metoprine has been researched along with trimetrexate in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Baccanari, DP; Boytos, CM; Caddell, JM; Comley, JC; Friedman, HS; Hunter, RN; Jones, ML; Joyner, SS; Knick, V; Kuyper, LF; Rudolph, SK; Stables, JN; Tansik, RL; Wilson, HR | 1 |
| Griffin, RJ; Grunwaldt, JD; Lambert, PA; Meek, MA; Queener, SF; Robson, C; Schmidt, D | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Assaraf, YG; Borgnia, MJ | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
10 other study(ies) available for metoprine and trimetrexate
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Candidiasis; Cell Division; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Multiple; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Mice, SCID; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Pneumonia, Pneumocystis; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1996 |
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Liver; Lymphoma, Large B-Cell, Diffuse; Mice; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimethamine; Pyrimidines; Quinidine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1993 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |