metribolone and diphenyleneiodonium

metribolone has been researched along with diphenyleneiodonium* in 1 studies

Other Studies

1 other study(ies) available for metribolone and diphenyleneiodonium

Article	Year
Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase. Prostate cancer and prostatic diseases, 2010, Volume: 13, Issue:1 Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22(phox) and gp91(phox) subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation. Topics: Acetophenones; Acetylcysteine; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Humans; Male; Membrane Glycoproteins; Metribolone; Mice; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Neoplasm Transplantation; Nitriles; Onium Compounds; Oxidative Stress; Prostatic Neoplasms; Radiation-Sensitizing Agents; Reactive Oxygen Species; Tosyl Compounds	2010

Article

Year

Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase.

Prostate cancer and prostatic diseases, 2010, Volume: 13, Issue:1

Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22(phox) and gp91(phox) subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation.

Topics: Acetophenones; Acetylcysteine; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Humans; Male; Membrane Glycoproteins; Metribolone; Mice; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Neoplasm Transplantation; Nitriles; Onium Compounds; Oxidative Stress; Prostatic Neoplasms; Radiation-Sensitizing Agents; Reactive Oxygen Species; Tosyl Compounds

2010