, LDL; Liver; Mevalonic Acid; Milk; Orotic Acid; Polyisoprenyl Phosphates; Rats; Sesquiterpenes; Squalene; Ubiquinone | 1983 |
Cholesterol synthesis and nerve regeneration.
Topics: Animals; Axons; Azacosterol; Cholesterol; Desmosterol; Goldfish; Mevalonic Acid; Nerve Regeneration; Optic Nerve; Retina | 1984 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action.
Topics: Androstenes; Animals; Cholesterol; Epithelium; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Intestinal Mucosa; Intramolecular Transferases; Isomerases; Lipoproteins, LDL; Mevalonic Acid; Rats | 1984 |
Effects of hypothyroidism and cholesterol feeding on the clearance of chylomicron remnants in vivo and by rat hepatocyte monolayers.
Topics: Animals; Cells, Cultured; Cholesterol, Dietary; Cholic Acids; Chylomicrons; Hypercholesterolemia; Hypothyroidism; In Vitro Techniques; Lactones; Liver; Mevalonic Acid; Rats; Serum Albumin, Bovine | 1981 |
The tracing of the pathway of mevalonate's metabolism to other than sterols.
Topics: Animals; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Female; Mevalonic Acid; Rats; Rats, Inbred Strains; Sterols | 1982 |
Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.
Topics: Animals; Antigen-Antibody Complex; Hydroxymethylglutaryl CoA Reductases; Immune Sera; In Vitro Techniques; Kinetics; Liver; Mevalonic Acid; Molecular Weight; Rats | 1983 |
In vivo modulation of rat liver acyl-coenzyme A:cholesterol acyltransferase by phosphorylation and substrate supply.
Topics: Acyltransferases; Animals; Cholesterol; Chylomicrons; Female; Mevalonic Acid; Microsomes, Liver; Phosphorylation; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase | 1983 |
In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding.
Topics: Animals; Antigen-Antibody Complex; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Immune Sera; Immunoelectrophoresis, Two-Dimensional; Kinetics; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains | 1982 |
Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol Esters; Cholesterol, VLDL; Kinetics; Lipoproteins, VLDL; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Oleic Acid; Oleic Acids; Rats | 1982 |
Genetic and biochemical aspects of yeast sterol regulation involving 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Diploidy; Ergosterol; Feedback; Haploidy; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Saccharomyces cerevisiae; Squalene; Sterols | 1981 |
Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin.
Topics: Acetates; Androstenes; Animals; Anticholesteremic Agents; Carbon Radioisotopes; Cell Line; Glioma; Kinetics; Mevalonic Acid; Neuroblastoma; Rats; Sterols; Ubiquinone | 1982 |
Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent.
Topics: Lanthanum; Magnetic Resonance Spectroscopy; Mevalonic Acid; Stereoisomerism | 1982 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa.
Topics: Alkaline Phosphatase; Animals; Cells, Cultured; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lactones; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rabbits | 1981 |
The biosynthesis of progesterone by fowl granulosa cells in vitro from 14C-labelled substrates.
Topics: Acetates; Aminoglutethimide; Animals; Caprylates; Chickens; Cholesterol; Female; Granulosa Cells; Iodoacetamide; Iodoacetates; Lactones; Luteinizing Hormone; Mevalonic Acid; Progesterone | 1981 |
The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts.
Topics: Cell Line; Cholesterol; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lactones; Lipoproteins, LDL; Mevalonic Acid; Parabens; Skin; Ubiquinone | 1980 |
Effect of colestipol on sterol metabolism in the rat.
Topics: Animals; Cholesterol; Colestipol; Feces; Lactones; Liver; Male; Mevalonic Acid; Polyamines; Rats; Sterols | 1980 |
Mevalonolactone derivatives as inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase.
Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Mevalonic Acid; Mice | 1980 |
Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes.
Topics: Animals; Cells, Cultured; Cholesterol; Cholesterol Esters; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lactones; Lipoproteins; Liver; Mevalonic Acid; Microsomes, Liver; Oleic Acids; Rats; Steroids; Sterol O-Acyltransferase | 1980 |
Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol.
Topics: Animals; Cholesterol; Cytosol; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Liver; Male; Mevalonic Acid; Perfusion; Phosphorylation; Rats | 1980 |
Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro.
