mevalonic acid has been researched along with lovastatin in 434 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (16.13) | 18.7374 |
| 1990's | 213 (49.08) | 18.2507 |
| 2000's | 111 (25.58) | 29.6817 |
| 2010's | 37 (8.53) | 24.3611 |
| 2020's | 3 (0.69) | 2.80 |
| Authors | Studies |
|---|---|
| Doi, O; Endo, A | 1 |
| Endo, A; Kuroda, M; Tanzawa, K; Tsujita, Y | 1 |
| Galick, H; Silber, JR; Siperstein, MD; Wu, JM | 1 |
| Bokoch, GM; Prossnitz, V | 1 |
| Nebert, DW; Puga, A; Raychaudhuri, B | 1 |
| Chen, Q; Florén, CH; Nilsson, A | 1 |
| Buchwald, H | 1 |
| Haklai, R; Kloog, Y; Lerner, S | 1 |
| Cox, AD; Der, CJ; Kato, K; Khosravi-Far, R | 1 |
| Maltese, WA; Overmeyer, JH | 1 |
| Brown, MS; Goldstein, JL; Kim, CM | 1 |
| Corsini, A; Paoletti, R; Soma, MR | 1 |
| Anderson, JV; Besser, GM; Maher, VM; Scoppola, A; Thompson, GR; Trainer, PJ | 1 |
| Larsson, O; Wejde, J | 1 |
| Beauchamp, RD; Ishizuka, J; Murakami, M; Rajaraman, S; Sumi, S; Thompson, JC; Townsend, CM; Uchida, T | 1 |
| Darzynkiewicz, Z; Mikulski, SM; Shogen, K; Viera, A | 1 |
| Bradfute, DL; Silva, CJ; Simoni, RD | 1 |
| Peffley, DM | 1 |
| Dayananda, D; Jen, KL; Kasim, SE; Khilnani, S; LeBoeuf, RC; Tallapaka, L | 1 |
| Fenton, RG; Kung, HF; Longo, DL; Smith, MR | 1 |
| Infante, J; Infante, R; Qin, W; Wang, SR | 1 |
| Fellermann, K; Grosshans, I; Herold, G; Reimann, FM; Rogler, G; Stange, EF | 1 |
| Eda, T; Hidaka, Y; Kamei, T; Yonemoto, M | 1 |
| Archer, BT; Jahn, R; Johnston, PA; Mignery, GA; Robinson, K; Südhof, TC | 1 |
| Hidaka, Y; Horie, M; Hotta, H; Iwasawa, Y; Kamei, T; Nagata, Y | 1 |
| Adams, JL; Berkhout, TA; Bossard, MJ; Mayer, RJ | 1 |
| Davies, JE; Ng, LL | 2 |
| Bernier, L; Braun, PE; De Angelis, D; Shtybel, WW | 1 |
| Bruno, S; Darzynkiewicz, Z; Jakóbisiak, M; Skierski, JS | 1 |
| Finegold, AA; Rine, J; Schafer, WR; Tamanoi, F; Whiteway, M | 1 |
| Chakrabarti, R; Engleman, EG | 1 |
| Kinsella, BT; Maltese, WA | 1 |
| Langan, TJ; Slater, MC | 1 |
| Haklai, R; Kloog, Y | 1 |
| Gebhardt, R | 1 |
| Cutts, JL; Deanin, GG; Oliver, JM; Pfeiffer, JR | 1 |
| Nyce, JW; Schulz, S | 1 |
| Illingworth, DR; Pappu, AS; Prihoda, JS; Smith, FE | 1 |
| Chappell, J; Vögeli, U | 1 |
| Cuthbert, JA; Lipsky, PE | 6 |
| Maher, VM; Rendell, NB; Scoppola, A; Taylor, GW; Thompson, GR | 1 |
| Chen, HW; Linna, J; Moke, M | 1 |
| Merler, E; Vincent, TS; Wülfert, E | 1 |
| Hidaka, Y; Kamei, T; Satoh, T | 1 |
| Kumagai, H; Omura, S; Tomoda, H | 1 |
| Bansal, N; Houle, A; Melnykovych, G | 1 |
| Dice, JF; Faust, JR | 1 |
| Alberts, AW; Beil, FU; Beisiegel, U; Eckardt, HG; Greten, H; Karkas, JD; Liou, R; Schrameyer-Wernecke, A; Till, AE | 1 |
| Hidaka, Y; Ishida, F; Kamei, T; Nagata, Y | 1 |
| Erdman, RA; Maltese, WA; Repko, EM; Sheridan, KM | 1 |
| Hagemenas, FC; Illingworth, DR; Pappu, AS | 1 |
| Barbu, V; Dautry, F | 1 |
| Maltese, WA; Sheridan, KM | 2 |
| Aktories, K; Hall, A; Just, I; Mohr, C | 1 |
| Barnhart, RL; Busch, SJ; Flanagan, MA; Jackson, RL; Martin, GA | 1 |
| Beck, L; Leonard, S; Sinensky, M | 1 |
| Bourne, JR; Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Solski, PA | 1 |
| Bankhurst, AD; Cutts, JL | 2 |
| Alberts, AW; Chan, IF; Gleeson, JM; Hejazi, JS; Kwong, L; Le, T; Wilson, DE | 1 |
| Bar-Nun, S; Chun, KT; Simoni, RD | 1 |
| Albright, E; Field, FJ; Kam, NT; Mathur, S | 1 |
| Hoefle, ML; Newton, RS; Roth, BD; Sliskovic, DR; Wilson, MW | 1 |
| Heuman, DM; Hylemon, PB; Pandak, WM; Vlahcevic, ZR | 2 |
| Doyle, JW; Kabakoff, BD; Kandutsch, AA | 1 |
| Brandt, KG; Kennelly, PJ; Rodwell, VW; Sherban, DG | 1 |
| Buddecke, E; Filipovic, I | 1 |
| Cohen, LH; Griffioen, M; van Miert, E | 1 |
| Barrios, C; Larsson, O; Latham, C; Ruiz, J; Wejde, J; Zetterberg, A; Zickert, P | 1 |
| Cimis, GM; Molowa, DT | 1 |
| Illingworth, DR; Maher, VM; Pappu, A; Thompson, GR | 1 |
| Dunnington, DJ; Greig, R; Prichett, W | 1 |
| Engström, W; Larsson, O; Sachsenmaier, W | 1 |
| Maltese, WA; Repko, EM | 1 |
| Bacon, S; Illingworth, DR; Pappu, AS | 1 |
| Bankhurst, AD; Cutts, JL; Scallen, TJ; Watson, J | 1 |
| Illingworth, DR; Pappu, AS | 2 |
| Cohen, LH; Griffioen, M | 1 |
| Kumagai, H; Omura, S; Tanaka, H; Tomoda, H | 1 |
| Alberts, AW; Duchai, DM; Germershausen, JI; Kornbrust, DJ; MacDonald, JS; Peter, CP; Stubbs, RJ | 1 |
| Azrolan, N; Coleman, PS; Sepp-Lorenzino, L | 1 |
| Langan, TJ; Volpe, JJ | 2 |
| Boogaard, A; Cohen, LH; Griffioen, M | 1 |
| Endo, A; Ikeura, R; Murakawa, S | 1 |
| Doyle, JW; Kandutsch, AA | 1 |
| Amin, D; Gustafson, S; Perrone, MH | 1 |
| Brown, MS; Goldstein, JL; Nakanishi, M | 1 |
| Brown, D; Simoni, RD | 1 |
| Endo, A; Hasumi, K; Shimizu, Y; Yamada, A | 1 |
| Bolds, J; Cabrera, JA; Havel, CM; Shields, PE; Watson, JA | 1 |
| Barbu, VD; Fairbanks, KP; Goodman, DS; Weinstein, IB; Witte, LD | 1 |
| Keller, RK | 1 |
| Faust, J; Krieger, M | 1 |
| Farnsworth, DE; Feyereisen, R | 1 |
| Mizuno, M; Shimamura, M; Takaku, F; Urabe, A | 1 |
| Florén, CH; Jensen, E; Nilsson, A | 1 |
| Braithwaite, AW; Palni, LM | 1 |
| Aprille, JR; Maltese, WA | 1 |
| Clarke, CF; Edwards, PA; Fogelman, AM | 1 |
| Barbu, V; Fairbanks, KP; Goodman, DS; Witte, LD | 1 |
| Cohen, LH; Griffioen, M; Havekes, L; Kempen, HJ; Schouten, D; van Hinsbergh, V | 1 |
| Ledin, SF; Perkins, SL; Stubbs, JD | 1 |
| Hatton, J; Middleton, B; White, DA | 1 |
| Davis, RA; Highsmith, WE; Kuan, JC; McNeal, MM; Schexnayder, JA | 1 |
| Krieger, M | 1 |
| Glomset, JA; Schmidt, RA; Schneider, CJ | 1 |
| Ahrens, EH; Alberts, AW; Brown, CD; Chen, J; De Schepper, PJ; Kolb, R; McNamara, DJ; Parker, TS; Tobert, J | 1 |
| Ditschuneit, H; Herold, G; Schneider, A; Stange, EF | 1 |
| Jeng, I; Klemm, N; Proctor, B | 1 |
| Maxwell, RE; Nawrocki, JW; Uhlendorf, PD | 1 |
| Golomb, HM; Saffold, C; West, EJ; Yachnin, S | 1 |
| Fairbanks, KP; Goodman, DS; Witte, LD | 1 |
| Glomset, JA; Habenicht, AJ; Ross, R | 1 |
| Hoffman, PC; Larson, RA; Richman, CM; Yachnin, S | 1 |
| Kimber, SJ; Osborn, JC; Surani, MA | 1 |
| Brown, MS; Goldstein, JL; Kita, T | 1 |
| Huneeus, VQ; Siperstein, MD; Wiley, MH | 1 |
| Gibbons, GF; Pullinger, CR | 1 |
| Brown, MS; Goldstein, JL | 1 |
| Endo, A | 1 |
| Cohen, DC; Gospodarowicz, D; Massoglia, SL | 1 |
| Yachnin, S | 1 |
| Glomset, JA; Habenicht, AJ; Ross, R; Schmidt, RA; Wight, TN | 1 |
| Akiyama, S; Kuwano, M; Masuda, A | 1 |
| Alavi, M; Ditschuneit, H; Preclik, G; Schneider, A; Stange, EF | 1 |
| Endo, A; Hardeman, EC; Ryan, J; Simoni, RD | 1 |
| Humphries, GM | 1 |
| Gayen, AK; Peffley, DM | 4 |
| Azzi, A; Boscoboinik, D; Latruffe, N | 1 |
| Kuipers, F; Lin, Y; Slooff, MJ; Smit, MJ; Vonk, RJ | 1 |
| Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Cipolla, MJ; Fletcher, WS; Harker, CT; McCarron, DA; Roullet, CM; Roullet, JB; Xue, H | 1 |
| Burton, PM; Chiou, M; Dunlap, B; Haller, J; Heller, R; Malonzo, E; Murakami, S; Salari, A; Swinney, DC; Walker, KA | 1 |
| Bernini, F; Bonfadini, G; Fumagalli, R; Scurati, N | 1 |
| Ishikawa, S; Kawasumi, M; Saito, T | 1 |
| Blegen, H; Larsson, O | 1 |
| Raymond, Y; Sasseville, AM | 1 |
| Aberg, F; Appelkvist, EL; Dallner, G; Guan, Z; Parmryd, I | 1 |
| Larsson, O | 2 |
| Catapano, AL; Corsini, A; Maggi, FM | 1 |
| Akkerman, JW; De Laat, SW; Gorter, G; Schootemeijer, A; Tertoolen, LG | 1 |
| Goin, M; Gomez de Alzaga, MB; Hammarstrom, S; Jimenez de Asua, L; Ortiz, MB | 1 |
| Baetta, R; Butti, G; Davegna, C; De Renzis, MR; Fumagalli, R; Magrassi, L; Mazzini, G; Paoletti, R; Pezzotta, S; Soma, MR | 1 |
| Ben-Baruch, G; Kloog, Y; Marom, M; Roitelman, J | 1 |
| Kung, HF; Manne, V; Zhao, J | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA; Palmoski, MJ; Wang-Iverson, D | 1 |
| Betteridge, L; Chan, P; Clunn, G; Gallagher, K; Hughes, A; Munro, E; Patel, M; Schachter, M; Sever, P; Wolfe, J | 1 |
| Brihuega, F; Chiloeches, A; Lasa, M; Montes, A; Toro, MJ | 1 |
| Collado-Escobar, D; Mollinedo, F; Pérez-Sala, D | 1 |
| Geerling, I; Herold, G; Jungwirth, R; Rogler, G; Stange, EF | 1 |
| Blazejewski, S; Dhumeaux, D; Mallat, A; Mavier, P; Preaux, AM; Rosenbaum, J | 1 |
| Fantle, K; McLain, T; Sinensky, M | 1 |
| Augusti-Tocco, G; Bruscalupi, G; Castellano, F; Columba, S; Di Croce, L; Trentalance, A | 1 |
| Engelke, KJ; Hacker, MP | 1 |
| Coleman, PS; Larocca, JN; Sepp-Lorenzino, L | 1 |
| Bellosta, S; Bernini, F; Bonfadini, G; Didoni, G; Fumagalli, R | 1 |
| Mollinedo, F; Pérez-Sala, D | 1 |
| Ruch, RJ; Sigler, K | 1 |
| Dalton, M; Fantle, K; Kupfer, A; McLain, T; Sinensky, M; Trujillo, M | 1 |
| Baetta, R; Battaini, F; Bergamaschi, S; Davegna, C; De Renzis, MR; Fumagalli, R; Govoni, S; Soma, MR | 1 |
| Barry, M; Bokoch, GM; Santoro, D; Solan, J; Terkeltaub, R | 1 |
| Kowluru, A; Metz, SA; Rabaglia, ME; Stock, JB | 1 |
| Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Botham, KM; Hoang, VQ; Pearce, NJ; Suckling, KE | 1 |
| Holcomb, S; McCarron, DA; Pappu, AS; Roullet, C; Roullet, JB; Xue, H | 1 |
| Davies, JE; Ng, LL; Wojcikiewicz, RJ | 1 |
| Ansorge, S; Bühling, F; Schulz, S | 1 |
| De Cuyper, I; van Doormaal, JJ; Wijnandts, PN; Wolthers, BG | 1 |
| Chiang, JY; Heuman, DM; Hylemon, PB; Jones, MP; Pandak, WM; Vlahcevic, ZR | 1 |
| Davignon, J; Giroux, LM; Naruszewicz, M | 1 |
| Charpentier, C; Divry, P; Gibson, KM; Hoffmann, GF; Hrebicek, M; Lehnert, W; Leichsenring, M; Mancini, J; Mayatepek, E; Sartor, K | 1 |
| Clark, RW; Gordon, DA; Parker, RA; Pearce, BC; Wright, JJ | 1 |
| Arellano, R; Grinstein, S | 1 |
| Bennis, F; Favre, G; Le Gaillard, F; Soula, G | 1 |
| Atluru, D; Kasiske, BL; Keane, WF; Kim, Y; O'Donnell, MP | 1 |
| Li, G; Regazzi, R; Roche, E; Wollheim, CB | 1 |
| Klaunig, JE; Madhukar, BV; Ruch, RJ; Trosko, JE | 1 |
| Aloj, SM; Bifulco, M; Garbi, C; Laezza, C | 1 |
| Carlberg, M; Hjertman, M; Larsson, O; Wejde, J | 1 |
| Guzelian, PS; Kocarek, TA; Schuetz, EG | 1 |
| Chen, GZ; Luján, HD; Mowatt, MR; Nash, TE | 1 |
| Bischoff, KM; Rodwell, VW | 1 |
| Erl, W; Weber, C; Weber, PC | 1 |
| Belloni, P; Corsini, A; Folco, G; Fumagalli, R; Granata, A; Hernandez, A; Paoletti, R; Viganõ, T | 1 |
| Del Puppo, M; Galli Kienle, M; Rauli, S | 1 |
| Liu, L; Prasanna, P; Samid, D; Thibault, A | 1 |
| Lewis, LS | 1 |
| Blaskovich, MA; McGuire, TF; Romero, G; Sebti, SM; Xu, XQ | 1 |
| Benders, AA; Oosterhof, A; Smit, JW; Veerkamp, JH | 1 |
| Carlberg, M; Larsson, O | 1 |
| Chambers, C; Keller, RK; Ness, GC; Zhao, Z | 1 |
| Andersson, T; Grönroos, E; Schippert, A; Sjölander, A; Zheng, L | 1 |
| Blegen, H; Carlberg, M; Dricu, A; Hjertman, M; Höög, A; Larsson, O; Wang, M; Zickert, P | 1 |
| Hendry, BM; Owen, JS; Scoble, JE; Streather, CP | 1 |
| Guijarro, C; Kashtan, CE; Kasiske, BL; Keane, WF; Kim, Y; Massy, ZA; O'Donnell, MP; Schoonover, CM | 1 |
| Guijarro, C; Keane, WF | 1 |
| Ku, EC | 1 |
| Guyton, JR; Hughes, H; Karsan, D; Lenz, ML; Mathews, B; Selinger, E; Smith, CV | 1 |
| Colette, C; Crastes De Paulet, A; Descomps, B; Farnier, M; Feillet, C; Monnier, LH; Percheron, C | 1 |
| Nakata, H; Nishio, E; Tomiyama, K; Watanabe, Y | 1 |
| Andersson, M; Bakhiet, M; Löw, P | 1 |
| Firth, JC; Marais, AD; Mountney, J; Naoumova, RP; Rendell, NB; Taylor, GW; Thompson, GR | 1 |
| Assie, N; Bruniquel, F; Degryse, AD; Delhon, A; Oms, P; van Haverbeke, G | 1 |
| Kada, M; Komai, T; Kurakata, S; Nomoto, K; Shimada, Y | 1 |
| Dotti, MT; Federico, A; Lindenthal, B; Lütjohann, D; Simatupang, A; von Bergmann, K | 1 |
| Donetti, E; Fumagalli, R; Paoletti, R; Parolini, C; Soma, MR | 1 |
| Kanayama, Y; Negoro, N; Okamura, M; Takeda, T; Umetani, N | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 1 |
| Blench, I; Croft, S; Field, H; Field, MC | 1 |
| Badimon, L; Martínez-González, J | 1 |
| Murota, S; Sato-Suzuki, I | 1 |
| Ikegami, T; Kano, M; Matsuzaki, Y; Miyamoto, J; Miyazaki, H; Osuga, T; Shoda, J; Tanaka, N | 1 |
| Hamilton, TD; Keefer, BE; Spicer, LJ | 1 |
| Iwama, A; Nara, Y; Sawamura, M; Yamori, Y | 1 |
| Cunningham, GR; Marcelli, M; Padayatty, SJ; Shao, TC | 1 |
| Anouja, F; Caillet-Fauquet, P; Mousset, S; Wattiez, R | 1 |
| Amin, D; Bilder, GE; Bush, RC; Galczenski, HF; Hele, DJ; Maguire, MP; Needle, SN; Neuenschwander, K; Perrone, MH; Rutledge, RZ; Scotese, AC | 1 |
| Arnaboldi, L; Corsini, A; Ferraboschi, P; Fumagalli, R; Gelb, MH; McGeady, P; Paoletti, R; Quarato, P; Raiteri, M; Santaniello, E; Tagliabue, C; Verri, D | 1 |
| Chan, PC; Lafrenière, R; Parsons, HG | 1 |
| Chiloeches, A; García, N; Lasa, M; Montes, A; Toro, MJ | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA | 2 |
| Cenedella, RJ | 1 |
| Galli, C; Marangoni, F; Petroni, A; Risé, P; Visioli, F | 1 |
| Blegen, H; Carlberg, M; Dricu, A; Hjertman, M; Larsson, O; Malec, M; Wang, M; Wejde, J | 1 |
| Colombo, C; Galli, C; Risé, P | 1 |
| Guijarro, C; Kasiske, BL; Keane, WF; Massy, ZA; O'Donnell, MP | 1 |
| Biwa, T; Hakamata, H; Horiuchi, S; Kobori, S; Matsumura, T; Sakai, M; Sato, Y; Shichiri, M; Takemura, T | 1 |
| Bettelheim, F; Lin, LR; Rao, PV; Reddy, VN; Robison, WG; Zigler, JS | 1 |
| Namboodiri, AM; Pahan, K; Sheikh, FG; Singh, I | 1 |
| Badimon, L; Llorente-Cortés, V; Martínez-González, J; Vidal, F; Viñals, M | 1 |
| Becker, A; Hrboticky, N; Kruse, HJ; Weber, PC | 1 |
| De Caterina, R; Lenzi, S | 1 |
| La Fata, V; Laufs, U; Liao, JK; Plutzky, J | 1 |
| Coxon, FP; Graham, R; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, G | 1 |
| Kaul, D; Kaur, M; Sobti, RC | 1 |
