metyrapone and proadifen

metyrapone has been researched along with proadifen in 129 studies

Research

Studies (129)

Timeframe	Studies, this research(%)	All Research%
pre-1990	95 (73.64)	18.7374
1990's	23 (17.83)	18.2507
2000's	9 (6.98)	29.6817
2010's	2 (1.55)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Buisson, D; Lewin, G; Quintin, J	1
Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Grundlin, R; Moldéus, P; Orrenius, S; Vadi, H	1
Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M	1
Ivanetich, KM; Lucas, SA; Marsh, JA	1
Bäckström, D; Ehrenberg, A; Eriksson, LE; Grasdalen, H	1
Grudin, R; Moldèus, P; Orrenius, S; Vadi, H	1
Beckett, AH; Gorrod, JW; Temple, DJ	1
Bridges, JW; Chakraborty, J; Shirkey, RS	1
Ichihara, S; Sawahata, T; Watabe, T	1
Jakobsson, SW; Masters, BS; Okita, RT; Prough, RA	1
Cottrell, RC; Gangolli, SD; Lake, BG; Phillips, JC	1
Pelkonen, O	1
McGowan, C; Sylvester, JT	1
Agosin, M; Capdevila, J; Naquira, C; Paulin, J	1
Berg, A; Carlstrom, K; Gustafsson, JA; Ingelman-Sundberg, M	1
Burgschat, H; Netter, KJ	1
Ahokas, JT	1
McDonagh, AF; Schmid, R	1
King, LJ; Parke, DV; Wolf, CR	1
Gangolli, SD; Heading, CE; Lake, BG; Lloyd, AG; Minski, MJ; Phillips, JC	1
Capdevila, J; Moldéus, P; Orrenius, S; Vadi, H	1
Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM	1
Betz, G; Tsai, P; Weakley, R	1
Helia, O; Pauliková, I	1
Hext, PM; Lock, EA	1
Barr, J; Brendel, K; Fisher, R; Gandolfi, AJ; Putnam, CW; Sipes, IG; Zukoski, CF	1
Ruse, MJ; Waring, RH	1
Chen, NQ; Holtzman, JL; Srivastava, SP	1
Dearfield, KL; Huber, BE; Jacobson-Kram, D; Williams, JR	1
Adams, SP; Notides, AC	1
Hamid, AB; Smith, JE	1
Cederbaum, AI; Krikun, G	1
Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM	1
Hayashi, S; Ishikawa, T; Murakami, K; Noshiro, M; Okuda, K; Shimosato, T	1
Kammerer, RC; Lampe, MA	1
Beyerinck, RA; Brass, EP; Garrity, MJ	1
Numazawa, M; Satoh, S	1
Freeman, JJ; Hayes, EP	1
Athar, M; Bickers, DR; Mukhtar, H	1
Smith, AG; Stewart, FP	1
Ioannides, C; Lewis, DF; Parke, DV	1
Bartsch, H; Hietanen, E; Kobljakov, V	1
Buhler, DR; Carpenter, HM; Williams, DE	1
Berlin, T; Larsson, R; Moldéus, P; Olsson, LI; Ross, D	1
Ensley, HE; Feigen, LP; Ignarro, LJ; Pretus, HA	1
Wickramasinghe, SN	1
Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T	1
Delaissé, JM; Nyns, EJ	1
Gillette, PN; Kappas, A; Rifkind, AB; Song, CS	1
Hellmer, KH; Tabarelli-Poplawski, S; Uehleke, H	1
Illing, HP; Kunke, S; Netter, KJ	1
O'Brien, PJ; Rahimtula, AD	1
Kahl, GF; Magnussen, MP; Netter, KJ	1
Dean, PD; Whitehouse, MW	1
Siiteri, PK; Thompson, EA	1
Illing, HP; Netter, KJ	1
Breyer, U	1
Douch, PG; Smith, JN; Turner, JC	1
Archakov, AI; Kretovich, WL; Melik-Sarkissian, SS; Raikchinstein, MV	1
Borg, KO; Grundin, R; Moldéus, P; Orrenius, S; Skånberg, I; von Bahr, C	1
Ikeda, M; Imamura, T; Otsuji, H	1
Hildebrandt, AG	1
Furukawa, T; Shigematsu, A; Takahashi, S	1
Sladek, NE	1
Castro, JA; D'Acosta, N; de Castro, CR; de Ferreyra, EC; Díaz Gómez, MI	1
Frommer, U; Ullrich, V; Weber, P	1
Archakov, AI; Kretovich, VL; Melik-Sarkisian, SS; Raĭkhinshteĭn, MV	2
Anders, MW	1
Levine, WG	1
Casida, JE; Engel, JL; Matthews, HB; Skrinjarić-Spoljar, M	1
Bird, CC; Crawford, AM; Currie, AR; Stirling, BF	1
Kahl, GF; Netter, KJ	1
Brown, LM; Ford-Hutchinson, AW	1
Agosin, M	1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A	1
Peach, MJ; Saye, JA; Singer, HA	1
Ch'ih, JJ; Devlin, TM; Lin, T	1
Baillie, TA; Prickett, KS	1
Bast, A; Bragt, PC; Parnham, MJ; Zijlstra, FJ	1
Hall, ST; Houston, JB; Rhodes, JC	1
Pripfl, T; Richter, C; Winterhalter, KH	1
Hales, BF; Jain, R	1
Bryan, AH; Greiner, JW; Janss, DH; Malan-Shibley, LB	1
Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT	1
Brittebo, EB	1
Margolis, S; Schwartz, MA	1
DePierre, JW; Meijer, J	1
Belitskiĭ, GA; Kiseleva, MG; Prikhod'ko, AZ	1
Netter, KJ	1
Bulger, WH; Kupfer, D	1
Barber, HE; Kitteringham, NR; Petrie, JC	1
Herrmann-Kluwe, CL; Hook, JB; Kluwe, WM	1
Porter, WR; Trager, WF; Wheeler, C	1
Ruenitz, PC; Toledo, MM	1
Kitagawa, H; Naminohira, S; Saito, H; Sakai, T; Ueno, K	1
Grafstöm, R; Stohs, SJ	1
Hollenberg, PF; Koop, DR	1
Colby, HD; Heaps, PR; Johnson, PB; Marquess, ML; Pope, MR	1
Chen, C; Laskowski, P	1
Benford, DJ; Bridges, JW	1
Sidransky, H; Verney, E	1
Kupfer, D; Mani, C; Parkinson, A; Pearce, R	1
Bend, JR; Knickle, LC	1
Commandeur, JN; Goeptar, AR; Groot, EJ; Scheerens, H; Vermeulen, NP	1
Liu, W; Rosazza, JP	1
Berger, BJ; Fairlamb, AH	1
Cantoni, L; Fantuzzi, G; Ghezzi, P; Sironi, M	1
Pistelli, A; Salvemini, D; Vane, J	1
Brien, JF; Liu, Z; Marks, GS; McLaughlin, BE; Nakatsu, K	1
Huang, H; Jurima-Romet, M; Paul, CJ; Solomonraj, G; Thomas, BH	1
Black, KA; Novicki, DL; Smith, GJ; Vincent, JL	1
Bland, TJ; Robertson, IG	1
Juvonen, RO; Kojo, A; Komulainen, H; Liesivuori, J; Pasanen, M; Pennanen, S	1
Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M	1
Cox, HH; Doddema, HJ; Faber, BW; Harder, W; Radhoe, H; Van Heiningen, WN	1
Alfonso, A; Gill, DL; Graber, MN	1
Babol, J; Lundström, K; Squires, EJ	1
Leal, WS; Wojtasek, H	1
Archakov, AI; Karuzina, II; Lisitsa, AV; Petushkova, NA; Zgoda, VG	1
Długoński, J; Lisowska, K	1
Linster, CL; Van Schaftingen, E	1
Rosazza, JP; Sanchez-Gonzalez, M	1
Celander, MC; James, MO; Lou, Z; Rowland-Faux, L	1
Ishihara, Y; Shiba, D; Shimamoto, N	1
Huang, P; Hueni, SE; Lash, LH; Parker, JC; Putt, DA	1
Kubickova, B; Martinkova, M; Stiborova, M	1

Reviews

5 review(s) available for metyrapone and proadifen

Article	Year
The enzymatic formation of bilirubin. Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244 Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen	1975
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions. Biochemical Society symposium, 1972, Volume: 34 Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis	1972
