mevaldic acid has been researched along with meglutol in 1 studies
*Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. [MeSH]
*Meglutol: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. [MeSH]
| Studies (mevaldic acid) | Trials (mevaldic acid) | Recent Studies (post-2010) (mevaldic acid) | Studies (meglutol) | Trials (meglutol) | Recent Studies (post-2010) (meglutol) |
|---|---|---|---|---|---|
| 7 | 0 | 2 | 143 | 2 | 25 |
| Protein | Taxonomy | mevaldic acid (IC50) | meglutol (IC50) |
|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandt, KG; Kennelly, PJ; Rodwell, VW; Sherban, DG | 1 |
1 other study(ies) available for mevaldic acid and meglutol
| Article | Year |
|---|---|
Rat liver 3-hydroxy-3-methylglutaryl-CoA reductase. Catalysis of the reverse reaction and two half-reactions.
Topics: Animals; Catalysis; Coenzyme A; Cytosol; Glutaral; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Meglutol; Mevalonic Acid; NAD; NADP; Naphthalenes; Rats; Spectrophotometry | 1985 |