Topics: Acyl Coenzyme A; Acyltransferases; Animals; Cholesterol Esters; Cholesterol, Dietary; Cholestyramine Resin; Cholic Acids; Circadian Rhythm; Diet, Atherogenic; Fasting; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lactones; Male; Mevalonic Acid; Microsomes, Liver; Oleic Acids; Polyethylene Glycols; Progesterone; Rats; Sterol O-Acyltransferase; Subcellular Fractions; Surface-Active Agents | 1980 |
Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification.
Topics: Animals; Cells, Cultured; Cholesterol; Cholesterol Esters; Culture Media; Glycerol; Hydroxycholesterols; Lactones; Lipoproteins, VLDL; Liver; Mevalonic Acid; Rats; Sterol O-Acyltransferase; Triglycerides | 1980 |
Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Hypolipidemic Agents; Lovastatin; Marine Toxins; Mevalonic Acid; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 1995 |
Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cattle; Cells, Cultured; Cholesterol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Fibroblasts; Humans; Kinetics; Mevalonic Acid; Skin; Sterols; Tetranitromethane; Theophylline; Thionucleotides | 1993 |
Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro.
Topics: Animals; Anticholesteremic Agents; Cell Count; Cell Cycle; Cell Division; Cells, Cultured; Cholesterol; Cholesterol, LDL; Culture Media; Cytological Techniques; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Mevalonic Acid; Muscle, Smooth, Vascular; Resting Phase, Cell Cycle; S Phase; Squalene; Swine | 1995 |
Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts.
Topics: Apolipoproteins B; Benzoquinones; Cholesterol; Cholesterol Esters; Fibroblasts; Genistein; Humans; Hyperlipoproteinemias; Isoflavones; Lactams, Macrocyclic; Mevalonic Acid; Nitriles; Phenols; Protein-Tyrosine Kinases; Proteins; Quinones; Rifabutin; Triglycerides; Tyrphostins | 1995 |
Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma.
Topics: beta Carotene; Carotenoids; Free Radicals; Mevalonic Acid; Oxygen; Peroxides; Photochemistry; Reactive Oxygen Species; Singlet Oxygen; tert-Butylhydroperoxide; Xanthophylls; Yeasts | 1995 |
Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cells, Cultured; Cholesterol; Embryo, Mammalian; Farnesyl-Diphosphate Farnesyltransferase; Mevalonic Acid; Protein Prenylation; Rats; Rats, Sprague-Dawley; Squalene; Tricarboxylic Acids; Tumor Cells, Cultured | 1995 |
Prenylation-dependent targeting of G-protein-coupled receptor kinases.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cattle; Cell Line; Chlorocebus aethiops; DNA Primers; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; GTP-Binding Proteins; Mevalonic Acid; Molecular Sequence Data; Mutagenesis, Insertional; Phosphorylation; Polymerase Chain Reaction; Protein Kinases; Protein Prenylation; Radioisotope Dilution Technique; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Restriction Mapping; Rod Cell Outer Segment; Transfection; Tritium | 1995 |
Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures.
Topics: Animals; beta-Cyclodextrins; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cyclodextrins; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sterols; Tricarboxylic Acids | 1995 |
Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Chromatography, High Pressure Liquid; Helminth Proteins; Mevalonic Acid; Molecular Weight; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Protein Prenylation; Protein Processing, Post-Translational; Signal Transduction; Tritium | 1995 |
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Topics: Animals; Cell Line; Chlorocebus aethiops; Cholesterol; Cysteine; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Kinetics; Mevalonic Acid; Neoplasm Proteins; Protein Biosynthesis; Protein Prenylation; Proteins; Rats; Tritium; Tumor Cells, Cultured; Ubiquinone | 1995 |
In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2).
Topics: Alkaline Phosphatase; Cell Differentiation; Cell Division; Cholesterol; Culture Media; Depression, Chemical; Humans; Intestinal Mucosa; Lipoproteins; Lovastatin; Mevalonic Acid; Microscopy, Electron; Microvilli; Oligo-1,6-Glucosidase; Sucrase; Time Factors; Tumor Cells, Cultured | 1995 |
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
Topics: Animals; Blotting, Northern; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Dactinomycin; Dimethylallyltranstransferase; Enzyme Induction; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Immunoblotting; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Sprague-Dawley; Receptors, LDL; RNA, Messenger; Tricarboxylic Acids | 1994 |
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
Topics: Adrenal Cortex; Adrenodoxin; Animals; Base Sequence; Blotting, Western; Brain Chemistry; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Female; Male; Mevalonic Acid; Molecular Sequence Data; Neuroglia; Rats; Ribonucleases; RNA Probes; RNA, Messenger; Steroids | 1993 |
The regulation of bile acid synthesis in cultured hamster hepatocytes.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chenodeoxycholic Acid; Cholestyramine Resin; Cholic Acid; Cholic Acids; Cricetinae; Hydroxycholesterols; Imidazoles; Lipoproteins, LDL; Liver; Lovastatin; Male; Mesocricetus; Mevalonic Acid; Taurocholic Acid; Urea | 1993 |
Mevalonate availability and cardiovascular functions.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Blood Pressure; In Vitro Techniques; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Systole; Vascular Resistance | 1993 |
Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cyclohexanols; Diterpenes; Ethers, Cyclic; Female; Mevalonic Acid; Mice; Okadaic Acid; Protein Prenylation; Skin Neoplasms; Tumor Necrosis Factor-alpha | 1993 |
Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5).
Topics: Animals; Biological Transport; Cell Compartmentation; Cells, Cultured; Chick Embryo; Cytosol; Fibroblasts; GTP-Binding Proteins; Membranes; Methionine; Methylation; Mevalonic Acid; Protein Prenylation; Protein Processing, Post-Translational; rab4 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Recombinant Proteins; Sindbis Virus | 1993 |
Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1993 |
Regulation of isoprenoid metabolism in rat liver: near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis.
Topics: Animals; Cholesterol; Dietary Fats; Dolichol Phosphates; In Vitro Techniques; Liver; Male; Mevalonic Acid; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Tritium; Ubiquinone | 1993 |
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Genes, ras; GTP-Binding Proteins; Humans; Methionine; Mevalonic Acid; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Protein Biosynthesis; Proto-Oncogene Proteins; Rabbits; rap GTP-Binding Proteins; Reticulocytes; Sequence Homology, Amino Acid; Transcription, Genetic; Transfection | 1993 |
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cysteine; Genes, ras; GTP-Binding Proteins; Methionine; Mevalonic Acid; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rab5 GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Transfection; Tritium | 1993 |
Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells.
Topics: Animals; Cells, Cultured; Cholesterol Esters; Dietary Fats; Gene Expression; Humans; Hydroxymethylglutaryl CoA Reductases; Lipoproteins, VLDL; Liver; Mevalonic Acid; Rabbits; Receptors, LDL; RNA, Messenger; Sterol O-Acyltransferase | 1996 |
Purification and properties of Rab3A.
Topics: Animals; Brain; Cattle; Cell Fractionation; Cell Line; Cell Membrane; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; Durapatite; Escherichia coli; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indicators and Reagents; Kinetics; Mevalonic Acid; Nerve Tissue Proteins; Phosphorus Radioisotopes; Protein Processing, Post-Translational; rab3 GTP-Binding Proteins; Radioisotope Dilution Technique; Recombinant Proteins; Spodoptera; Sulfur Radioisotopes; Transfection; Tritium | 1995 |
Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines.
Topics: Animals; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Female; Kinetics; Liver; Mevalonic Acid; Quinuclidines; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Tritium | 1996 |
Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver.
Topics: Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Cycloheximide; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Half-Life; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Tricarboxylic Acids | 1996 |
Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.
Topics: Animals; Benzodiazepines; COS Cells; Enzyme Inhibitors; GTP-Binding Proteins; HL-60 Cells; Humans; Interferon-gamma; Mevalonic Acid; Oligopeptides; Protein Prenylation; Transfection; Tritium | 1996 |
Reduced cholesterol esterification in CaCo-2 cells by indirect action of pravastatin.
Topics: Caco-2 Cells; Cell Division; Cell Survival; Cholesterol; Esterification; Humans; Intestinal Mucosa; Intestines; Lipoproteins; Liposomes; Mevalonic Acid; Microsomes; Pravastatin; Sterol O-Acyltransferase | 1996 |
Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Anticarcinogenic Agents; Carcinogens; Cyclohexanols; Enzyme Inhibitors; Female; Lipid Metabolism; Mevalonic Acid; Mice; Mice, Inbred Strains; Okadaic Acid; Protein Prenylation; Skin Neoplasms; Sterols; Transferases; Ubiquinone | 1996 |
Effect of YM 9429, a potent teratogen, on cholesterol biosynthesis in cultured cells and rat liver microsomes.
Topics: Animals; Cholesterol; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Liver Neoplasms, Experimental; Mevalonic Acid; Microsomes, Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Piperidines; Rats; Smith-Lemli-Opitz Syndrome; Teratogens; Tumor Cells, Cultured | 1996 |
Inhibition of vitellogenin production by allatostatin in the German cockroach.
Topics: Animals; Blotting, Western; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hormone Antagonists; Indoles; Mevalonic Acid; Neuropeptides; Vitellogenins | 1996 |
Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei.
Topics: Animals; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Microscopy, Electron; Protein Prenylation; Protozoan Proteins; Trypanosoma brucei brucei | 1996 |
Feasibility of an immunoassay for mevalonolactone.
Topics: Animals; Antibody Formation; Haptens; Hemocyanins; Hydrogen-Ion Concentration; Immunoassay; Mevalonic Acid; Rabbits; Stereoisomerism | 1997 |
Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Carrier Proteins; GTP-Binding Proteins; Mevalonic Acid; Mice; Monoterpenes; Phosphates; Protein Prenylation; rab GTP-Binding Proteins; rap GTP-Binding Proteins; ras Proteins; Terpenes; Transferases | 1997 |
Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts.
Topics: Acetates; Apolipoproteins B; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Fibroblasts; Genistein; Humans; Hyperlipoproteinemias; Mevalonic Acid; Proteins; Time Factors | 1998 |
Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols.
Topics: Animals; Anticholesteremic Agents; Base Sequence; Cholesterol; Cloning, Molecular; Consensus Sequence; Gene Expression Regulation; Genes, Reporter; Liver; Mevalonic Acid; Molecular Sequence Data; Promoter Regions, Genetic; Rats; Sequence Analysis, DNA; Sequence Deletion; Sterol Esterase; Sterols; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Probing cataractogenesis associated with mevalonic aciduria.
Topics: Animals; Body Water; Cataract; Cell Membrane Permeability; Crystallins; Electrophoresis, Polyacrylamide Gel; Female; Lens, Crystalline; Male; Mevalonic Acid; Organ Culture Techniques; Potassium; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium | 1998 |
Isoprenylation of polypeptides in the nematode Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatography, High Pressure Liquid; Detergents; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Helminth Proteins; Immunoblotting; Mevalonic Acid; Octoxynol; Polyethylene Glycols; Protein Prenylation; ras Proteins; Tritium | 1998 |
Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells.
Topics: Animals; Anticarcinogenic Agents; Carbon Radioisotopes; Diet; Epithelial Cells; Female; GTP-Binding Proteins; Mammary Glands, Animal; Mevalonic Acid; Protein Prenylation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Terpenes | 1998 |
Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Gas; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; In Vitro Techniques; Kidney; Liver; Mevalonic Acid; Mice; Tricarboxylic Acids | 1998 |
NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery.
Topics: Animals; Aorta; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; Cell Line; DNA; Eukaryotic Cells; Extracellular Matrix; Fibronectins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Quinolines; Rabbits; Simvastatin; Transforming Growth Factor beta; Tunica Intima; Tunica Media | 1998 |
Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
Topics: Alendronate; Animals; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line; Cycloheximide; Diphosphonates; Enzyme Activation; Enzyme Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Protein Biosynthesis; Protein Synthesis Inhibitors | 1998 |
New types of antimicrobial compounds produced by Lactobacillus plantarum.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Benzoic Acid; Enterobacteriaceae; Fusarium; Hot Temperature; Hydantoins; Lactic Acid; Lactobacillus; Mevalonic Acid; Microbial Sensitivity Tests; Neuropeptides; Peptides, Cyclic | 1999 |
Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein.
Topics: Adolescent; Animals; Blotting, Western; Cattle; Cell Membrane; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Humans; Lens, Crystalline; Mevalonic Acid; Microsomes; Microsomes, Liver; Molecular Weight; Progesterone; Progesterone-Binding Globulin; Protein Prenylation; Rats; Rats, Sprague-Dawley | 1999 |
Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms.
Topics: Antineoplastic Agents; Ascorbic Acid; Cell Division; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neuroblastoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells.
Topics: Alkyl and Aryl Transferases; Animals; Cell Differentiation; Cell Division; Dexamethasone; Genes, ras; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Pancreatic Neoplasms; Rats; Tritium; Tumor Cells, Cultured | 1999 |
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.
Topics: Animals; Chromatography, Liquid; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mass Spectrometry; Mevalonic Acid; Rats; Rats, Wistar; Reference Standards | 2001 |
Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation.
Topics: Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Pentanols; Pinus; Pinus ponderosa; Terpenes; Xylulose | 2001 |
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Topics: Animals; Antigens, CD; Cell Polarity; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukosialin; Lovastatin; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Pyrimidines; Sialoglycoproteins; Spleen; src-Family Kinases; T-Lymphocytes | 2002 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Topics: Animals; Anticholesteremic Agents; Cell Differentiation; Cell Survival; Culture Media; Cyclic AMP; Cysteine Endopeptidases; Lovastatin; Mevalonic Acid; Multienzyme Complexes; Nerve Degeneration; Neuroblastoma; Neurons; Pravastatin; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
[Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)].
Topics: Air; Animals; Aphids; Depression, Chemical; Ecology; Ethers; Gas Chromatography-Mass Spectrometry; Hemiptera; Hormone Antagonists; Juvenile Hormones; Mevalonic Acid; Reproduction; Volatilization | 2002 |
Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols.
Topics: Acyclic Monoterpenes; Alcohols; Aldehydes; Deuterium; Gas Chromatography-Mass Spectrometry; Mevalonic Acid; Monoterpenes; Plant Leaves; Solutions; Stereoisomerism; Syringa; Xylose | 2003 |
Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cholesterol; Humans; Mevalonic Acid; Mitogen-Activated Protein Kinases; Phytosterols; Protein Prenylation; Sitosterols; Tumor Cells, Cultured | 2003 |
Cholesterol synthesis in rat brain: differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14.
Topics: Animals; Brain; Cholesterol; Lactones; Mevalonic Acid; Potassium; Rats | 1962 |
Methodology for synthesis and isolation of 5-phosphomevalonic acid.
Topics: Chromatography, Ion Exchange; Magnetic Resonance Spectroscopy; Mevalonic Acid | 2003 |
Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.
Topics: Animals; Cell Division; Dinoprost; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lovastatin; Mevalonic Acid; Mice; Mitogens; Molecular Chaperones; Oncostatin M; Peptides; Protein Prenylation; Proteins; Swiss 3T3 Cells | 2004 |
Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.
Topics: Atorvastatin; Biological Assay; Calibration; Cell Line; Chromatography, Liquid; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Pyrroles; Simvastatin | 2004 |
Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes.
Topics: Animals; Apolipoproteins B; Calmodulin; Carbon Radioisotopes; Cholesterol; Glycerides; Hepatocytes; Lipoproteins, VLDL; Mevalonic Acid; Oleic Acid; Rats; Sulfonamides; Tritium | 2004 |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin | 2004 |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
Topics: Acetates; Aldehydes; Animals; Carbon Radioisotopes; Deuterium; Esters; Fatty Acids; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Lovastatin; Male; Mevalonic Acid; Pheromones; Propionates; Sesquiterpenes; Tribolium; Volatilization | 2005 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Cell Movement; Chemokine CCL2; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Activators; Humans; Lovastatin; Mevalonic Acid; Protein Kinases; rho GTP-Binding Proteins; Ribonucleotides; U937 Cells | 2006 |
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.
Topics: Acetates; Acyclic Monoterpenes; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cholesterol; Fats; Fatty Acids; Humans; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Mevalonic Acid; Phospholipids; Phosphorus; Terpenes; Tumor Cells, Cultured | 2006 |
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies.