[Role of cytochrome P-450 in mixed function oxidation and metabolism of anesthetics]. Masui. The Japanese journal of anesthesiology, 1974, Volume: 23, Issue:2 Topics: Anesthetics; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Proadifen	1974
Enhancement and inhibition of drug metabolism. Annual review of pharmacology, 1971, Volume: 11 Topics: Acetone; Animals; Drug Antagonism; Drug Interactions; Enzyme Inhibitors; Humans; Kinetics; Metyrapone; Microsomes, Liver; Nitriles; Oxidoreductases; Pharmaceutical Preparations; Proadifen; Pyridines; Rabbits; Rats	1971
Inhibition of oxidative drug metabolism in microsomes. Pharmacology & therapeutics, 1980, Volume: 10, Issue:3 Topics: Animals; Benzoflavones; Binding Sites; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Kinetics; Metyrapone; Microsomes; Models, Biological; Oxidation-Reduction; Pharmaceutical Preparations; Proadifen	1980

Other Studies

124 other study(ies) available for metyrapone and proadifen

Article	Year
Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites. Journal of natural products, 2007, Volume: 70, Issue:6 Topics: Aspergillus niger; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Flavones; Molecular Structure	2007
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship	2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Proceedings: Isolated liver cells: a valuable tool for the study of drug metabolism. Zeitschrift fur klinische Chemie und klinische Biochemie, 1975, Volume: 13, Issue:8 Topics: Alprenolol; Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Liver; Metyrapone; NADP; Proadifen; Rats	1975
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1976, Volume: 6, Issue:10 Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes	1976
Enflurane and methoxyflurane. Their interaction with hepatic cytochrome P-450 in vitro. Biochemical pharmacology, 1979, Mar-15, Volume: 28, Issue:6 Topics: Animals; Cytochrome P-450 Enzyme System; Enflurane; Fluorides; In Vitro Techniques; Kinetics; Liver; Male; Methoxyflurane; Methyl Ethers; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats	1979
Heterogeneity of cytochrome P-450 in rat liver microsomes: selective interaction of metyrapone and SKF 525-A with different fractions of microsomal cytochrome P-450. FEBS letters, 1975, Dec-15, Volume: 60, Issue:2 Topics: Animals; Binding Sites; Camphor; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Lidocaine; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Spectrum Analysis	1975
Drug metabolism in isolated rat liver cells. Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00 Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium	1975
The differentiation of N-oxidation and N-dealkylation of N-ethyl-N-methylaniline by rabbit liver microsomes as distinct metabolic routes. Xenobiotica; the fate of foreign compounds in biological systems, 1975, Volume: 5, Issue:8 Topics: 2,2'-Dipyridyl; Acetone; Aniline Compounds; Animals; Chloromercuribenzoates; Cysteamine; Cytochrome P-450 Enzyme System; Dealkylation; Dithiothreitol; Ethylmaleimide; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Rats; Subcellular Fractions	1975
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver. Biochemical pharmacology, 1979, Sep-15, Volume: 28, Issue:18 Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats	1979
Hepatic microsomal biotransformation of 1,3,5(10),16-estratetraen-3-o1 to 16,17-epiestriol and estriol via 16 alpha,17 alpha- and 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ols. The Journal of biological chemistry, 1979, Nov-10, Volume: 254, Issue:21 Topics: Animals; Carbon Monoxide; Chromatography, Gas; Epoxy Compounds; Estrenes; Estriol; Female; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metyrapone; Microsomes, Liver; Proadifen; Rats; Stereoisomerism	1979
Lauric acid hydroxylation in human liver and kidney cortex microsomes. Biochemical pharmacology, 1979, Dec-01, Volume: 28, Issue:23 Topics: Adult; Animals; Benzoflavones; Humans; Hydroxylation; In Vitro Techniques; Kidney Cortex; Lauric Acids; Male; Metyrapone; Microsomes; Microsomes, Liver; Middle Aged; Proadifen; Swine	1979
The hepatic metabolism of 15N labelled dimethylnitrosamine in the rat. Biochemical pharmacology, 1977, Apr-15, Volume: 26, Issue:8 Topics: Aminoacetonitrile; Animals; Dimethylnitrosamine; Formaldehyde; Liver; Male; Methanol; Metyrapone; Nitrogen; Nitrosamines; Proadifen; Rats	1977
Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta. Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:4* Topics: Adrenal Glands; Aminopyrine; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Flavonoids; Humans; Liver; Male; Maternal-Fetal Exchange; Metyrapone; Placenta; Pregnancy; Proadifen; Rats; Smoking; Testosterone	1977
The effects of agents that bind to cytochrome P-450 on hypoxic pulmonary vasoconstriction. Circulation research, 1978, Volume: 43, Issue:3 Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Extracorporeal Circulation; Hypoxia; Lung; Metyrapone; Muscle, Smooth; Proadifen; Prostaglandins F; Swine; Vasoconstriction	1978
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital. Science (New York, N.Y.), 1976, Oct-08, Volume: 194, Issue:4261 Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Phenobarbital; Proadifen; Ribosomes; Trypanosoma cruzi	1976
Demonstration of a cytochrome P-450-dependent steroid 15beta-hydroxylase in Bacillus megaterium. Biochemical and biophysical research communications, 1975, Oct-27, Volume: 66, Issue:4 Topics: Bacillus megaterium; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Imidazoles; Kinetics; Metyrapone; Multienzyme Complexes; Proadifen; Progesterone; Protein Binding; Steroid Hydroxylases	1975
