Page last updated: 2024-09-04

metyrapol and etomidate

metyrapol has been researched along with etomidate in 2 studies

Compound Research Comparison

Studies
(metyrapol)
Trials
(metyrapol)
Recent Studies (post-2010)
(metyrapol)
Studies
(etomidate)
Trials
(etomidate)
Recent Studies (post-2010) (etomidate)
18012,071401576

Protein Interaction Comparison

ProteinTaxonomymetyrapol (IC50)etomidate (IC50)
Cytochrome P450 11B1, mitochondrialHomo sapiens (human)0.0005
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.0009

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM1
Atucha, E; Berger, ML; Hammerschmidt, F; Sieghart, W; Zolle, I1

Other Studies

2 other study(ies) available for metyrapol and etomidate

ArticleYear
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship

2008
Structure-activity relationship of etomidate derivatives at the GABA(A) receptor: Comparison with binding to 11beta-hydroxylase.
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Anesthetics, Intravenous; Animals; Binding Sites; Chemistry, Pharmaceutical; Drug Design; Etomidate; Inhibitory Concentration 50; Male; Models, Chemical; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship

2009