| Khan, M; Pahan, K; Singh, I | 1 |
| Bitterman, P; Greatens, T; Kratzke, RA; Polunovsky, VA; Rubins, JB; Tan, AT | 1 |
| Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ | 1 |
| Chorváth, B; Chovancová, J; Duraj, J; Hunáková, L; Sedlák, J; Suliková, M | 1 |
| Kanda, Y; Nishio, E; Watanabe, Y | 1 |
| Haneda, T; Kashiwagi, Y; Kikuchi, K; Miyata, S; Osaki, J | 1 |
| Bifulco, M; Bruni, CB; Bucci, C; Laezza, C; Santillo, M | 1 |
| Laufs, U; Liao, JK | 1 |
| Benford, HL; Coxon, FP; Rogers, MJ; Russell, RG | 1 |
| Michikawa, M; Yanagisawa, K | 2 |
| Alonso, DF; De Lorenzo, MS; Farina, HG; Gabri, MR; Gomez, DE; Skilton, G | 1 |
| Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM | 1 |
| Abbruzzese, JL; Ferrandina, G; Freedman, RS; Loercher, A; Melichar, B; Verschraegen, CF | 1 |
| Harwood, HJ; Lindsey, S; Petras, SF | 1 |
| Bitterman, PB; Dahm, C; Levrey, H; Polunovsky, VA; Rubins, J; Tan, A | 1 |
| Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
| Dricu, A; Girnita, L; Larsson, O; Nilsson, G; Wang, M; Wejde, J; Xie, Y | 1 |
| Bassa, BV; Kamanna, VS; Kirschenbaum, MA; Roh, DD; Vaziri, ND | 1 |
| Choi, JW; Jung, SE | 1 |
| Bukhman, VM; Dudnik, IuV; Leont'eva, OV; Trenin, AS | 1 |
| Löwik, C; Papapoulos, S; van beek, E; van der Pluijm, G | 1 |
| Becke, D; Bruchelt, G; Girgert, R; Schweizer, P; Vogt, Y | 1 |
| Chen, X; Herliczek, T; Keyomarsi, K; Lowe, M; Porter, DC; Rao, S | 1 |
| Aloj, SM; Bifulco, M; Laezza, C | 1 |
| Kim, BS; Kim, TS; Min, JS; Noh, SH; Rha, SY; Roh, JK; Yoo, NC | 1 |
| Foster, BA; Ghosh, PM; Ghosh-Choudhury, N; Greenberg, NM; Kreisberg, JI; Mott, GE; Moyer, ML; Thomas, CA | 1 |
| Agarwal, B; Bhendwal, S; Halmos, B; Holt, PR; Moss, SF; Ramey, WG | 1 |
| Avner, R; Faust, JR; Polak-Charcon, S; Ravid, T; Roitelman, J | 1 |
| Jakóbisiak, M; Lamprecht, J; Paweletz, N; Schrorter, D; Stoehr, M; Wójcik, C | 1 |
| Avalos, J; Cerdá-Olmedo, E; Domenech, CE; Fernández-Martín, R; Giordano, W | 1 |
| Fawcett, TW; Gorospe, M; Holbrook, NJ; Hudgins, WR; Shack, S | 1 |
| Macaulay, RJ; Wang, W | 1 |
| Bochar, DA; Kim, DY; Rodwell, VW; Stauffacher, CV | 1 |
| Elkin, RG; Yan, Z | 1 |
| Han, DC; Kim, SI; Lee, HB | 1 |
| Aboushadi, N; Gentile, A; Jessani, N; Krisans, SK; Shackelford, JE | 1 |
| Lin, JK; Lin-Shiau, SY; Wang, IK | 2 |
| Kasai, S; Nagai, K; Stern, PH; Woo, JT | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
| Beinfeld, MC; Vishnuvardhan, D | 1 |
| Breithardt, G; Fan, L; March, KL; Müller, JG; Schmidt, A; Sindermann, JR; Troyer, D; Weigel, KA | 1 |
| González-Pacanowska, D; Hurtado, R; Montalvetti, A; Peña-Díaz, J; Ruiz-Pérez, LM | 1 |
| Albani, D; Bruno, A; Diomede, L; Fruscella, P; Guglielmotti, A; Mantovani, A; Massimiliano, L; Pinza, M; Polentarutti, N; Romano, M; Salmona, M; Sironi, M; Sottocorno, M; Vecchi, A | 1 |
| Buhagiar, KA; Bundgaard, H; Gray, DF; Hansen, PS; Jessup, W; Kjeldsen, K; Mihailidou, AS; Rasmussen, HH | 1 |
| Ikeda, U; Inaba, H; Ohki, R; Shimada, K; Shimpo, M; Takahashi, M; Yamamoto, K | 1 |
| Förstermann, U; Hausding, M; Kleinert, H; Rodriguez-Pascual, F; von Eichel-Streiber, C; Witteck, A | 1 |
| Joseph, SB; Kast, HR; Laffitte, BA; Mangelsdorf, DJ; Repa, JJ; Tontonoz, P; Wilpitz, DC | 1 |
| Halasy-Nagy, J; Reszka, AA; Rodan, GA | 1 |
| Alvarez, AM; García-Román, N; Lorenzo, MJ; Montes, A; Toro, MJ | 1 |
| Chiang, JY; Kimmel, R; Stroup, D | 1 |
| Benzaquen, M; Dimitroulakos, J; Freedman, MH; Kamel-Reid, S; Moore, MJ; Penn, LZ; Ye, LY; Yeger, H | 1 |
| Belles, X; Buesa, C; Casals, N; Hegardt, FG; Marrero, PF | 1 |
| Breithardt, G; Kroke, A; Müller, JG; Pinkernell, K; Pulawski, E; Skaletz-Rorowski, A; Waltenberger, J | 1 |
| Fernández, C; Ferruelo, AJ; Gómez-Coronado, D; Lasunción, MA; Martínez-Botas, J; Suárez, Y | 1 |
| Eberlein, M; Goppelt-Struebe, M; Heusinger-Ribeiro, J | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Bertoglio, J; Blaie, S; Bolla, M; Boquet, P; Créminon, C; Degraeve, F; Habib, A; Lévy-Toledano, S; Quéré, I | 1 |
| Bede, JC; Goodman, WG; Teal, PE; Tobe, SS | 1 |
| Chamberlain, LH | 1 |
| Hansen, PR; Kristiansen, MT; Ledet, T; Nabipour, MT; Olesen, P; Rasmussen, LM | 1 |
| Chen, H; Liu, R; Xing, Y | 1 |
| Fujita, T; Izumo, N; Koida, M; Nakamuta, H | 1 |
| Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL | 2 |
| Essig, M; Friedlander, G; Laouari, D; Ledoux, S; Michel, JB; Runembert, I; Trugnan, G | 1 |
| Chen, T; Gubina, E; Kozlowski, S; Lizzio, EF; Zhang, L | 1 |
| Yoneda, T | 1 |
| Allen, GS; Johnson, MD; Okediji, EJ; Toms, SA; Woodard, A | 1 |
| Getz, B; Ingle, JN; Karpeisky, MY; Mikhailov, SN; Padyukova, NSh; Reinholz, GG; Sanders, ES; Spelsberg, TC | 1 |
| Andreatta, C; Cole, WC; Edwards-Prasad, J; Koustas, WT; Kumar, B; Prasad, KN | 1 |
| Duriez, P; Fruchart, JC; Hazzan, M; Kandoussi, A; Martin, F; Noël, C; Staels, B | 1 |
| Hanada, A; Kamiya, Y; Kasahara, H; Kuzuyama, T; Takagi, M; Yamaguchi, S | 1 |
| Buurman, SW; Frenkel, J; Houten, SM; Kuis, W; Mandey, SH; Rijkers, GT; Wanders, RJ; Waterham, HR | 1 |
| Ballard, AJ; Demer, LL; Gharavi, N; Mody, N; Parhami, F; Tintut, Y | 1 |
| Muranaka, T; Nagata, N; Suzuki, M; Yoshida, S | 1 |
| Catalano, R; Cordell, B; Naidu, A; Xu, Q | 1 |
| Kato, H; Miyazawa, Y; Muranaka, T; Yoshida, S | 1 |
| Chase, AJ; Luan, Z; Newby, AC | 1 |
| Hohl, RJ; Holstein, SA | 1 |
| Bacon, SP; Illingworth, DR; Pappu, AS | 1 |
| Bach, TJ; Grosdemange-Billiard, C; Hemmerlin, A; Hoeffler, JF; Kagan, IA; Meyer, O; Rohmer, M; Tritsch, D | 1 |
| Banger, N; Berdel, WE; Chou, TC; Kiehl, M; Koch, OM; Müller-Tidow, C; Probst, M; Serve, H; Sindermann, JR; Zühlsdorf, M | 1 |
| Bank, I; Chess, L; Goldstein, I; Koltakov, A; Li, J; Nir-Glickman, E; Roitelman, J | 1 |
| Fernandes, G; Sun, D | 1 |
| Butler, NS; Hunninghake, GW; Monick, MM; Powers, LS | 1 |
| Csonka, C; Csont, T; Ferdinandy, P; Giricz, Z; Onody, A | 1 |
| Bergdahl, A; Hellstrand, P; Persson, E; Swärd, K | 1 |
| Burger, F; Graber, P; Kwak, BR; Lüscher, TF; Mach, F; Matter, CM; Mulhaupt, F; Pelli, G; Veillard, NR | 1 |
| Chou, CK; Lin, YL; Mettling, C; Shiao, MS | 1 |
| Giri, S; Rattan, R; Singh, AK; Singh, I | 2 |
| Distl, R; Glöckner, F; Meske, V; Ohm, TG; Schönheit, B; Tamanai, M; Treiber-Held, S | 1 |
| Andela, VB; O'Keefe, RJ; Pirri, M; Puzas, EJ; Rosenblatt, JD; Rosier, RN; Schwarz, EM | 1 |
| Dong, J; Fujii, S; Furumoto, T; Goto, D; Imagawa, S; Kaneko, T; Kitabatake, A; Mishima, T; Nakai, Y; Zaman, TA | 1 |
| Chen, CW; Chen, JC; Huang, KC; Lin, WW | 1 |
| Boronat, A; Ferrer, A; Forés, O; González, V; Martinez-García, JF; Phillips, MA; Rodríguez-Concepción, M | 1 |
| Domínguez, A; Ruiz-Velasco, N; Vega, MA | 1 |
| Dello Russo, C; Navarra, P; Preziosi, P; Tringali, G; Vairano, M | 1 |
| Coso, OA; Giráldez, AN; Giulianelli, S; Jimenez de Asua, L; Rudland, PS; Sauane, M | 1 |
| Kamide, Y; Kato, H; Kato, T; Masuda, K; Muranaka, T; Nagata, N; Ohyama, K; Sato, S; Seki, H; Suzuki, M; Tabata, S; Yoshida, S | 1 |
| Clark, DS; Gerber, R; Ryan, JD | 1 |
| Hedl, M; Rodwell, VW | 1 |
| Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H | 1 |
| Elson, CE; Mo, H | 1 |
| Anthony, MD; Edwards, RH; Fortin, DL; Kubo, S; Nakamura, K; Troyer, MD | 1 |
| Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y | 1 |
| Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL | 1 |
| Chatterjee, S; Fang, L; Song, J; Wei, H | 1 |
| Dimitroulakos, J; Goss, G; Hanson, JE; Lagarde, AE; Lorimer, IA; Mantha, AJ | 1 |
| Coxon, FP; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, GG | 1 |
| Rogers, MJ; Rojas-Navea, J; Thompson, K | 1 |
| Hamadmad, SN; Henry, MK; Hohl, RJ | 1 |
| Kim, J; Matsuyama, S; Suzuki, T | 1 |
| Bragado, MJ; Cerezo-Guisado, MI; García-Marín, LJ; González-Fernández, L; Langmesser, S; Lorenzo, MJ | 1 |
| Etemadmoghadam, D; Fraser, SA; Kandane, RK; Kanellis, J; Kemp, BE; Levidiotis, V; Mount, PF; Power, DA | 1 |
| Bertini, S; Bifulco, M; Caruso, MG; Fiorentino, L; Laezza, C; Macchia, M; Messa, C; Minutolo, F; Notarnicola, M; Portella, G; Stingo, S | 1 |
| Adeagbo-Sheikh, J; Austen, BM; Farrant, JK; Parsons, RB; Price, GC; Subramaniam, D | 1 |
| Dimitroulakos, J; Goss, G; Lorimer, IA | 1 |
| Bestari, K; Brain, RA; Lissemore, LI; Reitsma, TS; Sibley, PK; Solomon, KR | 1 |
| Duleba, AJ; Foyouzi, N; Kwintkiewicz, J; Piotrowski, P; Rzepczynska, I | 1 |
| Balogh, Z; Fóris, G; Fülöp, P; Koncsos, P; Kosztáczky, B; Paragh, G; Seres, I | 1 |
| Hamblin, MW; Sjögren, B; Svenningsson, P | 1 |
| Golab, J; Issat, T; Jakóbisiak, M | 1 |
| Antoun, TA; Badr, KF; Badreddine, R; Bertoglio, J; Habib, A; Nasrallah, MS; Nemer, G; Shamseddeen, I | 1 |
| Aldieri, E; Betta, PG; Bosia, A; Gazzano, E; Ghigo, D; Orecchia, S; Pescarmona, G; Riganti, C; Silvagno, F | 1 |
| Bravo, L; Gupta, J; McAnally, JA; Mo, H; Sodhani, S | 1 |
| Ebetino, FH; Edwards, CM; Hulley, PA; Roelofs, AJ; Rogers, MJ; Russell, RG | 1 |
| Hohl, RJ; Martins, JB; Murry, DJ; Schmidt, MS; Xing, D | 1 |
| Bergsagel, PL; Boutros, PC; Bros, C; Clendening, JW; Jurisica, I; Khosravi, F; Martirosyan, A; Penn, LZ; Stewart, AK; Wong, WW | 1 |
| Hamadmad, SN; Hohl, RJ | 1 |
| Llorente, A; Sandvig, K; van Deurs, B | 1 |
| Harris, KW; Lehenkari, PP; Merrell, MA; Selander, KS; Wakchoure, S | 1 |
| Golde, TE; Landreth, G; Ostrowski, SM; Wilkinson, BL | 1 |
| Dimitroulakos, J; Morley, M; Niknejad, N | 1 |
| Towler, MJ; Weathers, PJ | 1 |
| Burke, LP; Kukoly, CA | 1 |
| Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I | 1 |
| Beales, IL; Ogunwobi, OO | 1 |
| Heber, D; Hong, MY; Seeram, NP; Zhang, Y | 1 |
| Hussein, D; Mo, H | 1 |
| Brañes, J; Carvajal, J; Chen-Lin, K; Cuello, M; Gejman, R; Kato, S; Oliva, B; Owen, GI; Sadarangani, A; Smalley, S | 1 |
| Fitzgerald, K; Kashanin, D; O'Dowd, F; Robinson, AJ; Walsh, GM; Williams, V | 1 |
| Fessler, MB | 1 |
| Esemuede, N; Gahtan, V; Lee, T; Maier, KG; Sumpio, BE | 1 |
| Costanzo, A; Cruz, J; Ennis, FA; Jameson, JM; Terajima, M | 1 |
| Acimovic, J; Björkhem-Bergman, L; Eriksson, LC; Parini, P; Torndal, UB | 1 |
| Hosaka, M; Moriguchi, T; Shinozuka, K; Suda, M; Takeuchi, T; Tsuchiya, M; Yokota-Hashimoto, H; Zhang, S | 1 |
| Barter, MJ; Catterall, JB; Cawston, TE; Hui, W; Lakey, RL; Young, DA | 1 |
| Ahn, T; Jung, HC; Kang, JY; Kim, D; Kim, DH; Kim, KH; Lee, YJ; Pan, JG; Park, KD; Park, SH; Yun, CH | 1 |
| Hiasa, J; Ibrahim, HM; Kameyama, K; Nishikawa, Y; Shiga, I; Xuan, X | 1 |
| Fritz, G; Huelsenbeck, J; Nilsson, S | 1 |
| Gartner, U; McLean, WH; Smith, FJ; Zhao, Y | 1 |
| Bil, J; Golab, J; Issat, T; Jakobisiak, M; Nowis, D; Winiarska, M | 1 |
| Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H | 1 |
| Ebisu, S; Egawa, K; Goto, T; Hohsaka, T; Kato, S; Kawada, T; Kim, YI; Miyagawa, H; Murakami, S; Nagai, H; Sakamoto, T; Taimatsu, A; Takahashi, N | 1 |
| Bachmann, AL; Prüfer, D; Sand, J; Schaller, H; Schmidt, T; Schulze Gronover, C; van Deenen, N | 1 |
| Chang, TC; Ho, PY; Hsu, SP; Lee, WS; Liang, YC; Zhong, WB | 1 |
| Alcazar-Fuoli, L; Bignell, E; Blatzer, M; Cairns, T; Grimalt, JO; Gründlinger, M; Haas, H; Lopez, JF; Puempel, T; Yasmin, S | 1 |
| Amet, Y; Antoun, J; Corcos, L; Goulitquer, S; Le Jossic-Corcos, C; Plée-Gautier, E; Salaün, JP; Simon, B | 1 |
| Hollis, BW; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I | 1 |
| Shi, J; Xu, Z; Yao, F; Zhao, H; Zhong, C; Zhu, J | 1 |
| Du, X; Han, R; Liang, X; Liang, Z; Liu, F; Liu, Y; Yang, D; Zhao, J | 1 |
| Behmanesh, M; Ebrahimzadeh, H; Kazempour Osaloo, S; Ramak, P; Sharifi, M | 1 |
| Elfakhani, M; Hussein, D; Mills, N; Mo, H; Torabi, S; Verbeck, GF | 1 |
| Bentinger, M; Brismar, K; Chojnacki, T; Dallner, G; Danikiewicz, W; Kaczorowska, E; Kania, M; Swiezewska, E; Tekle, M; Wojcik, J | 1 |
| Trenin, AS | 1 |
| Barszczyk, A; Charlton, MP; Feng, ZP; Quan, Y; Sun, HS; Zheng, W | 1 |
| Hamid, PH; Hermosilla, C; Hirzmann, J; Taubert, A | 1 |
| Du, X; Guo, W; Guo, Z; Jin, W; Liang, Z; Liu, Y; Yan, X; Yang, D; Zhang, C | 1 |
| Gerner, C; Grunt, T; Haider, F; Karlic, H; Proestling, K; Thaler, R; Varga, F | 1 |
| Crovella, S; Kleiner, G; Marcuzzi, A; Monasta, L; Piscianz, E; Tricarico, PM | 1 |
| Gu, J; Jung, JG; Kashima, H; Kobayashi, Y; Kuan, JC; Shih, IeM; Sokoll, L; Visvanathan, K; Wang, TL; Wu, RC; Xuan, J | 1 |
| Chen, CC; Ho, CT; Huang, SP; Huang, TC; Liu, TY | 1 |
| Alarcon, VB; Marikawa, Y | 1 |
| Mo, H; Shen, CL; Torabi, S; Yeganehjoo, H | 1 |
| Braga, L; Celsi, F; Crovella, S; Gratton, R; Tricarico, PM | 1 |
| D'Acunto, WC; Gbelcová, H; Knejzlík, Z; Kolář, M; Repiská, V; Rimpelová, S; Ruml, T; Šáchová, J; Strnad, H; Vítek, L | 1 |
| Demyanets, S; Hohensinner, PJ; Huber, K; Kaun, C; Krychtiuk, KA; Lenz, M; Pentz, R; Stojkovic, S; Thaler, B; Wojta, J; Zuckermann, A | 1 |
| Chen, Z; Duan, Q; Gong, L; Wang, R; Wen, Q; Wu, P; Xia, F; Xiao, Y; Xie, S; Xu, H; Yang, T; Zhao, T; Zheng, Z; Zhou, W; Zhu, L | 1 |
| Rao, PS; Rao, US | 1 |
| Asperti, M; Bernardi, S; Cassandri, M; Codenotti, S; Fanzani, A; Gastaldello, S; Giacomini, A; Mandracchia, D; Marampon, F; Mignani, L; Mitola, S; Monti, E; Parolini, S; Poli, M; Rezzola, S; Rota, R; Russo, D; Tabellini, G; Tomasini, D; Triggiani, L; Vezzoli, M; Zizioli, D | 1 |
| Du, W; Feng, Y; Lou, Y; Niu, J; Wang, S; Yin, C; Yue, A; Zhao, J | 1 |
13 review(s) available for mevalonic acid and lovastatin
| Article | Year |
|---|---|
Protein prenylation: key to ras function and cancer intervention?