Application of A. C.-polarography in a study of p-nitroanisole metabolism and its kinetic properties. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 201, Issue:2 Topics: Animals; Anisoles; Catechols; Dealkylation; Hydroxylation; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Phenobarbital; Polarography; Proadifen; Proteins; Rats; Time Factors	1977
Metabolism of 2,5-diphenyloxazole (PPO) by trout liver microsomal mixed function monooxygenase. Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochromes; Flavonoids; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxazoles; Oxidoreductases; Proadifen; Rats; Salmonidae; Species Specificity; Spectrometry, Fluorescence; Trout	1976
Anaerobic dechlorination of trichlorofluoromethane by liver microsomal preparations in vitro. Biochemical Society transactions, 1975, Volume: 3, Issue:1 Topics: Anaerobiosis; Animals; Carbon Tetrachloride; Chlorine; Cytochrome P-450 Enzyme System; Hydrocarbons, Fluorinated; Kinetics; Metyrapone; Microsomes, Liver; Oxygen; Partial Pressure; Proadifen; Rats; Time Factors	1975
Comparative studies on hepatic dimethylnitrosamine demethylase and some xenobiotic-metabolizing enzymes in the rat. Biochemical Society transactions, 1975, Volume: 3, Issue:1 Topics: Aniline Hydroxylase; Animals; Azides; Cyanides; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Kinetics; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Proadifen; Pyrazoles; Rats; Time Factors; Triazoles	1975
The metabolism of benzo(alpha)pyrene in isolated rat liver cells. Cancer research, 1975, Volume: 35, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Cells, Cultured; Flavonoids; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rotenone; Solubility; Stimulation, Chemical	1975
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450. Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00 Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors	1975
Heterogeneity of cytochrome P-450 in rat testis microsomes. The Journal of biological chemistry, 1976, May-10, Volume: 251, Issue:9 Topics: Animals; Binding, Competitive; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes; Proadifen; Protein Binding; Rats; Steroid Hydroxylases; Testis	1976
Rat hepatic microsomal metabolism of oxyprothepine: the role of inhibitors on S-oxygenation. Die Pharmazie, 1992, Volume: 47, Issue:1 Topics: Animals; Antimetabolites; Carbon Monoxide; Dibenzothiepins; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains	1992
The accumulation and metabolism of 3-trifluoromethylpyridine by rat olfactory and hepatic tissues. Toxicology, 1992, Volume: 72, Issue:1 Topics: Animals; Autoradiography; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Liver; Male; Metyrapone; Olfactory Mucosa; Proadifen; Pyridines; Rats	1992
In-vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices. Human & experimental toxicology, 1991, Volume: 10, Issue:5 Topics: Adolescent; Adult; Aged; Chlorobenzenes; Female; Humans; In Vitro Techniques; Liver; Male; Metyrapone; Middle Aged; Proadifen	1991
The S-oxidation of thioamides by rat liver microsomes. Biochemical Society transactions, 1991, Volume: 19, Issue:2 Topics: Amines; Animals; Ethionamide; Kinetics; Male; Methimazole; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains	1991
The effect of substrates and inhibitors of cytochrome P-450 on the NADPH inhibition of the ATP-dependent, hepatic, microsomal calcium pump. FEBS letters, 1990, Dec-10, Volume: 276, Issue:1-2 Topics: Aminopyrine; Animals; Benzphetamine; Calcium; Calcium-Transporting ATPases; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Male; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains	1990
Induction of sister chromatid exchanges in human and rat hepatoma cell lines by cyclophosphamide and phosphoramide mustard and the effects of cytochrome P-450 inhibitors. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Metyrapone; Phosphoramide Mustards; Poly A; Proadifen; Rats; RNA; RNA, Messenger; Sister Chromatid Exchange	1986
Reduction of irreversible binding of diethylstilbestrol in hamster renal cortex by inhibitors of cytochrome P-450. Toxicology and applied pharmacology, 1987, Mar-30, Volume: 88, Issue:1 Topics: Animals; Butylated Hydroxytoluene; Carbon Monoxide; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Dicumarol; Dienestrol; Diethylstilbestrol; Isoenzymes; Kidney Cortex; Male; Metyrapone; Microsomes, Liver; Proadifen; Time Factors	1987
Degradation of aflatoxin by Aspergillus flavus. Journal of general microbiology, 1987, Volume: 133, Issue:8 Topics: Aflatoxin B1; Aflatoxins; Aspergillus flavus; Cycloheximide; Cytochrome c Group; Metyrapone; NADP; Periodic Acid; Potassium Cyanide; Proadifen	1987
Evaluation of microsomal pathways of oxidation of alcohols and hydroxyl radical scavenging agents with carbon monoxide and cobalt protoporphyrin IX. Biochemical pharmacology, 1985, Aug-15, Volume: 34, Issue:16 Topics: Alcohols; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Deferoxamine; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Porphyrins; Proadifen; Protoporphyrins; Rats; Rats, Inbred Strains; Superoxides	1985
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases. The Journal of biological chemistry, 1987, Feb-05, Volume: 262, Issue:4 Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature	1987
Aryl hydrocarbon hydroxylase activity in rat submandibular glands. Journal of dental research, 1986, Volume: 65, Issue:1 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Carbon Monoxide; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Oxygenases; Proadifen; Rats; Rats, Inbred Strains; Submandibular Gland; Time Factors	1986
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole	1987
