metyrapol has been researched along with metyrapone in 16 studies
| Studies (metyrapol) | Trials (metyrapol) | Recent Studies (post-2010) (metyrapol) | Studies (metyrapone) | Trials (metyrapone) | Recent Studies (post-2010) (metyrapone) |
|---|---|---|---|---|---|
| 18 | 0 | 1 | 3,415 | 128 | 250 |
| Protein | Taxonomy | metyrapol (IC50) | metyrapone (IC50) |
|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | 4.8 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2.8659 | |
| Cytochrome P450 2C8 | Homo sapiens (human) | 5 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 4.6 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 7.83 | |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | 4.7357 | |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | 0.0181 | |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | 0.0838 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Counsell, RE; Napoli, JL | 1 |
| Beierwaltes, WH; Gildersleeve, DL; Hays, SJ; Tobes, MC; Wieland, DM | 1 |
| Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM | 1 |
| Atucha, E; Berger, ML; Hammerschmidt, F; Sieghart, W; Zolle, I | 1 |
| Gebel, T; Maser, E | 1 |
| Gebel, T; Maser, E; Netter, KJ | 1 |
| Maser, E; Netter, KJ | 1 |
| Damani, LA; Usansky, JI | 1 |
| Legrum, W; Maser, E | 1 |
| Lunardi, J; Satre, M; Vignais, PV | 1 |
| Chiarotto, JA; Wainer, IW | 1 |
| Havlícek, V; Pospísil, S; Sedmera, P; Tax, J | 1 |
| Asada, S; Fukuyama, Y; Horisaka, E; Iwakawa, S; Maetani, K; Matsuzawa, R; Nagamine, S | 1 |
| Cass, QB; Cassiano, NM; Degani, AL; Wainer, IW | 1 |
| Budziszewska, B; Chocyk, A; Grzegorzewska, M; Hess, G; Maćkowiak, M; Wedzony, K | 1 |
| Higuchi, T; Murata, H; Otagiri, M | 1 |
16 other study(ies) available for metyrapol and metyrapone
| Article | Year |
|---|---|
New inhibitors of steroid 11beta-hydroxylase. Structure--activity relationship studies of metyrapone-like compounds.
Topics: Adrenal Cortex; Animals; Cattle; Corticosterone; Desoxycorticosterone; In Vitro Techniques; Kinetics; Metyrapone; Mitochondria; Steroid Hydroxylases; Structure-Activity Relationship | 1977 |
Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues.
Topics: Adrenal Cortex; Animals; Cattle; Cytochrome P-450 Enzyme System; Indicators and Reagents; Kinetics; Metyrapone; Mitochondria; Steroid 11-beta-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship | 1984 |
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2008 |
Structure-activity relationship of etomidate derivatives at the GABA(A) receptor: Comparison with binding to 11beta-hydroxylase.
Topics: Anesthetics, Intravenous; Animals; Binding Sites; Chemistry, Pharmaceutical; Drug Design; Etomidate; Inhibitory Concentration 50; Male; Models, Chemical; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2009 |
Characterization of carbonyl reducing activity in continuous cell lines of human and rodent origin.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cytosol; Humans; Metyrapone; Microsomes; NADP; Quercetin; Rodentia; Subcellular Fractions | 1992 |
Carbonyl reduction of metyrapone in human liver.
Topics: Alcohol Oxidoreductases; Dicumarol; Dihydrotestosterone; Female; Humans; Immune Sera; Immunoblotting; Indomethacin; Liver; Male; Metyrapone; Oxidation-Reduction; Quercetin; Subcellular Fractions | 1991 |
Reductive metabolism of metyrapone by a quercitrin-sensitive ketone reductase in mouse liver cytosol.
Topics: Alcohol Oxidoreductases; Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytosol; Immunoblotting; Liver; Metyrapone; Mice; Microsomes, Liver; Oxidation-Reduction; Quercetin | 1991 |
Assay of metyrapone, metyrapol and the isomeric mono-N-oxides of metyrapone in biological fluids by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Isomerism; Male; Metyrapone; Oxides; Rats; Rats, Inbred Strains | 1991 |
Alteration of the inhibitory effect of metyrapone by reduction to metyrapol during the metabolism of methacetin in vivo in mice.
Topics: 7-Alkoxycoumarin O-Dealkylase; Acetamides; Animals; Breath Tests; Carbon Dioxide; Chromatography, High Pressure Liquid; Female; In Vitro Techniques; Liver; Metyrapone; Mice; Microsomes, Liver; Oxidation-Reduction; Oxygenases | 1985 |
( 3 H)metyrapol as a tool for studies of interactions of deoxycorticosterone with adrenal cortex mitochondria.
Topics: Adrenal Glands; Androstenes; Animals; Binding Sites; Binding, Competitive; Borohydrides; Carbon Monoxide; Cattle; Chemical Phenomena; Chemistry; Desoxycorticosterone; Hydroxylation; Ketosteroids; Kinetics; Metyrapone; Mitochondria; Oxygen Consumption; Sulfites; Tritium | 1972 |
Determination of metyrapone and the enantiomers of its chiral metabolite metyrapol in human plasma and urine using coupled achiral-chiral liquid chromatography.
Topics: Chromatography, Liquid; Humans; Metyrapone; Reproducibility of Results; Spectrophotometry, Ultraviolet; Stereoisomerism | 1995 |
Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.
Topics: Anti-Bacterial Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metyrapone; Monensin; Pyridines; Streptomyces | 1994 |
Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11 beta-hydroxylase in the rat.
Topics: Adrenal Glands; Animals; Enzyme Inhibitors; Male; Metyrapone; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase | 1997 |
Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Metyrapone; Stereoisomerism | 2002 |
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Corticosterone; Dentate Gyrus; Dopamine Uptake Inhibitors; Down-Regulation; Ki-67 Antigen; Long-Term Potentiation; Male; Memory; Memory Disorders; Metyrapone; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Cell Adhesion Molecule L1; Neurons; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sialic Acids; Spironolactone | 2008 |
Oral pharmacokinetics and in-vitro metabolism of metyrapone in male rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Alcohol Oxidoreductases; Animals; Chromatography, High Pressure Liquid; Cytosol; Humans; Liver; Male; Metyrapone; Microsomes, Liver; Rats, Wistar | 2016 |