mevalonolactone has been researched along with lovastatin in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (27.78) | 18.7374 |
| 1990's | 18 (50.00) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q; Florén, CH; Nilsson, A | 1 |
| Haklai, R; Kloog, Y; Lerner, S | 1 |
| Dayananda, D; Jen, KL; Kasim, SE; Khilnani, S; LeBoeuf, RC; Tallapaka, L | 1 |
| Fellermann, K; Grosshans, I; Herold, G; Reimann, FM; Rogler, G; Stange, EF | 1 |
| Bernier, L; Braun, PE; De Angelis, D; Shtybel, WW | 1 |
| Bansal, N; Houle, A; Melnykovych, G | 1 |
| Albright, E; Field, FJ; Kam, NT; Mathur, S | 1 |
| Heuman, DM; Hylemon, PB; Pandak, WM; Vlahcevic, ZR | 2 |
| Buddecke, E; Filipovic, I | 1 |
| Keller, RK | 1 |
| Farnsworth, DE; Feyereisen, R | 1 |
| Clarke, CF; Edwards, PA; Fogelman, AM | 1 |
| Ledin, SF; Perkins, SL; Stubbs, JD | 1 |
| Davis, RA; Highsmith, WE; Kuan, JC; McNeal, MM; Schexnayder, JA | 1 |
| Ditschuneit, H; Herold, G; Schneider, A; Stange, EF | 1 |
| Maxwell, RE; Nawrocki, JW; Uhlendorf, PD | 1 |
| Gibbons, GF; Pullinger, CR | 1 |
| Alavi, M; Ditschuneit, H; Preclik, G; Schneider, A; Stange, EF | 1 |
| Azzi, A; Boscoboinik, D; Latruffe, N | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA; Palmoski, MJ; Wang-Iverson, D | 1 |
| Geerling, I; Herold, G; Jungwirth, R; Rogler, G; Stange, EF | 1 |
| Botham, KM; Hoang, VQ; Pearce, NJ; Suckling, KE | 1 |
| Holcomb, S; McCarron, DA; Pappu, AS; Roullet, C; Roullet, JB; Xue, H | 1 |
| Chambers, C; Keller, RK; Ness, GC; Zhao, Z | 1 |
| Blench, I; Croft, S; Field, H; Field, MC | 1 |
| Benford, HL; Coxon, FP; Rogers, MJ; Russell, RG | 1 |
| Becke, D; Bruchelt, G; Girgert, R; Schweizer, P; Vogt, Y | 1 |
| Chen, T; Gubina, E; Kozlowski, S; Lizzio, EF; Zhang, L | 1 |
| Andreatta, C; Cole, WC; Edwards-Prasad, J; Koustas, WT; Kumar, B; Prasad, KN | 1 |
| Coso, OA; Giráldez, AN; Giulianelli, S; Jimenez de Asua, L; Rudland, PS; Sauane, M | 1 |
| Clark, DS; Gerber, R; Ryan, JD | 1 |
| Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H | 1 |
| Kim, J; Matsuyama, S; Suzuki, T | 1 |
| Etemadmoghadam, D; Fraser, SA; Kandane, RK; Kanellis, J; Kemp, BE; Levidiotis, V; Mount, PF; Power, DA | 1 |
| Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H | 1 |
36 other study(ies) available for mevalonolactone and lovastatin
| Article | Year |
|---|---|
Lipoprotein receptor mediated metabolism of [14C]arachidonic acid labeled chylomicron remnants by Hep G2 cells.
Topics: Arachidonic Acid; Biological Transport; Cholesterol Esters; Chylomicrons; Glycerides; Humans; Lovastatin; Mevalonic Acid; Phospholipids; Receptors, Cell Surface; Receptors, Lipoprotein; Tumor Cells, Cultured | 1992 |
Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; GTP-Binding Proteins; Lovastatin; Methylation; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Pheochromocytoma; Protein Prenylation; Protein Processing, Post-Translational; Rats; Tumor Cells, Cultured | 1992 |
Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat.
Topics: Adipose Tissue; Animals; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Kinetics; Lipid Metabolism; Lipids; Lipoproteins, VLDL; Liver; Lovastatin; Male; Mevalonic Acid; Polyethylene Glycols; Rats; Rats, Zucker; Triglycerides | 1992 |
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells.
Topics: Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Intestinal Mucosa; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Radioligand Assay; Sterol O-Acyltransferase; Tumor Cells, Cultured | 1992 |
Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cytosol; Glioma; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Protein Binding; Protein Processing, Post-Translational | 1991 |
Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.
Topics: Cell Division; Cell Survival; Cycloheximide; Dactinomycin; Deoxyribonucleases; Dexamethasone; DNA Damage; Humans; Hydroxycholesterols; In Vitro Techniques; Leukemia, T-Cell; Lovastatin; Mevalonic Acid; Mifepristone; Nuclear Proteins; Tumor Cells, Cultured | 1991 |
Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Colonic Neoplasms; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Sterol O-Acyltransferase; Triglycerides | 1990 |
Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains | 1990 |
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine | 1986 |
The mechanism and regulation of dolichyl phosphate biosynthesis in rat liver.