Inhibition of prostaglandin E2 catabolism and potentiation of hepatic prostaglandin E2 action in rat hepatocytes by inhibitors of oxidative metabolism. Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7 Topics: Aminopyrine; Animals; Benzoflavones; Dinoprostone; Glucagon; Glycogen; Liver; Male; Metyrapone; Oxidation-Reduction; Proadifen; Prostaglandins E; Rats; Rats, Inbred Strains	1988
Kinetic studies of inhibition of estradiol 2- and 16 alpha-hydroxylases in rat liver microsomes with various cytochrome P-450 inhibitors. Journal of steroid biochemistry, 1988, Volume: 29, Issue:2 Topics: Aminoglutethimide; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 2; Hydroxylation; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1988
Microsomal metabolism of acetonitrile to cyanide. Effects of acetone and other compounds. Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6 Topics: Acetone; Acetonitriles; Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Ethanol; Female; Metyrapone; Microsomes, Liver; NAD; Proadifen; Proteins; Rats; Rats, Inbred Strains; Time Factors	1988
Cytochrome P-450 dependent metabolism of testosterone in rat skin. Biochemical and biophysical research communications, 1987, Jun-15, Volume: 145, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Metyrapone; Microsomes; NADP; Pregnancy; Proadifen; Rats; Rats, Inbred Strains; Skin; Steroid Hydroxylases; Testosterone	1987
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole	1986
Molecular dimensions of the substrate binding site of cytochrome P-448. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Animals; Binding Sites; Computers; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochromes; Ellipticines; Enzyme Induction; Hydroxylation; Metyrapone; Models, Molecular; Proadifen; Protein Conformation; Quinacrine; Substrate Specificity	1986
Role of different cytochrome P-450 isozymes in the demethylation of various substrates. General pharmacology, 1986, Volume: 17, Issue:5 Topics: 1,2-Dimethylhydrazine; Aminopyrine; Animals; Cytochrome P-450 Enzyme System; Dimethylhydrazines; Dimethylnitrosamine; In Vitro Techniques; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Proadifen; Rats; Substrate Specificity	1986
Hexachlorobenzene-induced porphyria in Japanese quail: an in vitro study of changes in cytochrome P-450 and monooxygenases. Journal of toxicology and environmental health, 1985, Volume: 16, Issue:2 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; Chlorobenzenes; Coturnix; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Hexachlorobenzene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxygenases; Porphyrias; Proadifen	1985
Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2 Topics: Acetaminophen; Aminophenols; Animals; Arachidonic Acid; Arachidonic Acids; Glutathione; Glutathione Disulfide; Humans; Indomethacin; Kidney; Kinetics; Linolenic Acids; Lipid Peroxides; Male; Metyrapone; Microsomes; Models, Chemical; NADP; Phenetidine; Proadifen; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rabbits	1985
Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone. Prostaglandins, 1985, Volume: 30, Issue:4 Topics: Chromatography, High Pressure Liquid; Glycine max; Kinetics; Lipoxygenase Inhibitors; Metyrapone; Plants; Proadifen	1985
Observations on the biochemical basis of ethanol metabolism by human macrophages. Alcohol and alcoholism (Oxford, Oxfordshire), 1986, Volume: 21, Issue:1 Topics: Amitrole; Carbon Monoxide; Catalase; Cell Survival; Cells, Cultured; Ethanol; Humans; Macrophages; Metyrapone; NADP; Proadifen; Pyrazoles	1986
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:2 Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry	1986
Detection of cytochrome P-450 in subcellular fractions of Endomycopsislipolytica grown on n-hexadecane. Archives internationales de physiologie et de biochimie, 1974, Volume: 82, Issue:1 Topics: Alkanes; Ascomycota; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucose; Metyrapone; Mixed Function Oxygenases; Oxidation-Reduction; Proadifen; Spectrophotometry; Subcellular Fractions; Ultracentrifugation	1974
Drug stimulation of -aminolevulinic acid synthetase and cytochrome P-450 in vivo in chick embryo liver. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 185, Issue:2 Topics: 5-Aminolevulinate Synthetase; Age Factors; Aminoglutethimide; Aminopyrine N-Demethylase; Animals; Anticonvulsants; Central Nervous System Stimulants; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dichlorodiphenyldichloroethane; Dose-Response Relationship, Drug; Enzyme Induction; Hypnotics and Sedatives; Liver; Metyrapone; Proadifen; Stimulation, Chemical; Time Factors; Tranquilizing Agents	1973
Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 279, Issue:1 Topics: Anaerobiosis; Animals; Carbon Monoxide; Carbon Radioisotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Glutathione; Halothane; In Vitro Techniques; Kidney; Lung; Metyrapone; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Proadifen; Protein Binding; Rabbits; Spectrophotometry; Sulfites	1973
On the spectral intermediate at 440 nm formed during mixed function substrate oxidation. Biochemical pharmacology, 1974, Sep-15, Volume: 23, Issue:18 Topics: Acetanilides; Aniline Compounds; Animals; Barbiturates; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pentobarbital; Proadifen; Protein Binding; Rats; Spectrophotometry, Ultraviolet	1974
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450. Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1 Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors	1974