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Fungal Proteins; GTP-Binding Proteins; Humans; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); ras Proteins; Saccharomyces cerevisiae; Transferases | 1992 |
Cholesterol and mevalonic acid modulation in cell metabolism and multiplication.
Topics: Animals; Cell Division; Cholesterol; Glioma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Muscles; Simvastatin | 1992 |
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.
Topics: Animals; Cell Division; Cell Line; Cholesterol; Cricetinae; Cricetulus; Feedback; Female; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Naphthalenes; Ovary | 1980 |
[Regulation of cholesterol synthesis, as focused on the regulation of HMG-CoA reductase (author's transl)].
Topics: Animals; Cholesterol; Glucagon; Humans; Hydroxymethylglutaryl CoA Reductases; Insulin; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Microsomes, Liver; Naphthalenes; Phosphorylation; Rats | 1980 |
Regulation of coenzyme Q biosynthesis.
Topics: Alkyl and Aryl Transferases; Animals; Cholesterol; Dimethylallyltranstransferase; Dolichols; Enzyme Activation; Eukaryotic Cells; Farnesyltranstransferase; Golgi Apparatus; Isoenzymes; Lovastatin; Mevalonic Acid; Microbodies; Models, Biological; Organ Specificity; Polyisoprenyl Phosphates; Rats; Transferases; Tumor Cells, Cultured; Ubiquinone | 1994 |
Pharmacology of competitive inhibitors of HMG-CoA reductase.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cattle; Cells, Cultured; Chick Embryo; Cholesterol; Cricetinae; Dogs; Guinea Pigs; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lipoproteins; Lovastatin; Mevalonic Acid; Mice; Organ Specificity; Rabbits; Rats; Simvastatin | 1995 |
Effects of lipids on the pathogenesis of progressive renal failure: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in the prevention of glomerulosclerosis.
Topics: Animals; Anticholesteremic Agents; Cell Division; Collagen; Colony-Stimulating Factors; Extracellular Matrix Proteins; Gene Expression; Glomerular Mesangium; Glomerulonephritis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kidney; Kidney Failure, Chronic; Lovastatin; Mevalonic Acid | 1996 |
Regulation of mesangial cell proliferation by the mevalonate pathway.
Topics: Animals; Cell Division; Cells, Cultured; Cholesterol; Glomerular Mesangium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Polyisoprenyl Phosphates; Sesquiterpenes | 1997 |
[Prevention and therapy of vascular damage and endothelial dysfunction with hypocholesteremic agents].
Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Diet; Endothelium, Vascular; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Mevalonic Acid; Middle Aged; Physical Exertion; Primary Prevention; Simvastatin; Time Factors | 1998 |
[Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action].
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Lovastatin; Mevalonic Acid; Osteogenesis; Osteoporosis; Stimulation, Chemical; Transforming Growth Factor beta | 2002 |
The mevalonate synthesis pathway as a therapeutic target in cancer.
Topics: Acute-Phase Proteins; Alendronate; Alkyl and Aryl Transferases; Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Polyisoprenyl Phosphates; Tumor Cells, Cultured | 2003 |
Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Cycle; Cell Division; Clinical Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neoplasms; Protein Processing, Post-Translational; Terpenes | 2004 |
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; ErbB Receptors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Protein Kinase Inhibitors | 2006 |
3 trial(s) available for mevalonic acid and lovastatin
| Article | Year |
|---|---|
Lovastatin versus bezafibrate: efficacy, tolerability, and effect on urinary mevalonate.
Topics: Adult; Aged; Bezafibrate; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Single-Blind Method | 1990 |
The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Clinical Trials as Topic; Heterozygote; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; In Vitro Techniques; Leukocytes, Mononuclear; Lipoproteins; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Receptors, LDL; Simvastatin | 1990 |
Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Liver; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome; Triglycerides | 1995 |
418 other study(ies) available for mevalonic acid and lovastatin
| Article | Year |
|---|---|
Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium.
Topics: Animals; Cells, Cultured; Depression, Chemical; Desmosterol; Fatty Acids; Growth Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Nucleic Acids; Phospholipids; Triglycerides | 1978 |
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Acetates; Animals; Binding, Competitive; Caprylates; Cholesterol; Fatty Acids; Gallbladder; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kidney; Kinetics; Lactones; Liver; Lovastatin; Male; Mevalonic Acid; Mice; Naphthalenes; Naphthols; Organ Specificity; Pyrans; Rats; Sterols | 1977 |
The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence.
Topics: Amino Acids; Animals; Cell Nucleus; DNA; DNA Replication; DNA-Directed DNA Polymerase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Ornithine Decarboxylase; Protein Biosynthesis; Rats; Resting Phase, Cell Cycle; RNA; Tetrahydrofolate Dehydrogenase; Time Factors; Tumor Cells, Cultured | 1992 |
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
Topics: Butadienes; Enzyme Activation; GTP-Binding Proteins; Hemiterpenes; Humans; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; NADH, NADPH Oxidoreductases; NADPH Oxidases; Pentanes; Respiratory Burst; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin.
Topics: Animals; Cell Line; Cell Nucleus; Cycloheximide; Cytochrome P-450 Enzyme System; DNA Probes; Enzyme Activation; Enzyme Repression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Mice; Plasmids; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Transcription, Genetic; Transfection | 1992 |
Lipoprotein receptor mediated metabolism of [14C]arachidonic acid labeled chylomicron remnants by Hep G2 cells.
Topics: Arachidonic Acid; Biological Transport; Cholesterol Esters; Chylomicrons; Glycerides; Humans; Lovastatin; Mevalonic Acid; Phospholipids; Receptors, Cell Surface; Receptors, Lipoprotein; Tumor Cells, Cultured | 1992 |
Cholesterol inhibition, cancer, and chemotherapy.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Cholesterol; Dogs; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Rats | 1992 |
Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; GTP-Binding Proteins; Lovastatin; Methylation; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Pheochromocytoma; Protein Prenylation; Protein Processing, Post-Translational; Rats; Tumor Cells, Cultured | 1992 |
Isoprenoid requirement for intracellular transport and processing of murine leukemia virus envelope protein.
Topics: Animals; Cell Compartmentation; Gene Products, gag; GTP-Binding Proteins; Hexosaminidases; In Vitro Techniques; Lovastatin; Mevalonic Acid; Mice; Protein Precursors; Protein Processing, Post-Translational; Tumor Cells, Cultured; Viral Envelope Proteins; Virion | 1992 |
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Gene Library; Genes, Dominant; Humans; Lovastatin; Membrane Proteins; Membrane Transport Proteins; Mesocricetus; Mevalonic Acid; Molecular Sequence Data; Oligodeoxyribonucleotides; Point Mutation; Polymerase Chain Reaction; Protein Conformation; Proteins; Rats; RNA, Messenger; Transfection | 1992 |
Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cushing Syndrome; Cytochrome P-450 Enzyme System; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Mitotane; Simvastatin | 1992 |
Dolichol delays G1-arrest for one cell cycle in human fibroblasts subjected to depletion of serum or mevalonate.
Topics: Cell Cycle; Cells, Cultured; Culture Media, Serum-Free; Dolichols; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interphase; Lovastatin; Mevalonic Acid; Proteins | 1992 |
Inhibition of pancreatic adenocarcinoma cell growth by lovastatin.
Topics: Animals; Cell Division; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Lovastatin; Mevalonic Acid; Mice; Mice, Nude; Pancreatic Neoplasms; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Egg Proteins; Humans; Kinetics; Lovastatin; Lung Neoplasms; Mevalonic Acid; Oocytes; Pancreatic Neoplasms; Ribonucleases | 1992 |
Squalene synthase-deficient mutant of Chinese hamster ovary cells.
Topics: Acetates; Animals; CHO Cells; Cholesterol; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Flow Cytometry; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Mutagenesis | 1992 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cricetinae; Gene Expression Regulation, Enzymologic; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lovastatin; Mesocricetus; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Protein Processing, Post-Translational; RNA, Messenger | 1992 |
Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat.
Topics: Adipose Tissue; Animals; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Kinetics; Lipid Metabolism; Lipids; Lipoproteins, VLDL; Liver; Lovastatin; Male; Mevalonic Acid; Polyethylene Glycols; Rats; Rats, Zucker; Triglycerides | 1992 |
Regulation of intracellular actin polymerization by prenylated cellular proteins.
Topics: Actin Cytoskeleton; Actins; Blood; Calcium; Cell Line; Dimethylallyltranstransferase; Humans; Lovastatin; Mevalonic Acid; Polyisoprenyl Phosphates; Polymers; Protein Processing, Post-Translational; Proteins; Sesquiterpenes | 1992 |
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
Topics: Acetates; Animals; Anticholesteremic Agents; Apolipoproteins B; Cell Line; Cholesterol; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Gene Expression Regulation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Liver; Lovastatin; Mevalonic Acid; Rats; Receptors, LDL; RNA, Messenger; Simvastatin | 1992 |
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells.
Topics: Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Intestinal Mucosa; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Radioligand Assay; Sterol O-Acyltransferase; Tumor Cells, Cultured | 1992 |
Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733).
Topics: Animals; Anticholesteremic Agents; Aorta, Thoracic; Benzylamines; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Fibrinogen; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Nifedipine; Platelet-Derived Growth Factor; Pravastatin; Simvastatin; Sterols; Swine; Thiophenes | 1992 |
rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Drosophila melanogaster; GTP-Binding Proteins; Humans; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Nerve Tissue Proteins; Protein Biosynthesis; rab3 GTP-Binding Proteins; Sequence Homology, Nucleic Acid; Synaptic Vesicles | 1991 |
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells.
Topics: Acetates; Anticholesteremic Agents; Benzylamines; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cycloheximide; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Nucleic Acid Hybridization; Oxygenases; RNA, Neoplasm; Simvastatin; Squalene Monooxygenase; Thiophenes | 1991 |
Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells.
Topics: Carcinoma, Hepatocellular; Cell-Free System; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Lanosterol; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Receptors, LDL; Sterol 14-Demethylase; Sterols; Tumor Cells, Cultured | 1991 |
HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts.
Topics: Blastomeres; Carrier Proteins; Extracellular Space; Humans; Hydrogen-Ion Concentration; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Membranes; Lovastatin; Lymphocytes; Mevalonic Acid; Simvastatin; Sodium-Hydrogen Exchangers | 1991 |
Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cytosol; Glioma; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Protein Binding; Protein Processing, Post-Translational | 1991 |
Cell cycle-specific effects of lovastatin.
Topics: Cell Cycle; Cell Survival; Humans; In Vitro Techniques; Ki-67 Antigen; Lovastatin; Mevalonic Acid; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras); Tumor Cells, Cultured | 1991 |
Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation.
Topics: Amino Acid Sequence; Cell Membrane; Cloning, Molecular; Epitopes; GTP-Binding Proteins; Hemagglutinins, Viral; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Mutation; Oncogene Protein p21(ras); Orthomyxoviridae; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Signal Transduction; Suppression, Genetic | 1990 |
Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation.
Topics: Antibodies, Monoclonal; Antigens, CD; Blotting, Northern; Cell Division; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ionomycin; Lovastatin; Mevalonic Acid; Mitogens; RNA; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1991 |
rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.
Topics: Animals; Base Sequence; Blotting, Western; Carboxylic Acids; Cell Line; Cysteine; DNA; Gene Expression; GTP-Binding Proteins; Haplorhini; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Precipitin Tests; Protein Processing, Post-Translational; rab5 GTP-Binding Proteins; Recombinant Proteins | 1992 |
Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms.
Topics: Animals; Astrocytes; Cells, Cultured; Cycloheximide; Dolichols; G1 Phase; Glycoproteins; Interphase; Kinetics; Lovastatin; Mevalonic Acid; Rats; S Phase; Tunicamycin | 1991 |
Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.
Topics: Adenosine; Animals; Deoxyadenosines; Dimethyl Sulfoxide; GTP-Binding Proteins; Guanosine Triphosphate; Lovastatin; Membrane Proteins; Methylation; Mevalonic Acid; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Protein Processing, Post-Translational; Thionucleosides; Tumor Cells, Cultured | 1991 |
Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes.
Topics: Acetates; Animals; Anticholesteremic Agents; Cell Survival; Cells, Cultured; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Fatty Acid Synthases; Garlic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Liver; Lovastatin; Male; Mevalonic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase | 1991 |
Role of isoprenoid metabolism in IgE receptor-mediated signal transduction.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Calcium; Cell Division; Inositol 1,4,5-Trisphosphate; Ionomycin; Lovastatin; Mevalonic Acid; Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Blotting, Western; Cell Compartmentation; Cell Division; Cell Membrane; Colonic Neoplasms; Dehydroepiandrosterone; Humans; In Vitro Techniques; Lovastatin; Mevalonic Acid; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Terpenes; Tumor Cells, Cultured | 1991 |
The influence of simvastatin on adrenal corticosteroid production and urinary mevalonate during adrenocorticotropin stimulation in patients with heterozygous familial hypercholesterolemia.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Anticholesteremic Agents; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Mevalonic Acid; Middle Aged; Simvastatin | 1991 |
Inhibition of a plant sesquiterpene cyclase by mevinolin.
Topics: Acetates; Acetic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Lyases; Isomerases; Kinetics; Lovastatin; Mevalonic Acid; Plants; Sesquiterpenes | 1991 |
Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates.
Topics: Cell Division; Cell Line; DNA; Humans; Hydroxymethylglutaryl CoA Reductases; Lipoproteins, LDL; Lovastatin; Lymphocytes; Mevalonic Acid; Sterols | 1991 |
Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry.
Topics: Adolescent; Adult; Anticholesteremic Agents; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Middle Aged; Simvastatin | 1991 |
Isoprenoid formation and cell-mediated immunological functions.
Topics: Cells, Cultured; Cholesterol; Cytotoxicity, Immunologic; Depression, Chemical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Cellular; Immunologic Surveillance; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lovastatin; Mevalonic Acid; Recombinant Proteins; Terpenes; Tumor Cells, Cultured; Tunicamycin | 1991 |
Inhibition of growth factor signaling pathways by lovastatin.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Genes, fos; Growth Substances; Humans; Infant, Newborn; Insulin-Like Growth Factor I; Lovastatin; Male; Mevalonic Acid; Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Skin; Thymidine; Transcription, Genetic | 1991 |
Regulation of squalene epoxidase in HepG2 cells.
Topics: Binding, Competitive; Carcinoma, Hepatocellular; Cholesterol; Detergents; Enzyme Induction; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Liver; Liver Neoplasms; Lovastatin; Mevalonic Acid; Microsomes, Liver; Octoxynol; Oxygenases; Polyethylene Glycols; Simvastatin; Squalene Monooxygenase; Tumor Cells, Cultured | 1990 |
Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells.
Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Cell Division; Fatty Acids, Unsaturated; Fungi; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Lactones; Lovastatin; Mevalonic Acid; Molecular Structure; Naphthalenes; Oxo-Acid-Lyases; Soil Microbiology; Vero Cells | 1990 |
Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.
Topics: Cell Division; Cell Survival; Cycloheximide; Dactinomycin; Deoxyribonucleases; Dexamethasone; DNA Damage; Humans; Hydroxycholesterols; In Vitro Techniques; Leukemia, T-Cell; Lovastatin; Mevalonic Acid; Mifepristone; Nuclear Proteins; Tumor Cells, Cultured | 1991 |
Evidence for isopentenyladenine modification on a cell cycle-regulated protein.
Topics: Adenine; Animals; Antibodies; Binding, Competitive; Blotting, Western; Cell Cycle; Cricetinae; Cricetulus; DNA; Isopentenyladenosine; Liver; Lovastatin; Mevalonic Acid | 1991 |
Effects of simvastatin (MK-733) on branched pathway of mevalonate.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cholesterol; DNA; Dolichols; Humans; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Proteins; Simvastatin; Thymidine; Tumor Cells, Cultured; Tyrosine; Ubiquinone | 1990 |
Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.
Topics: Animals; Cell Line; Cell Membrane; Cytosol; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine Triphosphate; Immunoblotting; Leukemia, Erythroblastic, Acute; Lovastatin; Methylation; Mevalonic Acid; Mice; Molecular Weight; Protein Binding; Protein Processing, Post-Translational; Rats | 1990 |
Mevalonate deprivation alters the induction of fos and myc by growth factors.
Topics: Blotting, Northern; Cells, Cultured; Dactinomycin; Epidermal Growth Factor; Gene Expression; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Immunoblotting; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Lovastatin; Mevalonic Acid; Mice; Molecular Weight; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras) | 1990 |
Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase.
Topics: ADP Ribose Transferases; Animals; Botulinum Toxins; Cell Membrane; Clostridium botulinum; Cytoskeleton; GTP-Binding Proteins; In Vitro Techniques; Lovastatin; Membrane Proteins; Mevalonic Acid; Microinjections; Oocytes; Oogenesis; Polyisoprenyl Phosphates; Progesterone; rhoB GTP-Binding Protein; Xenopus laevis | 1990 |
Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2.
Topics: Carcinoma, Hepatocellular; Cell Line; Cholesterol; Gene Expression Regulation; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipase; Liver Neoplasms; Lovastatin; Mevalonic Acid; RNA Probes; RNA, Messenger; Transcription, Genetic | 1990 |
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
Topics: Animals; Cell Line; Cholesterol; Genes, ras; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Methionine; Mevalonic Acid; Oncogene Protein p21(ras); Protein Precursors; Protein Processing, Post-Translational; Transfection | 1990 |
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Exons; Farnesol; Genetic Vectors; Humans; Lovastatin; Mevalonic Acid; Mice; Mutation; Oligonucleotide Probes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Transfection | 1990 |
Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation.
Topics: Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipid Metabolism; Lipoproteins, LDL; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Proteins; Sterols | 1990 |
Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2.
Topics: Acetates; Antibody-Dependent Cell Cytotoxicity; Chemotaxis, Leukocyte; Cholesterol; Cytotoxicity, Immunologic; DNA Replication; Humans; In Vitro Techniques; Interleukin-2; Killer Cells, Natural; Lovastatin; Mannose; Mevalonic Acid; Phenotype; Protein Biosynthesis; Thymidine; Time Factors; Tritium | 1990 |
Plasma apolipoprotein E, high density lipoprotein1 (HDL1) and urinary mevalonate excretion in pancreatectomized diabetic dogs: effects of insulin and lovastatin.
Topics: Animals; Apolipoproteins B; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dogs; Insulin; Lipoproteins, HDL; Lovastatin; Male; Mevalonic Acid; Pancreatectomy | 1990 |
The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Female; Hydroxymethylglutaryl CoA Reductases; Intracellular Membranes; Lovastatin; Mevalonic Acid; Ovary; Proteins; Recombinant Fusion Proteins; Transfection | 1990 |
Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Colonic Neoplasms; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Sterol O-Acyltransferase; Triglycerides | 1990 |
Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.
Topics: Animals; Chemical Phenomena; Chemistry; Cholesterol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Liver; Lovastatin; Mevalonic Acid; Molecular Conformation; Molecular Structure; Pyrazoles; Rats; Structure-Activity Relationship | 1990 |
Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains | 1990 |
Relationships among dolichyl phosphate, glycoprotein synthesis, and cell culture growth.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cholesterol; DNA Replication; Dolichol Monophosphate Mannose; Dolichol Phosphates; Glycoproteins; Kinetics; Lovastatin; Male; Mannose; Mevalonic Acid; Mice; Mice, Inbred C3H; Microsomes, Liver; Polyisoprenyl Phosphates; Radioisotope Dilution Technique; Tritium | 1990 |
Rat liver 3-hydroxy-3-methylglutaryl-CoA reductase. Catalysis of the reverse reaction and two half-reactions.
Topics: Animals; Catalysis; Coenzyme A; Cytosol; Glutaral; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Meglutol; Mevalonic Acid; NAD; NADP; Naphthalenes; Rats; Spectrophotometry | 1985 |
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine | 1986 |
Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by lovastatin.
Topics: Cytotoxicity, Immunologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Interferon-gamma; Interleukin-2; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Mitogens | 1989 |
Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols.
Topics: Androstenes; Carcinoma, Hepatocellular; Cholesterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Isomerases; Lipoproteins, HDL; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Sterols; Tumor Cells, Cultured | 1989 |
Abolition of mevinolin-induced growth inhibition in human fibroblasts following transformation by simian virus 40.
Topics: Cell Division; Cell Transformation, Viral; Culture Media; Dolichols; Gene Expression Regulation, Enzymologic; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Simian virus 40; Sterols | 1989 |
Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells.
Topics: Carcinoma, Hepatocellular; DNA, Neoplasm; Gene Expression Regulation; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxo-Acid-Lyases; Receptors, LDL; RNA, Messenger; Tumor Cells, Cultured | 1989 |
Plasma mevalonate response in lovastatin-related myopathy.
Topics: Aged; Creatine Kinase; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Muscular Diseases | 1989 |
Stimulation of anchorage independent proliferation of human adrenocortical carcinoma cells by inhibition of cholesterol biosynthesis.
Topics: Adrenal Cortex Neoplasms; Cell Adhesion; Cell Division; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
The effects of tunicamycin, mevinolin and mevalonic acid on HMG-CoA reductase activity and nuclear division in the myxomycete Physarum polycephalum.
Topics: Cell Nucleus; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Physarum; Tunicamycin | 1989 |
Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability.
Topics: Animals; Cell Line; Cholesterol; Cycloheximide; Dolichols; Kinetics; Leucine; Lovastatin; Mevalonic Acid; Protein Processing, Post-Translational; Tritium; Ubiquinone | 1989 |
Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, LDL; Dose-Response Relationship, Drug; Female; Humans; Hyperlipoproteinemia Type II; Kinetics; Lovastatin; Male; Mevalonic Acid; Middle Aged | 1989 |
Role of mevalonic acid in the regulation of natural killer cell cytotoxicity.
Topics: Cell Line; Cell Survival; Cells, Cultured; Cholesterol; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Dolichols; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Sterols | 1989 |
Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholesterol and 24-hour urinary mevalonate excretion in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lovastatin; Male; Mevalonic Acid | 1989 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites.
Topics: Androstenes; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Enzyme Activation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Immunoblotting; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; RNA, Messenger; Tumor Cells, Cultured | 1988 |
F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Topics: Acetates; Acetic Acid; Acetyl Coenzyme A; Acetyl-CoA C-Acetyltransferase; Animals; Carbohydrate Sequence; Cell Line; Fatty Acids, Unsaturated; Hydroxymethylglutaryl-CoA Synthase; Lactones; Liver; Lovastatin; Mevalonic Acid; Oxo-Acid-Lyases; Rats; Sterols | 1987 |
Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits.
Topics: Animals; Cholesterol, Dietary; Eating; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lovastatin; Mevalonic Acid; Rabbits; Species Specificity | 1989 |
Cellular distribution of cholesterogenesis-linked, phosphoisoprenylated proteins in proliferating cells.
Topics: Animals; Cell Division; Cell Nucleus; Cholesterol; Cytosol; Electrophoresis, Polyacrylamide Gel; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intermediate Filaments; Isoelectric Point; Lovastatin; Lymphoma; Mevalonic Acid; Mice; Molecular Weight; Phosphates; Phosphoproteins; Polyisoprenyl Phosphates; Tumor Cells, Cultured | 1989 |
Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acyl Coenzyme A; Animals; Bucladesine; Cell Differentiation; Cells, Cultured; Cholesterol; Lovastatin; Mevalonic Acid; Naphthalenes; Neuroglia; Oligodendroglia; Rats; Rats, Inbred Strains | 1987 |
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity.
Topics: Androstenes; Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Imidoesters; Lipid Metabolism; Liver Neoplasms; Lovastatin; Mevalonic Acid; Naphthalenes; Triparanol | 1987 |
Growth inhibition of yeast by compactin (ML-236B) analogues.
Topics: Anti-Bacterial Agents; Culture Media; Lovastatin; Mevalonic Acid; Mitosporic Fungi; Saccharomycetales | 1988 |
Requirement for mevalonate in cycling cells: quantitative and temporal aspects.
Topics: Animals; Autoradiography; Cell Cycle; Cell Line; Cell Survival; Cholesterol; DNA; Flow Cytometry; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid | 1988 |
Lovastatin is hypertriglyceridemic in Syrian golden hamsters.
Topics: Animals; Cholesterol; Cricetinae; Fatty Acids, Nonesterified; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Liver; Lovastatin; Mesocricetus; Mevalonic Acid; Time Factors | 1988 |
Assessment of functional low-density lipoprotein receptor activity on lymphocytes of normal subjects and patients with familial hypercholesterolemia.
Topics: Cell Division; Cholesterol, LDL; Heterozygote; Homozygote; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Lovastatin; Lymphocytes; Mevalonic Acid; Receptors, LDL | 1988 |
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.
Topics: Animals; Cell Division; Cell Line; Homeostasis; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Protein Biosynthesis; Protein Processing, Post-Translational; RNA, Messenger; Transfection | 1988 |
Mevalonate deprivation leads to aneuploidy in Chinese hamster ovary cells.
Topics: Aneuploidy; Animals; Cell Line; Chromosomes; Cricetinae; DNA; Drug Resistance; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mutation; Ovary | 1988 |
Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Naphthalenes; Phenotype; Receptors, LDL | 1987 |
Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability.
Topics: Acyl Coenzyme A; Halobacterium; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipids; Lovastatin; Mevalonic Acid; NADP; Naphthalenes | 1986 |
Effects of mevinolin and mevalonate on cell growth in several transformed cell lines.
Topics: Animals; Cell Division; Cell Line; DNA; Fibroblasts; Humans; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred C3H; Naphthalenes; Thymidine | 1986 |
The mechanism and regulation of dolichyl phosphate biosynthesis in rat liver.
Topics: Acetates; Acetic Acid; Animals; Cholesterol; Cholestyramine Resin; Chromatography, High Pressure Liquid; Circadian Rhythm; Dolichol Phosphates; Farnesyl-Diphosphate Farnesyltransferase; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Polyisoprenyl Phosphates; Rats; Time Factors | 1986 |
Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.
Topics: Animals; Cell Line; Cholesterol; Cricetinae; Cricetulus; Female; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lanosterol; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Ovary; Phenotype; Receptors, LDL; Temperature | 1987 |
Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures.
Topics: Animals; Animals, Newborn; Brain; Cell Division; Cells, Cultured; Cholesterol; Culture Media; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Lovastatin; Mevalonic Acid; Naphthalenes; Neuroglia; Rats; Rats, Inbred Strains | 1987 |
Characterization and regulation of HMG-CoA reductase during a cycle of juvenile hormone synthesis.
Topics: Animals; Cockroaches; Corpora Allata; Cycloheximide; Enzyme Activation; Farnesol; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; Lovastatin; Mevalonic Acid; Microsomes; Sesquiterpenes; Stereoisomerism | 1987 |
Partial prevention of compactin (ML-236B) inhibition of in vitro hematopoiesis by dolichol and dolichyl phosphate.
Topics: Animals; Bone Marrow Cells; Cell Cycle; Cell Differentiation; Cells, Cultured; Diterpenes; Dolichol Phosphates; Dolichols; Erythropoiesis; Granulocytes; Hematopoiesis; Liver; Lovastatin; Macrophages; Mevalonic Acid; Mice; Naphthalenes | 1986 |
Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid.
Topics: Animals; Cells, Cultured; Cholesterol; Chylomicrons; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Linoleic Acid; Linoleic Acids; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rats; Rats, Inbred Strains | 1987 |
Inhibition of mevalonate synthesis with compactin does not prevent DNA replication in cultured animal cells.
Topics: Animals; Cells, Cultured; Cricetinae; DNA Replication; HeLa Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes | 1986 |
Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Cholesterol; Lovastatin; Mevalonic Acid; Mice; Mitochondria; Naphthalenes; Neuroblastoma; Oxygen Consumption; Ubiquinone | 1985 |
Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver.
Topics: Amanitins; Animals; Cell Nucleus; Cholestyramine Resin; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Naphthalenes; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 1985 |
Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis.
Topics: Acetates; Acetylcholinesterase; Animals; Axons; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cholesterol; Cycloheximide; Glycoproteins; Growth Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Neuroblastoma; Terpenes | 1985 |
Studies on cell proliferation and mevalonic acid metabolism in cultured human fibroblasts.
Topics: Arteriosclerosis; Cell Division; Cells, Cultured; Culture Media; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Naphthalenes; Platelet-Derived Growth Factor | 1985 |
Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors.
Topics: Child; DNA Replication; Female; Humans; Hyperlipoproteinemia Type II; Immunosuppression Therapy; Lipoproteins, LDL; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Naphthalenes; Phytohemagglutinins; Receptors, Cell Surface; Receptors, LDL | 1984 |
Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2.
Topics: Animals; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lipoproteins, LDL; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Naphthalenes; Receptors, Cell Surface; Receptors, LDL | 1984 |
Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium.
Topics: Animals; Bucladesine; Cholesterol; Concanavalin A; Cricetinae; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mice; Naphthalenes | 1982 |
A mevalonate requirement for maintenance of fatty acid and protein synthesis during hormonally stimulated development of mammary gland in vitro.
Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Fatty Acids; Female; Hydroxymethylglutaryl CoA Reductases; Insulin; Leucine; Lovastatin; Mammary Glands, Animal; Mevalonic Acid; Microsomes; Naphthalenes; Organ Culture Techniques; Pregnancy; Prolactin; Protein Biosynthesis; Rabbits; Tritium | 1984 |
Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cells, Cultured; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rats; Rats, Inbred Strains | 1983 |
The use of amphotericin B to detect inhibitors of cellular cholesterol biosynthesis.
Topics: Acyl Coenzyme A; Amphotericin B; Animals; Cell Line; Cell Survival; Cholesterol; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Mevalonic Acid; Naphthalenes | 1983 |
Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.
Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Kinetics; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Protein Processing, Post-Translational; Tritium | 1984 |
Plasma mevalonate as a measure of cholesterol synthesis in man.
Topics: Cholesterol; Circadian Rhythm; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Naphthalenes | 1984 |
Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation.
Topics: Animals; Anticholesteremic Agents; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol Esters; Ileum; Intestinal Mucosa; Jejunum; Kinetics; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Organ Culture Techniques; Rabbits; Tritium | 1984 |
Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A.
Topics: Androstenes; Animals; Anticholesteremic Agents; Cell Line; Glioma; Hydroxybenzoates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Mevalonic Acid; Naphthalenes; Parabens; Rats; Tyrosine; Ubiquinone | 1984 |
Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Pentanoic Acids; Rats; Rats, Inbred F344; Sterols; Valerates | 1983 |
Increased cholesterol biosynthesis in leukemic cells from patients with hairy cell leukemia.
Topics: Acetates; Adult; B-Lymphocytes; Cells, Cultured; Cholesterol; Concanavalin A; DNA; Female; Humans; Hydroxycholesterols; Leukemia, Hairy Cell; Lovastatin; Male; Mevalonic Acid; Middle Aged; Naphthalenes | 1983 |
Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.
Topics: Anticholesteremic Agents; Cells, Cultured; Cholesterol; DNA Replication; Fibroblasts; Humans; Infant, Newborn; Kinetics; Lovastatin; Male; Mevalonic Acid; Mitogens; Naphthalenes; Platelet-Derived Growth Factor; Skin Physiological Phenomena | 1984 |
Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.
Topics: Acetates; Animals; Cell Cycle; Cell Line; Cells, Cultured; Cholesterol; DNA; Growth Substances; Haplorhini; Hydroxycholesterols; Kinetics; Lovastatin; Macaca; Mevalonic Acid; Mice; Mitogens; Muscle, Smooth, Vascular; Naphthalenes; Platelet-Derived Growth Factor; Thymidine | 1980 |
Cholesterol and mevalonic acid are independent requirements for the in vitro proliferation of human bone marrow granulocyte progenitor cells: studies using ML-236B.
Topics: Acetates; Cell Division; Cholesterol; DNA; Hematopoietic Stem Cells; Humans; Hydroxycholesterols; Lovastatin; Mevalonic Acid; Naphthalenes; Optical Rotation | 1983 |
Mevalonate reverses the developmental arrest of preimplantation mouse embryos by Compactin, an inhibitor of HMG Co A reductase.
Topics: Animals; Blastocyst; Cell Division; Cholesterol; Diosgenin; Electrophoresis, Polyacrylamide Gel; Glycopeptides; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Peptide Biosynthesis | 1983 |
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.
Topics: Alkaline Phosphatase; Animals; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Drug; Feedback; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Mevalonic Acid; Mice; Naphthalenes | 1980 |
Isopentenyladenine as a mediator of mevalonate-regulated DNA replication.
Topics: Adenine; Animals; Cells, Cultured; Cricetinae; DNA Replication; Isopentenyladenosine; Kidney; Lovastatin; Mevalonic Acid; Nalidixic Acid; Naphthalenes; Structure-Activity Relationship | 1980 |
Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol Esters; Cholesterol, VLDL; Kinetics; Lipoproteins, VLDL; Liver; Lovastatin; Mevalonic Acid; Naphthalenes; Oleic Acid; Oleic Acids; Rats | 1982 |
Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation.
Topics: Cholesterol; Concanavalin A; Humans; Ketocholesterols; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Mitogens; Naphthalenes; Phytohemagglutinins; Pokeweed Mitogens; Sterols; T-Lymphocytes; Time Factors | 1980 |
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components.
Topics: Animals; Aorta; Cattle; Endothelium; Feedback; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, HDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Naphthalenes; Sterols | 1982 |
Mevalonic acid as an initiator of cell growth. Studies using human lymphocytes and inhibitors of endogenous mevalonate biosynthesis.
Topics: Concanavalin A; DNA; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Naphthalenes | 1982 |
A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.
Topics: Animals; Cell Adhesion; Cell Division; Cells, Cultured; Cholesterol; DNA; Dolichols; Growth Substances; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Peptides; Platelet-Derived Growth Factor; Protein Biosynthesis | 1982 |
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein.
Topics: Acetates; Animals; Cell Line; Clone Cells; Cricetinae; Drug Resistance; Endocytosis; Genes, Regulator; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketocholesterols; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Sterols | 1982 |
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa.
Topics: Alkaline Phosphatase; Animals; Cells, Cultured; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lactones; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Rabbits | 1981 |
Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Genetic Variation; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Ovary | 1981 |
Difference in the ability of compactin and oxidized cholesterol, both known inhibitors of cholesterol biosynthesis, to suppress in vitro immune responses.
Topics: Animals; Cell Division; Cells, Cultured; Cholesterol; DNA; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Immunocompetence; Lovastatin; Lymphocytes; Mevalonic Acid; Naphthalenes | 1981 |
Mevalonate regulates polysome distribution and blocks translation-dependent suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA: relationship to translational control.
Topics: Actins; Animals; Cell Line; Cricetinae; Cycloheximide; Drug Synergism; Gene Expression Regulation; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mesocricetus; Mevalonic Acid; Polyribosomes; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Messenger; Suppression, Genetic | 1995 |
Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Hypolipidemic Agents; Lovastatin; Marine Toxins; Mevalonic Acid; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 1995 |
Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture.
Topics: Acetates; Acetic Acid; Adolescent; Adult; Animals; Cells, Cultured; Child; Child, Preschool; Cholesterol; Dose-Response Relationship, Drug; Humans; Liver; Lovastatin; Male; Mevalonic Acid; Propionates; Rats; Rats, Wistar; Triglycerides | 1995 |
The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate.
Topics: Alternative Splicing; Animals; Base Sequence; Cell Line; Cricetinae; DNA, Complementary; Gene Expression Regulation, Enzymologic; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Polyribosomes; Protein Biosynthesis; Ribosomal Proteins; Ribosomes; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic | 1995 |
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Mevalonate availability affects human and rat resistance vessel function.
Topics: Adult; Aged; Animals; Blood Vessels; Calcium; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mesenteric Arteries; Mevalonic Acid; Middle Aged; Rats; Rats, Wistar; Vasoconstriction | 1995 |
Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity.
Topics: Acetates; Aniline Compounds; Animals; Anticholesteremic Agents; Apolipoproteins B; Cell Line; Cholesterol; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Dietary Fats; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Mesocricetus; Mevalonic Acid; Microsomes, Liver; Oxidoreductases; Receptors, LDL; RNA, Messenger; Sterol 14-Demethylase; Sulfides | 1995 |
HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages.
Topics: Animals; Carbocyanines; Cholesterol Esters; Diterpenes; Endocytosis; Fatty Acids, Monounsaturated; Fluorescent Dyes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Simvastatin | 1995 |
Simvastatin inhibits the cellular signaling and proliferative action of arginine vasopressin in cultured rat glomerular mesangial cells.
Topics: Animals; Arginine Vasopressin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Glomerular Mesangium; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inositol 1,4,5-Trisphosphate; Kinetics; Lovastatin; Male; Mevalonic Acid; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Simvastatin; Tetradecanoylphorbol Acetate; Thymidine | 1995 |
Inhibitory effect of mevalonate on the EGF mitogenic signaling pathway in human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Cell Line; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin-Like Growth Factor I; Kinetics; Lovastatin; Mevalonic Acid; Signal Transduction; Transcription, Genetic; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1994 |
Lamin A precursor is localized to intranuclear foci.
Topics: Amino Acid Sequence; Carcinoma, Squamous Cell; Cell Line; Cell Nucleus; Cysteine; DNA, Complementary; Fluorescent Antibody Technique; Humans; Lamin Type A; Lamins; Lovastatin; Mevalonic Acid; Nuclear Proteins; Protein Precursors; Protein Prenylation; Protein Processing, Post-Translational; Recombinant Proteins; Tumor Cells, Cultured | 1995 |
Effect of virus-transformation and growth factor stimulation on isoprene biosynthesis in human fibroblasts: a correlation to cell growth.
Topics: Butadienes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Culture Media; Dolichols; Fibroblasts; Hemiterpenes; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Pentanes; Platelet-Derived Growth Factor; Simian virus 40 | 1995 |
Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01.
Topics: Adenylyl Cyclases; Carbocyanines; Cell Line; Cholesterol; Fluorescent Dyes; Humans; Lipid Metabolism; Lovastatin; Megakaryocytes; Membrane Fluidity; Mevalonic Acid; Phospholipids; Signal Transduction; Simvastatin; Type C Phospholipases | 1995 |
Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2 alpha in Swiss mouse 3T3 cells.
Topics: 3T3 Cells; Animals; Dinoprost; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glycosylation; Lovastatin; Mevalonic Acid; Mice; Mitosis; S Phase | 1995 |
In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin.
Topics: Animals; Astrocytoma; Carmustine; Cell Cycle; Cell Division; Cell Line; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Cells, Cultured | 1995 |
Lack of correlation between 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lovastatin resistance in nerve growth factor treated PC-12 cells.
Topics: Animals; Blood; Cell Survival; Drug Resistance; Fibroblast Growth Factor 2; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Nerve Growth Factors; PC12 Cells; Rats; Up-Regulation | 1994 |
Farnesylation of p21 Ras proteins in Xenopus oocytes.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Cells, Cultured; Conserved Sequence; Farnesyltranstransferase; Female; Kinetics; Lovastatin; Mammals; Mevalonic Acid; Microinjections; Molecular Sequence Data; Oocytes; Oogenesis; Peptides; Polyisoprenyl Phosphates; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Sesquiterpenes; Transferases; Tritium; Xenopus laevis | 1994 |
In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis.
Topics: Adenine; Cell Division; Cells, Cultured; Cholesterol; Coronary Disease; Farnesol; Humans; Isopentenyladenosine; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Saphenous Vein | 1994 |
Effects of lovastatin on adenylyl cyclase activity and G proteins in GH4C1 cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; GTP-Binding Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Pituitary Gland; Protein Prenylation; Rats | 1995 |
Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Apoptosis; Cell Cycle; Cell Line; Cycloheximide; DNA, Neoplasm; Endodeoxyribonucleases; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; Piperazines; Protein Kinase C; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2).
Topics: Alkaline Phosphatase; Cell Differentiation; Cell Division; Cholesterol; Culture Media; Depression, Chemical; Humans; Intestinal Mucosa; Lipoproteins; Lovastatin; Mevalonic Acid; Microscopy, Electron; Microvilli; Oligo-1,6-Glucosidase; Sucrase; Time Factors; Tumor Cells, Cultured | 1995 |
Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells.
Topics: Actins; Adenine; Analysis of Variance; Autoradiography; Cell Division; Cells, Cultured; Cholesterol, LDL; Desmin; DNA; Farnesol; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Liver; Lovastatin; Mevalonic Acid; Simvastatin | 1994 |
Expression of prelamin A but not mature lamin A confers sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells.
Topics: Animals; Cholesterol; Cricetinae; Dexamethasone; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Lamin Type A; Lamins; Lovastatin; Mevalonic Acid; Mice; Nuclear Proteins; Protein Precursors; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Stem Cells; Teratocarcinoma; Transfection; Tumor Cells, Cultured | 1994 |
Characterization of the response of growth and differentiation to lipoproteins and agents affecting cholesterol metabolism in murine neuroblastoma cells.
Topics: Animals; Cell Differentiation; Cell Division; Cholesterol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Lovastatin; Mevalonic Acid; Mice; Neuroblastoma; Tumor Cells, Cultured | 1994 |
A non-characteristic response of L1210 cells to lovastatin.
Topics: Animals; Cell Cycle; DNA, Neoplasm; G1 Phase; G2 Phase; Kinetics; Leukemia L1210; Lovastatin; Mevalonic Acid; Mice; Mitosis; Protein Prenylation; S Phase; Thymidine; Tumor Cells, Cultured | 1994 |
Isoprenylated proteins in myelin.
Topics: Animals; Brain Stem; Cytosol; GTP-Binding Proteins; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosorbent Techniques; Lovastatin; Mevalonic Acid; Myelin Proteins; Myelin Sheath; Protein Prenylation; Rats; Rats, Sprague-Dawley; Tritium | 1994 |
Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages.
Topics: Acetylation; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Cholesterol Esters; Diterpenes; Dose-Response Relationship, Drug; Esterification; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin | 1993 |
Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.
Topics: Apoptosis; Cell Division; Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; Protein Prenylation; Simvastatin; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association.
Topics: Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cyclohexenes; Growth Inhibitors; In Vitro Techniques; Limonene; Liver; Lovastatin; Menthol; Mevalonic Acid; Proto-Oncogene Proteins p21(ras); Rats; Terpenes; Tumor Cells, Cultured | 1994 |
The processing pathway of prelamin A.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cysteine; Dexamethasone; Gene Expression; Humans; Lamin Type A; Lamins; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Nuclear Proteins; Plasmids; Protein Precursors; Protein Prenylation; Protein Processing, Post-Translational; Transfection | 1994 |
PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment.
Topics: Animals; Astrocytoma; Cell Cycle; Demecolcine; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyurea; Lovastatin; Mevalonic Acid; Protein Kinase C; Rats; Simvastatin; Tumor Cells, Cultured | 1994 |
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.
Topics: Cell Division; Cell Line; Cell Survival; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; GTP-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-8; Lovastatin; Mevalonic Acid; Monocytes; Protein Prenylation; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate | 1994 |
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins.
Topics: Acetates; Acetylcysteine; Animals; Cerulenin; Cyclohexenes; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Lovastatin; Male; Mevalonic Acid; Monoterpenes; Palmitic Acid; Palmitic Acids; Peptides; Protein O-Methyltransferase; Protein Prenylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Terpenes; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wasp Venoms | 1993 |
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.
Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes | 1993 |
The regulation of bile acid synthesis in cultured hamster hepatocytes.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chenodeoxycholic Acid; Cholestyramine Resin; Cholic Acid; Cholic Acids; Cricetinae; Hydroxycholesterols; Imidazoles; Lipoproteins, LDL; Liver; Lovastatin; Male; Mesocricetus; Mevalonic Acid; Taurocholic Acid; Urea | 1993 |
Mevalonate availability and cardiovascular functions.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Blood Pressure; In Vitro Techniques; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Systole; Vascular Resistance | 1993 |
Cell cycle-specific growth inhibition of human breast cancer cells induced by metabolic inhibitors.
Topics: Antimetabolites; Breast Neoplasms; Cell Cycle; Cell Division; DNA, Neoplasm; Female; Glycosylation; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Neoplasm Proteins; Tumor Cells, Cultured; Tunicamycin | 1993 |
3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibition modulates vasopressin-stimulated Ca2+ responses in rat A10 vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inositol Phosphates; Intracellular Membranes; Lovastatin; Manganese; Mevalonic Acid; Muscle, Smooth, Vascular; Rats; Simvastatin; Vasopressins | 1994 |
Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes.
Topics: Cell Cycle; Cyclohexenes; DNA; Humans; In Vitro Techniques; Limonene; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Monoterpenes; Protein Prenylation; Terpenes | 1994 |
Determination of changes in serum lathosterol during treatment with simvastatin to evaluate the role of lathosterol as a parameter for whole body cholesterol synthesis.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Chromatography, Gas; Female; Half-Life; Humans; Isomerism; Kinetics; Lovastatin; Male; Mevalonic Acid; Simvastatin | 1993 |
Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.
Topics: Animals; Biliary Fistula; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Enterohepatic Circulation; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Male; Mevalonic Acid; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 1993 |
Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1993 |
Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages.
Topics: Drug Interactions; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Macrophage Activation; Macrophages; Mevalonic Acid; Monocytes; Oxidation-Reduction; Simvastatin; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Clinical and biochemical phenotype in 11 patients with mevalonic aciduria.
Topics: Abnormalities, Multiple; Cerebellar Ataxia; Failure to Thrive; Female; Humans; Infant; Intellectual Disability; Lovastatin; Male; Mevalonic Acid; Phenotype; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Prednisone | 1993 |
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Acetates; Acetic Acid; Androstenes; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Chickens; CHO Cells; Cholesterol; Chromans; Cricetinae; Gene Expression Regulation, Enzymologic; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Suppression, Genetic; Tritium; Tumor Cells, Cultured; Vitamin E | 1993 |
Simvastatin and intracellular pH regulation by the Na+/H+ antiport of SV40-virus-transformed human MRC5 fibroblasts.
Topics: Carrier Proteins; Cell Line, Transformed; Cell Transformation, Viral; Cholesterol; Fibroblasts; Humans; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Simvastatin; Sodium-Hydrogen Exchangers | 1993 |
Role of isoprenylation in intracellular pH regulation of granulocytes.
Topics: Granulocytes; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Kinetics; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Protein Prenylation; Tumor Cells, Cultured | 1993 |
Importance of mevalonate-derived products in the control of HMG-CoA reductase activity and growth of human lung adenocarcinoma cell line A549.
Topics: Adenocarcinoma; Cholesterol, LDL; Feedback; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Lung Neoplasms; Mevalonic Acid | 1993 |
Lovastatin inhibits proliferation of rat mesangial cells.
Topics: Adenine; Animals; Cell Division; Cells, Cultured; DNA; DNA Replication; Dose-Response Relationship, Drug; Farnesol; Glomerular Mesangium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Kinetics; Lovastatin; Mevalonic Acid; Rats; Thymidine | 1993 |
Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins.
Topics: Animals; Bombesin; Calcium; Cell Line; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Lovastatin; Membrane Potentials; Mesocricetus; Mevalonic Acid; Vasopressins | 1993 |
Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.
Topics: Animals; Cell Communication; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Drug Interactions; Epithelial Cells; Genes, ras; Intercellular Junctions; Kinetics; Liver; Liver Neoplasms, Experimental; Lovastatin; Male; Mevalonic Acid; Phenotype; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344 | 1993 |
Mevalonate controls cytoskeleton organization and cell morphology in thyroid epithelial cells.
Topics: Actin Cytoskeleton; Animals; Cell Adhesion; Cell Line; Cytoskeleton; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Lovastatin; Mevalonic Acid; Microtubules; Thyroid Gland; Time Factors | 1993 |
Isoprenoid regulation of cell growth: identification of mevalonate-labelled compounds inducing DNA synthesis in human breast cancer cells depleted of serum and mevalonate.
Topics: Blood; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; Culture Media; DNA; Dolichols; Glycosylation; Humans; Lovastatin; Mevalonic Acid; Tumor Cells, Cultured; Tunicamycin | 1993 |
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fibric Acids; Hydroxycholesterols; Hypolipidemic Agents; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Mevalonic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Isoprenylation of proteins in the protozoan Giardia lamblia.
Topics: Acetylcysteine; Animals; Cholesterol; Cyclohexenes; Dolichols; Giardia lamblia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Limonene; Lipid Metabolism; Lovastatin; Mevalonic Acid; Monoterpenes; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Protozoan Proteins; Terpenes; Ubiquinone | 1995 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli.
Topics: Acyl Coenzyme A; Acylation; Aldehydes; Carrier Proteins; Escherichia coli; Genes, Bacterial; Halobacteriaceae; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Membrane Proteins; Membrane Transport Proteins; Mevalonic Acid; Molecular Weight; NADP; Potassium Chloride; Recombinant Fusion Proteins; Stereoisomerism | 1996 |
Lovastatin induces differentiation of Mono Mac 6 cells.
Topics: Acyl Coenzyme A; Biomarkers; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Monocytes; Tumor Necrosis Factor-alpha; Umbilical Veins | 1995 |
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation.
Topics: Bronchi; Cell Division; Diterpenes; Enzyme Inhibitors; Humans; Lovastatin; Lung; Mevalonic Acid; Muscle, Smooth; Simvastatin | 1995 |
Inhibition of cholesterol synthesis and hepatic 3-hydroxy-3-methylglutaryl--CoA reductase in rats by simvastatin and pravastatin.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Division; Drug Synergism; Glioma; Humans; Lipid Metabolism; Lovastatin; Mevalonic Acid; Neoplasm Invasiveness; Phenylacetates; Tumor Cells, Cultured; Ubiquinone | 1996 |
Statins, cholesterol, and mevalonate pathways?
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Simvastatin | 1996 |
Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Fibroblasts; Humans; Insulin; Lovastatin; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; ras Proteins; Rats; Receptor, Insulin; Tyrosine | 1996 |
Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells.
Topics: Animals; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Cholesterol; Creatine Kinase; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Lovastatin; Mevalonic Acid; Muscle Proteins; Muscle, Skeletal; Phospholipids; Pravastatin; Rats; Rats, Wistar; Simvastatin | 1996 |
Stimulatory effect of PDGF on HMG-CoA reductase activity and N-linked glycosylation contributes to increased expression of IGF-1 receptors in human fibroblasts.
Topics: Cell Division; DNA; Enzyme Inhibitors; Fibroblasts; Glucosamine; Glycosylation; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Insulin-Like Growth Factor I; Lovastatin; Male; Mevalonic Acid; Platelet-Derived Growth Factor; Receptor, IGF Type 1; S Phase | 1996 |
Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver.
Topics: Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Cycloheximide; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Half-Life; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Tricarboxylic Acids | 1996 |
Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho.
Topics: ADP Ribose Transferases; Botulinum Toxins; Calcium; Cell Line; Cytochalasin D; Cytosol; Enzyme Inhibitors; Epithelium; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Intestines; Isoenzymes; Kinetics; Leukotriene D4; Lovastatin; Membrane Proteins; Mevalonic Acid; Protein Prenylation; rhoB GTP-Binding Protein; Signal Transduction; Type C Phospholipases | 1996 |
Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth.
Topics: Base Sequence; Cell Division; Cell Line; Cell Membrane; Colonic Neoplasms; DNA Primers; DNA, Neoplasm; Dolichol Phosphates; Enzyme Inhibitors; Gene Expression; Glycosylation; Growth Substances; Hepatoblastoma; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin-Like Growth Factor I; Kinetics; Liver Neoplasms; Lovastatin; Melanoma; Mevalonic Acid; Models, Biological; Molecular Sequence Data; Oligonucleotides, Antisense; Protein Processing, Post-Translational; Receptor, IGF Type 1; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Incubation of porcine high-density lipoprotein with the apical surface of LLC-PK1 renal tubular cells sustains the properties of orientated monolayers.
Topics: Albumins; Animals; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Hypolipidemic Agents; Inulin; Kidney Tubules, Proximal; Lipoproteins, HDL; LLC-PK1 Cells; Lovastatin; Mevalonic Acid; Monosaccharide Transport Proteins; Nephrotic Syndrome; Simvastatin; Swine | 1996 |
Lovastatin inhibits lipopolysaccharide-induced NF-kappaB activation in human mesangial cells.
Topics: Base Sequence; Blood; Cells, Cultured; Enzyme Inhibitors; Glomerular Mesangium; Humans; Lipopolysaccharides; Lovastatin; Mevalonic Acid; Molecular Sequence Data; NF-kappa B; Oligonucleotide Probes; Time Factors | 1996 |
Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway.
Topics: Anticholesteremic Agents; Carboxy-Lyases; Carcinoma, Hepatocellular; Cholesterol; Fatty Acids; Homeostasis; Humans; Kinetics; Liver Neoplasms; Lovastatin; Mevalonic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants.
Topics: Animals; Antioxidants; Aorta; Butylated Hydroxytoluene; Cell Death; Cells, Cultured; Copper; Culture Media; Deferoxamine; Enzyme Inhibitors; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketocholesterols; Lipid Peroxidation; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Oxidation-Reduction; Probucol; Swine; Thiobarbituric Acid Reactive Substances; Vitamin E | 1995 |
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1).