Topics: Acetates; Acetic Acid; Animals; Cholesterol; Cholestyramine Resin; Chromatography, High Pressure Liquid; Circadian Rhythm; Dolichol Phosphates; Farnesyl-Diphosphate Farnesyltransferase; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Polyisoprenyl Phosphates; Rats; Time Factors | 1986 |
Characterization and regulation of HMG-CoA reductase during a cycle of juvenile hormone synthesis.
Topics: Animals; Cockroaches; Corpora Allata; Cycloheximide; Enzyme Activation; Farnesol; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; Lovastatin; Mevalonic Acid; Microsomes; Sesquiterpenes; Stereoisomerism | 1987 |
Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver.
Topics: Amanitins; Animals; Cell Nucleus; Cholestyramine Resin; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Naphthalenes; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 1985 |
Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium.
Topics: Animals; Bucladesine; Cholesterol; Concanavalin A; Cricetinae; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mice; Naphthalenes | 1982 |
Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cells, Cultured; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rats; Rats, Inbred Strains | 1983 |
Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation.
Topics: Animals; Anticholesteremic Agents; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol Esters; Ileum; Intestinal Mucosa; Jejunum; Kinetics; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Organ Culture Techniques; Rabbits; Tritium | 1984 |
Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Pentanoic Acids; Rats; Rats, Inbred F344; Sterols; Valerates | 1983 |
Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol Esters; Cholesterol, VLDL; Kinetics; Lipoproteins, VLDL; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Oleic Acid; Oleic Acids; Rats | 1982 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa.
Topics: Alkaline Phosphatase; Animals; Cells, Cultured; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lactones; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rabbits | 1981 |
Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Hypolipidemic Agents; Lovastatin; Marine Toxins; Mevalonic Acid; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 1995 |
In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2).
Topics: Alkaline Phosphatase; Cell Differentiation; Cell Division; Cholesterol; Culture Media; Depression, Chemical; Humans; Intestinal Mucosa; Lipoproteins; Lovastatin; Mevalonic Acid; Microscopy, Electron; Microvilli; Oligo-1,6-Glucosidase; Sucrase; Time Factors; Tumor Cells, Cultured | 1995 |
The regulation of bile acid synthesis in cultured hamster hepatocytes.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chenodeoxycholic Acid; Cholestyramine Resin; Cholic Acid; Cholic Acids; Cricetinae; Hydroxycholesterols; Imidazoles; Lipoproteins, LDL; Liver; Lovastatin; Male; Mesocricetus; Mevalonic Acid; Taurocholic Acid; Urea | 1993 |
Mevalonate availability and cardiovascular functions.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Blood Pressure; In Vitro Techniques; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Systole; Vascular Resistance | 1993 |
Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1993 |
Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver.
Topics: Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Cycloheximide; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Half-Life; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Tricarboxylic Acids | 1996 |
Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei.
Topics: Animals; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Microscopy, Electron; Protein Prenylation; Protozoan Proteins; Trypanosoma brucei brucei | 1996 |
Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
Topics: Alendronate; Animals; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line; Cycloheximide; Diphosphonates; Enzyme Activation; Enzyme Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Protein Biosynthesis; Protein Synthesis Inhibitors | 1998 |
Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms.
Topics: Antineoplastic Agents; Ascorbic Acid; Cell Division; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neuroblastoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Topics: Animals; Antigens, CD; Cell Polarity; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukosialin; Lovastatin; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Pyrimidines; Sialoglycoproteins; Spleen; src-Family Kinases; T-Lymphocytes | 2002 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Topics: Animals; Anticholesteremic Agents; Cell Differentiation; Cell Survival; Culture Media; Cyclic AMP; Cysteine Endopeptidases; Lovastatin; Mevalonic Acid; Multienzyme Complexes; Nerve Degeneration; Neuroblastoma; Neurons; Pravastatin; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.
Topics: Animals; Cell Division; Dinoprost; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lovastatin; Mevalonic Acid; Mice; Mitogens; Molecular Chaperones; Oncostatin M; Peptides; Protein Prenylation; Proteins; Swiss 3T3 Cells | 2004 |
Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.
Topics: Atorvastatin; Biological Assay; Calibration; Cell Line; Chromatography, Liquid; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Pyrroles; Simvastatin | 2004 |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin | 2004 |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
Topics: Acetates; Aldehydes; Animals; Carbon Radioisotopes; Deuterium; Esters; Fatty Acids; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Lovastatin; Male; Mevalonic Acid; Pheromones; Propionates; Sesquiterpenes; Tribolium; Volatilization | 2005 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Cell Movement; Chemokine CCL2; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Activators; Humans; Lovastatin; Mevalonic Acid; Protein Kinases; rho GTP-Binding Proteins; Ribonucleotides; U937 Cells | 2006 |
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E | 2011 |