Kinetic experiments on the binding of metyrapone to liver microsomes. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 265, Issue:3 Topics: Aniline Compounds; Animals; Binding Sites; Biotransformation; Cytochromes; Kinetics; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Proadifen	1969
The effects of mepyrapone (SU 4885) and some hypercholesterolaemic drugs on hepatic sterol and fatty acid oxidation. Biochemical pharmacology, 1967, Volume: 16, Issue:3 Topics: Animals; Anticholesteremic Agents; Carnitine; Cattle; Cholesterol; Drug Antagonism; Fatty Acids; Female; Liver; Male; Metyrapone; Mice; Mitochondria; Myocardium; NAD; Oxidation-Reduction; Oxidoreductases; Proadifen; Pyridines; Rats; Sterols; Triparanol	1967
The involvement of human placental microsomal cytochrome P-450 in aromatization. The Journal of biological chemistry, 1974, Sep-10, Volume: 249, Issue:17 Topics: Aminoglutethimide; Androstenedione; Animals; Binding Sites; Binding, Competitive; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Humans; Kinetics; Metyrapone; Microsomes; Microsomes, Liver; Nandrolone; Placenta; Pregnancy; Proadifen; Protein Binding; Rabbits; Receptors, Cell Surface; Spectrophotometry; Spectrophotometry, Ultraviolet; Steroids; Swine; Tritium	1974
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation. Xenobiotica; the fate of foreign compounds in biological systems, 1974, Volume: 4, Issue:9 Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry	1974
Metabolism of the phenothiazine drug perazine by liver and lung microsomes from various species. Biochemical pharmacology, 1971, Volume: 20, Issue:12 Topics: Animals; Cats; Chromatography, Thin Layer; Cytochromes; Dealkylation; Guinea Pigs; Hydroxylation; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxides; Phenothiazines; Proadifen; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfoxides; Swine; Tranquilizing Agents	1971
NADPH-dependent cleavage of carbamates. Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Dec-08, Volume: 10, Issue:23 Topics: Administration, Oral; Animals; Bees; Carbamates; Coleoptera; Diptera; Glucosephosphate Dehydrogenase; Glucosephosphates; Houseflies; Hydrolysis; In Vitro Techniques; Injections, Intraperitoneal; Insecticides; Metyrapone; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Piperonyl Butoxide; Proadifen; Tritium	1971
The binding of microsomal hydroxylation substrates to cytochrome P-450Rh and its effect on the nitrogen fixation by lupin bacteroids. FEBS letters, 1974, Aug-30, Volume: 44, Issue:3 Topics: Aniline Compounds; Binding Sites; Camphor; Cytochrome P-450 Enzyme System; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes; Nitrogen Fixation; Plants; Proadifen; Protein Binding; Rhizobium; Spectrophotometry; Spectrophotometry, Ultraviolet; Ultracentrifugation	1974
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug. Acta pharmacologica et toxicologica, 1974, Volume: 35, Issue:3 Topics: Administration, Oral; Alprenolol; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Imipramine; Injections, Intravenous; Liver; Male; Methods; Metyrapone; Microsomes, Liver; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry; Time Factors; Tritium	1974
Comparative studies on hepatic N- and O-demethylation. Japanese journal of pharmacology, 1972, Volume: 22, Issue:4 Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide	1972
Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism. Cancer research, 1972, Volume: 32, Issue:9 Topics: Alkylation; Animals; Azaguanine; Binding, Competitive; Carcinoma 256, Walker; Cyclophosphamide; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Male; Meperidine; Mercaptopurine; Metyrapone; Microsomes, Liver; Morphine; Phenacetin; Proadifen; Probenecid; Quinine; Rats	1972
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity. Toxicology and applied pharmacology, 1973, Volume: 25, Issue:4 Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic	1973
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1973, Volume: 354, Issue:5 Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors	1973
[Spectral properties of cytochrome P-450 from lupin nodule bacteroids]. Doklady Akademii nauk SSSR, 1974, Jul-11, Volume: 216, Issue:5 Topics: Aniline Compounds; Animals; Camphor; Cytochrome P-450 Enzyme System; Hexobarbital; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rhizobium; Spectrophotometry	1974
[Effect of substrates and microsomal hydroxylation inhibitors on the nitrogen-fixing activity of lupin bacteroids]. Doklady Akademii nauk SSSR, 1974, Jul-21, Volume: 216, Issue:6 Topics: Aniline Compounds; Camphor; Cytochrome P-450 Enzyme Inhibitors; Hexobarbital; Metyrapone; Nitrogen Fixation; Oxygen Consumption; Proadifen; Rhizobium	1974
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism. The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:2 Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium	1972
Response of hepatic microsomal mixed-function oxidases to various types of insecticide chemical synergists administered to mice. Biochemical pharmacology, 1971, Volume: 20, Issue:7 Topics: Alkynes; Aniline Compounds; Animals; Anisoles; Benzopyrans; Carbamates; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dimethyl Sulfoxide; Dioxoles; Drug Synergism; Enzyme Induction; Ethers; Hexobarbital; Hydrocarbons, Halogenated; Hydroxylation; In Vitro Techniques; Indoles; Insecticides; Male; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidoreductases; Pesticide Synergists; Pesticides; Piperonyl Butoxide; Proadifen; Pyrazoles; Rotenone; Sleep; Spectrophotometry; Sulfites; Thiadiazoles; Time Factors	1971
Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A). British journal of cancer, 1970, Volume: 24, Issue:3 Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Benz(a)Anthracenes; Embryo, Mammalian; Female; Metyrapone; Organ Size; Placenta; Pregnancy; Proadifen; Rats	1970
The effect of metyrapone on cellular respiration and microsomal drug oxidation. Biochemical pharmacology, 1970, Volume: 19, Issue:1 Topics: Amobarbital; Animals; Biological Transport, Active; Cytochromes; Electrons; Glycolysis; In Vitro Techniques; Lactates; Liver; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxygen Consumption; Perfusion; Proadifen; Protein Binding; Pyruvates; Rats	1970
The destruction of cytochrome P-450 by alclofenac: possible involvement of an epoxide metabolite. Biochemical pharmacology, 1982, Jan-15, Volume: 31, Issue:2 Topics: Animals; Cysteine; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Male; Metyrapone; Mice; Mice, Inbred DBA; Microsomes, Liver; Phenylacetates; Proadifen	1982
The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1983, Volume: 75, Issue:2 Topics: Aerobiosis; Animals; Metronidazole; Metyrapone; Phenobarbital; Proadifen; Species Specificity; Time Factors; Trypanosoma cruzi	1983
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats. Archives of toxicology, 1984, Volume: 56, Issue:1 Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine	1984
Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta. Blood vessels, 1984, Volume: 21, Issue:5 Topics: Animals; Aorta; Calcium; Cytochrome P-450 Enzyme Inhibitors; Endothelium; Ionophores; Male; Methacholine Chloride; Methacholine Compounds; Metyrapone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Proadifen; Rabbits	1984
Effect of inhibitors of microsomal enzymes on aflatoxin B1-induced cytotoxicity and inhibition of RNA synthesis in isolated rat hepatocytes. Biochemical and biophysical research communications, 1983, Aug-30, Volume: 115, Issue:1 Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Survival; In Vitro Techniques; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rats, Inbred Strains; Transcription, Genetic	1983
Metabolism of valproic acid by hepatic microsomal cytochrome P-450. Biochemical and biophysical research communications, 1984, Aug-16, Volume: 122, Issue:3 Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Valproic Acid	1984
Comparison of the effects of inhibitors of cytochrome P-450-mediated reactions on human platelet aggregation and arachidonic acid metabolism. Biochimica et biophysica acta, 1981, Oct-12, Volume: 677, Issue:2 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Butanones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Malondialdehyde; Metyrapone; Microsomes, Liver; Platelet Aggregation; Proadifen; Rats; Thromboxanes	1981
Inhibition of antipyrine metabolite formation in rats in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:9 Topics: Animals; Antipyrine; Benzoflavones; Cimetidine; Cytochrome P-450 Enzyme System; Male; Metyrapone; Proadifen; Rats; Rats, Inbred Strains	1984
Tyrosine . copper(II) inhibits lipid peroxidation in rat liver microsomes. FEBS letters, 1980, Feb-25, Volume: 111, Issue:1 Topics: Animals; Copper; Kinetics; Lipid Peroxides; Male; Metyrapone; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Proadifen; Rats; Superoxide Dismutase; Tyrosine; Zinc	1980
Characteristics of the activation of cyclophosphamide to a mutagen by rat liver. Biochemical pharmacology, 1980, Volume: 29, Issue:2 Topics: Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Flavonoids; In Vitro Techniques; Liver; Male; Metyrapone; Mutagens; NADP; Phenobarbital; Proadifen; Rats; Salmonella typhimurium	1980
Aryl hydrocarbon hydroxylase and epoxide hydratase activities: age effects in mammary epithelial cells of Sprague-Dawley rats. Journal of the National Cancer Institute, 1980, Volume: 64, Issue:5 Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Enzyme Induction; Epithelium; Epoxide Hydrolases; Female; Liver; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Polycyclic Compounds; Proadifen; Rats	1980
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites. Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship	1980
N-Demethylation of aminopyrine by the nasal mucosa in mice and rats. Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:3 Topics: Aminopyrine N-Demethylase; Animals; Autoradiography; Carbon Dioxide; Kinetics; Male; Metyrapone; Mice; Mice, Inbred C57BL; Nasal Mucosa; Proadifen; Rats; Rats, Inbred Strains; Species Specificity	1982
Effects of drugs and sterols on cholesterol 7 alpha-hydroxylase activity in rat liver microsomes. Journal of lipid research, 1983, Volume: 24, Issue:1 Topics: Aminoglutethimide; Animals; Ascorbic Acid; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Cimetidine; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rats, Inbred Strains; Steroid Hydroxylases; Sterols	1983
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system. Journal of steroid biochemistry, 1983, Volume: 18, Issue:4 Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone	1983
[Cytochrome P-450 and aryl hydroxylase activity in cells of a long-term transplantable tumor]. Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:7 Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes; Neoplasm Transplantation; Neoplasms, Experimental; Oxygenases; Proadifen; Time Factors	1983
beta-Diethylaminoethyl-2, 2-diphenylpentanoate (SKF 525-A)-mediated translocation of uterine estrogen receptor from the cytosolic to the nuclear compartment in isolated rat uteri. Molecular pharmacology, 1982, Volume: 21, Issue:3 Topics: Adrenalectomy; Animals; Castration; Cell Nucleus; Cytosol; Female; In Vitro Techniques; Kinetics; Metyrapone; Proadifen; Rats; Rats, Inbred Strains; Receptors, Estrogen; Uterus	1982
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat. British journal of pharmacology, 1982, Volume: 77, Issue:4 Topics: Animals; Biotransformation; Chlorpromazine; Imipramine; Kinetics; Liver; Male; Metyrapone; Proadifen; Propranolol; Rats; Rats, Inbred Strains; Spinal Cord	1982