Topics: Acyclic Monoterpenes; Deuterium; Fragaria; Fruit; Gas Chromatography-Mass Spectrometry; Mevalonic Acid; Monoterpenes; Plant Leaves; Sesquiterpenes; Stereoisomerism; Xylulose | 2006 |
Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.
Topics: Animals; Calibration; Chromatography, Liquid; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Molecular Structure; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry | 2007 |
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
Topics: Animals; Biomarkers; Cholesterol; Creatine Kinase; Drug Antagonism; Drug Therapy, Combination; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Muscle, Skeletal; Muscular Diseases; Oxazepines; Piperidines; Pyridines | 2007 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.
Topics: Arabidopsis; Carbon Isotopes; Carbon-Carbon Double Bond Isomerases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genetic Complementation Test; Hemiterpenes; Mevalonic Acid; Mutation; Organ Specificity; Phenotype; Plant Infertility; Protein Transport; Subcellular Fractions; Terpenes; Xylulose | 2008 |
Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Carbon Isotopes; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid | 2008 |
Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.
Topics: Acyl Coenzyme A; Bacterial Proteins; Culture Media; Gene Expression Regulation, Bacterial; Mevalonic Acid; Mutation; Myxococcus xanthus; Terpenes | 2009 |
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.
Topics: Acyl Coenzyme A; Animals; Cyclopropanes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Magnetic Resonance Spectroscopy; Mevalonic Acid; Quinolines; Rats; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2009 |
Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence.
Topics: Arabidopsis; Arabidopsis Proteins; Flowers; Homeostasis; Mevalonic Acid; Mutagenesis, Insertional; Mutation; Phytosterols; Plant Leaves; Seeds; Squalene | 2010 |
Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.
Topics: Alitretinoin; Animals; Cells, Cultured; Cholesterol; Farnesol; Hydroxycholesterols; Hydroxysteroids; Ketocholesterols; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Transforming Growth Factor beta; Tretinoin | 2009 |
Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins.
Topics: Biomarkers; Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Mevalonic Acid; Middle Aged; Reference Values; Tandem Mass Spectrometry | 2011 |
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E | 2011 |
Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi.
Topics: Alkyl and Aryl Transferases; Cyclization; Cytochrome P-450 Enzyme System; Deuterium; Diterpenes; Fusarium; Gibberellins; Mevalonic Acid; Multigene Family; Plant Proteins; Sesquiterpenes; Stereoisomerism | 2011 |
Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells.
Topics: Animals; Atorvastatin; Cell Line; Cell Survival; Gene Expression Regulation; Heptanoic Acids; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Myoblasts; Oxidative Stress; Pyridines; Pyrroles; Rats; Selenium; Selenoproteins | 2012 |
Labelling studies on the biosynthesis of terpenes in Fusarium fujikuroi.
Topics: Fusarium; Gibberellins; Magnetic Resonance Spectroscopy; Mevalonic Acid; Terpenes | 2014 |
The stereochemical course of tricho-acorenol biosynthesis.
Topics: Gas Chromatography-Mass Spectrometry; Mevalonic Acid; Molecular Structure; Sesquiterpenes; Stereoisomerism; Trichoderma | 2013 |
Mevalonolactone: an inhibitor of Staphylococcus epidermidis adherence and biofilm formation.
Topics: Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Dose-Response Relationship, Drug; Mevalonic Acid; Microbial Sensitivity Tests; Particle Size; Staphylococcus epidermidis; Structure-Activity Relationship; Surface Properties | 2014 |
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.
Topics: Cathepsin B; Cathepsin L; Cell Membrane; Cysteine Endopeptidases; Glucose; HEK293 Cells; Humans; Mevalonic Acid; Muscle Fibers, Skeletal; Oxidation-Reduction; Oxidative Phosphorylation; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin | 2014 |
(-)-R-mevalonolactone studied by ROA and SERS spectroscopy.
Topics: Mevalonic Acid; Molecular Conformation; Spectrum Analysis, Raman | 2014 |
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.
Topics: Animals; Anticarcinogenic Agents; Cell Line; Ciliary Motility Disorders; Humans; I-kappa B Proteins; Isothiocyanates; Mevalonic Acid; Mice; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteins; Proteolysis; Sulfoxides; Zebrafish; Zebrafish Proteins | 2014 |
Pogostol biosynthesis by the endophytic fungus Geniculosporium.
