metoprolol and doxazosin

metoprolol has been researched along with doxazosin in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's2 (12.50)18.2507
2000's9 (56.25)29.6817
2010's4 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Funakoshi, J; Kakumoto, M; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cox, DA; Leader, JP; Milson, JA; Singleton, W1
Buchholz, C; Freudenberger, R; Kalman, J; Kukin, ML; Mannino, M; Ocampo, O1
Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H1
Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T1
Clark, AL; Cleland, JG; Nikitin, NP; Thackray, SD; Witte, KK1
Acikel, C; Caglar, K; Celik, T; Eyileten, T; Oguz, Y; Sonmez, A; Vural, A; Yavuz, I; Yenicesu, M; Yilmaz, MI1
Davenport, AP; Dhaun, N; Ferro, CJ; Goddard, J; Haynes, WG; Webb, DJ1
Borel Rinkes, IH; Cromheecke, GJ; Scholten, A; Valk, GD; Vriens, MR1
Hamada, N; Hosoda, H; Kamimura, R; Kangawa, K; Kojima, M; Mifune, H; Miyahara, K; Nishi, Y; Nuruki, N; Setoyama, K; Tajiri, Y1

Reviews

1 review(s) available for metoprolol and doxazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

6 trial(s) available for metoprolol and doxazosin

ArticleYear
The antihypertensive effects of doxazosin: a clinical overview.
    British journal of clinical pharmacology, 1986, Volume: 21 Suppl 1

    Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Kinetics; Male; Metoprolol; Middle Aged; Nadolol; Prazosin; Propanolamines; Random Allocation; Risk; Triglycerides

1986
Combined alpha-beta blockade (doxazosin plus metoprolol) compared with beta blockade alone in chronic congestive heart failure.
    The American journal of cardiology, 1996, Mar-01, Volume: 77, Issue:7

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Chronic Disease; Doxazosin; Drug Therapy, Combination; Female; Heart Failure; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Treatment Outcome

1996
Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5

    Topics: Adrenergic Antagonists; Aged; Blood Flow Velocity; Blood Platelets; Blood Pressure; Carbazoles; Carvedilol; Chronic Disease; Cyclic GMP; Double-Blind Method; Doxazosin; Drug Hypersensitivity; Drug Therapy, Combination; Female; Follow-Up Studies; Forearm; Heart Failure; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Nitroglycerin; Propanolamines; Vasodilator Agents

1998
The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Blood Pressure; Cardiac Output, Low; Chronic Disease; Double-Blind Method; Doxazosin; Dyspnea; Exercise; Exercise Test; Forced Expiratory Volume; Heart Rate; Humans; Metoprolol; Middle Aged; Oxygen Consumption; Respiration Disorders

2003
Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome.
    Nephrology (Carlton, Vic.), 2007, Volume: 12, Issue:2

    Topics: Adiponectin; Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Body Mass Index; Calcium Channel Blockers; Doxazosin; Female; Humans; Hypertension; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Metoprolol; Middle Aged; Predictive Value of Tests; Prospective Studies; Ramipril; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan

2007
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:11

    Topics: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Doxazosin; Enalapril; Endothelin Receptor Antagonists; Furosemide; Hemodynamics; Humans; Kidney Failure, Chronic; Male; Metoprolol; Middle Aged; Peptides, Cyclic; Prospective Studies

2007

Other Studies

9 other study(ies) available for metoprolol and doxazosin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Interaction of digoxin with antihypertensive drugs via MDR1.
    Life sciences, 2002, Feb-15, Volume: 70, Issue:13

    Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Drug Interactions; Humans; Time Factors

2002
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
    Immunopharmacology, 2000, Volume: 48, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha

2000
Hemodynamic instability during resection of pheochromocytoma in MEN versus non-MEN patients.
    European journal of endocrinology, 2011, Volume: 165, Issue:1

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Adult; Blood Pressure; Cohort Studies; Doxazosin; Female; Hemodynamics; Humans; Hypertension; Intraoperative Complications; Male; Metoprolol; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Pheochromocytoma; Retrospective Studies

2011
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Doxazosin; Gastric Mucosa; Gene Expression Regulation; Ghrelin; Hypertension; Insulin Resistance; Male; Metoprolol; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; RNA, Messenger; Stomach; Tetrazoles; Time Factors; Vasodilator Agents

2012