Inhibition of mixed-function oxidase activities in vitro and in vivo: comparisons between kidney and liver. Journal of applied toxicology : JAT, 1982, Volume: 2, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Kidney; Liver; Male; Metyrapone; Mice; Mice, Inbred ICR; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Piperonyl Butoxide; Proadifen	1982
Stereochemical aspects of the metabolism of phenprocoumon in rat liver microsomes. Biochemical pharmacology, 1981, Jul-01, Volume: 30, Issue:13 Topics: 4-Hydroxycoumarins; Animals; Biotransformation; Carbon Monoxide; Chemical Phenomena; Chemistry; Hydroxylation; In Vitro Techniques; Metyrapone; Microsomes, Liver; NAD; Phenprocoumon; Proadifen; Rats; Stereoisomerism	1981
Chemical and biochemical characteristics of O-demethylation of chlorotrianisene in the rat. Biochemical pharmacology, 1981, Aug-15, Volume: 30, Issue:16 Topics: Animals; Chemical Phenomena; Chemistry; Chlorotrianisene; Dealkylation; Female; Male; Metyrapone; Microsomes, Liver; NADP; Proadifen; Rats; Rats, Inbred Strains	1981
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice. Research communications in chemical pathology and pharmacology, 1981, Volume: 34, Issue:1 Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Pregnancy; Proadifen	1981
Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells. Drug and chemical toxicology, 1981, Volume: 4, Issue:2 Topics: Animals; Benzoflavones; Benzopyrenes; Coumarins; Cytochrome P-450 CYP1A1; Female; Intestine, Small; Methylcholanthrene; Metyrapone; Microsomes; Oxidoreductases; Proadifen; Rats; Rats, Inbred Strains; Rotenone	1981
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences. Molecular pharmacology, 1980, Volume: 17, Issue:1 Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity	1980
Comparative effects of mixed function oxidase inhibitors on adrenal and hepatic xenobiotic metabolism in the guinea pig. Biochemical pharmacology, 1980, Mar-15, Volume: 29, Issue:6 Topics: Adrenal Glands; Animals; Benzoflavones; Benzopyrene Hydroxylase; Ethylmorphine-N-Demethylase; Liver; Male; Metyrapone; Mice; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Proadifen	1980
Bond cleavage of diethylstilbestrol of vicinal diol by a rat liver enzyme. Archives of biochemistry and biophysics, 1980, Volume: 202, Issue:1 Topics: Animals; Cyanides; Diethylstilbestrol; Metyrapone; Microsomes, Liver; Proadifen; Rats	1980
Characterization of the activation of hepatic microsomal hydroxylation by betamethasone and alpha naphthoflavone. Biochemical pharmacology, 1980, Sep-01, Volume: 29, Issue:17 Topics: Animals; Benzoflavones; Betamethasone; Enzyme Activation; Flavonoids; Hydroxylation; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats	1980
Effect of metyrapone on tryptophan binding to rat hepatic nuclei. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:1 Topics: Animals; Cell Nucleus; Dose-Response Relationship, Drug; Female; Hydroxylation; Liver; Metyrapone; Proadifen; Proteins; Rats; Rats, Sprague-Dawley; RNA; Tritium; Tryptophan	1994
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis, 1994, Volume: 15, Issue:12 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin	1994
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids. Molecular pharmacology, 1994, Volume: 45, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles	1994
Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450. Cancer research, 1994, May-01, Volume: 54, Issue:9 Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Doxorubicin; Drug Interactions; Glutathione; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Maleates; Metyrapone; Mitomycin; Proadifen; Rats; Rats, Wistar; Time Factors	1994
A soluble Bacillus cereus cytochrome P-450cin system catalyzes 1,4-cineole hydroxylations. Applied and environmental microbiology, 1993, Volume: 59, Issue:11 Topics: Amines; Bacillus cereus; Cyclohexane Monoterpenes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexanes; Hydroxylation; Imidazoles; Metyrapone; Monoterpenes; NAD; Oxygen; Oxygenases; Proadifen; Solubility; Terpenes	1993
Cytochrome P450 in trypanosomatids. Biochemical pharmacology, 1993, Jul-06, Volume: 46, Issue:1 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes, Liver; Pentamidine; Proadifen; Rats; Subcellular Fractions; Trypanosomatina	1993
Inhibitors of cytochrome P450 suppress tumor necrosis factor production. Cellular immunology, 1993, Volume: 150, Issue:2 Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Humans; Lipoxygenase Inhibitors; Male; Metyrapone; Mice; Monocytes; Proadifen; Tumor Necrosis Factor-alpha	1993
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Metyrapone; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Proadifen; Rabbits; Sulfobromophthalein	1993
Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in metabolic activation of glyceryl trinitrate in rabbit aorta. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3 Topics: Animals; Aorta; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hemeproteins; Hypoxia; In Vitro Techniques; Male; Metyrapone; Nitric Oxide; Nitroglycerin; Proadifen; Rabbits; Vasodilation	1993
Metabolism of phenazopyridine by isolated rat hepatocytes. Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:2 Topics: Animals; Benzoflavones; Detergents; Enzyme Induction; In Vitro Techniques; Indomethacin; Liver; Male; Metyrapone; Octoxynol; Phenazopyridine; Polyethylene Glycols; Proadifen; Rats; Rats, Wistar	1993