Topics: 3T3 Cells; Acyclic Monoterpenes; Animals; Azo Compounds; Cell Differentiation; Cholesterol; Enzyme Inhibitors; Farnesol; Glycerolphosphate Dehydrogenase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lovastatin; Mevalonic Acid; Mice; Terpenes | 1996 |
Lovastatin inhibits interferon-gamma-induced Trypanosoma brucei brucei proliferation: evidence for mevalonate pathway involvement.
Topics: Animals; Antiprotozoal Agents; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Lovastatin; Mevalonic Acid; Trypanosoma brucei brucei | 1996 |
Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Coronary Disease; Enzyme Inhibitors; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipids; Lipoproteins, LDL; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Pyrroles; Simvastatin | 1996 |
Biochemical changes and morphological alterations of liver and kidney in hamsters after administration of the HMG-coenzyme A reductase inhibitor, simvastatin: prevention and reversibility by mevalonate.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cricetinae; Dietary Fats; Eating; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lovastatin; Male; Mevalonic Acid; Necrosis; Simvastatin | 1995 |
Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro.
Topics: Cyclosporine; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Interleukin-2; Killer Cells, Natural; Lovastatin; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Mevalonic Acid; Phytohemagglutinins; Pravastatin; Simvastatin; Sterols | 1996 |
Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Circadian Rhythm; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Reproducibility of Results; Simvastatin; Xanthomatosis, Cerebrotendinous | 1996 |
Inhibition of isoprenoid biosynthesis and arterial smooth-muscle cell proliferation.
Topics: Animals; Anticholesteremic Agents; Bromodeoxyuridine; Carotid Arteries; Cell Division; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluorescent Antibody Technique, Indirect; Fluvastatin; Image Processing, Computer-Assisted; Indoles; Infusion Pumps, Implantable; Injections, Intraperitoneal; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Simvastatin | 1995 |
Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages.
Topics: Cell Line; Dactinomycin; Enzyme Inhibitors; Farnesol; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Macrophages; Membrane Proteins; Mevalonic Acid; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Tetradecanoylphorbol Acetate | 1996 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei.
Topics: Animals; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Microscopy, Electron; Protein Prenylation; Protozoan Proteins; Trypanosoma brucei brucei | 1996 |
Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model.
Topics: Animals; Anticholesteremic Agents; Cell Division; Cell Survival; DNA; Humans; Lovastatin; Mevalonic Acid; Muscle, Smooth; Pravastatin | 1996 |
Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells.
Topics: Acyl Coenzyme A; Animals; Cell Division; Enzyme Inhibitors; Lovastatin; Mevalonic Acid; Neurites; PC12 Cells; Pravastatin; Rats; Simvastatin | 1996 |
Simultaneous determination of plasma mevalonate and 7alpha-hydroxy-4-cholesten-3-one levels in hyperlipoproteinemia: convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation.
Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholestenones; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipoproteinemias; Intestinal Absorption; Liver; Lovastatin; Male; Mevalonic Acid; Middle Aged; RNA, Messenger; Simvastatin | 1997 |
Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis.
Topics: Androstenedione; Animals; Anticholesteremic Agents; Cattle; Cell Division; Cells, Cultured; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Female; Granulosa Cells; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin-Like Growth Factor I; Lovastatin; Luteinizing Hormone; Mevalonic Acid; Ovary; Progesterone; Simvastatin; Stimulation, Chemical; Theca Cells | 1996 |
Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cricetinae; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Lyases; Mesocricetus; Mevalonic Acid; Naphthols; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic; Tricarboxylic Acids | 1997 |
Effect of lovastatin and fluoromevalonate on phosphatidylinositol 3-kinase activity stimulated with PDGF.
Topics: Animals; Anticholesteremic Agents; Aorta, Thoracic; Carboxy-Lyases; Cell Division; Enzyme Inhibitors; In Vitro Techniques; Lovastatin; Male; Mevalonic Acid; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thymidine | 1995 |
Lovastatin-induced apoptosis in prostate stromal cells.
Topics: Apoptosis; Cholesterol; Dihydrotestosterone; Diterpenes; DNA; Enzyme Inhibitors; Finasteride; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Male; Mevalonic Acid; Prostate; Prostatic Hyperplasia; Stromal Cells; Testosterone | 1997 |
The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins.
Topics: Amino Acid Sequence; Animals; Cell Cycle; Cell Survival; Dexamethasone; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Viral; Isoelectric Point; Lovastatin; Mevalonic Acid; Minute Virus of Mice; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Rats; S Phase; Tubulin; Viral Nonstructural Proteins | 1997 |
RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase.
Topics: Animals; Anticholesteremic Agents; Callithrix; Cholesterol; Cholestyramine Resin; Drug Synergism; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Quinolines; Rats; Rats, Sprague-Dawley | 1997 |
Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation.
Topics: Animals; Aorta; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Simvastatin | 1997 |
Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes.
Topics: Carbocyanines; Cell Division; Endocytosis; Flow Cytometry; Fluorescent Dyes; Genistein; Hydroxyurea; Interleukin-2; Isoflavones; Lipoproteins, LDL; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Monensin; Phytohemagglutinins; Receptors, Interleukin-2; Receptors, LDL | 1997 |
Lovastatin decreases prolactin and growth hormone gene expression in GH4C1 cells through a cAMP dependent mechanism.
Topics: Animals; Anticholesteremic Agents; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Gene Expression; Genes, Reporter; Growth Hormone; GTP-Binding Proteins; Kinetics; Lovastatin; Mevalonic Acid; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Rats; Signal Transduction | 1997 |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids | 1997 |
HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Autoradiography; Cells, Cultured; Cholesterol; Densitometry; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotope Labeling; Lovastatin; Mevalonic Acid; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Polyisoprenyl Phosphates; Pravastatin; Pregnancy; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Scintillation Counting; Sesquiterpenes; Tritium | 1997 |
Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols.
Topics: Androstenes; Animals; Cattle; Cells, Cultured; Cholesterol; Enzyme Inhibitors; Epithelium; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Lens, Crystalline; Lovastatin; Mevalonic Acid; RNA Processing, Post-Transcriptional; RNA, Messenger; Squalene | 1997 |
Manipulation of the fate of long chain polyunsaturated fatty acids in cultured cells.
Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Cholesterol; Enzyme Inhibitors; Ethanol; Fatty Acids, Unsaturated; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linoleic Acid; Linoleic Acids; Liver Neoplasms; Lovastatin; Mevalonic Acid; Monocytes; Neuroblastoma; Simvastatin; Tumor Cells, Cultured | 1997 |
Mevalonate-regulated mechanisms in cell growth control: role of dolichyl phosphate in expression of the insulin-like growth factor-1 receptor (IGF-1R) in comparison to Ras prenylation and expression of c-myc.
Topics: Cell Division; Cell Membrane; Colonic Neoplasms; DNA, Neoplasm; Dolichol Phosphates; Glycosylation; Humans; Kinetics; Lovastatin; Melanoma; Mevalonic Acid; Neoplasm Proteins; Polymerase Chain Reaction; Protein Prenylation; ras Proteins; Receptor, IGF Type 1; Skin Neoplasms; Tumor Cells, Cultured | 1997 |
Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells.
Topics: Acetates; Cell Line; Cholesterol; Diterpenes; Enzyme Inhibitors; Esterification; Fatty Acids, Unsaturated; Glycerol; Glycolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Linoleic Acid; Linoleic Acids; Lipids; Lovastatin; Mevalonic Acid; Monocytes; Simvastatin | 1997 |
HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein.
Topics: Animals; Arteriosclerosis; Cell Division; Cholesterol; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Macrophages; Male; Mevalonic Acid; Mice; Mice, Inbred C3H; Oxidation-Reduction; Pravastatin; Simvastatin | 1997 |
Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism.
Topics: Acyl Coenzyme A; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Humans; Leukemia; Lovastatin; Lymphoma; Mevalonic Acid; Neoplasm Proteins; ras Proteins; Tumor Cells, Cultured | 1997 |
Role of small GTP-binding proteins in lovastatin-induced cataracts.
Topics: Animals; Cataract; Cell Differentiation; Cell Division; Cells, Cultured; Epithelium; GTP-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Lens, Crystalline; Lovastatin; Macaca mulatta; Mevalonic Acid; Microscopy, Electron, Scanning; Organ Culture Techniques; Protein Prenylation; Rabbits; Rats; Rats, Sprague-Dawley | 1997 |
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
Topics: Alkyl and Aryl Transferases; Animals; Anticholesteremic Agents; Astrocytes; Cells, Cultured; Cytokines; Enzyme Induction; Enzyme Inhibitors; Humans; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lovastatin; Macrophages; Mevalonic Acid; Microglia; Mitogens; NF-kappa B; Nitric Acid; Nitric Oxide Synthase; Phenylacetates; Polyisoprenyl Phosphates; Rats; Sesquiterpenes; Tumor Necrosis Factor-alpha | 1997 |
Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells.
Topics: Cells, Cultured; DNA; Gene Expression Regulation; Genes, fos; Genes, ras; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Protein Processing, Post-Translational; Pulmonary Artery; RNA, Messenger; Signal Transduction | 1997 |
Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin.
Topics: Acetates; Amides; Aniline Compounds; Animals; Anticholesteremic Agents; Cell Line; Cholesterol; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipoproteins, LDL; Lipoproteins, VLDL; Lovastatin; Mevalonic Acid; Monocytes; Muscle, Smooth; Oleic Acid; Organosilicon Compounds; Rats; Rats, Wistar; Sulfides; Triglycerides | 1997 |
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
Topics: Animals; Aorta; Arteriosclerosis; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Nitric Oxide Synthase; RNA, Messenger; Saphenous Vein; Simvastatin; Transcription, Genetic | 1998 |
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
Topics: Alendronate; Animals; Apoptosis; Bone Resorption; Cells, Cultured; Clodronic Acid; Diphosphonates; Enzyme Inhibitors; Etidronic Acid; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Macrophages; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; Protein Processing, Post-Translational; ras Proteins; Risedronic Acid; Structure-Activity Relationship | 1998 |
Receptor-Ck-dependent regulation of genes involved in the cell cycle.
Topics: Butanols; Cell Cycle; Cells, Cultured; Cholesterol; Cyclin D; Cyclins; Cyclohexenes; DNA; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, myc; Humans; Hydroxycholesterols; Limonene; Lovastatin; Lymphocytes; Mevalonic Acid; Phosphatidic Acids; Receptors, Lipoprotein; RNA, Messenger; Signal Transduction; Terpenes | 1998 |
Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Cells, Cultured; Drug Synergism; Fatty Acids; Fibroblasts; Gene Deletion; Humans; Intracellular Fluid; Lovastatin; Mevalonic Acid; Oxidation-Reduction; Phenylacetates; Skin; X Chromosome | 1998 |
Lovastatin induces apoptosis in malignant mesothelioma cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Cell Membrane; Cell Survival; Cytosol; DNA, Neoplasm; Dose-Response Relationship, Drug; Farnesol; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mesothelioma; Mevalonic Acid; Protein Prenylation; ras Proteins; Tumor Cells, Cultured | 1998 |
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.
Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Weight; Nerve Tissue Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Thymidine; Tumor Cells, Cultured | 1998 |
Human multidrug-resistant (MRP,p190) myeloid leukemia HL-60/ADR cells in vitro: resistance to the mevalonate pathway inhibitor lovastatin.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Drug Resistance, Multiple; HL-60 Cells; Humans; Leukemia, Myeloid; Lovastatin; Mevalonic Acid | 1997 |
Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates.
Topics: Adrenergic alpha-Agonists; Animals; Anticholesteremic Agents; Aorta, Thoracic; Carbon Radioisotopes; Cell Count; Cells, Cultured; Cholesterol; Drug Interactions; Farnesol; Hypertrophy; Leucine; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Phenylephrine; Protein Prenylation; Rats; Receptors, Adrenergic, alpha-1; Transferases | 1998 |
Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Lovastatin; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Myocardium; Naphthalenes; Physical Stimulation; Protein Biosynthesis; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Stress, Mechanical | 1998 |
Control of Rab5 and Rab7 expression by the isoprenoid pathway.
Topics: Animals; Cell Line; Cycloheximide; Gene Expression Regulation; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Lovastatin; Mevalonic Acid; Protein Prenylation; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; rab7 GTP-Binding Proteins; Rats; RNA, Messenger; Thyroid Gland; Time Factors; Transcription, Genetic | 1998 |
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
Topics: ADP Ribose Transferases; Bacterial Toxins; Botulinum Toxins; Cells, Cultured; Cytosol; Cytotoxins; Endothelium, Vascular; Escherichia coli Proteins; Gene Expression Regulation, Enzymologic; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Lovastatin; Membrane Proteins; Mevalonic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polyisoprenyl Phosphates; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA Processing, Post-Transcriptional; RNA, Messenger; Sesquiterpenes | 1998 |
Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
Topics: Alendronate; Animals; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line; Cycloheximide; Diphosphonates; Enzyme Activation; Enzyme Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Protein Biosynthesis; Protein Synthesis Inhibitors | 1998 |
Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.
Topics: Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Apoptosis; Cells, Cultured; Cerebral Cortex; Cholesterol; Cholesterol, VLDL; DNA Fragmentation; In Situ Nick-End Labeling; Lovastatin; Mevalonic Acid; Neurons; Rats; Rats, Sprague-Dawley; Squalene | 1998 |
Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Female; Inhibitory Concentration 50; Lovastatin; Mammary Neoplasms, Experimental; Mevalonic Acid; Mice; Mice, Inbred BALB C; Tumor Cells, Cultured | 1998 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured | 1998 |
Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines.
Topics: Aminobutyrates; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion Molecules; Cell Division; Cisplatin; Drug Screening Assays, Antitumor; Fatty Acids; Female; HLA Antigens; Humans; Kynurenine; Lovastatin; Mevalonic Acid; Ovarian Neoplasms; Paclitaxel; Phenylacetates; Transforming Growth Factors; Tumor Cells, Cultured | 1998 |
HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells.
Topics: Alkyl and Aryl Transferases; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Cell Line; Cholesterol; Enzyme Induction; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Rats; Tricarboxylic Acids | 1999 |
Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders.
Topics: Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Granulation Tissue; Guinea Pigs; Humans; Lovastatin; Lung; Mevalonic Acid; Protein Processing, Post-Translational; Pulmonary Fibrosis; ras Proteins; Reference Values; Wound Healing | 1999 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
Regulatory role of mevalonate and N-linked glycosylation in proliferation and expression of the EWS/FLI-1 fusion protein in Ewing's sarcoma cells.
Topics: Amino Acid Sequence; Blotting, Western; Cell Division; Cell Nucleus; Cytoplasm; DNA, Neoplasm; Down-Regulation; Gene Expression Regulation; Glucosamine; Glycosylation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Oligonucleotides, Antisense; Oncogene Proteins, Fusion; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing; Time Factors; Transcription Factors; Tumor Cells, Cultured; Tunicamycin | 1999 |
Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cells, Cultured; Cholesterol; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Glomerular Mesangium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; MAP Kinase Kinase Kinases; Mevalonic Acid; Mice; Mitogen-Activated Protein Kinase Kinases; Platelet-Derived Growth Factor; Polyisoprenyl Phosphates; Protein Kinase Inhibitors; Protein Kinases; Sesquiterpenes; Signal Transduction | 1999 |
Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells.
Topics: Anticholesteremic Agents; Apoptosis; Cell Division; Cell Line; Chromatin; Cycloheximide; Dactinomycin; DNA Fragmentation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Microscopy, Electron; Microscopy, Fluorescence; Neuroglia; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
[The cytotoxicity of mevalonate, lovastatin and carminomycin with respect to MOLT-4 human malignant T-lymphoblasts in vitro].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carubicin; Cell Survival; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Humans; Lovastatin; Mevalonic Acid; T-Lymphocytes; Tumor Cells, Cultured | 1999 |
The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates.
Topics: Animals; Bone and Bones; Bone Resorption; Culture Techniques; Diphosphonates; Dose-Response Relationship, Drug; Female; Ibandronic Acid; Lovastatin; Mevalonic Acid; Mice; Models, Chemical; Nitrogen; Pregnancy; Protein Prenylation | 1999 |
Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death.
Topics: 3T3 Cells; Acetates; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cerebral Cortex; Cholesterol; Embryo, Mammalian; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, VLDL; Lovastatin; Mevalonic Acid; Mice; Neurons; PC12 Cells; Rabbits; Rats; Rats, Sprague-Dawley; Squalene; Tricarboxylic Acids | 1999 |
Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms.
Topics: Antineoplastic Agents; Ascorbic Acid; Cell Division; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neuroblastoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase.
Topics: Cell Cycle; Cyclin-Dependent Kinases; Cysteine Endopeptidases; G1 Phase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Microsomes; Multienzyme Complexes; Prodrugs; Protease Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1999 |
Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells.
Topics: Animals; Cattle; Cell Differentiation; Cell Division; Cell Line; DNA; Farnesol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Protein Prenylation; Rats; Thyroid Gland; Thyrotropin | 1999 |
Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer.
Topics: Anticoagulants; Antineoplastic Agents; Carrier Proteins; Cell Adhesion; Cell Division; Cell Movement; Cytokines; Doxorubicin; Drug Synergism; Gelatinases; Humans; Lovastatin; Matrix Metalloproteinase 2; Metalloendopeptidases; Mevalonic Acid; Midkine; Neoplasm Metastasis; Pentosan Sulfuric Polyester; Peptide Hydrolases; Phenotype; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Stomach Neoplasms; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1999 |
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.
Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Division; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Flow Cytometry; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Lovastatin; Mevalonic Acid; Microscopy, Electron; Polyisoprenyl Phosphates; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells.
Topics: Animals; Cell Division; Cell Line; CHO Cells; Cricetinae; Drug Resistance; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lipids; Lipoproteins; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Microscopy, Electron; Promoter Regions, Genetic; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; RNA, Messenger; Transfection | 1999 |
Lovastatin induces mitotic abnormalities in various cell lines.
Topics: Anticholesteremic Agents; Cell Line; Centromere; Fluorescent Antibody Technique; HeLa Cells; Humans; Lovastatin; Mevalonic Acid; Mitosis | 1999 |
Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi.
Topics: Acyl Coenzyme A; Amino Acid Sequence; Blotting, Southern; Carotenoids; DNA, Fungal; Fungal Proteins; Gibberella; Gibberellins; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Physical Chromosome Mapping; Polymerase Chain Reaction; Sequence Alignment; Sterols; Time Factors | 1999 |
Activation of the cholesterol pathway and Ras maturation in response to stress.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological | 1999 |
Mevalonate prevents lovastatin-induced apoptosis in medulloblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Northern; Cell Size; DNA, Neoplasm; Drug Interactions; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Medulloblastoma; Mevalonic Acid; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.
Topics: Acyl Coenzyme A; Acylation; Chromatography, Agarose; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; RNA, Transfer, Arg; Sulfolobus | 1999 |
Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens.