Topics: Carbon Isotopes; Cyclization; Fungi; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Mevalonic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism | 2014 |
Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Disease Models, Animal; Endothelium, Vascular; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Lung Injury; Macrophages; Male; Mevalonic Acid; Monocrotaline; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Pulmonary Edema; Pyrimidines; Rats, Sprague-Dawley; Reperfusion Injury; Rosuvastatin Calcium; Sulfonamides; Up-Regulation | 2015 |
Characterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: biosynthesis of (+)-eremophilene and its hydroxylation.
Topics: Alkyl and Aryl Transferases; Cloning, Molecular; Cytochrome P-450 Enzyme System; Escherichia coli; Fungal Proteins; Gas Chromatography-Mass Spectrometry; Hydroxylation; Magnetic Resonance Spectroscopy; Mevalonic Acid; Molecular Structure; Multigene Family; Myxococcales; Retinoic Acid 4-Hydroxylase; Sesquiterpenes; X-Ray Diffraction | 2015 |
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
Topics: Anti-Bacterial Agents; Basidiomycota; Mevalonic Acid; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Propionates; Stereoisomerism; Terpenes; Thailand | 2015 |
Structural Revision and Elucidation of the Biosynthesis of Hypodoratoxide by (13) C,(13) C COSY NMR Spectroscopy.
Topics: Ascomycota; Carbon Isotopes; Magnetic Resonance Spectroscopy; Mevalonic Acid; Molecular Conformation; Sesquiterpenes | 2015 |
Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria.
Topics: Animals; Brain; Liver; Membrane Potential, Mitochondrial; Mevalonate Kinase Deficiency; Mevalonic Acid; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Rats; Rats, Wistar | 2017 |
Modeling of Dolichol Mass Spectra Isotopic Envelopes as a Tool to Monitor Isoprenoid Biosynthesis.
Topics: Arabidopsis; Carbon Isotopes; Chromatography, Gas; Dolichols; Erythritol; Isotope Labeling; Metabolic Networks and Pathways; Mevalonic Acid; Models, Theoretical; Osmotic Pressure; Phytosterols; Sorbitol; Spectrometry, Mass, Electrospray Ionization; Sugar Phosphates; Terpenes; Xylulose | 2017 |
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival.
Topics: Animals; Cell Count; Cell Death; Cell Survival; Gene Deletion; Hydroxymethylglutaryl CoA Reductases; Integrases; Lymphocyte Activation; Mevalonic Acid; Mice, Inbred C57BL; Phenotype; Polyisoprenyl Phosphates; Protein Prenylation; T-Lymphocytes; T-Lymphocytes, Regulatory | 2017 |
Purification of biomevalonate from fermentation broth and conversion of biomevalonate into biomevalonolactone.
Topics: Acetates; Bioreactors; Escherichia coli; Fermentation; Metabolic Engineering; Mevalonic Acid; Phosphoric Acids; Stereoisomerism | 2017 |
Prolonged treatment with mevalonolactone induces oxidative stress response with reactive oxygen species production, mitochondrial depolarization and inflammation in human glioblastoma U-87 MG cells.
Topics: Glioblastoma; Humans; Inflammation; Mevalonate Kinase Deficiency; Mevalonic Acid; Oxidative Stress; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Reactive Oxygen Species | 2018 |
cDNA cloning, prokaryotic expression and functional analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) in Pogostemon cablin.
Topics: Animals; Cloning, Molecular; DNA, Complementary; Escherichia coli; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Pogostemon; Sesquiterpenes | 2019 |
Mevalonate kinase deficiency masked by cytomegalovirus infection and obscure liver disease.
Topics: alpha 1-Antitrypsin Deficiency; Cytomegalovirus Infections; Diagnosis, Differential; Humans; Hyperbilirubinemia; Infant; Liver Diseases; Male; Mevalonate Kinase Deficiency; Mevalonic Acid | 2019 |
Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
Topics: Animals; Fibrosis; Humans; Inflammasomes; Inflammation; Liver; Liver Cirrhosis; Mevalonic Acid; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Rats | 2022 |
Limb girdle muscular disease caused by
Topics: Animals; Autoantibodies; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Muscular Diseases; Mutation | 2023 |