Flow cytometric analysis of xenobiotic metabolism activity in isolated rat hepatocytes. Cytometry, 1993, Volume: 14, Issue:3 Topics: Animals; Benzoflavones; Flow Cytometry; Fluoresceins; Light; Liver; Male; Metyrapone; Mixed Function Oxygenases; Proadifen; Rats; Xenobiotics	1993
Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10 Topics: Acridines; Acridones; Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cimetidine; Cytosol; Kinetics; Liver; Male; Methimazole; Metyrapone; Microsomes, Liver; NAD; Proadifen; Rats; Rats, Wistar	1993
CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. Human & experimental toxicology, 1996, Volume: 15, Issue:5 Topics: Aged; Animals; Antibodies, Monoclonal; Caproates; Cytochrome P-450 Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Isoenzymes; Male; Methylation; Metyrapone; Mice; Microsomes, Liver; Middle Aged; NADPH-Ferrihemoprotein Reductase; Occupational Exposure; Proadifen; Quinidine; Rats; Rats, Wistar; Troleandomycin	1996
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:6 Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Predisposition to Disease; Guinea Pigs; Halothane; Liver; Liver Circulation; Male; Metyrapone; Microsomes, Liver; Necrosis; Portal System; Proadifen; Pyrazoles	1996
Styrene metabolism in Exophiala jeanselmei and involvement of a cytochrome P-450-dependent styrene monooxygenase. Applied and environmental microbiology, 1996, Volume: 62, Issue:4 Topics: Air Pollutants; Biodegradation, Environmental; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Exophiala; Metyrapone; Oxygenases; Proadifen; Spectrophotometry; Styrene; Styrenes	1996
Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. The Journal of biological chemistry, 1997, Nov-21, Volume: 272, Issue:47 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Cycle; Cell Division; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Indoles; Masoprocol; Metyrapone; Muscle, Smooth; Proadifen; Signal Transduction; Thapsigargin	1997
Hepatic metabolism of skatole in pigs by cytochrome P4502E1. Journal of animal science, 1998, Volume: 76, Issue:3 Topics: Allyl Compounds; Animals; Antioxidants; Chlorzoxazone; Crosses, Genetic; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Female; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Skatole; Sulfides; Swine	1998
Degradation of an alkaloid pheromone from the pale-brown chafer, Phyllopertha diversa (Coleoptera: Scarabaeidae), by an insect olfactory cytochrome P450. FEBS letters, 1999, Sep-24, Volume: 458, Issue:3 Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Coleoptera; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Insect Proteins; Mass Spectrometry; Metyrapone; Microsomes; Molecular Structure; Proadifen; Quinazolines; Sex Attractants	1999
Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation. Toxicology in vitro : an international journal published in association with BIBRA, 2002, Volume: 16, Issue:1 Topics: alpha-Tocopherol; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Iron; Lipid Peroxidation; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Protoporphyrins; Rabbits; Steroid Hydroxylases	2002
Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 85, Issue:1 Topics: Biotransformation; Cortodoxone; Cunninghamella; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Metyrapone; Phenanthrenes; Proadifen; Triazoles	2003
Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes. The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38 Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Ascorbic Acid; Barbital; Buthionine Sulfoximine; Cells, Cultured; Chlorobutanol; Chromatography, High Pressure Liquid; Clotrimazole; Diamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Galactosamine; Glucuronates; Glucuronic Acid; Hepatocytes; Imidazoles; Imidazolidines; Metyrapone; Models, Chemical; Preservatives, Pharmaceutical; Proadifen; Rats; Rats, Wistar; Resorcinols; Time Factors; Xenobiotics; Xylulose	2003
Microbial transformations of chalcones: hydroxylation, O-demethylation, and cyclization to flavanones. Journal of natural products, 2004, Volume: 67, Issue:4 Topics: Aspergillus; Biotransformation; Catalysis; Chalcone; Cyclization; Cytochrome P-450 Enzyme System; Flavanones; Hydroxylation; Kinetics; Metyrapone; Molecular Mimicry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenylthiourea; Proadifen	2004
Properties and regional expression of a CYP3A-like protein in channel catfish intestine. Aquatic toxicology (Amsterdam, Netherlands), 2005, May-15, Volume: 72, Issue:4 Topics: Analysis of Variance; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Dihydroxydihydrobenzopyrenes; Erythromycin; Ictaluridae; Intestinal Mucosa; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Proadifen; Steroid Hydroxylases; Xenobiotics	2005
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition. Toxicology and applied pharmacology, 2006, Jul-15, Volume: 214, Issue:2 Topics: Animals; Antioxidants; Benzoquinones; Catecholamines; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione Disulfide; Hepatocytes; Imidazolines; Iron Chelating Agents; Ketoconazole; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Molecular Structure; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances	2006
Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione. Toxicology, 2007, Jun-03, Volume: 235, Issue:1-2 Topics: Animals; Biotransformation; Carcinogens, Environmental; Cell Survival; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hepatocytes; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Metyrapone; Microsomes; Proadifen; Pyridines; Rats; Rats, Inbred F344; Tetrachloroethylene; Trichloroethylene	2007
Effects of cytochrome P450 inhibitors on peroxidase activity. Neuro endocrinology letters, 2012, Volume: 33 Suppl 3 Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin	2012