Topics: Animals; Atorvastatin; Chickens; Enzyme Inhibitors; Female; Fertility; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insemination, Artificial; Lovastatin; Mevalonic Acid; Oviposition; Pyrroles; Simvastatin | 1999 |
Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells.
Topics: Albuminuria; Animals; Blood Glucose; Cells, Cultured; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Fibronectins; Glomerular Mesangium; Kidney Glomerulus; Lovastatin; Male; Mevalonic Acid; Organ Size; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Transforming Growth Factor beta | 2000 |
Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition.
Topics: Acetic Acid; Acetyl-CoA C-Acetyltransferase; Adenosine Triphosphate; Animals; Carbon Radioisotopes; Cell Cycle; Cell Survival; CHO Cells; Cholesterol; Clone Cells; Cricetinae; Deuterium Oxide; Enzyme Activation; Fatty Acids, Unsaturated; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Lactones; Leupeptins; Lovastatin; Mevalonic Acid; Peroxisomes; Phosphorylation; Simvastatin; Tritium | 2000 |
Induction of apoptosis by lovastatin through activation of caspase-3 and DNase II in leukaemia HL-60 cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Fractionation; Cytochrome c Group; DNA Fragmentation; DNA, Neoplasm; Endodeoxyribonucleases; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Membrane Potentials; Mevalonic Acid; Mitochondria; Poly(ADP-ribose) Polymerases | 2000 |
Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts.
Topics: Actins; Animals; Apoptosis; Bone Resorption; Calcitriol; Calcium; Coculture Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lovastatin; Male; Membrane Fusion; Mevalonic Acid; Mice; Osteoclasts; Parathyroid Hormone; Polyisoprenyl Phosphates; Sesquiterpenes | 2000 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture.
Topics: Animals; Colforsin; Endocrine Gland Neoplasms; Lovastatin; Mevalonic Acid; Mice; Rats; Sincalide; Tumor Cells, Cultured | 2000 |
Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture.
Topics: Animals; Antigens, Nuclear; Aorta; Apoptosis; Cattle; CDC2-CDC28 Kinases; Cell Division; Cell Survival; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Ki-67 Antigen; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Nuclear Proteins; Pravastatin; Protein Serine-Threonine Kinases; Rats; Retinoblastoma Protein; Simvastatin; Tumor Suppressor Protein p53 | 2000 |
Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.
Topics: Amino Acid Sequence; Ammonium Sulfate; Animals; Blotting, Northern; Blotting, Western; Cell Membrane; Cells, Cultured; Chromatography; Chromatography, Gel; Chromosome Mapping; Durapatite; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketoconazole; Kinetics; Leishmania major; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Protein Structure, Tertiary; RNA Processing, Post-Transcriptional; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2000 |
Inhibition of monocyte chemotactic protein-1 synthesis by statins.
Topics: Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Lovastatin; Mevalonic Acid; Monocytes; Pravastatin; RNA, Messenger; Simvastatin | 2000 |
HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density.
Topics: 4-Nitrophenylphosphatase; Animals; Cell Membrane; Cholesterol; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lovastatin; Male; Mevalonic Acid; Muscle, Skeletal; Myocardium; Ouabain; Patch-Clamp Techniques; Potassium; Rabbits; Rats; Rats, Wistar; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase | 2000 |
Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells.
Topics: Analysis of Variance; Anticholesteremic Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Matrix Metalloproteinase 1; Mevalonic Acid; Polyisoprenyl Phosphates; Pravastatin; Sesquiterpenes; Squalene; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II.
Topics: 3T3 Cells; Animals; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Cytokines; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polyisoprenyl Phosphates; Promoter Regions, Genetic; Pyrroles; rho GTP-Binding Proteins; Tumor Cells, Cultured | 2000 |
Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Membrane; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Electrophoresis; Gene Expression; Genes, ras; Lovastatin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mevalonic Acid; Mice; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Prenylation; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1; Transcription, Genetic | 2000 |
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anticholesteremic Agents; Apolipoproteins E; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Differentiation; Cells, Cultured; Cholesterol; Diet, Atherogenic; Dimerization; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Lipids; Liver Neoplasms; Liver X Receptors; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Knockout; Organic Chemicals; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.
Topics: Cell Cycle; Cell Division; Cells, Cultured; Cholesterol; Cyclin-Dependent Kinases; Diphosphonates; Esophageal Diseases; Farnesyl-Diphosphate Farnesyltransferase; Humans; Keratinocytes; Lovastatin; Mevalonic Acid; Models, Biological; Phosphorylation; Protein Prenylation; Retinoblastoma Protein | 2001 |
Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition.
Topics: Animals; Anticholesteremic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cell Division; Cell Line, Transformed; Cholesterol; Lovastatin; Mevalonic Acid; Neurons; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Sesquiterpenes; Squalene; Stem Cells | 2001 |
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Topics: Animals; Binding Sites; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Cricetinae; Gene Expression Regulation; Humans; Hydroxycholesterols; Liver; Lovastatin; Luciferases; Mevalonic Acid; Nicotinic Acids; Organ Specificity; Polyisoprenyl Phosphates; Rats; Receptors, Retinoic Acid; Receptors, Steroid; Response Elements; Retinoid X Receptors; Species Specificity; Tetrahydronaphthalenes; Transcription Factors; Transcription, Genetic; Transfection | 2001 |
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.
Topics: Adult; Antineoplastic Agents; Apoptosis; Child; Chromatography, High Pressure Liquid; Female; Flow Cytometry; Formazans; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Microscopy, Electron; Neoplasms; Tetrazolium Salts; Tumor Cells, Cultured | 2001 |
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene.
Topics: Animals; Base Sequence; Cockroaches; Gene Expression Regulation, Enzymologic; Genes, Insect; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Insect Proteins; Introns; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Retroelements; Species Specificity | 2001 |
Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; MAP Kinase Signaling System; Marine Toxins; Mevalonic Acid; Muscle, Smooth; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Polyisoprenyl Phosphates; Protein Isoforms; Protein Kinase C; Protein Prenylation; ras Proteins; Time Factors | 2001 |
Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives.
Topics: Apoptosis; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line; Cholesterol; Cholesterol, LDL; Dose-Response Relationship, Drug; G1 Phase; G2 Phase; Humans; Lovastatin; Mevalonic Acid | 2001 |
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).
Topics: Actins; Blotting, Northern; Cell Line; Connective Tissue Growth Factor; Cytoskeleton; Dose-Response Relationship, Drug; Gene Expression Regulation; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Lovastatin; Lysophospholipids; Mevalonic Acid; Polyisoprenyl Phosphates; Pravastatin; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Simvastatin | 2001 |
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured | 2001 |
Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.
Topics: Amides; Aorta; Apoptosis; Bacterial Proteins; Bacterial Toxins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dactinomycin; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Interleukin-1; Isoenzymes; Leucine; Lovastatin; Membrane Proteins; Mevalonic Acid; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein Prenylation; Pyridines; rho GTP-Binding Proteins; Time Factors | 2001 |
Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria.
Topics: Aldose-Ketose Isomerases; Animals; Carbon Radioisotopes; Carotenoids; Cells, Cultured; Cyperus; Cytochrome P-450 Enzyme Inhibitors; Electron Transport Complex IV; Enzyme Inhibitors; Erythritol; Fosfomycin; Insecta; Juvenile Hormones; Lovastatin; Mevalonic Acid; Miconazole; Models, Biological; Models, Chemical; Multienzyme Complexes; Oxidoreductases; Sesquiterpenes; Sugar Phosphates | 2001 |
Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Aminopeptidases; Animals; Anticholesteremic Agents; Caveolin 2; Caveolins; Cells, Cultured; Cholesterol; Cystinyl Aminopeptidase; Glucose Transporter Type 1; Glucose Transporter Type 4; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Lovastatin; Mevalonic Acid; Mice; Monosaccharide Transport Proteins; Muscle Proteins | 2001 |
Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.
Topics: Cell Membrane; Cells, Cultured; Cytokines; E-Selectin; Endothelium, Vascular; Half-Life; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Membrane Proteins; Mevalonic Acid; NF-kappa B; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2001 |
Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells.
Topics: Animals; Cells, Cultured; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-1; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley | 2001 |
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Calcium; Cell Line; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Fatty Acids, Monounsaturated; Fluvastatin; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Osteoblasts; Osteogenesis; Phosphates; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line; Cycloheximide; Dactinomycin; Humans; K562 Cells; Lovastatin; Mevalonic Acid; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases.
Topics: 5'-Nucleotidase; Animals; beta-Cyclodextrins; Cell Hypoxia; Cell Membrane; Cells, Cultured; Cholesterol; Cyclodextrins; Dose-Response Relationship, Drug; Endocytosis; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Platelet Aggregation; Polyisoprenyl Phosphates; Protein Prenylation; Rats; rho GTP-Binding Proteins; RNA, Messenger | 2002 |
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Topics: Animals; Antigens, CD; Cell Polarity; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukosialin; Lovastatin; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Pyrimidines; Sialoglycoproteins; Spleen; src-Family Kinases; T-Lymphocytes | 2002 |
Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase.
Topics: Aged; Cell Division; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; MAP Kinase Kinase 1; Meningeal Neoplasms; Meningioma; Mevalonic Acid; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Protein Serine-Threonine Kinases; Tumor Cells, Cultured | 2002 |
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.
Topics: Bone and Bones; Breast Neoplasms; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Female; Humans; Imidazoles; Lovastatin; Mevalonic Acid; Osteoblasts; Pregnancy; Structure-Activity Relationship; Tumor Cells, Cultured; Zoledronic Acid | 2002 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Topics: Animals; Anticholesteremic Agents; Cell Differentiation; Cell Survival; Culture Media; Cyclic AMP; Cysteine Endopeptidases; Lovastatin; Mevalonic Acid; Multienzyme Complexes; Nerve Degeneration; Neuroblastoma; Neurons; Pravastatin; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Clofibric Acid; Cyclosporine; Endothelin-1; Endothelium, Vascular; Fibric Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lovastatin; Mevalonic Acid; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Analysis of Variance; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Circadian Rhythm; Female; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lovastatin; Mevalonic Acid; Middle Aged; Periodicity; Probability; Prospective Studies; Sampling Studies; Simvastatin; Urinalysis | 2002 |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis.
Topics: Arabidopsis; Carbon Isotopes; Erythritol; Gibberellins; Lovastatin; Mevalonic Acid; Molecular Structure; Pentosephosphates; Plant Growth Regulators; Seedlings; Xylulose | 2002 |
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.
Topics: Antibodies; CD2 Antigens; CD28 Antigens; Cell Division; Cells, Cultured; Child; Diterpenes; Familial Mediterranean Fever; Farnesol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypergammaglobulinemia; Immunoglobulin D; Interleukin-1; Lovastatin; Male; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; T-Lymphocytes | 2002 |
Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred Strains; Osteoblasts; Osteocalcin; Pluripotent Stem Cells; Promoter Regions, Genetic; Stromal Cells | 2002 |
Isoprenoids influence expression of Ras and Ras-related proteins.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cycloheximide; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; K562 Cells; Leucine; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway.
Topics: Arabidopsis; Chlorophyll; Chloroplasts; Darkness; Erythritol; Hemiterpenes; Light; Lovastatin; Mevalonic Acid; Microscopy, Electron; Mutation; Organophosphorus Compounds; Plastids; Sugar Phosphates | 2002 |
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins.
Topics: Alkyl and Aryl Transferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Farnesyltranstransferase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Microglia; Neuroglia; Polyisoprenyl Phosphates; Protein Prenylation | 2002 |
Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content.
Topics: 2,4-Dichlorophenoxyacetic Acid; Adenine; Adenosine; Benzyl Compounds; Cells, Cultured; Cytokinins; Gene Expression Regulation; Glucose-1-Phosphate Adenylyltransferase; Hemiterpenes; Isopentenyladenosine; Kinetin; Lovastatin; Mass Spectrometry; Mevalonic Acid; Nicotiana; Nucleotidyltransferases; Organophosphorus Compounds; Plant Growth Regulators; Plastids; Purines; RNA, Messenger; Starch; Zeatin | 2002 |
Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level.
Topics: Animals; Autoradiography; Cells, Cultured; Cricetinae; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lovastatin; Mesocricetus; Mevalonic Acid; Molecular Biology; Monoterpenes; Plant Extracts; RNA | 2003 |
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.
Topics: Animals; Aorta; Cells, Cultured; Cholesterol, Dietary; Culture Media, Conditioned; Depression, Chemical; Foam Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Metalloproteases; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Rabbits; Saphenous Vein; Simvastatin; Squalene; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2003 |
Monoterpene regulation of Ras and Ras-related protein expression.
Topics: Cell Division; Gene Expression; Humans; Lovastatin; Menthol; Mevalonic Acid; Monoterpenes; Polyisoprenyl Phosphates; ras Proteins; Signal Transduction; Structure-Activity Relationship; Transferases; Tumor Cells, Cultured; Up-Regulation | 2003 |
Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Cholesterol, LDL; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lovastatin; Male; Mevalonic Acid; Middle Aged; Simvastatin | 2003 |
Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells.
Topics: Cytosol; Erythritol; Fosfomycin; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Nicotiana; Phytosterols; Plastids; Plastoquinone; Signal Transduction; Sugar Phosphates; Xylulose | 2003 |
Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon alpha-2; Interferon-alpha; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Serine; Threonine; Time Factors; Tyrosine | 2003 |
Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.
Topics: Cell Adhesion; Collagen Type IV; Flavonoids; Flow Cytometry; Herpesvirus 2, Saimiriine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrin alpha1beta1; Interferon-gamma; Lovastatin; MAP Kinase Kinase 1; Mevalonic Acid; Mitogen-Activated Protein Kinase Kinases; Phospholipase C gamma; Pravastatin; Protein Kinase C; Protein Serine-Threonine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2003 |
Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production.
Topics: Animals; Bone Marrow; Cytokines; Dendritic Cells; DNA; Electrophoretic Mobility Shift Assay; Female; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; T-Lymphocytes; Up-Regulation | 2003 |
Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure.
Topics: Animals; Cell Line; Drug Combinations; Enzyme Activation; Immune Tolerance; Immunosuppressive Agents; Lipopolysaccharides; Lovastatin; Macrophages; MAP Kinase Signaling System; Mevalonic Acid; Mice; Mitogen-Activated Protein Kinases; rho GTP-Binding Proteins; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis.
Topics: Animals; Blotting, Western; Cholesterol, Dietary; Electron Spin Resonance Spectroscopy; Farnesol; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lovastatin; Male; Mevalonic Acid; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Superoxides | 2003 |
Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery.
Topics: Animals; Anticholesteremic Agents; Basilar Artery; Calcium Channel Blockers; Calcium Channels, L-Type; Female; In Vitro Techniques; Lovastatin; Mevalonic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pilot Projects; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin | 2003 |
Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells.
Topics: Animals; Arteriosclerosis; Atorvastatin; Blotting, Western; CD40 Antigens; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblasts; Flow Cytometry; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interferon-gamma; Lovastatin; Macrophages; Mevalonic Acid; Mice; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Pravastatin; Pyrroles; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Simvastatin; Transcription Factors | 2003 |
Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion.
Topics: Anticholesteremic Agents; Cholesterol; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lovastatin; Membrane Microdomains; Mevalonic Acid; Tumor Cells, Cultured | 2003 |
Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha.
Topics: Animals; Brain; Cell Line, Transformed; Cell Line, Tumor; Cytokines; Enzyme Inhibitors; Gene Expression Regulation; Humans; I-kappa B Kinase; Interferon-gamma; Lipopolysaccharides; Lovastatin; Mevalonic Acid; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; rhoA GTP-Binding Protein | 2003 |
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.
Topics: Acyl Coenzyme A; Alzheimer Disease; Analysis of Variance; Animals; Anticholesteremic Agents; Astrocytes; Blotting, Western; Brain Chemistry; Calcium; Cerebral Cortex; Cholesterol; Dextrans; Drug Interactions; Filipin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microglia; Microtubules; Neurofibrillary Tangles; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; rho GTP-Binding Proteins; RNA, Messenger; tau Proteins; Tubulin | 2003 |
Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives.
Topics: Acute-Phase Reaction; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Interleukin-1; Interleukin-6; Liver Neoplasms; Lovastatin; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Up-Regulation | 2003 |
Statins induce suppressor of cytokine signaling-3 in macrophages.
Topics: Animals; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Interferon-gamma; Interleukin-6; Lovastatin; Macrophage Colony-Stimulating Factor; Macrophages; Mevalonic Acid; Mice; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Repressor Proteins; RNA, Messenger; Sesquiterpenes; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Up-Regulation | 2003 |
Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.
Topics: Alleles; Arabidopsis; Arabidopsis Proteins; Erythritol; Fosfomycin; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydroxymethylglutaryl CoA Reductases; Light; Lovastatin; Mevalonic Acid; Mutation; Photoreceptor Cells; Phytochrome; Phytochrome B; Signal Transduction; Sugar Phosphates; Terpenes; Transcription Factors | 2004 |
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.
Topics: Actins; Anticholesteremic Agents; CD36 Antigens; Cells, Cultured; Cytoskeleton; Diterpenes; Farnesol; Gene Expression Regulation; Humans; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Monocytes; Receptors, Cytoplasmic and Nuclear; rho GTP-Binding Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2004 |
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Autoimmune Diseases of the Nervous System; Cells, Cultured; Coculture Techniques; Cytokines; Dinoprostone; Down-Regulation; Drug Synergism; Encephalitis; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Prostaglandins; Rats; Sesquiterpenes | 2004 |
Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.
Topics: Animals; Cell Division; Dinoprost; DNA Replication; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lovastatin; Mevalonic Acid; Mice; Mitogens; Molecular Chaperones; Oncostatin M; Peptides; Protein Prenylation; Proteins; Swiss 3T3 Cells | 2004 |
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels.
Topics: Arabidopsis; Arabidopsis Proteins; Brassinosteroids; Cell Division; Cholestanols; Cysteine Endopeptidases; Cytokinins; Enzyme Inhibitors; Fertility; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Mutation; Phenotype; Phytosterols; Squalene; Steroids, Heterocyclic; Triterpenes | 2004 |
Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.
Topics: Atorvastatin; Biological Assay; Calibration; Cell Line; Chromatography, Liquid; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Pyrroles; Simvastatin | 2004 |
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.
Topics: Escherichia coli; Gene Expression; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Molecular Structure; Pseudomonas | 2004 |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin | 2004 |
Lipid rafts mediate the synaptic localization of alpha-synuclein.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; beta-Cyclodextrins; Brain Chemistry; Cell Compartmentation; Cell Membrane Permeability; Cells, Cultured; Cholesterol; Detergents; Digitonin; Fumonisins; HeLa Cells; Hippocampus; Humans; Kidney; Lovastatin; Membrane Lipids; Membrane Microdomains; Mevalonic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Nystatin; Protein Binding; Rats; Recombinant Fusion Proteins; Sphingolipids; Synucleins; Transfection | 2004 |
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha | 2004 |
Lipid metabolism in zebrafish.
Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish | 2004 |
Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Endothelial Cells; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Monomeric GTP-Binding Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Polyisoprenyl Phosphates; Signal Transduction | 2005 |
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor.
Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lovastatin; Lung Neoplasms; Mevalonic Acid; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Quinazolines; Signal Transduction; Tumor Cells, Cultured | 2005 |
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).
Topics: Animals; Bone Resorption; Cells, Cultured; Diphosphonates; GTP-Binding Proteins; History, 20th Century; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; ras Proteins | 2005 |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.
Topics: Animals; Butylamines; Cell Proliferation; Geranyltranstransferase; Hemiterpenes; Lovastatin; Lymphocyte Activation; Macrophages; Mevalonic Acid; Mice; Organophosphorus Compounds; Propylamines; Protein Prenylation; rap1 GTP-Binding Proteins; Signal Transduction; T-Lymphocyte Subsets; T-Lymphocytes | 2006 |
Erythropoietin receptor signal transduction requires protein geranylgeranylation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Erythropoietin; Glycosylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Janus Kinase 2; Lovastatin; Mevalonic Acid; Mice; Polyisoprenyl Phosphates; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Erythropoietin; Signal Transduction; STAT5 Transcription Factor | 2006 |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
Topics: Acetates; Aldehydes; Animals; Carbon Radioisotopes; Deuterium; Esters; Fatty Acids; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Lovastatin; Male; Mevalonic Acid; Pheromones; Propionates; Sesquiterpenes; Tribolium; Volatilization | 2005 |
Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts.
Topics: Animals; Apoptosis; Brain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Focal Adhesion Protein-Tyrosine Kinases; Lovastatin; Mevalonic Acid; Protein Kinase C-delta; Rats; Time Factors | 2006 |
Rho/ROCK pathway as a target of tumor therapy.
Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 2006 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Cell Movement; Chemokine CCL2; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Activators; Humans; Lovastatin; Mevalonic Acid; Protein Kinases; rho GTP-Binding Proteins; Ribonucleotides; U937 Cells | 2006 |
N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Line, Transformed; Drug Screening Assays, Antitumor; Geranyltranstransferase; Isopentenyladenosine; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasm Proteins; Protein Prenylation; Protein Processing, Post-Translational; Rats; Thyroid Gland | 2006 |
Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cells, Cultured; Cholesterol; Dimerization; Endopeptidases; Humans; Hypolipidemic Agents; Lovastatin; Mevalonic Acid; Models, Biological; Molecular Weight; Palmitic Acid; Protein Prenylation; Protein Transport; Simvastatin; Terpenes | 2006 |
Herbicidal effects of statin pharmaceuticals in Lemna gibba.
Topics: Atorvastatin; Chromatography, High Pressure Liquid; Heptanoic Acids; Herbicides; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Models, Chemical; Pharmaceutical Preparations; Plants; Plastoquinone; Pyrroles; Risk Assessment; Sitosterols; Sterols; Ubiquinone; Ultraviolet Rays | 2006 |
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway.
Topics: Animals; Blood; Cell Proliferation; Cells, Cultured; Drug Synergism; Enzyme Activation; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Lovastatin; Mevalonic Acid; Mitogen-Activated Protein Kinases; Progesterone; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Testosterone; Theca Cells | 2006 |
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia.
Topics: Aged; Cell Separation; Cholesterol; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Ligands; Lovastatin; Male; Mevalonic Acid; Middle Aged; Monocytes; Neuropeptides; Signal Transduction; Stimulation, Chemical; Superoxides | 2006 |
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors.
Topics: 5-Methoxytryptamine; Activating Transcription Factor 1; beta-Cyclodextrins; Binding, Competitive; Blotting, Western; Cholesterol; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fumonisins; HeLa Cells; Humans; Lovastatin; Mevalonic Acid; Phenols; Phosphorylation; Radioligand Assay; Receptors, Serotonin; Serine; Serotonin; Signal Transduction; Sulfonamides; Transfection; Tritium | 2006 |
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.
Topics: Anticholesteremic Agents; Antineoplastic Agents; Berberine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Lovastatin; Mevalonic Acid | 2006 |
Modulation of COX-2 expression by statins in human monocytic cells.
Topics: Cyclooxygenase 2; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Membrane Proteins; Mevalonic Acid; Monocytes; NF-kappa B; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Simvastatin; U937 Cells | 2007 |
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Asbestos, Crocidolite; Cattle; Cell Line, Tumor; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Humans; I-kappa B Kinase; Isoenzymes; Lovastatin; Mesothelioma; Mevalonic Acid; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Proto-Oncogene Proteins c-akt; Pyridines; rho GTP-Binding Proteins; Second Messenger Systems; Terpenes | 2007 |
Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Neoplasms; Terpenes; Tocotrienols | 2007 |
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Diphosphonates; Down-Regulation; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Multiple Myeloma; Phosphatidylcholines; Protein Prenylation | 2007 |
Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity.
Topics: Action Potentials; Adrenergic beta-Agonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antioxidants; Blood Pressure; Body Surface Potential Mapping; Cardiac Pacing, Artificial; Cyclic N-Oxides; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoproterenol; Lovastatin; Male; Mevalonic Acid; Microelectrodes; Myocardial Ischemia; Refractory Period, Electrophysiological; Research Design; Ventricular Fibrillation | 2007 |
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma.
Topics: Apoptosis; Disease Progression; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Multiple Myeloma | 2007 |
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation.
Topics: Anti-Bacterial Agents; Anticholesteremic Agents; Antiviral Agents; Biotinylation; Blotting, Western; Cell Line, Tumor; Cell Survival; Dolichols; Dose-Response Relationship, Drug; Erythropoietin; Glycosylation; Humans; Iodine Radioisotopes; Janus Kinase 2; Leucine; Lovastatin; Mevalonic Acid; Phosphorylation; Polyisoprenyl Phosphates; Protein Prenylation; Receptors, Erythropoietin; STAT5 Transcription Factor; Tunicamycin | 2007 |
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells.
Topics: beta-Cyclodextrins; Cell Line, Tumor; Cholesterol; Endocytosis; Humans; Lovastatin; Lysosomes; Male; Mevalonic Acid; Neoplasm Proteins; Prostatic Neoplasms; Secretory Vesicles | 2007 |
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; DNA; Humans; Lovastatin; Mevalonic Acid; Nitrogen; p38 Mitogen-Activated Protein Kinases; Polyisoprenyl Phosphates; rap1 GTP-Binding Proteins | 2007 |
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
Topics: Amyloid beta-Peptides; Animals; Bacterial Toxins; Cell Line, Tumor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lysosomes; Mevalonic Acid; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Prenylation; rab GTP-Binding Proteins; rho GTP-Binding Proteins; Simvastatin | 2007 |
Activation of the integrated stress response regulates lovastatin-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Eukaryotic Initiation Factor-2; Fibroblasts; Head and Neck Neoplasms; Humans; Lovastatin; Mevalonic Acid; Mice; Models, Biological; Phosphorylation; Prodrugs | 2007 |
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways.
Topics: Antimalarials; Artemisia annua; Artemisinins; Biomass; Carbon; Cotyledon; Cytosol; Hemiterpenes; Lovastatin; Mevalonic Acid; Miconazole; Models, Biological; Organophosphorus Compounds; Plastids | 2007 |
Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours.
Topics: Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid, Acute; Lovastatin; Mevalonic Acid | 2008 |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing | 2008 |
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Apoptosis; Barrett Esophagus; Caspase 3; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Esophageal Neoplasms; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Lovastatin; Mevalonic Acid; Nitrobenzenes; Polyisoprenyl Phosphates; Pravastatin; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Signal Transduction; Simvastatin; Sulfonamides | 2008 |
Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression.
Topics: Androgens; Anticholesteremic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Monascus; Prostate; Prostatic Neoplasms; Receptors, Androgen; Sterol Regulatory Element Binding Protein 2 | 2008 |
d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; G1 Phase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Pancreatic Neoplasms; Tocotrienols | 2009 |
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.
Topics: Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Epithelium; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genital Neoplasms, Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lovastatin; Mevalonic Acid; Ovarian Neoplasms; Polyisoprenyl Phosphates; Pravastatin; Sesquiterpenes; Signal Transduction; Simvastatin; Uterine Cervical Neoplasms; Water | 2010 |
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.
Topics: Antibodies, Monoclonal; Apoptosis; Cell Adhesion; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Eosinophils; Fatty Acids, Monounsaturated; Fluvastatin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Microfluidic Analytical Techniques; Microfluidics; Pravastatin; Recombinant Proteins; Simvastatin; Vascular Cell Adhesion Molecule-1 | 2009 |
Simvastatin as a potential therapeutic for acute respiratory distress syndrome.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Lung; Mevalonic Acid; Mice; Neutrophils; Respiratory Distress Syndrome; Simvastatin | 2009 |
Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis.
Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Models, Animal; Monomeric GTP-Binding Proteins; Muscle, Smooth, Vascular; ras Proteins; Signal Transduction; Thrombospondin 1; Tunica Intima; Tunica Media | 2011 |
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antigens, Viral; Cross Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Influenza A virus; Influenza, Human; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lovastatin; Lymphocyte Activation; Mevalonic Acid; Receptors, Antigen, T-Cell, gamma-delta; Species Specificity; T-Lymphocytes | 2010 |
Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Growth Processes; Cholesterol; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Neoplasms, Experimental; Lovastatin; Male; Mevalonic Acid; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Ubiquinone | 2010 |
Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells.
Topics: Animals; Anticholesteremic Agents; Cell Membrane; Cells, Cultured; Cholesterol; Chromogranins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Lovastatin; Metabolic Networks and Pathways; Mevalonic Acid; Mice; Rats; Rats, Wistar; Secretory Vesicles; Squalene | 2010 |
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
Topics: Animals; Cartilage, Articular; Cattle; Cells, Cultured; Collagen; Collagenases; Down-Regulation; Gelatinases; Gene Expression Regulation, Enzymologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1alpha; Lovastatin; Matrix Metalloproteinases; Mevalonic Acid; Nasal Cartilages; Oncostatin M; Signal Transduction; Simvastatin; Terpenes; Tissue Culture Techniques | 2010 |
Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants.
Topics: Amino Acid Substitution; Bacterial Proteins; Catalysis; Catalytic Domain; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Simvastatin; Stereoisomerism | 2011 |
Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages.
Topics: Animals; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Mice, Inbred C57BL; Receptors, LDL; Toxoplasma | 2011 |
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Cycle; Cell Proliferation; Cisplatin; Diphosphonates; DNA Damage; Doxorubicin; Fibrosarcoma; Humans; Lovastatin; Metformin; Mevalonic Acid; Osteosarcoma; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2011 |
Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita.
Topics: Anticholesteremic Agents; Cell Line; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Keratin-6; Lovastatin; Mevalonic Acid; Pachyonychia Congenita; Promoter Regions, Genetic; STAT1 Transcription Factor | 2011 |
Antitumor effects of the combination of cholesterol reducing drugs.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Berberine; Cell Cycle; Cell Line, Tumor; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms | 2011 |
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E | 2011 |
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Blotting, Western; Cell Differentiation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Luciferases; Mevalonic Acid; Mice; Nuclear Receptor Coactivator 1; Polyisoprenyl Phosphates; PPAR gamma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes | 2011 |
Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Amino Acid Motifs; Amino Acid Sequence; Biosynthetic Pathways; Catalytic Domain; Cloning, Molecular; DNA, Complementary; Escherichia coli; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genetic Complementation Test; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Models, Molecular; Molecular Sequence Data; Nicotiana; Organ Specificity; Phenotype; Phylogeny; Plant Roots; RNA, Messenger; Sequence Alignment; Sterols; Taraxacum | 2012 |
Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway.
Topics: Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Stability; Protein Transport; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Thyroid Neoplasms; Up-Regulation | 2011 |
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
Topics: Amphotericin B; Animals; Aspergillus fumigatus; Biomass; Biosynthetic Pathways; Enoyl-CoA Hydratase; Ergosterol; Ferric Compounds; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Gene Silencing; Genes, Fungal; Hydroxamic Acids; Hydroxymethylglutaryl CoA Reductases; Iron Deficiencies; Ligases; Lovastatin; Mevalonic Acid; Mice; Microbial Sensitivity Tests; Oxidative Stress; Pulmonary Aspergillosis; Pyrimidines; Siderophores; Triazoles; Up-Regulation; Virulence; Voriconazole | 2012 |
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism.
Topics: Apolipoprotein A-I; Cell Line, Tumor; Cholesterol; Coenzyme A Ligases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Eicosanoids; Enzyme Induction; Gene Knockdown Techniques; Humans; Hydroxyeicosatetraenoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Steroid; RNA, Messenger; RNA, Small Interfering; Sterol Regulatory Element Binding Proteins | 2012 |
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Biological Availability; Biosynthetic Pathways; Calcitriol; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppression Therapy; Inflammation; Lovastatin; Lymphoid Tissue; Mevalonic Acid; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Steroid Hydroxylases; Vitamin D; Vitamin D3 24-Hydroxylase | 2012 |
Mevalonate pathway is a therapeutic target in esophageal squamous cell carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; MAP Kinase Signaling System; Mevalonic Acid; Mice; Mice, Nude; Neoplasm Transplantation; Poly(ADP-ribose) Polymerases; Proliferating Cell Nuclear Antigen; Transplantation, Heterologous | 2013 |
Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots.
Topics: Abietanes; Cell Proliferation; Fosfomycin; Gene Expression Regulation, Plant; Genes, Plant; Glyceraldehyde; Lovastatin; Metabolic Networks and Pathways; Mevalonic Acid; Plant Roots; Salvia miltiorrhiza | 2012 |
Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad.
Topics: Aldose-Ketose Isomerases; Chromatography, High Pressure Liquid; Cymenes; Dose-Response Relationship, Drug; Fosfomycin; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Plant; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Monoterpenes; Plant Shoots; Polymerase Chain Reaction; Satureja; Sequence Homology, Nucleic Acid | 2013 |
Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adiponectin; Animals; CCAAT-Enhancer-Binding Proteins; Cell Survival; Down-Regulation; Fatty Acid-Binding Proteins; Gene Expression; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Leptin; Lovastatin; Mevalonic Acid; Mice; PPAR gamma; Sterol Regulatory Element Binding Protein 1; Triglycerides | 2014 |
Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol; Diabetes Mellitus, Experimental; Etidronic Acid; Hemiterpenes; Hep G2 Cells; Humans; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Organophosphorus Compounds; Rats; Rats, Wistar; Risedronic Acid; Squalene; Tricarboxylic Acids; Ubiquinone | 2014 |
[Microbial model of Halobacterium salinarum for screening inhibitors of sterol biosynthesis].
Topics: Antibiotics, Antineoplastic; Automation, Laboratory; Bacterial Proteins; Dactinomycin; Drug Discovery; Halobacterium salinarum; High-Throughput Screening Assays; Humans; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Microbial Viability; Mitomycin; Sterols; Streptonigrin | 2013 |
Differential roles of the mevalonate pathway in the development and survival of mouse Purkinje cells in culture.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Female; Lovastatin; Mevalonic Acid; Mice; Pregnancy; Purkinje Cells; Signal Transduction | 2015 |
Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cells, Cultured; Cholesterol; Eimeria; Endothelial Cells; Farnesyl-Diphosphate Farnesyltransferase; Fatty Acid Synthases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Merozoites; Mevalonic Acid; Sterol O-Acyltransferase; Tricarboxylic Acids | 2014 |
Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots.
Topics: Abietanes; Abscisic Acid; Dehydration; Droughts; Erythritol; Fosfomycin; Gene Expression Regulation, Plant; Lovastatin; Mevalonic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Plant Roots; Polyethylene Glycols; Salvia miltiorrhiza; Signal Transduction; Sugar Phosphates | 2015 |
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Diphosphonates; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Epigenesis, Genetic; Fatty Acids; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Mevalonic Acid; MicroRNAs; NADP; Neoplasms; Protein Processing, Post-Translational; Simvastatin; Vitamin D | 2015 |
Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency.
Topics: Animals; Apoptosis; Cell Line; Coculture Techniques; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Lovastatin; Membrane Potential, Mitochondrial; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Microglia; Neurons | 2015 |
Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models.
Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Replication; Female; Humans; Lovastatin; Mevalonic Acid; Mice; Ovarian Neoplasms; Signal Transduction; Tumor Suppressor Protein p53 | 2015 |
Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase.
Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cholesterol; Chromans; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HL-60 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactoylglutathione Lyase; Lovastatin; Mevalonic Acid; NF-kappa B; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyruvaldehyde; raf Kinases; Signal Transduction; Vitamin E | 2015 |
Statins inhibit blastocyst formation by preventing geranylgeranylation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Blastocyst; Cell Cycle Proteins; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Phosphoproteins; Polyisoprenyl Phosphates; Pravastatin; Prenylation; Quinuclidines; Sesquiterpenes; YAP-Signaling Proteins | 2016 |
Peroxisome proliferator-activated receptor γ down-regulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Differentiation; Down-Regulation; Glucose; Glucose Transporter Type 4; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Lovastatin; Mevalonic Acid; Mice; PPAR gamma; Protein Serine-Threonine Kinases; Rosiglitazone; Thiazolidinediones; Triglycerides; Vitamin E | 2016 |
25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Hydroxycholesterols; Inflammation; Interleukin-1beta; Lovastatin; Mevalonic Acid; Protein Prenylation; Signal Transduction | 2017 |
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
Topics: Anticholesteremic Agents; Atorvastatin; Cell Line, Tumor; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Profiling; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Indoles; Insulin-Secreting Cells; Lovastatin; Mevalonic Acid; Microarray Analysis; Mutation; Polyisoprenyl Phosphates; Protein Prenylation; Protein Transport; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Sesquiterpenes; Signal Transduction; Simvastatin | 2017 |
Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cyclohexenes; Cytokines; Diphosphonates; Fibroblasts; Fluvastatin; Gene Expression Regulation; Heart; Heart Diseases; Humans; Interleukin-33; Lovastatin; Mevalonic Acid; Monoterpenes; Myocardium; Myocytes, Cardiac; Pravastatin; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Thiazolidines | 2018 |
The mevalonate coordinates energy input and cell proliferation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Glucose; Humans; Lovastatin; Mevalonic Acid; Proteomics; Signal Transduction; Transcription Factors; Wnt Signaling Pathway; YAP-Signaling Proteins | 2019 |
Statins decrease the expression of c-Myc protein in cancer cell lines.
Topics: Atorvastatin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neoplasms; Proto-Oncogene Proteins c-myc; Simvastatin | 2021 |
Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors.
Topics: Animals; Child; Deoxyglucose; DNA Repair; DNA-Activated Protein Kinase; Doxorubicin; Glucose; Glycolysis; Hexokinase; Histones; Humans; Ki-67 Antigen; Lovastatin; Mevalonic Acid; MTOR Inhibitors; Oxidoreductases; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Rhabdomyosarcoma, Embryonal; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; TOR Serine-Threonine Kinases; Zebrafish | 2022 |
3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis.
Topics: Arabidopsis; Coenzyme A; Glycine max; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Squalene; Terpenes | 2023 |